Patents by Inventor Gabriel Padron Palomares

Gabriel Padron Palomares has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pre-M/M epitopes of dengue virus, synthetic peptides, chimeric proteins and their use
    Patent number: 6383488
    Abstract: The present invention relates to five synthetic peptides of pre-M/M protein of Dengue-2 virus, corresponding to amino acid sequences 3-31, 45-67, 57-92, 69-93 and 103-124. The anti-peptide immune response was evaluated in mice. Recombinant fusion proteins were also obtained, including regions of pre-M/M protein. The presence of B cell epitopes in both mice and humans was demonstrated in the pre-M/M protein peptides. Peptides 3-31 and 103-124 elicited neutralizing antibodies against the four serotypes of Dengue virus. Virus-specific proliferative responses were demonstrated in mice immunized with non-conjugated peptides 3-31 and 57-92. Mice immunized with conjugated peptides 3-31, 57-92, and 69-93 were protected when they were challenged with Dengue-2 virus. Thus, the presence of sequential epitopes in Pre-M/M protein of Dengue-2 virus was demonstrated, as well as their relevance in the immune response against this flavivirus.
    Type: Grant
    Filed: October 14, 1999
    Date of Patent: May 7, 2002
    Assignees: Centro de Ingeniera Genetic Y Biotechnologies (CIGB), Instituto de Medicina Tropical “Pedro Kouri”
    Inventors: Susana Vazquez Ramudo, Guadalupe Guzman Tirado, Gerardo Enrique Guillen Nieto, Orlando Luis Pardo Lazo, Glay Chinea Santiago, Ana Beatriz Perez Diaz, Maritza Pupo Antunez, Rosmari Rodriguez Roche, Osvaldo Reyes Acosta, Hilda Elisa Garay Perez, Gabriel Padron Palomares, Maylin Alvarez Vera, Luis Morier Diaz, Omaida Perez Insuita, Jose Luis Pelegrino Martinez De La Cotera