Abstract: A medicated module for an injection system to co-deliver at least two medicaments is disclosed where a primary delivery device containing a primary medicament accepts a medicated module containing a single dose of a secondary medicament and where both medicaments are delivered through a hollow needle. The medicated module does not require the user to manually engage a reservoir containing the secondary medicament. Instead, a rotating housing automatically activates the reservoir when the needle guard is retracted. The needle guard prevents accidental needle sticks after an injection, and locks after dose delivery.

Abstract: The present patent application relates to delivery devices, methods, and systems of delivering at least one medicament from a reservoir using an automatic delivery device. Such an automatic delivery device system may comprise a dose injecting mechanism and a dispense interface, such as a needle module. The dose injecting mechanism comprises a triggering mechanism. An activating member, such as a needle guard of the needle module, can be used to initiate the triggering mechanism to enable the device to administer the set dose. The single dispense interface may comprise a medicated module containing at least one dose of a secondary medicament. The dose injecting mechanism may comprise a dose setting mechanism.

Abstract: Disclosed herein are various examples of a drug delivery system and corresponding method for delivering three or more medicaments. The system includes two major components: an auto-injector device that contains at least two medicaments and a medicated module that contains at least one medicament. The medicated module interfaces with the auto-injector device such that a combination dose comprising all of the medicaments can be delivered via a single dispense interface of the medicated module. In order to deliver a pre-defined combination dose, a user need only set the dose of one of the medicaments contained in the auto-injector device and need only activate the system once by actuating a dose delivery button on the auto-injector device.

Abstract: A drug delivery device having a collar and a linkage component. The drug delivery device includes a variable dose setting mechanism, a fixed dose setting mechanism, a single dose setter, a collar, and a linkage component. The variable dose setting mechanism is operably coupled to a primary reservoir holding a first medicament and/or fluid. The fixed dose setting mechanism comprises a fixed dose piston rod that is operably coupled to a secondary reservoir holding a second medicament and/or fluid. Further, the single dose setter is operably coupled to the variable dose setting mechanism, and the collar is disposed on the variable dose setting mechanism. Still further, the linkage component may be disposed on the fixed dose setting mechanism, wherein the linkage component is capable of engagement with the collar. The delivery device is capable of delivering the second medicament and/or fluid by way of at least one discrete pulse of the second medicament and/or fluid.

Abstract: A drug delivery system to deliver two or more medicaments operable through a auto-injector drug delivery device and a single dispense interface. The device comprises a housing defining a primary reservoir containing a first medicament. A dosing mechanism operably connected to the primary reservoir. A single dispense interface is configured for fluid communication with the primary reservoir and a secondary reservoir of medicament containing at least one drug agent configured for fluid communication to the single dispense interface. A single activation of the dosing mechanism causes medicament from the primary reservoir and a non-user settable dose of the second medicament to be expelled through the single dispense interface.

Abstract: A medicated module for an injection system to co-deliver at least two medicaments is disclosed where a primary delivery device containing a primary medicament accepts a medicated module containing a single dose of a secondary medicament and where both medicaments are delivered through a hollow needle. The medicated module does not require the user to manually engage a reservoir containing the secondary medicament. Instead, a biasing member automatically activates the reservoir when the needle guard is retracted. The needle guard prevents accidental needle sticks before and after an injection, and locks after dose delivery.

Abstract: An ophthalmic drug delivery device containing a primary medicament reservoir and a replaceable medicated module containing a second medicament where the device has a selector to allow dispense of primary medicament or a combination of the primary and secondary medicaments such that a single activation of the ophthalmic drug delivery will deliver both medicaments to the user.

Abstract: A medicated module (4) for an injection system to co-deliver at least two medicaments is disclosed where a primary delivery device containing a primary medicament accepts a medicated module (4) containing a single dose of a secondary medicament and where both medicaments are delivered through a hollow needle (3). The medicated module (4) does not require the user to manually engage a reservoir (22) containing the secondary medicament. Instead, a biasing member (48) automatically activates the reservoir (22) when the needle guard (42) is retracted. The needle guard (42) prevents accidental needle sticks before and after an injection, and locks after dose delivery.

