Patents by Inventor Fumio Takagi

Fumio Takagi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20120122160
    Abstract: A thermal cycler includes a holder to which a biotip having a longitudinal direction is attached in such a manner that one end portion of the biotip is at a higher level than the other end portion, and that the distance between one end portion of the biotip and the rotational axis is shorter than the distance between the other end portion of the biotip and the rotational axis, a heating unit heats a first end portion of the biotip, a rotating unit rotates the holder, and a controller that controls the rotation speed of the rotating unit. The controller has a first mode a rotation speed at which the magnitude of the centrifugal force acting on the reaction mixture becomes smaller than the gravity, and a second mode a rotation speed at which the magnitude of the centrifugal force acting on the reaction mixture becomes greater than the gravity.
    Type: Application
    Filed: November 16, 2011
    Publication date: May 17, 2012
    Applicant: SEIKO EPSON CORPORATION
    Inventors: Yuji SAITO, Fumio TAKAGI
  • Patent number: 8092999
    Abstract: A biological sample reaction chip, including: a plurality of reaction containers; a reaction liquid introduction channel having a reaction liquid supply opening at a first end and an evacuation opening at a second end; and a reaction liquid quantifying channel, a third end of which is connected to one of the reaction containers, and a fourth end of which is connected to the reaction liquid introduction channel, wherein an interior of each of the reaction containers is coated with a reagent that is necessary for a reaction.
    Type: Grant
    Filed: January 27, 2009
    Date of Patent: January 10, 2012
    Assignee: Seiko Epson Corporation
    Inventor: Fumio Takagi
  • Patent number: 8021843
    Abstract: A biological sample reaction chip, including: a plurality of reaction vessels; a first channel connected to one end of each of the reaction vessels and comprising an opening for introducing a reaction solution; and a second channel connected to the other end of each of the reaction vessels, wherein when a capillary force of the first channel is defined as A, while a capillary force of connected portions between the reaction vessels and the first channel as B, a capillary force of the reaction vessels as C, a capillary force of connected portions of the second channel and the reaction vessels as D, and a capillary force of the second channel as E, the following is established: A<B<C<D and E<D.
    Type: Grant
    Filed: October 29, 2008
    Date of Patent: September 20, 2011
    Assignee: Seiko Epson Corporation
    Inventor: Fumio Takagi
  • Publication number: 20110183378
    Abstract: A nucleic acid amplification method includes introducing a liquid sample into a first chamber of a chip for use in nucleic acid amplification, the chip including a second chamber containing liquid that has a smaller specific gravity than the liquid sample and is immiscible with the liquid sample, injecting the liquid sample into the second chamber from the first chamber by a centrifugal force, regulating a temperature of an end of the chip, and rotating the chip about a rotation axis at a predetermined speed.
    Type: Application
    Filed: November 30, 2010
    Publication date: July 28, 2011
    Applicant: SEIKO EPSON CORPORATION
    Inventors: Fumio TAKAGI, Hiroshi KOEDA
  • Publication number: 20110139294
    Abstract: A method of filling a liquid sample includes: supplying the liquid sample to a first well of a biochip; adhering a cover and the substrate of the biochip in a loop-shaped area surrounding the first well and plural second wells on the substrate; moving the liquid sample from the first well to the second wells through a space between the cover and the substrate by rotating the biochip around a rotation axis in a state in which the biochip is arranged such that a distance from any one of the second wells to the rotation axis in a vertical direction with respect to the rotation axis is longer than a distance from the first well to the rotation axis in the vertical direction with respect to the rotation axis; and sealing the first well and the second wells by adhering the cover to the substrate to thereby seal.
    Type: Application
    Filed: December 9, 2010
    Publication date: June 16, 2011
    Applicant: SEIKO EPSON CORPORATION
    Inventor: Fumio TAKAGI
  • Patent number: 7919306
    Abstract: A biological sample reaction chip, including: a plurality of reactors disposed on one plane; a reaction fluid distribution channel connected via a microchannel to each reactor and provided on the plane on which the plurality of reactors are disposed; and a reaction fluid movement stopping unit, which is connected to an end point of the reaction fluid distribution channel and is capable of controlling movement of a reaction fluid.
    Type: Grant
    Filed: December 5, 2008
    Date of Patent: April 5, 2011
    Assignee: Seiko Epson Corporation
    Inventor: Fumio Takagi
  • Publication number: 20110065591
    Abstract: A biochip used for quantitative analysis of a target DNA contained in a sample, includes a type I chamber that includes: a primer that is designed to bind to the target DNA; a internal standard DNA of a first amount that has a sequence different from a sequence of the target DNA, and is amplifiable with the primer; and a fluorescent probe that is designed to bind to a part of an PCR product of the target DNA and to a part of an PCR product of the internal standard DNA, and fluoresces differently for the PCR product of the target DNA and the PCR product of the internal standard DNA, and a type II chamber including: the internal standard DNA of a second amount different from the first amount; and the primer and the fluorescent probe.
