Patents by Inventor Gabriele Amari

Gabriele Amari has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • AMIDO CYCLOHEXANE ACID DERIVATIVES AS LPA RECEPTOR INHIBITORS
    Publication number: 20230250093
    Abstract: The present invention relates to compounds of general formula (I) inhibiting lysophosphatidic acid receptor 1 (LPA1), particularly the invention relates to compounds that are Ami do cyclohexane acid derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of diseases or conditions associated with a dysregulation of LPA receptors, in particular fibrosis.
    Type: Application
    Filed: July 15, 2021
    Publication date: August 10, 2023
    Applicant: CHIESI FARMACEUTICI S.P.A.
    Inventors: Elisabetta ARMANI, Gabriele AMARI, Andrea RIZZI, Mafalda PAGANO, Luca RAVEGLIA, Claudia BEATO
  • QUINAZOLINE DERIVATIVES AS LPA RECEPTOR 2 INHIBITORS
    Publication number: 20230063121
    Abstract: The present invention relates to a compounds of general formula (I) inhibiting lysophosphatidic acid receptor 2 (LPA2), particularly the invention relates to compounds that are quinazoline derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of diseases or conditions associated with a dysregulation of LPA receptors, in particular fibrosis.
    Type: Application
    Filed: December 10, 2020
    Publication date: March 2, 2023
    Inventors: Gabriele AMARI, Elisabetta ARMANI, Mafalda PAGANO, Luca RAVEGLIA, Marta GIULIANI, Claudia BEATO
  • THIENOPYRIMIDINE DERIVATIVES AS LPA RECEPTOR 2 INHIBITORS
    Publication number: 20230061417
    Abstract: The present invention relates to a compounds of general formula (I) inhibiting lysophosphatidic acid receptor 2 (LPA2), particularly the invention relates to compounds that are thienopyrimidine derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of diseases or conditions associated with a dysregulation of LPA receptors, in particular fibrosis.
    Type: Application
    Filed: December 10, 2020
    Publication date: March 2, 2023
    Inventors: Gabriele AMARI, Elisabetta ARMANI, Mafalda PAGANO, Luca RAVEGLIA
  • AROMATIC AMIDO DERIVATIVES AS LPA RECEPTOR 2 INHIBITORS
    Publication number: 20230043672
    Abstract: The present invention relates to compounds of general formula (I) inhibiting lysophosphatidic acid receptor 2 (LPA2), particularly the invention relates to compounds that are aromatic amido derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of diseases or conditions associated with a dysregulation of LPA receptors, in particular fibrosis.
    Type: Application
    Filed: December 10, 2020
    Publication date: February 9, 2023
    Inventors: Gabriele AMARI, Elisabetta ARMANI, Mafalda PAGANO, Luca RAVEGLIA, Claudia BEATO
  • Aminoester derivatives
    Patent number: 10117860
    Abstract: Compounds of formula (I), defined herein, are both phosphodiesterase 4 (PDE4) enzyme inhibitors and muscarinic M3 receptor antagonists and are useful for the prevention and/or treatment of a disease of the respiratory tract.
    Type: Grant
    Filed: August 10, 2017
    Date of Patent: November 6, 2018
    Assignee: CHIESI FARMACEUTICI S.p.A.
    Inventors: Elisabetta Armani, Gabriele Amari, Carmelida Capaldi, Wesley Blackaby, Ian Linney, Hervé Van De Poël, Charles Baker-Glenn, Naimisha Trivedi
  • 3,5-dichloro,4-(3,4-(cyclo-)alkoxyphenyl)--2-carbonyloxy)ethyl)pyridine derivatives as PDE-4 inhibitors
    Patent number: 10087176
    Abstract: The invention relates to novel 3,5-dichloro,4-(3,4-(cyclo-) alkoxyphenyl)-2-carbonyloxy)ethyl)pyridine compounds which are inhibitors of the phosphodiesterase 4 (PDE4) enzyme and muscarinic M3 receptor antagonists, methods of preparing such compounds, compositions containing them and therapeutic use thereof.
    Type: Grant
    Filed: June 4, 2014
    Date of Patent: October 2, 2018
    Assignee: Chiesi Farmaceutici S.p.A.
    Inventors: Gabriele Amari, Elisabetta Armani, Mauro Riccaboni, Andrea Rizzi, Charles Baker-Glenn, Wesley Blackaby, Herve Van De Poel, Ben Whittaker
  • 1-phenyl-2-pyridinyl alkyl alcohol derivatives as phosphodiesterase inhibitors
    Patent number: 9944612
    Abstract: Compounds of formula (I) described herein are inhibitors of the phosphodiesterase 4 (PDE4) enzyme and are useful for the prevention and/or treatment of an allergic disease state or a disease of the respiratory tract characterized by airway obstruction.
