Patents by Inventor Galina Kuznetsov

Galina Kuznetsov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HEMIASTERLIN DERIVATIVES AND USES THEREOF IN THE TREATMENT OF CANCER
    Publication number: 20140309174
    Abstract: The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherein R1-R7, X1, X2, R, Q, and n are as defined herein.
    Type: Application
    Filed: November 12, 2013
    Publication date: October 16, 2014
    Applicant: Eisai Co., Ltd
    Inventors: James J. Kowalczyk, Galina Kuznetsov, Shawn Schiller, Boris M. Seletsky, Mark Spyvee, Hu Yang
  • Hemiasterlin derivatives and uses thereof in the treatment of cancer
    Patent number: 8633224
    Abstract: The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherein R1-R7, X1, X2, R, Q, and n are as defined herein.
    Type: Grant
    Filed: February 3, 2012
    Date of Patent: January 21, 2014
    Assignee: Eisai Co., Ltd.
    Inventors: James J. Kowalczyk, Galina Kuznetsov, Shawn Schiller, Boris M. Seletsky, Mark Spyvee, Hu Yang
  • HEMIASTERLIN DERIVATIVES AND USES THEREOF IN THE TREATMENT OF CANCER
    Publication number: 20120309938
    Abstract: The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherein R1-R7, X1, X2, R, Q, and n are as defined herein.
    Type: Application
    Filed: February 3, 2012
    Publication date: December 6, 2012
    Applicant: EISAI CO., LTD.
    Inventors: James J. KOWALCZYK, Galina KUZNETSOV, Shawn SCHILLER, Boris M. SELETSKY, Mark SPYVEE, Hu YANG
  • Hemiasterlin derivatives and uses thereof in the treatment of cancer
    Patent number: 8129407
    Abstract: The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherein R1-R7, X1, X2, R, Q, and n are as defined herein.
    Type: Grant
    Filed: February 27, 2009
    Date of Patent: March 6, 2012
    Assignee: Eisai Inc.
    Inventors: James J. Kowalczyk, Galina Kuznetsov, Shawn Schiller, Boris M. Seletsky, Mark Spyvee, Hu Yang
  • Tubulin Isotype Screening in Cancer Therapy Using Halichondrin B Analogs
    Publication number: 20100190843
    Abstract: Chemotherapeutic agents that interfere with microtubule assembly or disassembly in the cell are potent inhibitors of cell replication. Examples of such agents include halichondrin B analogs. It has been shown that the susceptibility of certain cancers to analogs of halichondrin B correlates with the expression of particular tubulin isotypes or other microtubule-associated proteins such as MAP-4 and stathmin. Correlations such as these may be used in identifying patients suitable for treatment using a particular chemotherapeutic agent. Such a system avoids treating patients with cytotoxic compounds where there is a minimal or no effect on the cancer. The invention also provides a system of establishing these correlations for different compounds and cancer types. The system will be particularly useful in establishing correlations between anti-microtubule agents and cancers such as lung, breast, and ovarian cancer. Kits and reagents useful in practicing the invention are also provided.
    Type: Application
    Filed: August 3, 2009
    Publication date: July 29, 2010
    Applicant: Eisai R&D Management Co., Ltd.
    Inventors: Sergei Agoulnik, Galina Kuznetsov, Bruce A. Littlefield
  • HEMIASTERLIN DERIVATIVES AND USES THEREOF IN THE TREATMENT OF CANCER
    Publication number: 20100063095
    Abstract: The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherein R1-R7, X1, X2, R, Q, and n are as defined herein.
    Type: Application
    Filed: February 27, 2009
    Publication date: March 11, 2010
    Inventors: James J. KOWALCZYK, Galina KUZNETSOV, Shawn SCHILLER, Boris M. SELETSKY, Mark SPYVEE, Hu YANG
  • Hemiasterlin derivatives and uses thereof in the treatment of cancer
    Patent number: 7528152
    Abstract: The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherein R1-R7, X1, X2, R, Q, and n are as defined herein.
    Type: Grant
    Filed: February 2, 2007
    Date of Patent: May 5, 2009
    Assignee: Eisai Co., Ltd.
    Inventors: James J. Kowalczyk, Galina Kuznetsov, Shawn Schiller, Boris M. Seletsky, Mark Spyvee, Hu Yang
  • Hemiasterlin derivatives and uses thereof in the treatment of cancer
    Publication number: 20080051434
    Abstract: The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherein R1-R7, X1, X2, R, Q, and n are as defined herein.
