Patents by Inventor Fumio Nakamura

Fumio Nakamura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210095012
    Abstract: The present invention mainly addresses the problem of providing an antibody against semaphorin 3A protein, said antibody enabling effective prevention and/or treatment of a disease, in which Sema 3A protein participates, such as a neurodegenerative disease, autoimmune disease, inflammatory disease, cancer, infectious disease, etc. or disseminated intravascular coagulation syndrome. An anti-Sema 3A antibody comprising CDRs having specific amino acid sequences (SEQ ID NOS: 1-6, 60-62, 64-66, 68-70, 72-74, 76-78, 80-82, 84-86 and 88-90) enables effective prevention and/or treatment of a disease, in which Sema 3A protein participates, such as a neurodegenerative disease, autoimmune disease, inflammatory disease, cancer, infectious disease, etc. or disseminated intravascular coagulation syndrome and, therefore, remarkably ameliorates symptoms associated with such a disease.
    Type: Application
    Filed: October 7, 2020
    Publication date: April 1, 2021
    Inventors: Yoshio Goshima, Fumio Nakamura, Naoya Yamashita, Hidetaka Seo, Shuichi Hashimoto, Koji Murakami, Naoki Takahash, Yukie Sasakura
  • Patent number: 10836814
    Abstract: The present invention mainly addresses the problem of providing an antibody against semaphorin 3A protein, said antibody enabling effective prevention and/or treatment of a disease, in which Sema 3A protein participates, such as a neurodegenerative disease, autoimmune disease, inflammatory disease, cancer, infectious disease, etc. or disseminated intravascular coagulation syndrome. An anti-Sema 3A antibody comprising CDRs having specific amino acid sequences (SEQ ID NOS: 1-6, 60-62, 64-66, 68-70, 72-74, 76-78, 80-82, 84-86 and 88-90) enables effective prevention and/or treatment of a disease, in which Sema 3A protein participates, such as a neurodegenerative disease, autoimmune disease, inflammatory disease, cancer, infectious disease, etc. or disseminated intravascular coagulation syndrome and, therefore, remarkably ameliorates symptoms associated with such a disease.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: November 17, 2020
    Assignees: YOKOHAMA CITY UNIVERSITY, CHIOME BEOSCIENCE INC.
    Inventors: Yoshio Goshima, Fumio Nakamura, Naoya Yamashita, Hidetaka Seo, Shuichi Hashimoto, Koji Murakami, Naoki Takahashi, Yukie Sasakura
  • Patent number: 10443085
    Abstract: Disclosed is a method for detecting a nucleic acid using a substance that suppresses, in the labeling step of the post-staining method, detachment of a target nucleic acid that has once hybridized with a capture probe immobilized on a support, which method enables detection of the target nucleic acid with a sensitivity equivalent to or higher than that achieved by a method using sodium ion even in cases where the substance is used at a lower concentration. The method for detecting a nucleic acid comprises the steps of: (1) hybridizing a capture probe with a target nucleic acid to form a double-stranded nucleic acid; bringing the formed double-stranded nucleic acid into contact with a solution containing a labeling substance and a divalent metal cation at a concentration of not less than 10 mM to introduce the labeling substance into the double-stranded nucleic acid; and detecting the labeling substance introduced into the double-stranded nucleic acid.
    Type: Grant
    Filed: June 19, 2013
    Date of Patent: October 15, 2019
    Assignee: TORAY INDUSTRIES, INC.
    Inventors: Fumio Nakamura, Yoji Ueda, Takafumi Arike
  • Publication number: 20190187797
    Abstract: In a display manipulation apparatus, a boundary line is defined around a detection target image to partition an inner area and an outer area. Under tracing manipulation in which a finger is moved continuously to trace two or more detection target images, in response to that a moving speed of the finger is equal to or less than a predetermined speed, a control circuit controls a vibration generator to be in an actuated state each time the finger passes through a position of the boundary line, whereas in response to that the moving speed is greater than the predetermined speed, the control circuit controls the vibration generator to be in a de-actuated state either (i) when the finger passes through a position of the boundary line and enters the inner area, or (ii) when the finger passes through a position of the boundary line and exits to the outer area.
    Type: Application
    Filed: June 15, 2017
    Publication date: June 20, 2019
    Inventor: Fumio NAKAMURA
  • Publication number: 20180208644
    Abstract: The present invention mainly addresses the problem of providing an antibody against semaphorin 3A protein, said antibody enabling effective prevention and/or treatment of a disease, in which Sema 3A protein participates, such as a neurodegenerative disease, autoimmune disease, inflammatory disease, cancer, infectious disease, etc. or disseminated intravascular coagulation syndrome. An anti-Sema 3A antibody comprising CDRs having specific amino acid sequences (SEQ ID NOS: 1-6, 60-62, 64-66, 68-70, 72-74, 76-78, 80-82, 84-86 and 88-90) enables effective prevention and/or treatment of a disease, in which Sema 3A protein participates, such as a neurodegenerative disease, autoimmune disease, inflammatory disease, cancer, infectious disease, etc. or disseminated intravascular coagulation syndrome and, therefore, remarkably ameliorates symptoms associated with such a disease.