    Type: Grant
    Filed: December 5, 2013
    Date of Patent: April 17, 2018
    Assignee: Chiesi Farmaceutici S.p.A.
    Inventors: Elisabetta Armani, Gabriele Amari, Oriana Esposito, Laura Carzaniga, Carmelida Capaldi
  • Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors
    Patent number: 9931327
    Abstract: Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols are useful as inhibitors of the phosphodiesterase 4 (PDE4) enzyme and the treatment of certain conditions such as COPD.
    Type: Grant
    Filed: September 24, 2015
    Date of Patent: April 3, 2018
    Assignee: CHIESI FARMACEUTICI S.p.A.
    Inventors: Elisabetta Armani, Gabriele Amari, Laura Carzaniga, Carmelida Capaldi, Oriana Esposito, Gino Villetti, Renato De Fanti
  • 3,5-dichloro,4-(3,4-(cyclo-)alkoxyphenyl)- 2-carbonyloxy)ethyl)pyridine derivatives as PDE-4 inhibitors
    Patent number: 9890151
    Abstract: The invention relates to novel 3,5-dichloro,4-(3,4-(cyclo-) alkoxyphenyl)-2-carbonyloxy)ethyl)pyridine compounds which are both inhibitors of the phosphodiesterase 4 (PDE4) enzyme and muscarinic M3 receptor antagonists, methods of preparing such compounds, compositions containing them and therapeutic use thereof.
    Type: Grant
    Filed: June 4, 2014
    Date of Patent: February 13, 2018
    Assignee: Chiesi Farmaceutici S.p.A.
    Inventors: Gabriele Amari, Elisabetta Armani, Mauro Riccaboni, Charles Baker-Glenn
  • AMINOESTER DERIVATIVES
    Publication number: 20180016265
    Abstract: Compounds of formula (I) are both phosphodiesterase 4 (PDE4) enzyme inhibitors and muscarinic M3 receptor antagonists and are useful for the prevention and/or treatment of diseases of the respiratory tract characterized by airway obstruction.
    Type: Application
    Filed: September 28, 2017
    Publication date: January 18, 2018
    Applicant: CHIESI FARMACEUTICI S.p.A.
    Inventors: Elisabetta ARMANI, Gabriele Amari, Wesley Blackaby, Herve Van De Poel, Charles Baker-Glenn, Naimisha Trivedi
  • Aminoester derivatives
    Patent number: 9809582
    Abstract: Compounds of formula (I) are both phosphodiesterase 4 (PDE4) enzyme inhibitors and muscarinic M3 receptor antagonists and are useful for the prevention and/or treatment of diseases of the respiratory tract characterized by airway obstruction.
    Type: Grant
    Filed: May 6, 2016
    Date of Patent: November 7, 2017
    Assignee: CHIESI FARMACEUTICI S.p.A.
    Inventors: Elisabetta Armani, Gabriele Amari, Wesley Blackaby, Herve Van De Poel, Charles Baker-Glenn, Naimisha Trivedi
  • Aminoester derivatives
    Patent number: 9763924
    Abstract: Compounds of formula (I), defined herein, are both phosphodiesterase 4 (PDE4) enzyme inhibitors and muscarinic M3 receptor antagonists and are useful for the prevention and/or treatment of a disease of the respiratory tract.
    Type: Grant
    Filed: May 28, 2015
    Date of Patent: September 19, 2017
    Assignee: Chiesi Farmaceutici S.p.A.
    Inventors: Elisabetta Armani, Gabriele Amari, Carmelida Capaldi, Wesley Blackaby, Ian Linney, Hervé Van De Poël, Charles Baker-Glenn, Naimisha Trivedi
  • 3,5-DICHLORO,4-(3,4-(CYCLO-)ALKOXYPHENYL)--2-CARBONYLOXY)ETHYL)PYRIDINE DERIVATIVES AS PDE-4 INHIBITORS
    Publication number: 20170152256
    Abstract: The invention relates to novel 3,5-dichloro,4-(3,4-(cyclo-) alkoxyphenyl)-2-carbonyloxy)ethyl)pyridine compounds which are inhibitors of the phosphodiesterase 4 (PDE4) enzyme and muscarinic M3 receptor antagonists, methods of preparing such compounds, compositions containing them and therapeutic use thereof.
    Type: Application
    Filed: June 4, 2014
    Publication date: June 1, 2017
    Applicant: Chiesi Farmaceutici S.p.A.
