Patents by Inventor Fritz Stahler
Fritz Stahler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 7737088Abstract: The present invention relates to arrays of biochemical and/or biofunctional elements such as nucleic acids (oligonucleotides, for example) or other biomolecules on a carrier surface and methods of producing such arrays using photoactivation of predetermined areas for synthesis using an illumination matrix that is computer-controlled to generate an exposure pattern. This exposure pattern can be adjusted and monitored by computer using a light sensor matrix, for example a CCD matrix, to allow precise, controlled illumination of specific regions and therefore attachment of array building blocks to those specific regions. The methods and compositions of the invention permit spatially resolved photochemical synthesis of polymer probes on a carrier.Type: GrantFiled: August 27, 1999Date of Patent: June 15, 2010Assignee: Febit Holding GmbHInventors: Cord F. Stähler, Peer F. Stähler, Manfred Müller, Fritz Stähler, Hans Lindner
-
Publication number: 20080214412Abstract: The present invention relates to arrays of biochemical and/or biofunctional elements such as nucleic acids (oligonucleotides, for example) or other biomolecules on a carrier surface and methods of producing such arrays using photoactivation of predetermined areas for synthesis using an illumination matrix that is computer-controlled to generate an exposure pattern. This exposure pattern can be adjusted and monitored by computer using a light sensor matrix, for example a CCD matrix, to allow precise, controlled illumination of specific regions and therefore attachment of array building blocks to those specific regions. The methods and compositions of the invention permit spatially resolved photochemical synthesis of polymer probes on a carrier.Type: ApplicationFiled: January 9, 2008Publication date: September 4, 2008Inventors: Cord F. Stahler, Peer F. Stahler, Manfred Muller, Fritz Stahler, Hans Lindner
-
Publication number: 20070031877Abstract: A method for producing a support for determining analytes. The method comprises the steps of (a) providing a support comprising at least one channel, comprising a conduit having an intake and an outlet for passing fluid from the intake to the outlet, in the support body, (b) passing liquid with building blocks for synthesizing polymeric receptors through the channel or channels of the support body, (c) site- and/or time-specifically immobilizing the receptor building blocks in each case on predetermined positions in the channel or channels by illumination and (d) repeating steps (b) and (c) until the required receptors have been synthesized in each case on the predetermined positions.Type: ApplicationFiled: August 28, 2006Publication date: February 8, 2007Applicant: febit biotech GmbHInventors: Cord Stahler, Peer Stahler, Manfred Muller, Fritz Stahler, Hans Lindner
-
Patent number: 7097974Abstract: A method for producing a support for determining analytes. The method comprises the steps of (a) providing a support comprising at least one channel, comprising a conduit having an intake and an outlet for passing fluid from the intake to the outlet, in the support body, (b) passing liquid with building blocks for synthesizing polymeric receptors through the channel or channels of the support body, (c) site- and/or time-specifically immobilizing the receptor building blocks in each case on predetermined positions in the channel or channels by illumination and (d) repeating steps (b) and (c) until the required receptors have been synthesized in each case on the predetermined positions.Type: GrantFiled: August 27, 1999Date of Patent: August 29, 2006Assignee: febit biotech GmbHInventors: Cord F. Stähler, Peer F. Stähler, Manfred Müller, Fritz Stähler, Hans Lindner
-
Publication number: 20040175734Abstract: A method for producing a support for determining analytes. The method comprises the steps of (a) providing a support comprising at least one channel, comprising a conduit having an intake and an outlet for passing fluid from the intake to the outlet, in the support body, (b) passing liquid with building blocks for synthesizing polymeric receptors through the channel or channels of the support body, (c) site- and/or time-specifically immobilizing the receptor building blocks in each case on predetermined positions in the channel or channels by illumination and (d) repeating steps (b) and (c) until the required receptors have been synthesized in each case on the predetermined positions.Type: ApplicationFiled: December 5, 2003Publication date: September 9, 2004Applicant: FeBiT Ferrarius Biotechnology GmbHInventors: Cord F. Stahler, Peer F. Stahler, Manfred Miller, Fritz Stahler, Hans Lindner
