Patents by Inventor Gail W. Sullivan

Gail W. Sullivan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2-propynyl adenosine analogs having A2A agonist activity and compositions thereof
    Patent number: 8158604
    Abstract: The invention provides compounds having the following general formula (I): wherein X, R1, R2, R7 and Z are as described here.
    Type: Grant
    Filed: February 24, 2010
    Date of Patent: April 17, 2012
    Assignee: University of Virginia Patent Foundation
    Inventors: Joel M. Linden, Jayson M. Rieger, Timothy L. Macdonald, Gail W. Sullivan, Lauren J. Murphree, Robert Alan Figler
  • 2-propynyl adenosine analogs with modified 5?-ribose groups having A2A agonist activity
    Patent number: 7989431
    Abstract: The invention provides compounds having the following general formula (I): wherein X, R1, R2, R7 and Z are as described herein.
    Type: Grant
    Filed: June 18, 2009
    Date of Patent: August 2, 2011
    Assignee: University of Virginia Patent Foundation
    Inventors: Jayson M. Rieger, Joel M. Linden, Timothy L. Macdonald, Gail W. Sullivan, Lauren J. Murphree, Robert Alan Figler
  • 2-PROPYNYL ADENOSINE ANALOGS WITH MODIFIED 5'-RIBOSE GROUPS HAVING A2A AGONIST ACTIVITY
    Publication number: 20110136755
    Abstract: The invention provides compounds having the following general formula (I): wherein X, R1, R2, R7 and Z are as described herein.
    Type: Application
    Filed: February 15, 2011
    Publication date: June 9, 2011
    Applicant: University of Virginia Patent Foundation
    Inventors: Jayson M. Rieger, Joel M. Linden, Timothy L. Macdonald, Gail W. Sullivan, Lauren J. Murphree, Robert Alan Figler
  • 2-polycyclic propynyl adenosine analogs having A2A agonist activity
    Patent number: 7875595
    Abstract: The invention provides compounds having the following general formula (I): wherein X, R1, R2, R7 and Z are as described herein.
    Type: Grant
    Filed: June 18, 2009
    Date of Patent: January 25, 2011
    Assignee: University of Virginia Patent Foundation
    Inventors: Jayson M. Rieger, Joel M. Linden, Timothy L. Macdonald, Gail W. Sullivan, Lauren J. Murphree, Robert Alan Figler, Robert Douglas Thompson
  • 2-PROPYNYL ADENOSINE ANALOGS HAVING A2A AGONIST ACTIVITY AND COMPOSITIONS THEREOF
    Publication number: 20100152127
    Abstract: The invention provides compounds having the following general formula (I): wherein X, R1, R2, R7 and Z are as described here.
    Type: Application
    Filed: February 24, 2010
    Publication date: June 17, 2010
    Applicant: University of Virginia Patent Foundation
    Inventors: Joel M. Linden, Jayson M. Rieger, Timothy L. Macdonald, Gail W. Sullivan, Lauren Jean Murphree, Robert Alan Figler
  • 2-propynyl adenosine analogs having A2A agonist activity and compositions thereof
    Patent number: 7737127
    Abstract: The invention provides compounds having the following general formula (I): wherein X, R1, R2, R7 and Z are as described here.
    Type: Grant
    Filed: March 26, 2007
    Date of Patent: June 15, 2010
    Assignee: University of Virginia Patent Foundation
    Inventors: Joel M. Linden, Jayson M. Rieger, Timothy L. Macdonald, Gail W. Sullivan, Lauren Jean Murphree, Robert Alan Figler
  • 2-POLYCYCLIC PROPYNYL ADENOSINE ANALOGS HAVING A2A AGONIST ACTIVITY
    Publication number: 20090298788
    Abstract: The invention provides compounds having the following general formula (I): wherein X, R1, R2, R7 and Z are as described herein.
    Type: Application
    Filed: June 18, 2009
    Publication date: December 3, 2009
    Inventors: Jayson M. Rieger, Joel M. Linden, Timothy L. Macdonald, Gail W. Sullivan, Lauren J. Murphree, Robert Alan Figler, Robert Douglas Thompson
  • 2-propynyl adenosine analogs with modified 5?-ribose groups having Aagonist activity
    Patent number: 7605143
    Abstract: The invention provides compounds having the following general formula (I): wherein X, R1, R2, R7 and Z are as described herein.