    Inventors: Gabriele AMARI, Elisabetta ARMANI, Mauro RICCABONI, Andrea RIZZI, Charles BAKER-GLENN, Wesley BLACKABY, Herve VAN DE POEL, Ben WHITTAKER
  • 3,5-DICHLORO,4-(3,4-(CYCLO-)ALKOXYPHENYL)- 2-CARBONYLOXY)ETHYL)PYRIDINE DERIVATIVES AS PDE-4 INHIBITORS
    Publication number: 20170145004
    Abstract: The invention relates to novel 3,5-dichloro,4-(3,4-(cyclo-) alkoxyphenyl)-2-carbonyloxy)ethyl)pyridine compounds which are both inhibitors of the phosphodiesterase 4 (PDE4) enzyme and muscarinic M3 receptor antagonists, methods of preparing such compounds, compositions containing them and therapeutic use thereof.
    Type: Application
    Filed: June 4, 2014
    Publication date: May 25, 2017
    Applicant: CHIESI FARMACEUTICI S.p.A.
    Inventors: Gabriele AMARI, Elisabetta ARMANI, Mauro RICCABONI, Charles BAKER-GLENN
  • Aminoester derivatives
    Patent number: 9636336
    Abstract: Compounds of formula (I) defined herein are both phosphodiesterase 4 (PDE4) enzyme inhibitors and muscarinic M3 receptor antagonists and are useful for treating diseases of the respiratory tract.
    Type: Grant
    Filed: May 31, 2016
    Date of Patent: May 2, 2017
    Assignee: CHIESI FARMACEUTICI S.p.A.
    Inventors: Gabriele Amari, Elisabetta Armani, Wesley Blackaby, Herve Van De Poeol, Charles Baker-Glenn, Naimisha Trivedi
  • Aminoester derivatives
    Patent number: 9597323
    Abstract: Compounds of formula (I) defined herein are both phosphodiesterase 4 (PDE4) enzyme inhibitors and muscarinic M3 receptor antagonists and are useful for treating diseases of the respiratory tract.
    Type: Grant
    Filed: May 31, 2016
    Date of Patent: March 21, 2017
    Assignee: CHIESI FARMACEUTICI S.p.A.
    Inventors: Gabriele Amari, Elisabetta Armani, Herve Van De Poeol, Charles Baker-Glenn, Naimisha Trivedi
  • AMINOESTER DERIVATIVES
    Publication number: 20160346260
    Abstract: Compounds of formula (I) defined herein are both phosphodiesterase 4 (PDE4) enzyme inhibitors and muscarinic M3 receptor antagonists and are useful for treating diseases of the respiratory tract.
    Type: Application
    Filed: May 31, 2016
    Publication date: December 1, 2016
    Applicant: CHIESI FARMACEUTICI S.p.A.
    Inventors: Gabriele AMARI, Elisabetta ARMANI, Herve VAN DE POEOL, Charles BAKER-GLENN, Naimisha TRIVEDI
  • AMINOESTER DERIVATIVES
    Publication number: 20160346268
    Abstract: Compounds of formula (I) defined herein are both phosphodiesterase 4 (PDE4) enzyme inhibitors and muscarinic M3 receptor antagonists and are useful for treating diseases of the respiratrory tract.
    Type: Application
    Filed: May 31, 2016
    Publication date: December 1, 2016
    Applicant: CHIESI FARMACEUTICI S.p.A.
    Inventors: Gabriele AMARI, Elisabetta Armani, Wesley Blackaby, Herve Van De Poeol, Charles Baker-Glenn, Naimisha Trivedi
  • AMINOESTER DERIVATIVES
    Publication number: 20160326147
    Abstract: Compounds of formula (I) are both phosphodiesterase 4 (PDE4) enzyme inhibitors and muscarinic M3 receptor antagonists and are useful for the prevention and/or treatment of diseases of the respiratory tract characterized by airway obstruction.
    Type: Application
    Filed: May 6, 2016
    Publication date: November 10, 2016
    Applicant: CHIESI FARMACEUTICI S.p.A.
    Inventors: Elisabetta ARMANI, Gabriele AMARI, Wesley BLACKABY, Herve VAN DE POEL, Charles BAKER-GLENN, Naimisha TRIVEDI
  • Carbamate derivatives
    Patent number: 9326976
    Abstract: Compounds of formula (I) defined herein are both phosphodiesterase 4 (PDE4) enzyme inhibitors and muscarinic M3 receptor antagonists and are useful for the prevention and/or treatment of diseases of the respiratory tract.
    Type: Grant
    Filed: May 28, 2015
    Date of Patent: May 3, 2016
    Assignee: CHIESI FARMACEUTICI S.p.A.
    Inventors: Elisabetta Armani, Gabriele Amari, Carmelida Capaldi, Charles Baker-Glenn