Patents by Inventor Gabor Kovacs
Gabor Kovacs has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4599327Abstract: 2,6-di-O-methyl-beta-cyclodextrin complexes of compounds of the formula (1a) ##STR1## wherein R.sup.2' stands for C.sub.1 to C.sub.12 alkyl or a group of the formula ##STR2## in which R.sup.11 is C.sub.1 to C.sub.4 alkyl;R.sup.12 is hydrogen or C.sub.1 to C.sub.4 alkyl;n is 0 or 1;p is 1 to 4;r is 1 to 4; andR.sup.3' and R.sup.4' are each C.sub.1 to C.sub.4 alkyl, or pharmaceutically salts thereof are disclosed, having analgesic activity.Type: GrantFiled: December 2, 1983Date of Patent: July 8, 1986Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara RTInventors: Mihaly Nogradi, Dezso Korbonits, Agnes Gottsegen, Sandor Antus, Zsuzsa Furst, Jozsef Knoll, Jozsef Szejtli, Agnes Stadler, Gabor Kovacs, Katalin Marmarosi
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Patent number: 4588713Abstract: Compounds of the formula ##STR1## are disclosed wherein R.sup.1 stands for hydrogen, C.sub.1-4 straight or branched alkyl or pharmacologically acceptable cation,R.sup.2 stands for hydrogen, C.sub.1-4 alkanoyl, benzoyl, or benzoyl substituted by C.sub.1-4 alkyl or halogen, and R.sup.2 can further represent tetrahydropyranyl, trialkylsilyl or alkoxyalkyl,A stands for ethylene, cis or trans-vinylene or --C.dbd.C--,n may represent 2, 3 or 4. The compounds are highly effective in the inhibition of thrombocyte aggregation while at the same time exert only a very small hypotensive effect.Type: GrantFiled: January 14, 1985Date of Patent: May 13, 1986Assignee: Chinoin Gyogyszer Vegyeszeti Termekek Gyara Rt.Inventors: Peter Gyory, Geza Galambos, Karoly Kanay, Jozsef Ivanics, Gyorgy Dorman, Gabor Kovacs, Istvan Stadler, Sandor Virag, Istvan Tomoskozi, Peter Kormoczky, Marianna Kovacs
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Patent number: 4565827Abstract: The invention relates to new, 7-substituted PGI.sub.2 -derivatives of formula (I) ##STR1## The new compounds have valuable therapeutical properties, and in particular show prostacyclin-like effects.Type: GrantFiled: October 27, 1981Date of Patent: January 21, 1986Assignee: CHINOIN Gyogyszer es Vegyeszeti Termekek Gyara R.T.Inventors: Istvan Szekely, Marianna Lovasz nee Gaspar, Gabor Kovacs, Krisztina Kekesi, Sandor Botar, Karoly Horvath, Peter Kormoczy, Pal Hadhazy, Istvan Rakoczy, Laszlo Fesus
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Patent number: 4565817Abstract: Antitussive compounds of the formula I ##STR1## or physiologically acceptable acid addition salts thereof are disclosed, where A stands for straight or branched chain C.sub.1-5 alkylene or ##STR2## R.sub.1 stands for straight or branched chain C.sub.1-10 alkyl, halogenoalkyl, hydroxyalkyl, C.sub.5-6 cycloalkyl, vinyl, 2-ethoxyethyl, carbonylalkyl or aminoalkyl of the formula ##STR3## wherein R stands for hydrogen or methyl, n is 0 to 3,R.sub.2 stands for hydrogen or straight or branched chain alkyl,R.sub.3 stands for hydrogen or straight or branched chain alkyl or,R.sub.2 and R.sub.3 together with the nitrogen atom may form a 5-6 membered ring, which ring can optionally contain an oxygen or a second nitrogen atom, the latter, optionally substituted by methyl or,R.sub.1 can stand for a phenyl group of the formulaR.sub.4 R.sub.5 C.sub.6 H.sub.3whereinR.sub.4 and R.sub.5 represent independently hydrogen, chlorine, hydroxy, methoxy, ethoxy, methyl or amino or,R.sub.Type: GrantFiled: March 11, 1983Date of Patent: January 21, 1986Assignee: Chinoin Gyogyszer-es Vegyeszeti Termekek Gyara R.T.Inventors: Dezso Korbonits, Maria Szomor nee Wundele, Gergely Heja, Ida Szvoboda nee Kanzel, Pal Kiss, Csaba Gonczi, Endre Palosi, Gabor Kovacs, Judit Kun, Emil Minker, Sandor Virag, Gyula Sebestyen, Tamas Szuts