    Type: Grant
    Filed: August 2, 2005
    Date of Patent: October 20, 2009
    Assignee: University of Virginia Patent Foundation
    Inventors: Jayson M. Rieger, Joel M. Linden, Timothy L. Macdonald, Gail W. Sullivan, Lauren J. Murphree, Robert Alan Figler
  • 2-PROPYNYL ADENOSINE ANALOGS WITH MODIFIED 5'-RIBOSE GROUPS HAVING A2A AGONIST ACTIVITY
    Publication number: 20090253647
    Abstract: The invention provides compounds having the following general formula (I): wherein X, R1, R2, R7 and Z are as described herein.
    Type: Application
    Filed: June 18, 2009
    Publication date: October 8, 2009
    Inventors: Jayson M. Rieger, Jeol M. Linden, Timothy L. MacDonald, Gail W. Sullivan, Lauren J. Murphree, Robert Alan Figler
  • 2-polycyclic propynyl adenosine analogs having A2A agonist activity
    Patent number: 7576069
    Abstract: The invention provides compounds having the following general formula (I): wherein X, R1, R2, R7 and Z are as described herein.
    Type: Grant
    Filed: August 2, 2005
    Date of Patent: August 18, 2009
    Assignee: University of Virginia Patent Foundation
    Inventors: Jayson M. Rieger, Joel M. Linden, Timothy L. Macdonald, Gail W. Sullivan, Lauren J. Murphree, Robert Alan Figler, Robert Douglas Thompson
  • ADJUNCTIVE TREATMENT OF BIOLOGICAL DISEASES
    Publication number: 20090170803
    Abstract: The present invention provides a therapeutic method for treating biological diseases that includes the administration of an effective amount of a suitable antibiotic agent, antifungal agent or antiviral agent in conjunction with an A2A adenosine receptor agonist. If no anti-pathogenic agent is known the A2A agonist can be used alone to reduce inflammation, as may occur during infection with antibiotic resistant bacteria, or certain viruses such as those that cause SARS or Ebola. Optionally, the method includes administration of a type IV PDE inhibitor.
    Type: Application
    Filed: April 10, 2003
    Publication date: July 2, 2009
    Inventors: Joel M. Linden, Gail W. Sullivan, W. Michael Scheld, Tom Gordon Obrig, Timothy L. MacDonald, Jayson M. Rieger
  • METHOD OF TREATING ENTERITIS, INTESTINAL DAMAGE, AND DIARRHEA FROM C. DIFFICILE WITH AN A2A ADENOSINE RECEPTOR AGONIST
    Publication number: 20080312160
    Abstract: A therapeutic method for treating intestinal damage, enteritis, diarrhea, or a combination thereof caused by a C. difficile is provided. The method includes administration to a patient in need thereof an effective amount of an A2A adenosine receptor agonist, optionally in combination with an effective amount of a stable glutamine derivative, e.g., alanyl-glutamine.
    Type: Application
    Filed: April 9, 2008
    Publication date: December 18, 2008
    Inventors: Richard L. Guerrant, Joel M. Linden, Cirle A. Warren, Gail W. Sullivan, Timothy L. Macdonald
  • 2-polycyclic propynyl adenosine analogs having A2A agonist activity
    Patent number: 7442687
    Abstract: The invention provides compounds having the following general formula (I): wherein X, R1, R2, R7 and Z are as described herein.
    Type: Grant
    Filed: August 2, 2005
    Date of Patent: October 28, 2008
    Assignee: The University of Virginia Patent Foundation
    Inventors: Jayson M. Rieger, Joel M. Linden, Timothy L. Macdonald, Gail W. Sullivan, Lauren J. Murphree, Robert Alan Figler, Robert Douglas Thompson
  • Method to reduce inflammatory response in transplanted tissue
    Patent number: 7427606
    Abstract: The present invention provides a therapeutic method for treating biological diseases that includes the administration of an effective amount of a suitable antibiotic agent, antifungal agent or antiviral agent in conjunction with an A2A adenosine receptor agonist. If no anti-pathogenic agent is known the A2A agonist can be used alone to reduce inflammation, as may occur during infection with antibiotic resistant bacteria, or certain viruses such as those that cause SARS or Ebola. Optionally, the method includes administration of a type IV PDE inhibitor.