    Type: Application
    Filed: February 2, 2007
    Publication date: February 28, 2008
    Applicant: EISAI CO., LTD.
    Inventors: James Kowalczyk, Galina Kuznetsov, Shawn Schiller, Boris Seletsky, Mark Spyvee, Hu Yang
  • Hemiasterlin derivatives and uses thereof
    Patent number: 7192972
    Abstract: The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherein R1–R7, X1, X2, R, Q, and n are as defined herein.
    Type: Grant
    Filed: March 21, 2003
    Date of Patent: March 20, 2007
    Assignee: Eisai Co., Ltd.
    Inventors: James J. Kowalczyk, Galina Kuznetsov, Shawn Schiller, Boris M. Seletsky, Mark Spyvee, Hu Yang
  • Tubulin isotype screening in cancer therapy using halichondrin B analogs
    Publication number: 20060154312
    Abstract: Chemotherapeutic agents that interfere with microtubule assembly or disassembly in the cell are potent inhibitors of cell replication. Examples of such agents include halichondrin B analogs. It has been shown that the susceptibility of certain cancers to analogs of halichondrin B correlates with the expression of particular tubulin isotypes or other microtubule-associated proteins such as MAP-4 and stathmin. Correlations such as these may be used in identifying patients suitable for treatment using a particular chemotherapeutic agent. Such a system avoids treating patients with cytotoxic compounds where there is a minimal or no effect on the cancer. The invention also provides a system of establishing these correlations for different compounds and cancer types. The system will be particularly useful in establishing correlations between anti-microtubule agents and cancers such as lung, breast, and ovarian cancer. Kits and reagents useful in practicing the invention are also provided.
    Type: Application
    Filed: December 7, 2005
    Publication date: July 13, 2006
    Inventors: Sergei Agoulnik, Galina Kuznetsov, Bruce Littlefield
  • Tubulin isotype screening in cancer therapy using hemiasterlin analogs
    Publication number: 20060148014
    Abstract: Chemotherapeutic agents that interfere with microtubule assembly or disassembly in the cell are potent inhibitors of cell replication. Examples of such agents include hemiasterlin analogs. It has been shown that the susceptibility of certain cancers to analogs of hemiasterlin correlates with the expression of particular tubulin isotypes or other microtubule-associated proteins such as MAP-4 and stathmin. Correlations such as these may be used in identifying patients suitable for treatment using a particular chemotherapeutic agent. Such a system avoids treating patients with cytotoxic compounds where there is a minimal or no effect on the cancer. The invention also provides a system of establishing these correlations for different compounds and cancer types. The system will be particularly useful in establishing correlations between anti-microtubule agents and cancers such as lung, breast, and ovarian cancer. Kits and reagents useful in practicing the invention are also provided.
    Type: Application
    Filed: December 7, 2005
    Publication date: July 6, 2006
    Inventors: Sergei Agoulnik, Galina Kuznetsov, Bruce Littlefield
  • Hemiasterlin derivatives and uses thereof
    Patent number: 7064211
    Abstract: The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherein R1–R7, X1, X2, R, Q, and n are as defined herein.
    Type: Grant
    Filed: September 22, 2003
    Date of Patent: June 20, 2006
    Assignee: Eisai Co., Ltd.
    Inventors: James J. Kowalczyk, Galina Kuznetsov, Shawn Schiller, Boris M. Seletsky, Mark Spyvee, Hu Yang
  • Hrmiasterlin derivatives and uses thereof
    Publication number: 20050239870
    Abstract: The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherein R1-R7, X1, X2, R, Q, and n are as defined herein.
    Type: Application
    Filed: March 21, 2003
    Publication date: October 27, 2005
    Applicant: EISAI CO., LTD.,
    Inventors: James Kowalczyk, Galina Kuznetsov, Shawn Schiller, Boris Seletsky, Mark Spyvee, Hu Yang
  • Hemiasterlin derivatives and uses thereof
    Publication number: 20040229819
    Abstract: The present invention provides compounds having formula (I): 1
    Type: Application
    Filed: September 22, 2003
    Publication date: November 18, 2004
    Inventors: James J. Kowalczyk, Galina Kuznetsov, Shawn Schiller, Boris M. Seletsky, Mark Spyvee, Hu Yang