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Patent number: 4520018Abstract: New PGI.sub.1 derivatives are disclosed as well as a process for the preparation thereof, pharmaceutical compositions containing same and methods of treatment employing same. The new compounds are useful to inhibit blood platelet aggregation induced by ADF, arachidic acid, or collagen, as well as to improve blood circulation and to inhibit gastric acid secretion.Type: GrantFiled: April 19, 1982Date of Patent: May 28, 1985Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt.Inventors: Vilmos Simonidesz, Jozsef Ivanics, Geza Galambos, Agnes Papp nee Behr, Gabor Kovacs, Judit Skopal, Ildiko Szilagyi
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Patent number: 4451483Abstract: 2,3,4-trinor-1,5-inter-m-phenylene-prostacycline derivatives of the formula (I), ##STR1## wherein R.sup.1 is hydrogen, a C.sub.1-4 alkyl group, an alkali metal cation or a primary, secondary, tertiary or quaternary ammonium cation,R.sup.2 and R.sup.3 each represent hydrogen or a C.sub.1-4 alkanoyl, benzoyl, substituted benzoyl, tetrahydropyranyl, ethoxyethyl or tri-(C.sub.1-4 alkyl)-silyl group,R.sup.4 is hydrogen or a C.sub.1-4 alkyl group, andR.sup.5 is a hexyl, heptyl, phenoxymethyl or m-trifluoromethylphenoxymethyl group, orR.sup.5 represents a group of the general formula ##STR2## and in this latter formula Z is an amino group or an optionally halo-substituted C.sub.1-4 alkanoylamino, benzoylamino or tosylamino group, andR.sup.6 is a C.sub.Type: GrantFiled: April 9, 1982Date of Patent: May 29, 1984Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt.Inventors: Istvan Szekely, Krisztina Kekesi, Mariann Lovasz nee Gaspar, Sandor Botar, Pal Hadhazy, Istvan Rakoczi, Laszlo Muszbek, Judit Skopal, Istvan Stadler, Karoly Horvath, Gabor Kovacs, Peter Kormoczy
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Patent number: 4450309Abstract: The invention relates to a new process for preparing unsaturated geminal dihalogen compounds. More particularly, the invention concerns a process for preparing compounds of the formula (I) ##STR1## wherein X is halogen,R.sup.1 is a straight or branched chained alkenyl group having 2 to 6 carbon atoms,by clearing the corresponding 1-substituted 2,2,2-trihaloethylesters.Type: GrantFiled: June 24, 1982Date of Patent: May 22, 1984Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyar Rt.Inventors: Rudolf Soos, Jozsef Nemes, Laszlo Vidra, Miklos Szelestei, Gabor Kovacs, Istvan Szekeley
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Patent number: 4438132Abstract: The invention relates to a process for the preparation of novel 4-oxo-PGI.sub.2 derivatives of formula I ##STR1## where (a) compounds of formula III ##STR2## are oxidized, then the obtained 5-substituted-4-oxo-PGI.sub.1 derivatives of general formula II ##STR3## are eliminated by the splitting off of the W-H-molecule, or (b) the compounds of formula IV ##STR4## are reacted in a solvent in the presence of a catalyst with compounds of general formula V ##STR5## then the obtained compounds of formula I are transformed if desired by saponification, hydrolysis, salt formation, insertion of a protection group to another compound which belongs to the compounds of formula I, too.The pharmaceutical products of the invention can be used for the treatment of circulatory diseases, they inhibit the aggregation of blood plaques, dilate the bronchi and inhibit the secretion of gastric acid.Type: GrantFiled: April 13, 1982Date of Patent: March 20, 1984Assignee: CHINOIN Gyogyszer es Vegyeszeti Termekek Gyara Rt.Inventors: Gaza Galambos, Vilmos Simonidesz, Istvan Szekely, Jozsef Ivanics, Krisztina Kekesi, Gabor Kovacs, Istvan Stadler, Peter Kormoczy, Karoly Horvath
