Abstract: Embodiments of the present disclosure relate to lipid-PEGylated solid support and phosphoramidites derivatives, methods for preparing the same, and their uses in the delivery of oligonucleotide drugs to the cellular targets.

Abstract: A method and a communication device for enabling execution of a virtual activity in a physical environment, wherein development of the virtual activity is presented to a user via at least one user interface of a communication device, the method including: determining a trajectory of the communication device; capturing and consolidating sensor data associated with the physical environment and virtual data associated with the virtual activity; generating at least two mutually dependent zones in the physical environment based on the captured and consolidated data and the trajectory of the communication device, and presenting an updated scene of the virtual activity, including at least parts of the zones via at least one of the user interfaces of the communication device.

Abstract: A method, system and apparatus are disclosed. According to one or more embodiments, a wireless device (WD) configured to communicate with a network node is provided. The WD is configured to, and/or includes a radio interface and/or processing circuitry configured to modify at least one wireless device configuration for at least one of receiving and processing at least a non-synchronization signal block (SSB) reference signal while in idle mode.

Abstract: A communication device comprises a modem and a transceiver, wherein the modem comprises digital baseband circuitry for generating a digital baseband signal for transmission, and the transceiver is configured to receive the digital baseband signal from the modem and to generate therefrom a radiofrequency signal for transmission by the communication device. The communication device controls the modem to operate in a first mode, and controls the modem to operate in a second mode. The first mode is a radar mode in which the modem generates radar baseband signals for transmission as one or more radar radiofrequency signals by the transceiver, and the second mode is a communication mode in which the modem generates information-containing baseband signals for transmission by the transceiver.

Abstract: A radar-enabled wireless communication device (12) is configured for exchanging communication signals with a wireless communication network (10) and for performing radar transmissions for surrounding-environment sensing. The device (12) classifies radar beam directions (30) as restricted or unrestricted, based on known or estimated interference with Uplink (UL) reception operations of the network (10) and adapts its radar transmissions based on the classifications. Classification operations may be autonomous, without requiring explicit network support, or may be based on one or radio network nodes (22) of the network (10) performing supporting procedures. Updating the classifications depends on, for example, one or more triggering conditions, such as changes in the position or orientation of the device (12), transmit-frequency changes, and changes in ambient conditions, such as the presence or intensity of rain.

Abstract: Disclosed are an ATX inhibitor, a preparation method therefor, and the use thereof, which belong to the technical field of pharmaceutical chemistry. In particular, the ATX inhibitor is a compound having the structure of formula I?, or a pharmaceutically acceptable salt, an ester, an isomer, a solvate, a prodrug or an isotope marker thereof. Compared with the existing ATX inhibitor GLPG-1690, the ATX inhibitor has higher inhibitory activity, also has excellent efficacy, in vitro/in vivo pharmacokinetic properties and safety, and has broad clinical application prospects.

Abstract: An AK3287 formulation, and a preparation method therefor and an application thereof. In mass fraction, the formulation comprises: 0.05-20% of AK3287; 0-30% of an absorption enhancer; 5-99.95% of an oil-phase substance; 0-25% of an emulsifier; 0-5% of a preservative; and 0-70% of water, wherein the structure of AK3287 is shown in the drawing. AK3287 molecules in the formulation have high exposure in the skin, and the formulation can reduce the thickness of the skin at a scar and the ratio of the maximum thickness of the skin at the scar to the thickness of the normal skin; moreover, the relative density of TGF-? and type I collagen in the skin is reduced.

Abstract: A node in a wireless communication system coordinates multistatic radar measurements, wherein the node controls a plurality of wireless communication devices. Coordination involves obtaining an indication that a first sensing area located within a geographic area that is served by the node is to be sensed by a first radar signal. A first multistatic radar group of wireless communication devices selected from a participating group of the plurality of wireless communication devices and the node is formed, wherein the first multistatic radar group comprises at least one device for transmitting the first radar signal and at least two devices for receiving one or more reflections of the transmitted first radar signal. The first multistatic radar group is controlled to introduce the first radar signal into the first sensing area and to receive the one or more reflections of the introduced first radar signal.

Abstract: One or more network nodes are configured for operation in a wireless communication network and, specifically, are configured to provide for co-existence between radar-scanning operations of a radar-enabled UE and network communications, where the radar transmissions are in a same or overlapping frequency range as regards the network communications. In an example implementation, a radio network node, referred to as an CONFIGURE ONE OR MORE access point or base station supports coexistence between radar sensing and network communications that are subject to interference from the radar sensing.

Abstract: A radar-enabled wireless communication device (12) is configured to communicate with a wireless communication network (10) and performs radar transmissions using a same or overlapping millimeter wave (mmW) frequency range, determine whether there are any neighboring wireless communication devices (32) that are vulnerable to interference from the radar transmissions and, if so, adapt radar transmissions in the affected radar beam directions or transmit assistance information enabling the vulnerable devices (32) to mitigate or avoid the interference. In a particular example, the wireless communication device (12) performs radar transmissions during a Downlink (DL) phase of the wireless communication network (10), such that the vulnerability determinations are with respect to DL interference at the neighboring wireless communication devices (32).

