Patents by Inventor Gary Blackburn

Gary Blackburn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10435630
    Abstract: System and method for reducing mutagen levels contained within a volume of petroleum aromatic extracts. The petroleum aromatic extracts are mixed with at least one solvent. This produces a mixture. Once mixed, some of the petroleum aromatic extracts dissolve. Others settle in the mixture. The petroleum aromatic extracts that have settled on the mixture are removed from the mixture and are ready for use. The mixture is heated to evaporate the solvent from the mixture. The evaporated solvent can be recaptured and reused. The residuum of the mixture contains petroleum aromatic extracts that can be partially recovered using traditional hydroprocessing techniques.
    Type: Grant
    Filed: February 5, 2017
    Date of Patent: October 8, 2019
    Inventor: Gary Blackburn
  • Patent number: 9874542
    Abstract: The invention relates to the use of signal processing methods in order to achieve higher signal to noise ratios, to increase the detection limits of target analytes. These techniques include the monitoring of the output signal at higher harmonic frequencies.
    Type: Grant
    Filed: October 14, 2014
    Date of Patent: January 23, 2018
    Assignee: CLINICAL MICRO SENSORS, INC.
    Inventors: Robert M. Umek, Gary Blackburn, Bruce D. Irvine, Robert Terbrueggen, Changjun Yu, Jost G. Vielmetter
  • Publication number: 20170226428
    Abstract: System and method for reducing mutagen levels contained within a volume of petroleum aromatic extracts. The petroleum aromatic extracts are mixed with at least one solvent. This produces a mixture. Once mixed, some of the petroleum aromatic extracts dissolve. Others settle in the mixture. The petroleum aromatic extracts that have settled on the mixture are removed from the mixture and are ready for use. The mixture is heated to evaporate the solvent from the mixture. The evaporated solvent can be recaptured and reused. The residuum of the mixture contains petroleum aromatic extracts that can be partially recovered using traditional hydroprocessing techniques.
    Type: Application
    Filed: February 5, 2017
    Publication date: August 10, 2017
    Inventor: Gary Blackburn
  • Patent number: 9428725
    Abstract: A flow-through device for capturing a biological material from a fluid specimen and lysing the fluid specimen. The flow through device may include a first chamber containing a portion of the fluid specimen and a solid phase material retained in the first chamber. The solid phase material may have an affinity for the biological material in the fluid specimen. The first chamber may include an inlet opening which allows flow of the fluid specimen into the first chamber. The first chamber may also include an outlet opening which allows flow of the fluid specimen out of the first chamber. The flow through device may include a second chamber fluidly connected to the first chamber. The second chamber may include a portion of the fluid specimen and an impeller. The impeller may in use impart rotational motion to the fluid specimen to mechanically lyse the fluid specimen.
    Type: Grant
    Filed: January 14, 2014
    Date of Patent: August 30, 2016
    Assignee: Claremont Biosolutions LLC
    Inventors: Mark Brown, Robert Doebler, Bruce Irvine, Tanya Ferguson, Gary Blackburn
  • Publication number: 20150126391
    Abstract: The invention relates to the use of signal processing methods in order to achieve higher signal to noise ratios, to increase the detection limits of target analytes. These techniques include the monitoring of the output signal at higher harmonic frequencies.
    Type: Application
    Filed: October 14, 2014
    Publication date: May 7, 2015
    Applicant: GenMark Diagnostics Inc.
    Inventors: Robert M. UMEK, Gary Blackburn, Bruce D. Irvine, Robert Terbrueggen, Changjun Yu, Jost G. Vielmetter
  • Publication number: 20140127773
    Abstract: Lysing may include agitating a specimen in a chamber along with a medium that includes a particulate lysing material that has an affinity for a biological material. Lysing material may include beads or other material which may be coated that facilitates binding. The medium may include a fluid with a high salt or low pH level. Binding of biological materials to solid surfaces may be induced by particular media. The biological material may be eluted by lowering a concentration of salt or increasing a pH level. Lysing materials with two or more different affinities may be employed. Lysing materials may include particles of different sizes. Heating may be used. Lysing may be performed in a flow through apparatus. Surfaces of solid materials may be modified to capture bacteria with high cell wall lipid content.
    Type: Application
    Filed: January 14, 2014
    Publication date: May 8, 2014
    Inventors: Mark Brown, Robert Doebler, Bruce Irvine, Tanya Ferguson, Gary Blackburn
  • Patent number: 8663974
    Abstract: Lysing may include agitating a specimen in a chamber along with a medium that includes a particulate lysing material that has an affinity for a biological material. Lysing material may include beads or other material which may be coated that facilitates binding. The medium may include a fluid with a high salt or low pH level. Binding of biological materials to solid surfaces may be induced by particular media. The biological material may be eluted by lowering a concentration of salt or increasing a pH level. Lysing materials with two or more different affinities may be employed. Lysing materials may include particles of different sizes. Heating may be used. Lysing may be performed in a flow through apparatus. Surfaces of solid materials may be modified to capture bacteria with high cell wall lipid content.