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Patent number: 4429123Abstract: The present invention relates to a process for the preparation of compounds of the general Formula I ##STR1## (wherein A is a straight or branched chain alkylene group having 1-5 carbon atoms;B is ethylene, Z or E vinylene, or ethynylene;R.sup.1 stands for hydrogen, an alkyl group having 1-5 carbon atoms or a pharmaceutically acceptable cation;R.sup.2 is hydrogen, an alkanoyl group having 1-5 carbon atoms or aroyl;R.sup.3 is hydrogen or methyl;R.sup.4 is a straight or branched chain alkyl group having 1-8 carbon atoms or an optionally monosubstituted aryloxymethyl group;R.sup.5 stands for hydrogen or an alkyl group having 1-5 carbon atoms)which comprises oxidizing a compound of the Formula III, IV or V ##STR2## or a mixture thereof R.sup.6 is hydrogen or an alkyl or alkanoyl group having 1-5 carbon atoms with a mild electrophilic oxidizing agent and if desired reacting the compound of the Formula I thus obtained wherein R.sup.Type: GrantFiled: April 13, 1982Date of Patent: January 31, 1984Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara R.T.Inventors: Istvan Tomoskozi, Istvan Szekely, Karoly Kanai, Peter Gyori, Gabor Kovacs
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Patent number: 4425349Abstract: The invention concerns new sulfur-containing isoquinoline derivatives. More particularly, the invention relates to isoquinoline derivatives of the general formula (I) ##STR1## wherein R independently represents hydrogen, hydroxyl or alkoxy having 1 to 4 carbon atoms,R.sup.1 is hydrogen, alkyl having 1 to 4 carbon atoms and optionally substituted with phenyl, phenyl optionally substituted with one or more halogen or alkoxy group, cyano or carbamoyl,R.sup.2 is phenyl optionally substituted with one or more halogen, alkoxy or carboxyl, or a group of the general formula A ##STR2## wherein R.sup.3 is hydrogen, a straight or branched chained alkyl having 1 to 4 carbon atoms or phenyl,m and n independently represent 0, 1 or 2, with the proviso that m+n is at least 1,R.sup.4 is hydrogen, phenyl, hydroxyl, acyloxy, carboxyl, alkoxycarbonyl having 1 to 6 carbon atoms, carbamoyl, carbazoyl or dialkylamino containing 1 to 6 carbon atoms in the alkyl moiety, orR.sup.Type: GrantFiled: May 25, 1982Date of Patent: January 10, 1984Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt.Inventors: Kalman Takacs, Maria H. Papp, Gabor Kovacs, Ilona K. Ajzert, Antal Simay, Peter Literati Nagy, Marian E. Puskas, Gyula Sebestyen, Istvan Stadler, Zoltan Sumeghy
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Patent number: 4425358Abstract: The invention relates to new optically active or racemic 13-thia-prostacycline derivatives of the Formula I ##STR1## wherein R.sup.1 is hydrogen, a pharmaceutically acceptable cation or a straight or branched chain alkyl group having 1-5 carbon atoms;R.sup.2 is straight or branched chain alkyl having 4-9 carbon atoms or monosubstituted phenoxymethyl;--A--B-- is --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH-- of Z-- or E-- configuration or --C.tbd.C--;one of the symbols X and Y is hydrogen, methyl or ethyl and the other is hydroxy, tetrahydropyranyoxy, 1-ethoxy-ethoxy or trialkylsilyloxy; orX and Y together form a --O--CH.sub.2 --CH.sub.2 --O-- group;Z is a sulfur atom or a --SO-- group.Type: GrantFiled: April 21, 1982Date of Patent: January 10, 1984Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara R.T.Inventors: Csaba Szantay, Lajos Novak, Jozsef Aszodi, Vilmos Simonidesz, Geza Galambos, Gabor Kovacs, Sandor Virag, Istvan Stadler, Peter Kormoczy
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Patent number: 4379164Abstract: A compound having vasodilative, bronchodilative, stomach-mucosa-protective and platelet-aggregation-inhibiting activity has the formulaA 4-thia- or 4-sulfinyl-PGI.sub.1 -compound of the formula I ##STR1## wherein Q stands for --S-- or --SO--,A stands for C.sub.1-6 straight or branched chain alkylene,B stands for ethylene, vinylene or ethinylene,R.sup.1 represents hydrogen or C.sub.1-4 alkyl,R.sup.2 represents C.sub.1-8 straight or branched chain alkyl or mono-substituted aryl-oxy-methyl,R.sup.3 stands for hydrogen or acetyl, andZ represents --COOH, --CN, --CH.sub.2 OH or --COOW, wherein W stands for an equivalent of a pharmacologically acceptable cation or C.sub.1-4 alkyl.Type: GrantFiled: October 23, 1981Date of Patent: April 5, 1983Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara R.T.Inventors: Istvan Tomoskozi, Peter Gyory, Gabor Kovacs, Sandor Virag, Peter Kormoczy, Istvan Stadler