Abstract: A wireless communications device that operates in a wireless communications system performs a radar function. This involves obtaining required radio frequency (RF) properties of a radar signal to be used for the radar function, wherein the radar function is one of a plurality of radar functions supported by the wireless communications device, each having a respective one of a plurality of different required RF properties. A transceiver of the wireless communications device is configured to transmit a predefined signal of the wireless communications system using time and frequency resources associated with the predefined signal of the wireless communications system and that satisfy the required RF properties of the radar signal. The configured transceiver is used to transmit the predefined signal of the wireless communications system.

Abstract: A radio frequency power recovery unit, comprises a plurality of rectennas, each comprising an antenna and a capacitor configured to be charged by energy received by the antenna; a plurality of switches, each configured to selectively connect a respective one of the plurality of rectennas to an energy storage device, such that the respective capacitor is charged by energy received by the ntenna while the respective switch is open, and such that the respective capacitor is discharged to the energy storage device while the respective switch is closed; and a control unit, configured to selectively open and close the switches in a predetermined sequence.

Abstract: The present disclosure provides an elastase inhibitor prodrug and use thereof, being a compound of formula I or a pharmaceutically acceptable salt, ester, isomer or solvate thereof, prodrugs or isotopically labeled compound. Compared with the compound 52 (control example) in WO 2018/175173 A1, the compound disclosed herein has the advantages of high pulmonary exposure and long half-life. The prodrugs of the present disclosure significantly increase the concentration and residence time of the active compound (control example) in the lungs with significant improvements in pharmacokinetics in vivo compared to the control example.

Abstract: A method for power management of a first communication device, which has first power resources, comprises detecting a second communication device operating in a same area as the first communication device and having second power resources being less constrained than the first power resources. The method also comprises connecting to the second communication device over a non-cellular connection and delegating to the second communication device to perform cellular connection management measurements for the first communication device through cellular communication with a network node.

Abstract: The present disclosure provides the synthesis and application of respiratory syncytial virus inhibitor, being a compound of formula I or a pharmaceutically acceptable salt, ester, isomer, solvate, prodrug or isotope label thereof. Compared with the existing inhibitors, the compounds of formula I have the advantages of superior activity and higher exposure in vivo.

Abstract: A wireless communication device having a receiving module, a transmitting module, and a processor which includes a determining module, and a processing module, wherein the wireless communication device is arranged to perform a method for power savings in a wireless communication system. Transmissions of a first set of reference symbols, RSs, and a second set of RSs are provided in the wireless communication system. The method includes obtaining information on the transmission of the second set of RSs, and determining which RS to use for idle mode tasks based on the obtained information on the transmission of the second set of RSs. The first set of RSs are provided periodically, and the second set of RSs are provided any of periodic, semi-persistent or aperiodic transmissions.

Abstract: Systems and methods are disclosed herein that relate to partially reconfiguring a Field Programmable Gate Array (FPGA) of a wireless communication device to provide time-slicing of modem and application functionality. In this manner, a low-cost, small size, and low power consumption implementation of the FPGA and thus the wireless communication device is provided.

Abstract: A method is disclosed—for a wireless communication device served by a network access node—of keeping a time reference at the wireless communication device. The wireless communication device is configured for operation according to at least first and second operational modes, the second operational mode having lower power consumption than the first operational mode. The method comprises (during operation according to the first operational mode) determining (for the second operational mode) desired timings of timing signals to be transmitted from the network access node, and transmitting a request signal to the network access node, wherein the request signal carries information of the desired timings of timing signals to be transmitted from the network access node. In some embodiments, the method further comprises receiving a response signal from the network access node, wherein the response signal carries information of actual timings of timing signals to be transmitted from the network access node.

Abstract: A wireless communication device comprises: an antenna; a radio frequency transceiver, for generating signals for transmission through the antenna, the radio frequency transceiver being connectable to the antenna through a switch; a backscattering block, for generating reflected signals for transmission through the antenna in response to received RF signals, the backscattering block being connectable to the antenna through said switch; and a battery. The switch is controlled by an output voltage of the battery, such that the radio frequency transceiver is connected to the antenna through the switch when the output voltage of the battery exceeds a threshold voltage, and the backscattering block is connected to the antenna through the switch when the output voltage of the battery is below the threshold voltage.

Abstract: According to certain embodiments, a wireless device is configured to operate in a regular-power mode and a low-power mode, and a method of detecting wireless device movement includes: performing a link characterization measurement in the low-power mode using a low-power radio; determining, based on the low-power radio link characterization measurement, that the wireless device is not stationary; and performing radio resource measurements in the regular-power mode. In particular embodiments, performing the link characterization measurement using the low-power radio includes measuring a stationary reference signal (e.g., secondary synchronization signal (SSS)). Measuring the stationary reference signal uses a time-domain correlation receiver on the stationary reference signal.