    Type: Grant
    Filed: December 23, 2011
    Date of Patent: March 4, 2014
    Assignee: Claremont BioSolutions LLC
    Inventors: Mark Brown, Robert Doebler, Bruce Irvine, Tanya Ferguson, Gary Blackburn
  • Publication number: 20120252008
    Abstract: Lysing may include agitating a specimen in a chamber along with a medium that includes a particulate lysing material that has an affinity for a biological material. Lysing material may include beads or other material which may be coated that facilitates binding. The medium may include a fluid with a high salt or low pH level. Binding of biological materials to solid surfaces may be induced by particular media. The biological material may be eluted by lowering a concentration of salt or increasing a pH level. Lysing materials with two or more different affinities may be employed. Lysing materials may include particles of different sizes. Heating may be used. Lysing may be performed in a flow through apparatus. Surfaces of solid materials may be modified to capture bacteria with high cell wall lipid content.
    Type: Application
    Filed: December 23, 2011
    Publication date: October 4, 2012
    Applicant: CLAREMONT BIOSOLUTIONS, LLC
    Inventors: Mark Brown, Robert Doebler, Bruce Irvine, Tanya Ferguson, Gary Blackburn
  • Patent number: 7935481
    Abstract: The present invention is directed to methods and compositions for the use of self-assembled monolayers to electronically detect nucleic acids, particularly alterations such as nucleotide substitutions (mismatches) and single nucleotide polymorphisms (SNPs).
    Type: Grant
    Filed: July 26, 2000
    Date of Patent: May 3, 2011
    Assignee: Osmetech Technology Inc.
    Inventors: Robert M. Umek, Gary Blackburn, Bruce D. Irvine, Robert H. Terbrueggen, Changjun Yu, Jost G. Vielmetter
  • Publication number: 20100028984
    Abstract: The invention is directed to a method of analyzing a plurality of biochips. In particular, the method includes inserting a first biochip in to a first station of an analysis device, inserting a second biochip into a second station of the analysis device, wherein each of the first and second biochips comprise a substrate that includes an array of detection electrodes, each including a different capture binding ligand, a different target analyte, and a label, and a plurality of electrical contacts, detecting current as an indication of the presence of the labels on the first biochip and detecting current as an indication of the presence of the labels on the second biochip.
    Type: Application
    Filed: July 17, 2007
    Publication date: February 4, 2010
    Inventors: Hau H. DUONG, Gary Blackburn, Jon F. Kayyem, Stephen D. O'Connor, Gary T. Olsen, Robert Pietri, Robert H. Terbrueggen
  • Patent number: 7655129
    Abstract: The invention relates to compositions and methods useful in the acceleration of binding of target analytes to capture ligands on surfaces. Detection proceeds through the use of an electron transfer moiety (ETM) that is associated with the target analyte, either directly or indirectly, to allow electronic detection of the ETM.
    Type: Grant
    Filed: April 12, 2004
    Date of Patent: February 2, 2010
    Assignee: Osmetech Technology Inc.
    Inventors: Gary Blackburn, Stephen E. Creager, Scott Fraser, Bruce D. Irvine, Thomas J. Meade, Stephen J. O'Connor, Robert H. Terbrueggen, Jost G. Vielmetter, Thomas W. Welch
  • Patent number: 7312087
    Abstract: The invention is directed to devices and methods that allow for simultaneous multiple biochip analysis. The method of analyzing the plurality of biochips includes inserting a first biochp into a first station of an analysis device, inserting a second biochip into a second station of the analysis device, wherein each of the first and second biochips include a substrate, the substrates including an array of detection electrodes, each electrode including a different capture binding ligand, a different target analyte, and a label, and a plurality of electrical contracts, detecting current as an indication of the presence of the labels on the first biochip, and detecting current as an indication of the presence of the labels on the first second biochip. The devices and method may be used with multiple cartridges comprising biochips comprising arrays, such as nucleic acid arrays, and allow for high throughput analysis of samples.
    Type: Grant
    Filed: January 11, 2001
    Date of Patent: December 25, 2007
    Assignee: Clinical Micro Sensors, Inc.
    Inventors: Hau H. Duong, Gary Blackburn, Jon F. Kayyem, Stephen D. O'Connor, Gary T. Olsen, Robert Pietri, Robert H. Terbrueggen
  • Publication number: 20070189921
    Abstract: The invention is directed to a method of analyzing a plurality of biochips. In particular, the method includes inserting a first biochip in to a first station of an analysis device, inserting a second biochip into a second station of the analysis device, wherein each of the first and second biochips comprise a substrate that includes an array of detection electrodes, each including a different capture binding ligand, a different target analyte, and a label, and a plurality of electrical contacts, detecting current as an indication of the presence of the labels on the first biochip and detecting current as an indication of the presence of the labels on the second biochip.