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Patent number: 4373104Abstract: Isoquinolines are disclosed of the formula (I) ##STR1## wherein R independently represents hydrogen, hydroxyl or alkoxy having 1 to 4 carbon atoms,R.sup.1 is hydrogen, alkyl having 1 to 4 carbon atoms and optionally substituted with phenyl, phenyl optionally substituted with one or more halogen or alkoxy group, cyano or carbomoyl,R.sup.2 is phenyl optionally substituted with one or more halogen, alkoxy or carboxyl, or a group of the general formula A ##STR2## wherein R.sup.3 is hydrogen, a straight or branched chained alkyl having 1 to 4 carbon atoms or phenyl,m and n independently represent 0, 1 or 2, with the proviso that m+n is at least 1,R.sup.4 is hydrogen, phenyl, hydroxyl, acyloxy, carboxyl, alkoxycarbonyl having 1 to 6 carbon atoms, carbamoyl, carbazoyl or dialkylamino containing 1 to 6 carbon atoms in the alkyl moiety, orR.sup.Type: GrantFiled: July 1, 1980Date of Patent: February 8, 1983Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek GyaraInventors: Kalman Takacs, Maria H. Papp, Gabor Kovacs, Ilona K. Ajzert, Antal Simay, Peter L. Nagy, Marian E. Puskas, Gyula Sebestyen, Istvan Stadler, Zoltan Sumeghy
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Patent number: 4330553Abstract: New PGI.sub.2 derivatives and a process for their preparation are disclosed of the formula (I) ##STR1## wherein Q is hydrogen, a pharmacologically acceptable cation, or lower alkyl;A is cis or trans --CH.dbd.CH--, --C.tbd.C--, or --CH.sub.2 --CH.sub.2 --;R.sup.13 is hydrogen or a C.sub.1 to C.sub.4 alkanoyl or is a blockinggroup of the formula R.sup.7 R.sup.8 R.sup.9 Si or ##STR2## wherein R.sup.7, R.sup.8 and R.sup.9 are the same or different and can be straight or branched chain alkyl groups having 1 to 4 carbon atoms and R.sup.10 and R.sup.11 are the same or different and can be hydrogen or methyl, and R.sup.12 represents methyl or ethyl, or is tetrahydropyran-2-yl;R.sup.4 is hydrogen or lower alkyl inthe .alpha. or .beta. steric position;R.sup.1 and R.sup.2 are each hydrogen or lower alkyl;Y is methylene, oxygen or an --NH-- group; andR.sup.3 is lower alkyl or phenyl which can be monosubstituted phenyl.Type: GrantFiled: November 10, 1980Date of Patent: May 18, 1982Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara R.T.Inventors: Vilmos Simonidesz, Agnes Papp nee Behr, Gabor Kovacs, Jozsef Ivanics, Julia Der nee Foldvary, Istvan Stadler, Istvan Pallagi
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Patent number: 4304938Abstract: 3-Phenoxybenzene derivatives are prepared by a method which comprises the steps of(a) chlorinating benzaldehyde with chlorine gas in the presence of a hydrocarbon and a Lewis acid catalyst to obtain 3-chlorobenzaldehyde; (b) reacting the 3-chlorobenzaldehyde with ethylene glycol to obtain 2-(3-chlorophenyl)-1,3-dioxolane; (c) etherifying said dioxolane with an alkali phenolate to yield the intermediate 2-(3-phenoxyphenyl)-1,3-dioxolane and converting this intermediate to the corresponding aldehyde, cyanohydrin, sulfonic acid salt or oxime derivative.Type: GrantFiled: December 21, 1979Date of Patent: December 8, 1981Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara RTInventors: Endre Palosi, Gergely Heja, Dezso Korbonits, Pal Kiss, Csaba Gonczi, Judit Cser nee Kun, Ida Szvoboda nee Kauzel, Gabor Kovacs, Gabor Szabo, Tamas Kallay, Laszlo Ledniczky
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Patent number: 4299972Abstract: A process is disclosed for the preparation of an optically active or racemic cyclopropanecarboxylic acid of the formula (I) ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and each is lower alkyl or halogen;R is a member of a group which contains various cyclic structures as set forth in the specification,the .about. valency bond represents .alpha.- and/or .beta.-configuration;the -- valency bond represents .beta.-configuration,which comprises reacting an optically active or racemic cyclopropanecarboxylic acid of the formula (VII) ##STR2## with a dimethyl-methylidene-ammonium salt of the formula (VIII) ##STR3## wherein X is halogen or lower alkoxy andY.sup.- is a halide or lower alkylsulfate ion in an anhydrous, inert organic solvent, and sebsequently reacting a dimethyl-acloxy-methylidene-ammonium salt thus obtained with an optically active, inactive or racemic alcohol of the formulaR--OHwithout isolation, in the presence of an organic base.Type: GrantFiled: July 1, 1980Date of Patent: November 10, 1981Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt.Inventors: Gabor Kovacs, Istvan Szekely, Marianne Lovasz nee Gaspar, Rudolf Soos, Joszef Dukai
