Abstract: The invention provides a novel class of clearable, tumor-targeting and human protein-based MRI nanoprobes and contrast agents and their compositions, and methods of preparation and use thereof.

Abstract: The invention provides a novel class of MRI contrast agents based on biogenic hemin and compositions and methods of preparation and use thereof.

Abstract: The invention provides a novel class of materials that possess triplet-triplet annihilation upconversion, compositions and methods of preparation and use thereof. The invention also relates to use of such materials and nanoparticles, for example, in stimulus-responsive, in situ delivery of biologically active agents.

Abstract: Various embodiments of the present technology provide an online and/or offline meeting system that utilizes a “scene” as a collaboration context and/or for collecting and grouping related multimedia based messages exchanged in discussions, and causes the related messages to be presented to participants of an online and/or offline meeting in a cinematic way. When an online meeting is over and the meeting session is ended, participants can still make offline communications using the scene as the collaboration context. Further, the present technology improves user experience in viewing or annotating non-text based content in a chat session.

Abstract: Provided are: a method for manufacturing a Ni-based heat-resistant superalloy wire having excellent bending workability; and a Ni-based heat-resistant superalloy wire. The method for manufacturing a Ni-based heat-resistant superalloy wire comprises a rod preparation step for preparing a Ni-based heat-resistant superalloy rod; and a rod processing step in which plastic working having a working rate of 40% or less is repeated several times toward the axis from the circumferential surface of the rod at a temperature of 500° C. or lower until the cumulative working rate reaches 60% or more to reduce the cross-sectional area of the rod. A Ni-based heat-resistant superalloy wire obtained by the manufacturing method has a plastic worked or recrystallized microstructure.

Abstract: A hot extrusion-molding method is for a Ni-based super heat-resistant alloy, wherein: a billet has a component composition for a precipitation strengthened-type Ni-based super heat-resistant alloy having a gamma prime phase equilibrium precipitation amount of 40 mol % or more at 700° C.; a lubrication glass pad is installed between a die and the billet; and adjustment is made so the relationship between the outer diameter DB (mm) of the billet at the time of insertion in a container and the inner diameter DC (mm) of the container satisfies (DC-DB): 2-8 mm, or adjustment is made so the relationship between the outer diameter DB? (mm) of the billet prior to being heated to a hot processing temperature and the inner diameter DC? (mm) of the container prior to being heated to a preheating temperature satisfies (DC??DB?): 3-9 mm. A production method is performed using the hot extrusion-molding method mentioned above.

Abstract: Ni-based super heat-resistant alloys have a composition in which the equilibrium precipitated amount of a gamma prime phase at 700° C. is 35 mol % or greater, and have grains having a maximum diameter of 75 nm or less in cross-sectional structure. One Ni-based super heat-resistant alloy manufacturing method includes preparing a raw material of a Ni-based super heat-resistant alloy having the aforementioned composition, and performing plastic processing of the raw material a plurality of times at a temperature of 500° C. or less so as to obtain a cumulative processing rate of 30% or greater. Another Ni-based super heat-resistant alloy manufacturing method includes preparing an alloy material having the aforementioned composition, a hardness of 500 HV or greater, and the aforementioned crystal grain maximum diameter, performing plastic processing of the alloy material at a temperature of 500° C. or less, and obtaining an alloy having a hardness of 500 HV or greater.

Abstract: The invention generally relates to materials and methods for creating and/or utilizing upconverting luminescence. More particularly, the invention relates to novel compositions (e.g., nanoparticles) and related methods of preparation and use that enable upconverting luminescence with an efficient excitation optimized at about 800 nm. A unique class of cascade sensitized tri-doped UCNPs with a biocompatiable 800 nm excitable property are disclosed herein, for example, tri-doped ?-NaYF4:Nd, Yb, Er (Tm)/NaYF4UCNPs, which employ Nd3+ as 800 nm photon sensitizer and Yb3+ as bridging ions, having strong green or blue upconversion emissions without photobleaching.

Abstract: Various embodiments of the present technology provide an online and/or offline meeting system that utilizes a “scene” as a collaboration context and/or for collecting and grouping related text and multimedia based messages exchanged in discussions, and causes the related texts and/or messages to be presented to participants of an online and/or offline meeting in a cinematic way. When an online meeting is over and the meeting session is ended, participants can still make offline communications using the scene as the collaboration context. Further, the present technology improves user experience in viewing or annotating non-text based content in a chat session.

Abstract: This invention provides a groundbreaking approach to PLNPs and their preparation. In particular, the synthetic methodology disclosed herein fundamentally differs from the traditional solid-state annealing reactions that require extreme and harsh reaction conditions. In one unique aspect of the invention, a simple, one-step mesoporous template method utilizing mesoporous silica nanoparticles (MSNs) is disclosed that affords in vivo rechargeable NIR-emitting mesoporous PLNPs with uniform size and morphology. In another unique aspect of the invention, the novel synthetic approach is based on aqueous-phase chemical reactions conducted in mild conditions, resulting in uniform and homogeneous PLNPs with desired size control (e.g., sub-10 nm).

