Patents by Inventor Gad Keren

Gad Keren has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20180280667
    Abstract: Described embodiments include apparatus (28) that includes a shunt (26). The shunt includes a flared distal portion (40), a flared proximal portion (44), and an intermediate portion (42), disposed between the distal portion and the proximal portion. The apparatus further includes a constricting flexible longitudinal element (38) passing circumferentially along the intermediate portion of the shunt, configured to constrict the intermediate portion of the shunt, and one or more proximal-portion-collapsing flexible longitudinal elements (36) configured to collapse the proximal portion of the shunt. Other embodiments are also described.
    Type: Application
    Filed: May 5, 2016
    Publication date: October 4, 2018
    Inventor: Gad Keren
  • Publication number: 20180250131
    Abstract: A differential pressure regulating device is provided for controlling in-vivo pressure in body, and in particularly in a heart. The device may include a shunt being positioned between two or more lumens in a body, to enable fluids to flow between the lumens, and an adjustable flow regulation mechanism being configured to selectively cover an opening of the shunt, to regulate the flow of fluid through the shunt in relation to a pressure difference between the body lumens. In some embodiments a control mechanism coupled to the adjustable flow regulation mechanism may be provided, to remotely activate the adjustable flow regulation mechanism.
    Type: Application
    Filed: August 3, 2017
    Publication date: September 6, 2018
    Applicant: V-Wave Ltd.
    Inventors: Dan ROTTENBERG, Ori J. BRAUN, Avraham ABA ZAKAY, Ascher SHMULEWITZ, Yoram ROZY, Gad KEREN
  • Patent number: 9943670
    Abstract: The present invention is thus directed to methods and apparatus for decreasing pressure in a first portion of a vessel of the cardiac structure of a patient by implanting a shunt communicating with an area outside said first portion, whereby a volume of blood sufficient to reduce pressure in said first portion is released.
    Type: Grant
    Filed: December 7, 2012
    Date of Patent: April 17, 2018
    Assignee: V-Wave Ltd.
    Inventors: Gad Keren, Randy Kesten
  • Publication number: 20170325956
    Abstract: A differential pressure regulating device is provided for controlling in-vivo pressure in body, and in particularly in a heart. The device may include a shunt being positioned between two or more lumens in a body, to enable fluids to flow between the lumens, and an adjustable flow regulation mechanism being configured to selectively cover an opening of the shunt, to regulate the flow of fluid through the shunt in relation to a pressure difference between the body lumens. In some embodiments a control mechanism coupled to the adjustable flow regulation mechanism may be provided, to remotely activate the adjustable flow regulation mechanism.
    Type: Application
    Filed: August 3, 2017
    Publication date: November 16, 2017
    Applicant: V-Wave Ltd.
    Inventors: Dan ROTTENBERG, Ori J. BRAUN, Avraham ABA ZAKAY, Ascher SHMULEWITZ, Yoram ROZY, Gad KEREN
  • Patent number: 9724499
    Abstract: A differential pressure regulating device is provided for controlling in-vivo pressure in a body, and in particularly in a heart. The device may include a shunt being positioned between two or more lumens in a body, to enable fluids to flow between the lumens, and an adjustable flow regulation mechanism being configured to selectively cover an opening of the shunt, to regulate the flow of fluid through the shunt in relation to a pressure difference between the body lumens. In some embodiments a control mechanism coupled to the adjustable flow regulation mechanism may be provided, to remotely activate the adjustable flow regulation mechanism.
    Type: Grant
    Filed: May 16, 2011
    Date of Patent: August 8, 2017
    Assignee: V-Wave Ltd.
    Inventors: Dan Rottenberg, Ori Braun, Avraham Aba Sakay, Ascher Shmulewitz, Yoram Rozy, Gad Keren
  • Publication number: 20160242901
    Abstract: A method of replacing a native cardiac valve with a prosthetic cardiac valve, the method comprising: expanding a wire mesh scaffolding in a chamber of the heart on a retrograde side of the native cardiac valve; while the scaffolding is expanded on the retrograde side of the valve positioning the prosthetic cardiac valve at the site of the native cardiac valve; expanding the prosthetic cardiac valve to replace the native cardiac valve; and collapsing the scaffolding to a collapsed state and removing the collapsed scaffolding from the chamber of the heart.
    Type: Application
    Filed: October 8, 2014
    Publication date: August 25, 2016
    Inventor: Gad Keren
  • Publication number: 20160045314
    Abstract: A brace for mounting to an annulus of a cardiac valve, the brace comprising: first and second bottom gripping wings for gripping the annulus; first and second top gripping wings for gripping the annulus; and a support bridge that connects the top wings to the bottom wings; wherein the brace is deformable from a delivery configuration to a deployed configuration and in the delivery configuration the top wings are oriented substantially back to back along an axis and the bottom wings are oriented substantially back to back along the same axis, and in the deployed configuration the first top and bottom gripping wings face each other to grip the annulus between them and the second top and bottom gripping wings face each other to grip the annulus between them.