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Patent number: 4283413Abstract: New compounds and a process for making the same, for use in inhibiting aggregation in human blood and inhibiting the growth of tumors, said compounds being of the general formula: ##STR1## wherein R is hydrogen, alkanoyl, substituted alkanoyl, aralkanoyl or aroyl and represents .alpha. or .beta. steric position or .alpha. and .beta. position, with the provision that if R stands for p-phenyl-benzoyl then methoxy in the position 2 may stand only in .alpha. or only in .beta. steric position.Type: GrantFiled: December 12, 1979Date of Patent: August 11, 1981Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara RT.Inventors: Tibor Szabo, Laszlo Institoris, Gabor Kovacs, Istvan Stadler, Bela Koszegi
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Patent number: 4281170Abstract: A method of making an insecticidal pyrethrin by oxidation in aprotic organic solvent. The compounds are of the formula: ##STR1## wherein R.sup.11 is straight or branched chain lower alkyl or 1-alkenyl or hydrogen;R and R.sup.12 are the same or different and are hydrogen, halogen or lower alkyl or one of the moieties R and R.sup.12 is lower alkoxycarbonyl.Type: GrantFiled: February 21, 1979Date of Patent: July 28, 1981Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara RtInventors: Istvan Szekely, Marianna Lovasz nee Gaspar, Gabor Kovacs, Rudolf Soos, Lajos Nagy, Bela Koszegi
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Patent number: 4257962Abstract: Racemic or optically active compounds with antitumor activity of the formula: ##STR1## wherein X is oxygen or sulfur;R.sup.1 is hydrogen, C.sub.1 to C.sub.4 alkanoyl, benzoyl or phenyl-substituted benzoyl;R.sup.2 is hydrogen or C.sub.1 to C.sub.4 alkanoyl;R.sup.3 is C.sub.2 to C.sub.40 straight or branched chain alkyl substituted by hydroxy, epoxy, amino, C.sub.1 to C.sub.6 alkylamino, C.sub.1 to C.sub.6 dialkylamino, C.sub.1 to C.sub.6 alkanoyloxy or, C.sub.1 to C.sub.4 alkoxycarbonyl; cyclohexyl, phenyl unsubstituted or substituted by halogen, amino, C.sub.1 to C.sub.4 alkyl-substituted amino, C.sub.1 to C.sub.4 alkoxy, nitro, or hydroxy; C.sub.1 to C.sub.6 alkanoyl; allyl or phenyl-C.sub.1 to C.sub.4 alkyl unsubstituted or substituted by a C.sub.2 to C.sub.6 alkene group; or where X is sulfur R.sup.3 is as defined above or is C.sub.1 to C.sub.40 straight or branched chain alkyl; and.about. represents the exo- or endo-steric position in the ring and indicates an .alpha.- or .beta.Type: GrantFiled: September 15, 1978Date of Patent: March 24, 1981Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt.Inventors: Tibor Szabo, Laszlo Institoris, Gabor Kovacs, Gyula Dalmadi, Bela Koszegi, Istvan Stadler
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Patent number: 4248888Abstract: Insecticidal compounds of the formula: ##STR1## wherein R.sup.11 is a straight or branched chain lower alkyl or 1-alkenyl or hydrogen;R and R.sup.12 are the same or different and are hydrogen, halogen, or straight or branched chained lower alkyl, or one of the moieties R and R.sup.12 is lower alkoxycarbonyl; the bonds represent .alpha.- and/or .beta.-configuration and the -- bonds represent .beta.-configuration.Type: GrantFiled: February 21, 1979Date of Patent: February 3, 1981Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara R.T.Inventors: Istvan Szekely, Marianna Lovasz, nee Gaspar, Gabor Kovacs, Rudolf Soos, Lajos Nagy, Bela Koszegi