Patents by Inventor Gabriel M. Galvin

Gabriel M. Galvin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CRYSTALLINE FORMS OF OBETICHOLIC ACID
    Publication number: 20210139528
    Abstract: The crystalline forms of obeticholic acid and methods of preparation and use thereof are described.
    Type: Application
    Filed: March 7, 2018
    Publication date: May 13, 2021
    Inventors: Gabriel M. GALVIN, Melissa REWOLINSKI
  • Methods for the preparation of obeticholic acid and derivatives thereof
    Patent number: 10604545
    Abstract: The present application relates to a method of preparing a bile acid derivative or a pharmaceutical acceptable salt, solvate, or amino acid conjugate thereof, comprising direct alkylation of a carbon atom at the C-6 position of 7 keto lithocholic acid (KLCA) with an alkylating agent and reduction of a keto group at the C-7 position.
    Type: Grant
    Filed: October 28, 2016
    Date of Patent: March 31, 2020
    Assignee: INTERCEPT PHARMACEUTICALS, INC.
    Inventor: Gabriel M Galvin
  • Methods for preparation of bile acids and derivatives thereof
    Patent number: 10604544
    Abstract: The present application relates to a method of preparing compounds of Formula (A) or a pharmaceutically acceptable salt, solvate, or amino acid conjugate thereof.
    Type: Grant
    Filed: August 5, 2016
    Date of Patent: March 31, 2020
    Assignee: INTERCEPT PHARMACEUTICALS, INC.
    Inventor: Gabriel M Galvin
  • METHODS FOR THE PREPARATION OF OBETICHOLIC ACID AND DERIVATIVES THEREOF
    Publication number: 20190062367
    Abstract: The present application relates to a method of preparing a bile acid derivative, or a pharmaceutical acceptable salt, solvate, or amino acid conjugate thereof, comprising direct alkylation at the C-6 position of KLCA.
    Type: Application
    Filed: October 28, 2016
    Publication date: February 28, 2019
    Inventor: Gabriel M Galvin
  • METHODS FOR PREPARATION OF BILE ACIDS AND DERIVATIVES THEREOF
    Publication number: 20180222937
    Abstract: The present application relates to a method of preparing compounds of Formula (A) or a pharmaceutically acceptable salt, solvate, or amino acid conjugate thereof.
    Type: Application
    Filed: August 5, 2016
    Publication date: August 9, 2018
    Inventor: Gabriel M Galvin
  • Process for preparing a dipeptidyl peptidase IV inhibitor and intermediates employed therein
    Patent number: 7420063
    Abstract: A process is provided for preparing a dipeptidyl peptidase IV inhibitor of the structure is treated with TFAA in isopropyl acetate to protect the tertiary hydroxyl group as a trifluoroacetate group to form 4 (which is a novel intermediate) which is converted to acid chloride compound 5 (which is a novel compound) using Vilsmeier reagent or other chloro reaget and coupled with compound 6 in a heterogeneous mixture of ethyl acetate and aqueous bicabonate to give compound 7 The N,O-bis(trifluoroacetyl) groups of compound 7 are deprotected to give free base compound 10.
    Type: Grant
    Filed: January 30, 2007
    Date of Patent: September 2, 2008
    Assignee: Bristol-Myers Squibb Company
    Inventors: Padam N. Sharma, Edward J. Gublo, Gabriel M. Galvin, Susan D. Boettger, Saibaba Racha
  • Process for preparing a dipeptidyl peptidase IV inhibitor and intermediates employed therein
    Patent number: 7186846
    Abstract: A process is provided for preparing a dipeptidyl peptidase IV inhibitor of the structure wherein is treated with TFAA in isopropyl acetate to protect the tertiary hydroxyl group as a trifluoroacetate group to form 4 (which is a novel intermediate) which is converted to acid chloride compound 5 (which is a novel compound) using Vilsmeier reagent or other chloro reagent and coupled with compound 6 in a heterogeneous mixture of ethyl acetate and aqueous bicarbonate to give compound 7 The N,O-bis(trifluoroacetyl) groups of compound 7 are deprotected to give free base compound 10.
    Type: Grant
    Filed: March 28, 2005
    Date of Patent: March 6, 2007
    Assignee: Bristol-Myers Squibb Company
    Inventors: Padam N. Sharma, Edward J. Gublo, Gabriel M. Galvin, Susan D. Boettger, Saibaba Racha