Abstract: A first input member (6) and a second input member (7) are arranged along a first axis (4) and coupled in such a manner that a movement of the first input member along the first axis is converted into a rotational movement of the second input member with respect to the body (1). A first output member (8) and a second output member (9) are arranged along a second axis (5) and coupled in such a manner that a rotational movement of the first output member is converted into a movement of the second output member along the second axis with respect to the body. The second input member and the first output member are releasably rotationally coupled.

Abstract: The instant application is directed to an assembly for a drug delivery device which is arranged to operate in two distinct modes, a priming mode starting from a pre-priming state and a dispense mode operating in a post-priming state, and a drug delivery device comprising this assembly. The assembly comprises a dose member, an actuating member and a piston rod which is configured to act on a bung of an assembled cartridge containing the drug. In the pre-priming state the actuating member is configured to be moved by a user such that the movement of the actuating member causes a movement of the dose member and such that the movement of the dose member causes a movement of the piston rod. In the post-priming state the dose member is configured to be moved by a user without causing a movement of the actuating member in order to perform a set and dispense action of the drug delivery device.

Abstract: According to one aspect, a resettable drive assembly for a drug delivery device is provided for. The resettable drive assembly may comprise a housing having a proximal end and a distal end, a piston rod being rotatable with respect to the housing and being axially displaceable with respect to the housing between a proximal start position and a distal end position, a drive member for distally displacing the piston rod towards the end position when dispensing a dose, and a stop member. The drive assembly may be configured such that the drive member is operable to interact with the piston rod for forming an unlockable first interlock, the first interlock being operable to block proximal movement of the piston rod with respect to the drive member. The drive assembly may be configured such that the stop member is operable to interact with the piston rod for forming an unlockable second interlock, the second interlock being operable to block proximal movement of the piston rod with respect to the housing.

Abstract: A drug delivery device (10) is given, comprising a body (12) and a moveable button member (14), wherein in a pre-ready state of the drug delivery device (10) there is a misalignment between the body (12) and the button member (14). This misalignment is perceivable by a user of the drug delivery device (10). In a ready state of the drug delivery device (10), the button member (14) and the body (12) are aligned and the alignment is perceivable by a user of the drug delivery device (10).

Abstract: A drug delivery device (4) for dispensing one or more doses of a drug is provided. The device (4) comprises a drive member (1) for driving a piston rod (5) and a dose member (46) for actuating the drive member (1). The piston rod (5) is coupled to the drive member (1) such that a relative translational movement of the drive member (1) and the piston rod (5) is allowed and a relative rotational movement is prevented. The drive member (1) is configured to be driven by the dose member (46) around the longitudinal axis in a first (110) and a second rotational direction (111) opposite to each other. Furthermore, a drug delivery device (4) is provided, wherein the drive member (1) has stable and unstable states and wherein in an unstable state the drive member (1) is biased by biasing means (3) towards a stable state.

Abstract: An injection device (1) for administering a fixed dose of a medication is provided. The injection device (1) comprises a housing (2) wherein a drive mechanism comprising a drive member (3) is at least partially enclosed and a dosing element (34) which is fixed relative to the drive member (3). Here, a dose can be set by rotating the dosing element (34) relative to the housing (2) in a dose set direction (105) and the dose can be dispensed by pushing the dosing element (34) towards the housing (2). Moreover, a method is provided for operating an injection device (1) for the administration of a fixed dose of a medication: A dose can be set by rotating a dosing element (34), a dose can be dispensed by pushing the dosing element (34) towards the housing (2) and a dose can be cancelled by rotating the dosing element (34) in a direction (106) opposite to the dose set direction (105).

