Abstract: The present invention relates to aqueous binder dispersions for cationic electrocoat materials, comprising as binders amine-modified, hydroxy-functional epoxy resins and comprising as crosslinker at least one fully blocked polyisocyanate blocked at least partly with 2,2-dimethyl-1,3-dioxolane-4-methanol, and also to the use of such cationic electrocoat materials for producing coating systems and to the use of crosslinkers based on polyisocyanates blocked with 2,2-dimethyl-1,3-dioxolane-4-methanol in aqueous binder dispersions.

Abstract: The invention relates to a method for producing a pigment paste and an electrocoat containing the paste, the past being made by mixing solid pigment particles with a grind resin in the presence of water and/or an organic liquid, wherein the grind resin includes a dispersion of core-shell particles in an epoxide prepolymer which is liquid at 20° C. and the core-shell particles have a silicone core and a polymer shell.

Abstract: The invention provides novel compounds and conjugates of these compounds useful for the delivery of biologically active substances. Further novel design criteria for chemically stabilized siRNA particular useful when covalently attached to a delivery polymer to achieve in vivo mRNA knock down are disclosed therein.

Abstract: A method for coating an uncoated or precoated metallic or plastics substrate by (a) applying an aqueous coating composition (W) whose constituents are free or substantially free from blocked isocyanate groups, which comprises an aqueous dispersion of an epoxide-amine adduct, and which comprises either no crosslinking agent or one or more nonblocked polyisocyanate crosslinking agents, to the substrate, (b) optionally applying one or more further coating compositions, and (c) curing the coating composition (W) and, where appropriate, the further coating composition(s) at temperatures of below 90° C.

Abstract: The present invention relates to aqueous binder dispersions for cationic electrocoat materials, comprising as binders amine-modified, hydroxy-functional epoxy resins and comprising as crosslinker at least one fully blocked polyisocyanate blocked at least partly with 2,2-dimethyl-1,3-dioxolane-4-methanol, and also to the use of such cationic electrocoat materials for producing coating systems and to the use of crosslinkers based on polyisocyanates blocked with 2,2-dimethyl-1,3-dioxolane-4-methanol in aqueous binder dispersions.

Abstract: The invention provides novel compounds and conjugates of these compounds useful for the delivery of biologically active substances. Further novel design criteria for chemically stabilized siRNA particular useful when covalently attached to a delivery polymer to achieve in vivo mRNA knock down are disclosed therein.

Abstract: The invention relates to a method for producing a pigment paste by mixing at least one pigment, consisting of solid particles, with a grind resin in the presence of water and/or an organic liquid, wherein the grind resin comprises a dispersion of core-shell particles in an epoxide prepolymer which is liquid at 20° C., or consists of such a dispersion, and the core-shell particles have a silicone core and a polymer shell. The invention also relates to an aqueous electrocoat material, to the use thereof, to a method for cataphoretic electrocoating, and to a coated article.

Abstract: The present invention relates to electrodeposition primer compositions comprising catalytically active core/shell particles CS. The electrodeposition primer compositions can be used more particularly for cathodic dip coating for the coating of automobile bodies or parts thereof.

Abstract: The invention provides novel compounds and conjugates of these compounds useful for the delivery of biologically active substances. Further novel design criteria for chemically stabilized siRNA particular useful when covalently attached to a delivery polymer to achieve in vivo mRNA knock down are disclosed therein.

Abstract: The invention provides use of novel compounds for delivery of nucleic acids, and conjugates of these compounds with nucleic acids. Further novel design criteria for chemically stabilized siRNA particular useful when covalently attached to said compounds and co-administered with a delivery polymer to achieve mRNA knock down in vivo are disclosed therein.

Abstract: The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted melittin delivery peptides. Delivery peptides provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery peptides.

Abstract: The present invention is directed compositions for delivery of RNA interference (RNAi) polynucleotides to cells in vivo. The compositions comprise amphipathic membrane active polyamines reversibly modified with enzyme cleavable dipeptide-amidobenzyl-carbonate masking agents. Modification masks membrane activity of the polymer while reversibility provides physiological responsiveness. The reversibly modified polyamines (dynamic polyconjugate or DPC) are further covalently linked to an RNAi polynucleotide or co-administered with a targeted RNAi polynucleotide-targeting molecule conjugate.

Abstract: The invention provides novel compounds and conjugates of these compounds useful for the delivery of biologically active substances. Further novel design criteria for chemically stabilized siRNA particular useful when covalently attached to a delivery polymer to achieve in vivo mRNA knock down are disclosed therein.

Abstract: The invention provides use of novel compounds for delivery of nucleic acids, and conjugates of these compounds with nucleic acids. Further novel design criteria for chemically stabilized siRNA particular useful when covalently attached to said compounds and co-administered with a delivery polymer to achieve mRNA knock down in vivo are disclosed therein.

Abstract: The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted melittin delivery peptides. Delivery peptides provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery peptides.

Abstract: The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted melittin delivery peptides. Delivery peptides provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery peptides.

Abstract: The present invention is directed compositions for delivery of RNA interference (RNAi) polynucleotides to cells in vivo. The compositions comprise amphipathic membrane active polyamines reversibly modified with enzyme cleavable dipeptide-amidobenzyl-carbonate masking agents. Modification masks membrane activity of the polymer while reversibility provides physiological responsiveness. The reversibly modified polyamines (dynamic polyconjugate or DPC) are further covalently linked to an RNAi polynucleotide or co-administered with a targeted RNAi polynucleotide-targeting molecule conjugate.

Abstract: A method for coating an uncoated or precoated metallic or plastics substrate by (a) applying an aqueous coating composition (W) whose constituents are free or substantially free from blocked isocyanate groups, which comprises an aqueous dispersion of an epoxide-amine adduct, and which comprises either no crosslinking agent or one or more nonblocked polyisocyanate crosslinking agents, to the substrate, (b) optionally applying one or more further coating compositions, and (c) curing the coating composition (W) and, where appropriate, the further coating composition(s) at temperatures of below 90° C.

Abstract: The present invention is directed compositions for delivery of RNA interference (RNAi) polynucleotides to cells in vivo. The compositions comprise amphipathic membrane active polyamines reversibly modified with enzyme cleavable dipeptide-amidobenzyl-carbonate masking agents. Modification masks membrane activity of the polymer while reversibility provides physiological responsiveness. The reversibly modified polyamines (dynamic polyconjugate or DPC) are further covalently linked to an RNAi polynucleotide or co-administered with a targeted RNAi polynucleotide-targeting molecule conjugate.

Abstract: The present invention is directed compositions for delivery of RNA interference (RNAi) polynucleotides to cells in vivo. The compositions comprise amphipathic membrane active polyamines reversibly modified with enzyme cleavable dipeptide-amidobenzyl-carbonate masking agents. Modification masks membrane activity of the polymer while reversibility provides physiological responsiveness. The reversibly modified polyamines (dynamic polyconjugate or DPC) are further covalently linked to an RNAi polynucleotide or co-administered with a targeted RNAi polynucleotide-targeting molecule conjugate.