    Type: Application
    Filed: January 11, 2001
    Publication date: August 16, 2007
    Inventors: Hau Duong, Gary Blackburn, Jon Kayyem, Stephen O'Connor, Gary Olsen, Robert Pietri, Robert Terbrueggen
  • Patent number: 7172897
    Abstract: The invention is directed to devices that allow for simultaneous multiple biochip analysis. In particular, the devices are configured to hold multiple cartridges comprising biochips comprising arrays such as nucleic acid arrays, and allow for high throughput analysis of samples.
    Type: Grant
    Filed: November 5, 2001
    Date of Patent: February 6, 2007
    Assignee: Clinical Micro Sensors, Inc.
    Inventors: Gary Blackburn, Hau H. Duong, Piotr Grodzinski, Jon Faiz Kayyem, Stephen D. O'Connor, Robert Pietri, Robert Henry Terbrueggen, Frederic Zenhausern, Gary T. Olsen
  • Patent number: 7087148
    Abstract: The invention relates to compositions and methods useful in the acceleration of binding of target analytes to capture ligands on surfaces. Detection proceeds through the use of an electron transfer moiety (ETM) that is associated with the target analyte, either directly or indirectly, to allow electronic detection of the ETM.
    Type: Grant
    Filed: November 13, 2000
    Date of Patent: August 8, 2006
    Assignee: Clinical Micro Sensors, Inc.
    Inventors: Gary Blackburn, Jost G. Vielmetter, Jon Faiz Kayyem
  • Publication number: 20060160205
    Abstract: The invention is directed to devices that allow for simultaneous multiple biochip analysis. In particular, the devices are configured to hold multiple cartridges comprising biochips comprising arrays such as nucleic acid arrays, and allow for high throughput analysis of samples.
    Type: Application
    Filed: November 5, 2001
    Publication date: July 20, 2006
    Inventors: Gary Blackburn, Hau Duong, Piotr Grodzinski, Jon Kayyem, Stephen O'Connor, Robert Pietri, Robert Terbrueggen, Frederic Zenhausern, Gary Olsen
  • Publication number: 20050244954
    Abstract: The invention relates to compositions and methods useful in the acceleration of binding of target analytes to capture ligands on surfaces. Detection proceeds through the use of an electron transfer moiety (ETM) that is associated with the target analyte, either directly or indirectly, to allow electronic detection of the ETM.
    Type: Application
    Filed: March 16, 2005
    Publication date: November 3, 2005
    Inventors: Gary Blackburn, Stephen Creager, Scott Fraser, Bruce Irvine, Thomas Meade, Stephen O'Connor, Robert Terbrueggen, Jost Vielmetter, Thomas Welch
  • Publication number: 20050164410
    Abstract: An apparatus for performing a binding assay for an analyte of interest present in a sample based upon measurement of electrochemiluminescence at an electrode surface comprising a cell defining a sample containing volume intersecting with inlet and outlet means, an electrode having a substantially horizontally positioned surface exposed to and positioned below a portion of the sample containing volume, means for impressing electrochemical energy upon said electrode sufficient to generate luminescence, means for magnetically collecting particles along said surface and means for measuring the luminescence generated at said electrode.
    Type: Application
    Filed: August 6, 2004
    Publication date: July 28, 2005
    Inventors: John Leland, Haresh Shah, John Kenten, Jack Goodman, George Lowke, Yuzaburo Namba, Gary Blackburn, Richard Massey
  • Patent number: 6875619
    Abstract: The present invention is directed to a variety of microfluidic devices with configurations including the use of biochannels or microchannels comprising arrays of capture binding ligands to capture target analytes in samples. The invention provides microfluidic cassettes or devices that can be used to effect a number of manipulations on a sample to ultimately result in target analyte detection or quantification.
    Type: Grant
    Filed: May 17, 2001
    Date of Patent: April 5, 2005
    Assignee: Motorola, Inc.
    Inventor: Gary Blackburn
  • Publication number: 20050053962
    Abstract: The invention relates to compositions and methods useful in the detection of nucleic acids using a variety of amplification techniques, including both signal amplification and target amplification. Detection proceeds through the use of an electron transfer moiety (ETM) that is associated with the nucleic acid, either directly or indirectly, to allow electronic detection of the ETM using an electrode.
    Type: Application
    Filed: November 15, 2004
    Publication date: March 10, 2005
    Inventors: Gary Blackburn, Bruce Irvine, Jon Kayyem, Edward Sheldon, Robert Terbrueggen