-
Patent number: 4916078Abstract: The present invention provides a process for carrying out an analytical determination by mixing and incubating a sample solution with at least one reagent and measuring a parameter in the reaction mixture, the sample solution being transported from an application point to a measurement point, wherein a sample solution is first transported to a soluble dry reagent, with at least partial dissolving of the latter, and then further transported to a measurement point, the transport taking place by two different forces, whereby, at least on a part of the transport path, it is brought about by a surface force acting on the solution as a first force, which, for the regulation of the transport velocity or transport direction, is superimposed by a centrifugal force and/or pressure force as a second force which, depending upon which transport state of the fluid is to be adjusted, is made greater or smaller than the first force.Type: GrantFiled: September 3, 1987Date of Patent: April 10, 1990Assignee: Boehringer Mannheim GmbHInventors: Sigmar Klose, Fritz Stahler
-
Patent number: 4898832Abstract: A process for carrying out an analytical determination by mixing and incubating a sample solution with at least one reagent and measuring a parameter in the reaction mixture, the sample solution being transported from an application point to a measurement point, wherein a sample solution is first transported to a soluble dry reagent, with at least partial dissolving of the latter, and then further transported to a measurement point, the transport taking place by two different forces, whereby, at least on a part of the transport path, it is brought about by a surface force acting on the solution as a first force, which, for the regulation of the transport velocity or transport direction, is superimposed by a centrifugal force and/or pressure force as a second force which, depending upon which transport state of the fluid is to be adjusted, is made greater or smaller than the first force.Type: GrantFiled: January 25, 1988Date of Patent: February 6, 1990Assignee: Boehringer Mannheim GmbHInventors: Sigmar Klose, Fritz Stahler
-
Patent number: 4515889Abstract: The present invention provides a process for carrying out analytical determinations by mixing and incubating a sample solution with at least one reagent and optically measuring a parameter in the incubated reaction mixture. The mixing, incubating and measuring are carried out during the action of a centrifugal force which forces the solution through a plurality of interconnected small hollow spaces having flow resistance so adapted with regard to one another as to mix the reaction components. Incubation may also take place before the reaction solution passes from the plurality of interconnected small hollow spaces into a measuring chamber in which the measurement is carried out.Type: GrantFiled: November 20, 1981Date of Patent: May 7, 1985Assignee: Boehringer Mannheim GmbHInventors: Sigmar Klose, Fritz Stahler, Hans Lange, Wolfgang Kleemann
-
Patent number: 4467030Abstract: A method for the determination of the thyroxine-binding index in serum, which method comprises mixing the serum sample to be determined with a defined amount of thyroxine and a defined amount of a determinable enzyme covalently bound to thyroxine, contacting the resulting solution with anti-thyroxine antibodies present in the solid phase, separating the liquid phase from the solid phase, and measuring the activity of said determinable enzyme in one of the phases as a measure of the tyroxine-binding index in said serum sample.Type: GrantFiled: May 15, 1981Date of Patent: August 21, 1984Assignee: Boehringer Mannheim GmbHInventors: Gerd Kleinhammer, Gerlinde Deutsch, Hans-Ralf Linke, Fritz Stahler, Wolfgang Gruber
-
Patent number: 4423227Abstract: Process for the preparation of reactive, couplable derivatives of the thyroid hormones 3,3',5-triiodothyronine (T.sub.3) and 3,3',5,5'-tetraiodothyronine (T.sub.4) by reaction with reactive carboxylic acid derivatives, which process comprises sylylating all the functional groups of the thyroid hormone by reaction with a reactive triorganosylyl derivative and then reacting the persylylated derivative of the thyroid hormone thus obtained with an activated carboxylic acid derivative.Type: GrantFiled: September 30, 1981Date of Patent: December 27, 1983Assignee: Boehringer Mannheim GmbHInventors: Hans-Georg Batz, Winfried Albert, Helmut Lenz, Hans-Ralf Linke, Fritz Stahler