    Type: Application
    Filed: March 4, 2014
    Publication date: February 18, 2016
    Inventors: Gad Keren, Allan C. Entis
  • Patent number: 9067989
    Abstract: The presently described subject matter is based on the finding that inhibition of eotaxin-2 by polyclonal or monoclonal antibodies, has a significant protective effect in animal models of inflammatory diseases such as rheumatoid arthritis, experimental autoimmune encephalomyelitis (EAE), colitis, diabetes, and atherosclerosis. Thus, provided are pharmaceutical compositions including specific anti-eotaxin 2 antibodies for use alone or in combination with other therapeutic agents in the treatment of inflammatory, autoimmune and cardiovascular diseases. Also provided are specific anti-eotaxin-2 monoclonal antibodies, and methods of treatment utilizing such antibodies.
    Type: Grant
    Filed: January 28, 2010
    Date of Patent: June 30, 2015
    Assignee: THE MEDICAL RESEARCH, INFRASTRUCTURE, AND HEALTH SERVICES FUND OF THE TEL AVIV MEDICAL CENTER
    Inventors: Jacob George, Gad Keren
  • Publication number: 20140163449
    Abstract: A differential pressure regulating device is provided for controlling in-vivo pressure in a body, and in particularly in a heart. The device may include a shunt being positioned between two or more lumens in a body, to enable fluids to flow between the lumens, and an adjustable flow regulation mechanism being configured to selectively cover an opening of the shunt, to regulate the flow of fluid through the shunt in relation to a pressure difference between the body lumens. In some embodiments a control mechanism coupled to the adjustable flow regulation mechanism may be provided, to remotely activate the adjustable flow regulation mechanism.
    Type: Application
    Filed: January 13, 2014
    Publication date: June 12, 2014
    Applicant: V-WAVE LTD.
    Inventors: Dan ROTTENBERG, Ori BRAUN, Avraham ABA ZAKAY, Ascher SHMULEWITZ, Yoram ROZY, Gad KEREN
  • Publication number: 20140128796
    Abstract: The present invention is thus directed to methods and apparatus for decreasing pressure in a first portion of a vessel of the cardiac structure of a patient by implanting a shunt communicating with an area outside said first portion, whereby a volume of blood sufficient to reduce pressure in said first portion is released.
    Type: Application
    Filed: January 13, 2014
    Publication date: May 8, 2014
    Applicant: V-WAVE LTD.
    Inventors: Gad KEREN, Randy KESTEN
  • Publication number: 20140128795
    Abstract: The present invention is thus directed to methods and apparatus for decreasing pressure in a first portion of a vessel of the cardiac structure of a patient by implanting a shunt communicating with an area outside said first portion, whereby a volume of blood sufficient to reduce pressure in said first portion is released.
    Type: Application
    Filed: January 13, 2014
    Publication date: May 8, 2014
    Applicant: V-WAVE LTD.
    Inventors: Gad KEREN, Randy KESTEN
  • Patent number: 8328751
    Abstract: The present invention is thus directed to methods and apparatus for decreasing pressure in a first portion of a vessel of the cardiac structure of a patient by implanting a shunt communicating with an area outside said first portion, whereby a volume of blood sufficient to reduce pressure in said first portion is released. Preferably, the first portion comprises the left ventricle and the pressure reduced is the end diastolic pressure, which is accomplished by having the shunt communicate with the left ventricle so a small volume of blood is released from the left ventricle to reduce the end diastolic pressure.
    Type: Grant
    Filed: May 13, 2011
    Date of Patent: December 11, 2012
    Assignee: V-Wave Ltd.
    Inventors: Gad Keren, Randy Kesten
  • Patent number: 8235933
    Abstract: The present invention is directed to methods and apparatus for decreasing pressure in the left atrium of a patient by implanting a valved shunt through the atrial septum, whereby a volume of blood sufficient to reduce pressure in said left atrium is released to the right atrium.
    Type: Grant
    Filed: May 13, 2011
    Date of Patent: August 7, 2012
    Assignee: V-Wave Ltd.
    Inventors: Gad Keren, Randy Kesten
  • Patent number: 8091556
    Abstract: Methods and apparatus for decreasing cardiac pressure in a patient by implanting a shunt communicating with an area outside a first portion, whereby a volume of blood sufficient to reduce pressure in a first portion is released. Preferably, the end diastolic pressure in the left ventricle is reduced, which is accomplished by having the shunt communicate with the left ventricle so a small volume of blood is released from the left ventricle. Most preferably, the shunt selectively permits flow when a pressure differential between the left ventricle and another chamber of a heart above a threshold pressure, so that shunting is prevented during left ventricular systole, or, alternatively, selectively permits flow when a pressure differential between the left ventricle and another chamber of a heart is between a lower threshold and a higher threshold. In certain embodiments a semi-passive check-valve is controlled and actuated by an external signal.