    Type: Application
    Filed: August 12, 2010
    Publication date: March 17, 2011
    Applicant: SEIKO EPSON CORPORATION
    Inventor: Fumio TAKAGI
  • Patent number: 7883901
    Abstract: A biogenic substance detector with high reaction efficiency and detection sensitivity is obtained. The biogenic substance detector includes: a plurality of chambers 1011 for hybridizing a target and a probe; and a passage 1012 provided between the chambers 1011. The cross-sectional area of the passage 1012 taken perpendicularly to the chamber-passage alignment direction is smaller than the cross-sectional area of each chamber 1011 taken perpendicularly to the chamber-passage alignment direction, and a probe-fixing area 1013 is provided over the entire inside wall of each chamber 1011. One kind of probe is fixed in one chamber 1011. In the hybridization step, the sample solution is made to move back and forth within the chambers 1011 and the passage 1012 using a pump 102.
    Type: Grant
    Filed: October 8, 2008
    Date of Patent: February 8, 2011
    Assignee: Seiko Epson Corporation
    Inventors: Rie Kitazawa, Fumio Takagi
  • Patent number: 7863054
    Abstract: A microfluidic system includes a plate-shaped microfluidic chip having a flow path, a liquid introduction tube for supplying liquid to the flow path, the liquid introduction tube having an end communicating with an end of the flow path and its other end that can be soaked in the liquid that is to be supplied to the flow path, and a liquid discharge head communicating with the other end of the flow path for discharging liquid that has passed through the flow path.
    Type: Grant
    Filed: November 27, 2006
    Date of Patent: January 4, 2011
    Assignee: Seiko Epson Corporation
    Inventor: Fumio Takagi
  • Publication number: 20100240048
    Abstract: A biological sample reaction chip includes, a first path having a first width, a second path having a second width wider than the first width wherein the first path and the second path being connected, a first opening through which a first liquid is introduced into the first path, and a second opening through which a second liquid unmixable with the first liquid is introduced into the first path.
    Type: Application
    Filed: February 25, 2010
    Publication date: September 23, 2010
    Applicant: SEIKO EPSON CORPORATION
    Inventor: Fumio TAKAGI
  • Publication number: 20100092339
    Abstract: A microfluidic system includes a plate-shaped microfluidic chip having a flow path, a liquid introduction tube for supplying liquid to the flow path, the liquid introduction tube having an end communicating with an end of the flow path and its other end that can be soaked in the liquid that is to be supplied to the flow path, and a liquid discharge head communicating with the other end of the flow path for discharging liquid that has passed through the flow path.
    Type: Application
    Filed: December 14, 2009
    Publication date: April 15, 2010
    Applicant: Seiko Epson Corporation
    Inventor: Fumio TAKAGI
  • Publication number: 20090197274
    Abstract: A biological sample reaction chip, including: a plurality of reaction containers; a reaction liquid introduction channel having a reaction liquid supply opening at a first end and an evacuation opening at a second end; and a reaction liquid quantifying channel, a third end of which is connected to one of the reaction containers, and a fourth end of which is connected to the reaction liquid introduction channel, wherein an interior of each of the reaction containers is coated with a reagent that is necessary for a reaction.
    Type: Application
    Filed: January 27, 2009
    Publication date: August 6, 2009
    Applicant: Seiko Epson Corporation
    Inventor: Fumio TAKAGI
  • Publication number: 20090162864
    Abstract: A biological substance detection cartridge, including: a reaction vessel for reacting a probe with a specific biological substance included in a sample solution, the reaction vessel having a region for fixing the probe for detecting the biological substance; a porous membrane facing the inside of the reaction vessel; a gas-liquid separation membrane superposed with the porous membrane; and a air discharge component which is provided on the opposite side of the gas-liquid separation membrane from the side contacting the porous membrane, and with which the interior can be kept at negative pressure during the reaction between the biological substance and the probe.
    Type: Application
    Filed: December 11, 2008
    Publication date: June 25, 2009
    Applicant: SEIKO EPSON CORPORATION
    Inventors: Rie KITAZAWA, Fumio TAKAGI
  • Publication number: 20090148912
    Abstract: A biological sample reaction chip, including: a plurality of reactors disposed on one plane; a reaction fluid distribution channel connected via a microchannel to each reactor and provided on the plane on which the plurality of reactors are disposed; and a reaction fluid movement stopping unit, which is connected to an end point of the reaction fluid distribution channel and is capable of controlling movement of a reaction fluid.