    Type: Grant
    Filed: December 2, 2004
    Date of Patent: September 23, 2008
    Assignee: University of Virginia Patent Foundation
    Inventors: Joel M. Linden, Kenneth Brayman, Gail W. Sullivan
  • Method to reduce an inflammatory response from arthritis
    Patent number: 7378400
    Abstract: The present invention provides a therapeutic method for treating an inflammatory response caused by autoimmune stimulation, comprising the administration to a patient in need thereof of an antiinflammatory amount amount of an A2A adenosine receptor agonist. The autoimmune stimulation can be caused by arthritis, particularly rheumatoid arthritis. Optionally, the method includes administration of a type IV PDE inhibitor.
    Type: Grant
    Filed: September 9, 2005
    Date of Patent: May 27, 2008
    Assignee: University of Virginia Patent Foundation
    Inventors: Jayson M. Rieger, Donald L. Kimpel, Joel M. Linden, Gail W. Sullivan
  • Pharmaceutical compositions having Aadenosine receptor agonist activity
    Patent number: 7226913
    Abstract: The present invention provides compositions for oral administration of compounds having A2A adenosine receptor agonist activity. These compositions are useful for treatment of inflammatory conditions.
    Type: Grant
    Filed: March 3, 2003
    Date of Patent: June 5, 2007
    Assignee: University of Virginia Patent Foundation
    Inventors: Joel M. Linden, Gail W. Sullivan, Ian J. Sarembock, Timothy MacDonald, Mark Okusa, Irving L. Kron, W. Michael Scheld
  • 2-propynyl adenosine analogs having Aagonist activity and compositions thereof
    Patent number: 7214665
    Abstract: The invention provides compounds having the following general formula (I): wherein X, R1, R2, R7 and Z are as described here.
    Type: Grant
    Filed: October 1, 2002
    Date of Patent: May 8, 2007
    Assignee: University of Virginia Patent Foundation
    Inventors: Joel M. Linden, Jayson M. Rieger, Timothy L. Macdonald, Gail W. Sullivan, Lauren Jean Murphree, Robert Alan Figler
  • Method and compositions for treating the inflammatory response
    Patent number: 6670334
    Abstract: Agonists of A2A adenosine receptors optionally, in combination with a Type IV phosphodiesterase (PDE) inhibitor are effective for the inhibition of an inflammatory response in mammalian tissue, in vivo or in vitro.
    Type: Grant
    Filed: January 7, 2002
    Date of Patent: December 30, 2003
    Assignee: University of Virginia Patent Foundation
    Inventors: Joel M. Linden, Jayson M. Rieger, Gail W. Sullivan, Timothy L. Macdonald
  • 2-propynyl adenosine analogs having A2A agonist activity and compositions thereof
    Publication number: 20030186926
    Abstract: The invention provides compounds having the following general formula (I): 1
    Type: Application
    Filed: October 1, 2002
    Publication date: October 2, 2003
    Inventors: Joel M. Linden, Jayson M. Rieger, Timothy L. MacDonald, Gail W. Sullivan, Lauren Jean Murphree, Robert Alan Figler
  • Methods and compositions for treating inflammatory response
    Publication number: 20030162742
    Abstract: Compositions for oral administration of compounds having A2A adenosine receptor antagonist activity are provided. These compositions are useful for treatment of inflammatory conditions.
    Type: Application
    Filed: March 3, 2003
    Publication date: August 28, 2003
    Applicant: University of Virginia Patent Foundation, University of Virginia.
    Inventors: Joel M. Linden, Gail W. Sullivan, Ian J. Sarembock, Timothy MacDonald, Mark Okusa, Irving L. Kron, W. Michael Scheld