    Type: Application
    Filed: December 19, 2017
    Publication date: July 26, 2018
    Inventors: Yoshio Goshima, Fumio Nakamura, Naoya Yamashita, Hidetaka Seo, Shuichi Hashimoto, Koji Murakami, Naoki Takahashi, Yukie Sasakura
  • Patent number: 9879075
    Abstract: The present invention mainly addresses the problem of providing an antibody against semaphorin 3A protein, said antibody enabling effective prevention and/or treatment of a disease, in which Sema 3A protein participates, such as a neurodegenerative disease, autoimmune disease, inflammatory disease, cancer, infectious disease, etc. or disseminated intravascular coagulation syndrome. An anti-Sema 3A antibody comprising CDRs having specific amino acid sequences (SEQ ID NOS: 1-6, 60-62, 64-66, 68-70, 72-74, 76-78, 80-82, 84-86 and 88-90) enables effective prevention and/or treatment of a disease, in which Sema 3A protein participates, such as a neurodegenerative disease, autoimmune disease, inflammatory disease, cancer, infectious disease, etc. or disseminated intravascular coagulation syndrome and, therefore, remarkably ameliorates symptoms associated with such a disease.
    Type: Grant
    Filed: February 6, 2014
    Date of Patent: January 30, 2018
    Assignee: Yokohama City University and Chiome Bioscience Inc.
    Inventors: Yoshio Goshima, Fumio Nakamura, Naoya Yamashita, Hidetaka Seo, Shuichi Hashimoto, Koji Murakami, Naoki Takahashi, Yukie Sasakura
  • Patent number: 9416403
    Abstract: A method of detecting a target nucleic acid by sandwich hybridization using a detection probe that hybridizes with the target nucleic acid, and a capture probe immobilized on a support wherein at least one nucleic acid base in the nucleic acid molecule(s) of the detection probe and/or capture probe with a photoreactive group includes irradiating, with light, a complex formed by hybridization between the target nucleic acid and the detection probe and/or capture probe to allow formation of a covalent bond(s) between the photoreactive group(s) and a nucleic acid base(s) in the target nucleic acid.
    Type: Grant
    Filed: August 29, 2013
    Date of Patent: August 16, 2016
    Assignee: Toray Industries, Inc.
    Inventors: Taisuke Hirano, Fumio Nakamura, Yoji Ueda, Kenzo Fujimoto
  • Patent number: 9358518
    Abstract: A support carrying an immobilized selective binding substance, that the support surface has a polymer containing the structural unit represented by the following General Formula (1) in an amount of 10% or more with respect all monomer units, and a selective binding substance is immobilized on the support surface by binding to the carboxyl group formed thereon via a covalent bond: (in General Formula (1), R1, R2, and R3 each represent an alkyl or aryl group or a hydrogen atom.
    Type: Grant
    Filed: July 28, 2010
    Date of Patent: June 7, 2016
    Assignee: Toray Industries, Inc.
    Inventors: Kunihisa Nagino, Fumio Nakamura, Hitoshi Nobumasa
  • Patent number: 9342055
    Abstract: Provided is an electronic watch capable of surely acquiring a movement start position and a stop position of a hand when the hand moves at high speed such as a case of manual correction by a winding stem or the like, while reducing a load on a CPU. The electronic watch includes: a decode circuit for outputting data corresponding to regions acquired by segmenting a movement range of the hand; and a position information circuit for automatically acquiring region data corresponding to the movement start position of the hand and region data corresponding to the stop position thereof and sending a notification to the CPU when acquiring both the data. In this manner, the CPU can stop until the acquisition of both the data, thereby reducing the load on the CPU.
    Type: Grant
    Filed: May 17, 2012
    Date of Patent: May 17, 2016
    Assignees: CITIZEN HOLDINGS CO., LTD., CITIZEN WATCH CO., LTD.
    Inventors: Tsuneharu Kasai, Masahiro Mamiya, Michihiro Enokida, Tetsuro Maruyama, Fumio Nakamura
  • Patent number: 9333478
    Abstract: A support carrying an immobilized selective binding substance, that the support surface has a polymer containing the structural unit represented by the following General Formula (1) in an amount of 10% or more with respect all monomer units, and a selective binding substance is immobilized on the support surface by binding to the carboxyl group formed thereon via a covalent bond: (in General Formula (1), R1, R2, and R3 each represent an alkyl or aryl group or a hydrogen atom.