-
Patent number: 4286057Abstract: Creatine kinase is determined by the reaction of creatine phosphate with adenosine diphosphate with the formation of adenosine triphosphate, reaction of the latter with luciferin and oxygen in the presence of luciferase and diadenosine pentaphosphate with the formation of oxyluciferin and adenosine monophosphate, and measurement of the light thereupon emitted, the reaction being performed with a saturated concentration of adenosine diphosphate and substrate, in the presence of 1 to 10 millimoles per liter of AMP at pH values of 5.8 to 7.5, with at least 50 units of luciferase per test. It is desirable to operate in the presence of diadenosine pentaphosphate or sodium fluoride and a sequestering agent.Type: GrantFiled: February 28, 1980Date of Patent: August 25, 1981Assignee: Boehringer Mannheim GmbHInventors: Karl Wulff, Fritz Stahler, Wolfgang Gruber
-
Patent number: 4278760Abstract: A method for the quantitative determination of an oxidized pyridine co-enzyme which comprises reacting a sample containing oxidized pyridine co-enzyme in the presence of its specific alcohol dehydrogenase with an aliphatic alcohol of 8 to 16 carbon atoms, oxidizing the aldehyde formed with reduced flavine mononucleotide and oxygen in the presence of luciferase and of the particular FMN-reductase which is independent of the co-enzyme to be determined and of the reduced substrate co-enzyme of the latter, and measuring the resulting light emission as a measure of the initial oxidized pyridine co-enzyme content.Type: GrantFiled: July 19, 1979Date of Patent: July 14, 1981Assignee: Boehringer Mannheim GmbHInventors: Karl Wulff, Fritz Stahler, Gerhard Michal
-
Patent number: 4276376Abstract: Control serum containing a defined content of creatine kinase comprising exogeneous creatine kinase in the form of swine serum and optionally additionally comprising human serum, other animal serum or serum albumin; and/or other enzyme substrates and metabolites occurring in serum.Type: GrantFiled: July 16, 1979Date of Patent: June 30, 1981Assignee: Boehringer Mannheim GmbHInventors: Dieter Hundt, Marianne Sedelmeyer, Peter Roschlau, Fritz Stahler, Wolfgang Gruber
-
Patent number: 4049702Abstract: .gamma.-Glutamyl-4-nitroanilide compounds of the formula ##STR1## wherein R is a .gamma.-glutamyl radical and X is an acid group, and salts of such compounds, are used to determine .gamma.-glutamyl-transpeptidase by contacting a sample suspected of containing .gamma.-glutamyltranspeptidase with said compound and glycylglycine and determining the liberation of the resulting p-nitro-aniline compound as a measure of the .gamma.-glutamyltranspeptidase activity initially present in the sample.Type: GrantFiled: June 23, 1975Date of Patent: September 20, 1977Assignee: Boehringer Mannheim G.m.b.H.Inventors: Erich Bernt, Wolfgang Gruber, Erich Haid, Fritz Stahler, August Wilhelm Wahlefeld, Gunter Weimann
-
Patent number: 3986931Abstract: .gamma.-Glutamyl-4-nitroanilide compounds of the formula ##SPC1##Wherein R is a .gamma.-glutamyl radical and X is an acid group, and salts of such compounds, are used to determine .gamma.-glutamyltranspeptidase by contacting a sample suspected of containing .gamma.-glutamyltranspeptidase with said compound and glycyl-glycine and determining the liberation of the resulting p-nitroaniline compound as a measure of the .gamma.-glutamyltranspeptidase activity initially present in the sample.Type: GrantFiled: August 4, 1975Date of Patent: October 19, 1976Assignee: Boehringer Mannheim G.m.b.H.Inventors: Erich Bernt, Wolfgang Gruber, Erich Haid, Fritz Stahler, August Wilhelm Wahlefeld, Gunter Weimann
-
Patent number: 3979447Abstract: .gamma.-Glutamyl-4-nitroanilide compounds of the formula ##SPC1##Wherein R is a .gamma.-glutamyl radical and X is an acid group, and salts of such compounds, are used to determine .gamma.-glutamyltranspeptidase by contacting a sample suspected of containing .gamma.-glutamyltranspeptidase with said compound and glycylglycine and determining the liberation of the resulting p-nitroaniline compound as a measure of the .gamma.-glutamyltranspeptidase activity initially present in the sample.Type: GrantFiled: November 27, 1973Date of Patent: September 7, 1976Assignee: Boehringer Mannheim G.m.b.H.Inventors: Erich Bernt, Wolfgang Gruber, Erich Haid, Fritz Stahler, August Wilhelm Wahlefeld, Gunter Weimann