Patents by Inventor Fumihiko Urano

Fumihiko Urano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11129871
    Abstract: Among the various aspects of the present disclosure is the provision of methods and compositions to treat or prevent an endoplasmic reticulum (ER) stress-mediated kidney disease in a subject, the method comprising administering to the subject a pharmaceutical composition comprising a therapeutically effective amount of an ER calcium channel stabilizing agent or an ER stress modulating agent (e.g., mesencephalic astrocyte-derived neurotrophic factor (MANF), compound K201).
    Type: Grant
    Filed: June 19, 2019
    Date of Patent: September 28, 2021
    Assignee: Washington University
    Inventors: Ying Chen, Fumihiko Urano, Yeawon Kim, Sun-Ji Park
  • Publication number: 20210128580
    Abstract: The present invention generally relates to compositions and methods for treating or preventing an endoplasmic reticulum stress disorder in subjects, including compositions and methods for treating or preventing Wolfram syndrome. The present invention also relates to methods for treating symptoms of neurodegenerative diseases.
    Type: Application
    Filed: March 6, 2018
    Publication date: May 6, 2021
    Applicants: Washington University, The United States of America, As Represented by the Secretary, Department Health and Human Service
    Inventors: Fumihiko Urano, Jana Mahadevan, Amy Clark, Ajit Jadhav, David Maloney, Brandon Harvey, Shyh-ming Yang, Mark Henderson
  • Patent number: 10845371
    Abstract: The invention provides, in part, methods for diagnosing a pancreatic ?-cell disorder, predicting a subject's risk of developing a pancreatic ?-cell disorder, monitoring pancreatic ?-cell function or pancreatic ?-cell mass in a subject at risk of developing a pancreatic ?-cell disorder, monitoring efficacy of a treatment of a pancreatic ?-cell disorder in a subject, identifying a subject having an increased risk of developing a pancreatic ?-cell disorder, selecting a subject for treatment of a pancreatic ?-cell disorder, selecting a subject for participation in a clinical study, and detecting endoplasmic reticulum stress in a pancreatic ?-cell. These methods include determining at least one level of soluble mesencephalic astrocyte-derived neurotrophic factor (MANF) in a biological sample from the subject. Also provided are pharmaceutical compositions containing a soluble MANF protein and kits containing an antibody or an antigen-binding antibod fragment that binds specifically to a soluble MANF.
    Type: Grant
    Filed: February 12, 2018
    Date of Patent: November 24, 2020
    Assignee: University of Massachusetts
    Inventors: Fumihiko Urano, Kohsuke Kanekura
  • Patent number: 10695324
    Abstract: The present invention generally relates to a method of treating or preventing an endoplasmic reticulum stress disorder in subjects, such as a method of treating or preventing Wolfram syndrome.
    Type: Grant
    Filed: September 30, 2019
    Date of Patent: June 30, 2020
    Assignee: Washington University
    Inventors: Fumihiko Urano, Simin Lu
  • Publication number: 20200030294
    Abstract: The present invention generally relates to a method of treating or preventing an endoplasmic reticulum stress disorder in subjects, such as a method of treating or preventing Wolfram syndrome.
    Type: Application
    Filed: September 30, 2019
    Publication date: January 30, 2020
    Applicant: Washington University
    Inventors: Fumihiko Urano, Simin Lu
  • Patent number: 10441574
    Abstract: The present invention generally relates to a method of treating or preventing an endoplasmic reticulum stress disorder in subjects, such as a method of treating or preventing Wolfram syndrome.
    Type: Grant
    Filed: November 13, 2015
    Date of Patent: October 15, 2019
    Assignee: Washington University
    Inventors: Fumihiko Urano, Simin Lu
  • Publication number: 20180321255
    Abstract: The invention provides, in part, methods for diagnosing a pancreatic ?-cell disorder, predicting a subject's risk of developing a pancreatic ?-cell disorder, monitoring pancreatic ?-cell function or pancreatic ?-cell mass in a subject at risk of developing a pancreatic ?-cell disorder, monitoring efficacy of a treatment of a pancreatic ?-cell disorder in a subject, identifying a subject having an increased risk of developing a pancreatic ?-cell disorder, selecting a subject for treatment of a pancreatic ?-cell disorder, selecting a subject for participation in a clinical study, and detecting endoplasmic reticulum stress in a pancreatic ?-cell. These methods include determining at least one level of soluble mesencephalic astrocyte-derived neurotrophic factor (MANF) in a biological sample from the subject. Also provided are pharmaceutical compositions containing a soluble MANF protein and kits containing an antibody or an antigen-binding antibod fragment that binds specifically to a soluble MANF.
