Patents by Inventor Garth Powis

Garth Powis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20030223980
    Abstract: The present invention relates to the use of thioredoxin as, inter alia, a cell growth stimulator, as well as a screen for agents that are useful in reducing or preventing thioredoxin-associated apoptosis inhibition and agents that are useful in inhibiting thioredoxin stimulated cell growth.
    Type: Application
    Filed: June 20, 2003
    Publication date: December 4, 2003
    Inventor: Garth Powis
  • Publication number: 20030109572
    Abstract: Novel Wortmannin analogs and their use in inhibiting inhibiting PI-3-kinase activity in mammals as well as tumor formation in a subject are described herein.
    Type: Application
    Filed: September 16, 2002
    Publication date: June 12, 2003
    Inventor: Garth Powis
  • Publication number: 20030109573
    Abstract: A method of inhibiting restenosis in a subject following coronary angioplasty, atherectomy, or arterial bypass graft surgery comprised of administering wortmannin analogs of the present invention is described herein.
    Type: Application
    Filed: September 16, 2002
    Publication date: June 12, 2003
    Inventor: Garth Powis
  • Publication number: 20020055131
    Abstract: The present invention relates to the use of thioredoxin as, inter alia, a cell growth stimulator, as well as a screen for agents that are useful in reducing or preventing thioredoxin-associated apoptosis inhibition and agents that are useful in inhibiting thioredoxin stimulated cell growth.
    Type: Application
    Filed: June 6, 2001
    Publication date: May 9, 2002
    Inventor: Garth Powis
  • Patent number: 6379970
    Abstract: A method of detecting peptide fragments of protein(s) that are differentially present in biological samples. The identity of the peptides may be determined and correlated with the protein(s) that are differentially present in the samples.
    Type: Grant
    Filed: April 30, 1999
    Date of Patent: April 30, 2002
    Assignee: The Arizona Board of Regents on behalf of the University of Arizona
    Inventors: Daniel C. Liebler, Thomas D. McClure, Garth Powis
  • Patent number: 6372772
    Abstract: The present invention is directed to a composition or formulation which inhibits or interferes with cellular redox function, and method of using same to restore normal cellular function. More specifically, the composition of the present invention interferes with or inhibits abnormal cellular proliferation and//restores or cellular apoptosis.
    Type: Grant
    Filed: July 31, 1998
    Date of Patent: April 16, 2002
    Assignee: Prolx Pharmaceuticals Corporation
    Inventors: D. Lynn Kirkpatrick, Garth Powis
  • Patent number: 6245754
    Abstract: The present invention relates to the preparation and biological activity of 3-deoxy-D-myo-inositol ether lipid analogs as inhibitors of phosphatidylinositol-3-kinase signaling and cancer cell growth. The compounds of the present invention are useful as anti-tumor agents which effectively inhibit the growth of mammalian cells.
    Type: Grant
    Filed: June 25, 1999
    Date of Patent: June 12, 2001
    Inventors: Alan P. Kozikowski, Lixin Qioa, Garth Powis
  • Patent number: 5378725
    Abstract: Wortmannin and certain of its analogs are inhibitors of phosphatidylinositol 3-kinase. The compounds are particularly useful for inhibiting phosphatidylinositol 3-kinase in mammals and for treating phosphatidylinositol 3-kinase-dependent conditions, especially neoplasms, in mammals.
    Type: Grant
    Filed: July 19, 1993
    Date of Patent: January 3, 1995
    Assignees: The Arizona Board of Regents, Eli Lilly and Company
    Inventors: Rosanne Bonjouklian, Chris J. Vlahos, Garth Powis
  • Patent number: 5227508
    Abstract: The invention provides 3-deoxy-3-substituted analogs of phosphatidylinositol which are useful to inhibit the growth of mammalian cells, i.e., to treat neoplastic conditions and other proliferative disorders of mammalian cells.
    Type: Grant
    Filed: January 24, 1992
    Date of Patent: July 13, 1993
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Alan P. Kozikowski, Werner Tuckmantel, Abdul H. Faug, Garth Powis
  • Patent number: 5210263
    Abstract: The present invention provides novel inositol phosphate analogs and a method for their use for detecting the phosphatidylinositol cycle-dependent calcium of a cell.
    Type: Grant
    Filed: May 15, 1990
    Date of Patent: May 11, 1993
    Assignees: University of Pittsburgh, Mayo Foundation For Medical Education and Research
    Inventors: Alan P. Kozikowski, Garth Powis