Abstract: The invention generally relates to materials and methods for creating and/or utilizing upconverting luminescence. More particularly, the invention relates to novel compositions (e.g., nanoparticles) and related methods of preparation and use that enable upconverting luminescence with an efficient excitation optimized at about 800 nm. A unique class of cascade sensitized tri-doped UCNPs with a biocompatiable 800 nm excitable property are disclosed herein, for example, tri-doped ?-NaYF4:Nd, Yb, Er (Tm)/NaYF4UCNPs, which employ Nd3+ as 800 nm photon sensitizer and Yb3+ as bridging ions, having strong green or blue upconversion emissions without photobleaching.

Abstract: An Ni-based super heat resistant alloy extruded material manufacturing method includes: (1) obtaining an ingot by casting molten metal having a component composition of a precipitation-strengthened Ni-based super heat resistant alloy wherein the equilibrium precipitation amount of gamma prime at 700° C. is at least 40 mol % and using it as a billet, wherein the billet is heated to a hot working temperature that is at least 1030° C. and is less than the gamma prime solvus temperature of the alloy; and (2) inserting the billet that has been heated to the hot working temperature into a container, imparting a compressive force to the billet from one end side of the container, and extruding the billet at an extrusion rate of 10 to 300 mm/s from a hole in a die placed at the other end side of the container, to yield an Ni-based super heat resistant alloy extruded material.

Abstract: The invention provides a novel class of NIR-absorbing biocompatible organic nanoparticles for effective imaging, targeting and treatment of deep-tissue cancers or tumors. The invention enables a new platform for precise cancer- or tumor-targeting theranostics and clinical cancer treatment.

Abstract: This invention provides a groundbreaking approach to PLNPs and their preparation. In particular, the synthetic methodology disclosed herein fundamentally differs from the traditional solid-state annealing reactions that require extreme and harsh reaction conditions. In one unique aspect of the invention, a simple, one-step mesoporous template method utilizing mesoporous silica nanoparticles (MSNs) is disclosed that affords in vivo rechargeable NIR-emitting mesoporous PLNPs with uniform size and morphology. In another unique aspect of the invention, the novel synthetic approach is based on aqueous-phase chemical reactions conducted in mild conditions, resulting in uniform and homogeneous PLNPs with desired size control (e.g., sub-10 nm).

Abstract: The invention generally relates to materials and methods for creating and/or utilizing upconverting luminescence. More particularly, the invention relates to novel compositions (e.g., nanoparticles) and related methods of preparation and use that enable upconverting luminescence with an efficient excitation optimized at about 800 nm. A unique class of cascade sensitized tri-doped UCNPs with a biocompatible 800 nm excitable property are disclosed herein, for example, tri-doped ?-NaYF4:Nd,Yb,Er(Tm)/NaYF4 UCNPs, which employ Nd3+ as 800 nm photon sensitizer and Yb3+ as bridging ions, having strong green or blue upconversion emissions without photobleaching.

Abstract: The invention provides novel biocompatible upconversion nanoparticle (UCNP) that comprises a core of cubic nanocrystals (e.g., comprising ?-Na Lna, Lnb Lnc F4) and an epitaxial shell (e.g., formed from CaF2; wherein Lnb is Yb), and related methods of preparation and uses thereof.

Abstract: A method for manufacturing a Ni-based super-heat-resistant alloy includes: a first cold working step for cold working a Ni-based super-heat-resistant alloy ingot, which has a composition in which the ?? mole ratio is at least 40%, at a working ratio of 5% to less than 30%; and a first heat treatment step for heat-treating the cold worked material, on which the first cold working was performed, at a temperature exceeding the ?? solid solution temperature. It is preferable that the manufacturing method also includes a second cold working step for performing, after the first heat treatment step, a second cold working on the heat-treated material at a working ratio of at least 20%, and a second heat treatment step for heat-treating the second cold worked material, on which the second cold working has been performed, at less than the ?? solvus temperature.

Abstract: The invention provides novel biocompatible upconversion nanoparticle (UCNP) that comprises a core of cubic nanocrystals (e.g., comprising ?-Na Lna, Lnb Lnc F4) and an epitaxial shell (e.g., formed from CaF2; wherein Lnb is Yb), and related methods of preparation and uses thereof.

Abstract: A ring design machine receives one or more selections of gemstones and one or more selections of settings and allows a user to “mix and match” gemstones and settings and view a selected gemstone in a compatible setting for that gemstone. To present the gemstone in the setting, the ring design machine presents a combination image that depicts the gemstone in the setting. The ring design machine, which may be implemented using a computer programmed by software, may present the combination image to the user in response to receiving a selection of the gemstone and a selection of the setting from the user via a network.

Abstract: A ring design machine receives one or more selections of gemstones and one or more selections of settings and allows a user to “mix and match” gemstones and settings and view a selected gemstone in a compatible setting for that gemstone. To present the gemstone in the setting, the ring design machine presents a combination image that depicts the gemstone in the setting. The ring design machine, which may be implemented using a computer programmed by software, may present the combination image to the user in response to receiving a selection of the gemstone and a selection of the setting from the user via a network.