    Type: Application
    Filed: February 12, 2018
    Publication date: November 8, 2018
    Inventors: Fumihiko Urano, Kohsuke Kanekura
  • Publication number: 20180214416
    Abstract: The present invention generally relates to a method of treating or preventing an endoplasmic reticulum stress disorder in subjects, such as a method of treating or preventing Wolfram syndrome.
    Type: Application
    Filed: November 13, 2015
    Publication date: August 2, 2018
    Applicant: Washington University
    Inventors: Fumihiko URANO, Simin LU
  • Patent number: 9891231
    Abstract: The invention provides, in part, methods for diagnosing a pancreatic ?-cell disorder, predicting a subject's risk of developing a pancreatic ?-cell disorder, monitoring pancreatic ?-cell function or pancreatic ?-cell mass in a subject at risk of developing a pancreatic ?-cell disorder, monitoring efficacy of a treatment of a pancreatic ?-cell disorder in a subject, identifying a subject having an increased risk of developing a pancreatic ?-cell disorder, selecting a subject for treatment of a pancreatic ?-cell disorder, selecting a subject for participation in a clinical study, and detecting endoplasmic reticulum stress in a pancreatic ?-cell. These methods include determining at least one level of soluble mesencephalic astrocyte-derived neurotrophic factor (MANF) in a biological sample from the subject. Also provided are pharmaceutical compositions containing a soluble MANF protein and kits containing an antibody or an antigen-binding antibod fragment that binds specifically to a soluble MANF.
    Type: Grant
    Filed: January 23, 2013
    Date of Patent: February 13, 2018
    Assignee: University of Massachusetts
    Inventors: Fumihiko Urano, Kohsuke Kanekura
  • Publication number: 20150198613
    Abstract: The invention provides, in part, methods for diagnosing a pancreatic ?-cell disorder, predicting a subject's risk of developing a pancreatic ?-cell disorder, monitoring pancreatic ?-cell function or pancreatic ?-cell mass in a subject at risk of developing a pancreatic ?-cell disorder, monitoring efficacy of a treatment of a pancreatic ?-cell disorder in a subject, identifying a subject having an increased risk of developing a pancreatic ?-cell disorder, selecting a subject for treatment of a pancreatic ?-cell disorder, selecting a subject for participation in a clinical study, and detecting endoplasmic reticulum stress in a pancreatic ?-cell. These methods include determining at least one level of soluble mesencephalic astrocyte-derived neurotrophic factor (MANF) in a biological sample from the subject. Also provided are pharmaceutical compositions containing a soluble MANF protein and kits containing an antibody or an antigen-binding antibod fragment that binds specifically to a soluble MANF.
    Type: Application
    Filed: January 23, 2013
    Publication date: July 16, 2015
    Inventors: Fumihiko Urano, Kohsuke Kanekura
  • Publication number: 20100221743
    Abstract: The present invention provides methods and reagents to quantify endoplasmic reticulum stress (ER stress) levels, and methods and compounds for treating ER stress disorders such as diabetes. Methods for quantifying ER stress in mammalian cells are exemplified.
    Type: Application
    Filed: March 5, 2010
    Publication date: September 2, 2010
    Applicant: UNIVERSITY OF MASSACHUSETTS
    Inventor: Fumihiko Urano
  • Publication number: 20090281040
    Abstract: The present invention provides methods for treating ER stress disorders and for identifying compounds for treating ER stress disorders.
    Type: Application
    Filed: May 8, 2009
    Publication date: November 12, 2009
    Inventors: Fumihiko Urano, Shinsuke Ishigaki, Sonya G. Fonesca
  • Publication number: 20070202544
    Abstract: The present invention provides methods and reagents to quantify endoplasmic reticulum stress (ER stress) levels, and methods and compounds for treating ER stress disorders such as diabetes. Methods for quantifying ER stress in mammalian cells are exemplified.
    Type: Application
    Filed: October 12, 2004
    Publication date: August 30, 2007
    Inventor: Fumihiko Urano