Abstract: An assembly of a drug delivery device with a longitudinal axis (L) is given, comprising a body (1) with a proximal end (2) and a distal end (3). The drug delivery device further comprises a drive assembly and a first button member (4). The drive assembly is at least partially arranged within the body (1) and is adapted to facilitate dispense of a medicinal product. The first button member (4) acts on the drive assembly to prepare the drug delivery device for dispensing the medicinal product. The first button member (4) is adapted to be detachable from the body (1) after the preparation of the drug delivery device is completed.

Abstract: An assembly of a drug delivery device comprises a body (10) having a distal end (11) and a proximal end (12), a drive assembly (4) arranged substantially within the body (10) to facilitate dispense of a medicinal product and a button member (5) arranged at the proximal end (12) of the body (10) and adapted to act upon the drive assembly (4). The drive assembly (4) has an initial pre-ready state, a transient state and a ready state; in the pre-ready and transient states the button member (5) is twistable with respect to the body (10) to act upon the drive assembly (4) and wherein in the ready state the button member (5) is axially moveable but not substantially twistable with respect to the body (10) to act upon the drive assembly (4) to dispense a dose of the medicinal product.

Abstract: A lead screw (5) with a screw thread (6) is arranged in a body (1) along an axis (4) and coupled to a lead screw nut (7) with a drive feature (8), so that the lead screw is helically rotatable in the lead screw nut. The lead screw and the lead screw nut are provided with stop features (9) interfering with a rotation of the lead screw in the lead screw nut when a force is applied to the lead screw in an axial direction. The lead screw nut has a surface area facing a guide feature (10) of the body. This surface area has a slope (12) varying around the axis. The assembly interacts such that the lead screw nut rotates in one rotational direction when a force is applied to the lead screw in the axial direction.

Abstract: A resettable drive assembly for a drug delivery device (1) is provided. The drive assembly comprises a drive unit (3) for driving a piston rod (5) in a dispense operation of the device (1). The drive unit (3) comprises a first drive member (35), a second drive member (37) and locking means preventing a relative rotational movement of the first (35) and the second drive member (37) during a dispense operation and allowing a relative rotational movement for enabling a resetting of the device (1). Moreover, a drug delivery device (1) comprising a resettable drive assembly is provided.

Abstract: A method for securing a cartridge (4) in a cartridge holder (3) is provided, the method comprising the steps of inserting the cartridge (4) into the cartridge holder (3), the cartridge holder (3) having a proximal end and a distal end, axially displacing the cartridge (4) in a proximal direction with respect to the cartridge holder (3) from a distal initial position to a proximal end position and securing the cartridge (4) in the end position against displacement in the distal direction with respect to the cartridge holder (3). An assembly for a drug delivery device (1) is provided comprising a cartridge (4), an adjusting member (12, 25, 28, 34) and a cartridge holder (3). The cartridge holder (3) has a distal end and a proximal end. The adjusting member (12, 25, 28, 34) is secured to the cartridge holder (3). The adjusting member (12, 25, 28, 34) holds a distal portion of the cartridge (4) at a distance with respect to a distal portion of the cartridge holder (3).

Abstract: According to one aspect, a drive assembly for a drug delivery device is provided for. The drive assembly may comprise a housing (10A, 10B, 10C) having a proximal end (100P) and a distal end (100D), a piston rod (20) being axially displaceable and rotatable with respect to the housing (10A, 10B, 10C) between a first angular position and a second angular position, a drive member (30) being axially displaceable, and a rotational bias member (50) being operable to transfer a resilient bias to the piston rod (20). The drive assembly may be configured such that, for setting a dose, the drive member (30) is proximally axially displaceable with respect to the housing (10A, 10B, 10C) and the piston rod (20) from a rest position to a dose set position. When setting the dose, the piston rod (20) may be rotated in a first rotational direction and, subsequent to the rotation in the first rotational direction, rotated in a second rotational direction with respect to the housing and the drive member.