    Type: Grant
    Filed: July 28, 2010
    Date of Patent: May 10, 2016
    Assignee: Toray Industries, Inc.
    Inventors: Kunihisa Nagino, Fumio Nakamura, Hitoshi Nobumasa
  • Publication number: 20150368327
    Abstract: The present invention mainly addresses the problem of providing an antibody against semaphorin 3A protein, said antibody enabling effective prevention and/or treatment of a disease, in which Sema 3A protein participates, such as a neurodegenerative disease, autoimmune disease, inflammatory disease, cancer, infectious disease, etc. or disseminated intravascular coagulation syndrome. An anti-Sema 3A antibody comprising CDRs having specific amino acid sequences (SEQ ID NOS: 1-6, 60-62, 64-66, 68-70, 72-74, 76-78, 80-82, 84-86 and 88-90) enables effective prevention and/or treatment of a disease, in which Sema 3A protein participates, such as a neurodegenerative disease, autoimmune disease, inflammatory disease, cancer, infectious disease, etc. or disseminated intravascular coagulation syndrome and, therefore, remarkably ameliorates symptoms associated with such a disease.
    Type: Application
    Filed: February 6, 2014
    Publication date: December 24, 2015
    Inventors: Yoshio Goshima, Fumio Nakamura, Naoya Yamashita, Hidetaka Seo, Shuichi Hashimoto, Koji Murakami, Naoki Takahashi, Yukie Sasakura
  • Publication number: 20150322483
    Abstract: Disclosed is a method for detecting a nucleic acid using a substance that suppresses, in the labeling step of the post-staining method, detachment of a target nucleic acid that has once hybridized with a capture probe immobilized on a support, which method enables detection of the target nucleic acid with a sensitivity equivalent to or higher than that achieved by a method using sodium ion even in cases where the substance is used at a lower concentration. The method for detecting a nucleic acid comprises the steps of: (1) hybridizing a capture probe with a target nucleic acid to form a double-stranded nucleic acid; bringing the formed double-stranded nucleic acid into contact with a solution containing a labeling substance and a divalent metal cation at a concentration of not less than 10 mM to introduce the labeling substance into the double-stranded nucleic acid; and detecting the labeling substance introduced into the double-stranded nucleic acid.
    Type: Application
    Filed: June 19, 2013
    Publication date: November 12, 2015
    Applicant: TORAY INDUSTRIES, INC.
    Inventors: Fumio NAKAMURA, Yoji UEDA, Takafumi ARIKE
  • Publication number: 20150240296
    Abstract: A method of detecting a target nucleic acid by sandwich hybridization using a detection probe that hybridizes with the target nucleic acid, and a capture probe immobilized on a support wherein at least one nucleic acid base in the nucleic acid molecule(s) of the detection probe and/or capture probe with a photoreactive group includes irradiating, with light, a complex formed by hybridization between the target nucleic acid and the detection probe and/or capture probe to allow formation of a covalent bond(s) between the photoreactive group(s) and a nucleic acid base(s) in the target nucleic acid.
    Type: Application
    Filed: August 29, 2013
    Publication date: August 27, 2015
    Inventors: Taisuke Hirano, Fumio Nakamura, Yoji Ueda, Kenzo Fujimoto
  • Publication number: 20150045249
    Abstract: A method detects nucleic acid with high sensitivity even when the target nucleic acid is detected by sandwich hybridization using neither nucleic acid amplification nor a sensitization technique. The method includes sequentially or simultaneously bringing a target nucleic acid or fragmentation product thereof, a plurality of detection probes, and a capture probe immobilized on a support, into contact with each other to hybridize the capture probe with the target nucleic acid or fragmentation product thereof and to hybridize the target nucleic acid or fragmentation product thereof with the plurality of detection probes, thereby binding the plurality of detection probes to the support through the capture probe and the target nucleic acid or fragmentation product thereof; and then detecting the plurality of detection probes bound to the support.
    Type: Application
    Filed: February 27, 2013
    Publication date: February 12, 2015
    Inventors: Yoji Ueda, Fumio Nakamura
  • Publication number: 20140086023
    Abstract: Provided is an electronic watch capable of surely acquiring a movement start position and a stop position of a hand when the hand moves at high speed such as a case of manual correction by a winding stem or the like, while reducing a load on a CPU. The electronic watch includes: a decode circuit for outputting data corresponding to regions acquired by segmenting a movement range of the hand; and a position information circuit for automatically acquiring region data corresponding to the movement start position of the hand and region data corresponding to the stop position thereof and sending a notification to the CPU when acquiring both the data. In this manner, the CPU can stop until the acquisition of both the data, thereby reducing the load on the CPU.