    Type: Application
    Filed: December 5, 2008
    Publication date: June 11, 2009
    Applicant: Seiko Epson Corporation
    Inventor: Fumio TAKAGI
  • Publication number: 20090123978
    Abstract: A biological sample reaction chip, including: a plurality of reaction vessels; a first channel connected to one end of each of the reaction vessels and comprising an opening for introducing a reaction solution; and a second channel connected to the other end of each of the reaction vessels, wherein when a capillary force of the first channel is defined as A, while a capillary force of connected portions between the reaction vessels and the first channel as B, a capillary force of the reaction vessels as C, a capillary force of connected portions of the second channel and the reaction vessels as D, and a capillary force of the second channel as E, the following is established: A<B<C<D and E<D.
    Type: Application
    Filed: October 29, 2008
    Publication date: May 14, 2009
    Applicant: SEIKO EPSON CORPORATION
    Inventor: Fumio TAKAGI
  • Publication number: 20090111192
    Abstract: A biogenic substance detector with high reaction efficiency and detection sensitivity is obtained. The biogenic substance detector includes: a plurality of chambers 1011 for hybridizing a target and a probe; and a passage 1012 provided between the chambers 1011. The cross-sectional area of the passage 1012 taken perpendicularly to the chamber-passage alignment direction is smaller than the cross-sectional area of each chamber 1011 taken perpendicularly to the chamber-passage alignment direction, and a probe-fixing area 1013 is provided over the entire inside wall of each chamber 1011. One kind of probe is fixed in one chamber 1011. In the hybridization step, the sample solution is made to move back and forth within the chambers 1011 and the passage 1012 using a pump 102.
    Type: Application
    Filed: October 8, 2008
    Publication date: April 30, 2009
    Applicant: SEIKO EPSON CORPORATION
    Inventors: Rie KITAZAWA, Fumio TAKAGI
  • Patent number: 7497544
    Abstract: Provided is a droplet discharging head, including: a nozzle formed on a first principal surface; a pressurized room having a pressurization unit that applies pressure on liquid discharged from the nozzle; a liquid retention unit in communication with the pressurized room; and a supply port that supplies liquid to the liquid retention unit; wherein the droplet discharging head is used by being mounted on a droplet discharging device in which the supply port is provided protrusively from a second principal surface positioned on the opposite side of the first principal surface.
    Type: Grant
    Filed: March 9, 2006
    Date of Patent: March 3, 2009
    Assignee: Seiko Epson Corporation
    Inventor: Fumio Takagi
  • Patent number: 7438860
    Abstract: It is an object of the present invention to provide a droplet discharging head suited to the discharge of a sample solution, and particularly one that contains a bio-related substance. This object is achieved by a droplet discharging head 1 for discharging a sample solution, wherein the portion of the inner walls of the droplet discharging head 1 that comes into contact with the sample solution is covered with a polymer composed of phosphorylcholine group-containing unsaturated compound units, or a copolymer including same. The droplet discharging head is preferably an electrostatic drive or piezoelectric drive type.
    Type: Grant
    Filed: May 20, 2004
    Date of Patent: October 21, 2008
    Assignees: Seiko Epson Corporation
    Inventors: Fumio Takagi, Kazuhiko Ishihara
  • Patent number: 7396511
    Abstract: Proposed is dispensing technology capable of reliably spotting a biological sample on a solid phase. A head chip applies a voltage pulse between a diaphragm and separate electrodes based on a drive control signal output from a head driver IC, and discharges a solution containing protein filled in a pressurized chamber as a result of the elastic deformation of the diaphragm. A drive pulse generation circuit generates a drive voltage pulse and supplies this to the head chip in order to discharge a solution containing protein from the head chip. The drive current detection circuit detects a drive current flowing between the diaphragm and separate electrodes. Since the waveform of the detected drive current and the peak current value and so on differ in the case where the discharge status is normal and in the case where it is abnormal, a defective discharge can be discriminated by detecting such change.
    Type: Grant
    Filed: July 25, 2003
    Date of Patent: July 8, 2008
    Assignee: Seiko Epson Corporation
    Inventors: Masahiro Fujii, Hiroshi Koeda, Fumio Takagi
  • Patent number: 7323224
    Abstract: A method for discharging a liquid containing a biological material includes adding as a dispense stabilizer a polymer composed of phosphorylcholine-group-containing unsaturated compound units or a copolymer including same to the liquid containing the biological material; and discharging the liquid containing the dispense stabilizer using an inkjet system.
    Type: Grant
    Filed: December 14, 2005
    Date of Patent: January 29, 2008
    Assignees: Seiko Epson Corporation, Kazuhiko Ishihara
    Inventors: Fumio Takagi, Kazuhiko Ishihara