    Type: Grant
    Filed: April 20, 2001
    Date of Patent: January 10, 2012
    Assignee: V-Wave Ltd.
    Inventors: Gad Keren, Randy Kesten
  • Patent number: 8070708
    Abstract: A differential pressure regulating device is provided for controlling in-vivo pressure in a body, and in particularly in a heart. The device may include a shunt being positioned between two or more lumens in a body, to enable fluids to flow between the lumens, and an adjustable flow regulation mechanism being configured to selectively cover an opening of the shunt, to regulate the flow of fluid through the shunt in relation to a pressure difference between the body lumens. In some embodiments a control mechanism coupled to the adjustable flow regulation mechanism may be provided, to remotely activate the adjustable flow regulation mechanism.
    Type: Grant
    Filed: February 3, 2005
    Date of Patent: December 6, 2011
    Assignee: V-Wave Limited
    Inventors: Dan Rottenberg, Ori Braun, Avraham Aba Zakay, Ascher Shmulewitz, Yoram Rozy, Gad Keren
  • Publication number: 20110280832
    Abstract: The presently described subject matter is based on the finding that inhibition of eotaxin-2 by polyclonal or monoclonal antibodies, has a significant protective effect in animal models of inflammatory diseases such as rheumatoid arthritis, experimental autoimmune encephalomyelitis (EAE), colitis, diabetes, and atherosclerosis. Thus, provided are pharmaceutical compositions including specific anti-eotaxin 2 antibodies for use alone or in combination with other therapeutic agents in the treatment of inflammatory, autoimmune and cardiovascular diseases. Also provided are specific anti-eotaxin-2 monoclonal antibodies, and methods of treatment utilizing such antibodies.
    Type: Application
    Filed: January 28, 2010
    Publication date: November 17, 2011
    Applicant: THE MEDICAL RESEARCH, INFRASTRUCTURE, AND HEALTH S ERNICES FUND OF THE TEL AVIV MEDICAL CENTER
    Inventors: Jacob George, Gad Keren
  • Publication number: 20110218478
    Abstract: The present invention is thus directed to methods and apparatus for decreasing pressure in a first portion of a vessel of the cardiac structure of a patient by implanting a shunt communicating with an area outside said first portion, whereby a volume of blood sufficient to reduce pressure in said first portion is released. Preferably, the first portion comprises the left ventricle and the pressure reduced is the end diastolic pressure, which is accomplished by having the shunt communicate with the left ventricle so a small volume of blood is released from the left ventricle to reduce the end diastolic pressure.
    Type: Application
    Filed: May 13, 2011
    Publication date: September 8, 2011
    Inventors: Gad Keren, Randy Kesten
  • Publication number: 20110218481
    Abstract: A differential pressure regulating device is provided for controlling in-vivo pressure in a body, and in particularly in a heart. The device may include a shunt being positioned between two or more lumens in a body, to enable fluids to flow between the lumens, and an adjustable flow regulation mechanism being configured to selectively cover an opening of the shunt, to regulate the flow of fluid through the shunt in relation to a pressure difference between the body lumens. In some embodiments a control mechanism coupled to the adjustable flow regulation mechanism may be provided, to remotely activate the adjustable flow regulation mechanism.
    Type: Application
    Filed: May 16, 2011
    Publication date: September 8, 2011
    Inventors: Dan Rottenberg, Ori Braun, Avraham Aba Zakay, Ascher Shmulewitz, Yoram Rozy, Gad Keren
  • Publication number: 20110218477
    Abstract: The present invention is thus directed to methods and apparatus for decreasing pressure in a first portion of a vessel of the cardiac structure of a patient by implanting a shunt communicating with an area outside said first portion, whereby a volume of blood sufficient to reduce pressure in said first portion is released. Preferably, the first portion comprises the left ventricle and the pressure reduced is the end diastolic pressure, which is accomplished by having the shunt communicate with the left ventricle so a small volume of blood is released from the left ventricle to reduce the end diastolic pressure.
    Type: Application
    Filed: May 13, 2011
    Publication date: September 8, 2011
    Inventors: Gad Keren, Randy Kesten
  • Publication number: 20110218479
    Abstract: A differential pressure regulating device is provided for controlling in-vivo pressure in a body, and in particularly in a heart. The device may include a shunt being positioned between two or more lumens in a body, to enable fluids to flow between the lumens, and an adjustable flow regulation mechanism being configured to selectively cover an opening of the shunt, to regulate the flow of fluid through the shunt in relation to a pressure difference between the body lumens. In some embodiments a control mechanism coupled to the adjustable flow regulation mechanism may be provided, to remotely activate the adjustable flow regulation mechanism.
    Type: Application
    Filed: May 16, 2011
    Publication date: September 8, 2011
    Inventors: Dan Rottenberg, Ori Braun, Avraham Aba Zakay, Ascher Shmulewitz, Yoram Rozy, Gad Keren