    Type: Application
    Filed: May 17, 2012
    Publication date: March 27, 2014
    Applicants: CITIZEN WATCH CO., LTD., CITIZEN HOLDINGS CO., LTD.
    Inventors: Tsuneharu Kasai, Masahiro Mamiya, Michihiro Enokida, Tetsuro Maruyama, Fumio Nakamura
  • Patent number: 8298832
    Abstract: The method of stirring a solution according to the present invention is a method of stirring a solution comprising contacting a selective binding substance immobilized on the surface of a carrier with a solution containing an analyte substance reactive with the selective binding substance, and mixing the fine particles or air bubbles into the solution containing an analyte substance, and moving the fine particles or air bubbles without allowing contact thereof with the selective binding substance-immobilized surface. The present invention provides a stirring method that accelerates the reaction of a carrier-immobilized selective binding substance with an analyte substance and detects a trace amount of analyte at high signal intensity and high S/N ratio. The present invention enables diagnosis and examination in the clinical setting by using a selective binding substance-immobilized carrier such as DNA chip.
    Type: Grant
    Filed: March 17, 2005
    Date of Patent: October 30, 2012
    Assignee: Toray Industries, Inc.
    Inventors: Yuki Takii, Kunihisa Nagino, Fumio Nakamura, Hitoshi Nobumasa
  • Patent number: 8252113
    Abstract: The object of this invention is to provide a method for producing a component for vacuum apparatus and a resin coating forming apparatus capable of easily forming a resin coating on an internal flow path complex in shape. The resin coating forming apparatus (21) comprises a monomer vapor supplying unit (23), a vacuum pumping line (24) for transporting monomer vapor, a connection portion (24c) connectable with the internal flow path of a component (22A) provided on part of the vacuum pumping line (24), and a temperature adjusting unit (31) for depositing the monomer vapor onto the internal flow path of the component (22A) connected with the connection portion (24c) to form a resin coating. The above arrangement permits the formation of a uniform, high-coverage resin coating on the internal flow path of the component (22A) by merely exposing the internal flow path to monomer vapor.
    Type: Grant
    Filed: March 23, 2006
    Date of Patent: August 28, 2012
    Assignee: ULVAC, Inc.
    Inventors: Masanobu Hatanaka, Yoshikazu Takahashi, Michio Ishikawa, Fumio Nakamura
  • Publication number: 20120127074
    Abstract: A screen operation system obtains operation information associated with an operation performed by a user with a pointing object relative to a screen of an image display apparatus controlled by an information processing apparatus and causes the information processing apparatus to execute processing associated with the operation information. The screen operation system includes a mobile information apparatus including a camera capturing an image of the screen of the image display apparatus; a display displaying the image captured by the camera; and a communicator communicating information with the information processing apparatus. The camera of the mobile information apparatus captures an image such that the pointing object is displayed overlapping a predetermined position on the screen of the image display apparatus. Based on captured image information obtained thereby, operation information is obtained.
    Type: Application
    Filed: November 15, 2011
    Publication date: May 24, 2012
    Applicant: PANASONIC CORPORATION
    Inventors: Fumio NAKAMURA, Satoru MIYANISHI
  • Publication number: 20110028347
    Abstract: A support carrying an immobilized selective binding substance, that the support surface has a polymer containing the structural unit represented by the following General Formula (1) in an amount of 10% or more with respect all monomer units, and a selective binding substance is immobilized on the support surface by binding to the carboxyl group formed thereon via a covalent bond: (in General Formula (1), R1, R2, and R3 each represent an alkyl or aryl group or a hydrogen atom.
    Type: Application
    Filed: July 28, 2010
    Publication date: February 3, 2011
    Applicant: TORAY INDUSTRIES, INC.
    Inventors: KUNIHISA NAGINO, FUMIO NAKAMURA, HITOSHI NOBUMASA
  • Publication number: 20110015097
    Abstract: A support carrying an immobilized selective binding substance, that the support surface has a polymer containing the structural unit represented by the following General Formula (1) in an amount of 10% or more with respect all monomer units, and a selective binding substance is immobilized on the support surface by binding to the carboxyl group formed thereon via a covalent bond: (in General Formula (1), R1, R2, and R3 each represent an alkyl or aryl group or a hydrogen atom.
    Type: Application
    Filed: July 28, 2010
    Publication date: January 20, 2011
    Applicant: TORAY INDUSTRIES, INC.
    Inventors: KUNIHISA NAGINO, FUMIO NAKAMURA, HITOSHI NOBUMASA