Patents by Inventor Gary G. Leisk

Gary G. Leisk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200246167
    Abstract: A bioresorbable biopolymer stents can be deployed within a blood vessel and resorbed by the body over a predetermined time period after the blood vessel has been remodeled. A ratcheting biopolymer stent can include a ratcheting mechanism that allows the biopolymer stent to be deployed on a small diameter configuration and then expanded to a predefined larger diameter configuration wherein after expansion, the ratcheting mechanism locks the biopolymer stent in the expanded configuration. A folding biopolymer stent can be deployed in a folded, small diameter configuration and then expanded to an unfolded configuration having a larger diameter. The bioresorbable biopolymer can include silk fibroin and blend that include silk fibroin materials.
    Type: Application
    Filed: August 19, 2019
    Publication date: August 6, 2020
    Inventors: Rodrigo R. Jose, David L. Kaplan, Mark Iafrati, Eun Seok Gil, Gary G. Leisk
  • Publication number: 20200108183
    Abstract: Provided herein relates to implantable devices and systems with dynamic silk coatings. In some embodiments, the dynamic silk coatings can be formed in situ or in vivo.
    Type: Application
    Filed: May 9, 2019
    Publication date: April 9, 2020
    Inventors: David L. Kaplan, Lee W. Tien, Gary G. Leisk, Tim Jia-Ching Lo, Cinzia Metallo, Fiorenzo Omenetto
  • Publication number: 20190255181
    Abstract: The present disclosure relates generally to compositions and methods for production of three-dimensional constructs with high mechanical strength and/or stiffness.
    Type: Application
    Filed: July 17, 2018
    Publication date: August 22, 2019
    Inventors: David L. Kaplan, Fiorenzo Omenetto, Gary G. Leisk, Tim Jia-Ching Lo, Benjamin Partlow, Rosario Friedman
  • Patent number: 10335519
    Abstract: Provided herein relates to implantable devices and systems with dynamic silk coatings. In some embodiments, the dynamic silk coatings can be formed in situ or in vivo.
    Type: Grant
    Filed: April 20, 2012
    Date of Patent: July 2, 2019
    Assignee: TRUSTEES OF TUFTS COLLEGE
    Inventors: David L. Kaplan, Lee W. Tien, Gary G. Leisk, Tim Jia-Ching Lo, Cinzia Metallo, Fiorenzo Omenetto
  • Publication number: 20190001272
    Abstract: The present disclosure provides, among other things, systems for processing silk. Provided systems purify silk fibroin solutions without inducing conformational changes in the silk proteins. Provided systems concentrate silk fibroin solutions. The present disclosure also provides methods of purifying and concentrating silk fibroin solutions. Provided systems and methods are useful for processing silk fibroin for any application.
    Type: Application
    Filed: December 16, 2016
    Publication date: January 3, 2019
    Inventors: Gary G. Leisk, David L. Kaplan, Benjamin P. Partlow, Tim Jia-Ching Lo
  • Patent number: 10034945
    Abstract: The present disclosure relates generally to compositions and methods for production of three-dimensional constructs with high mechanical strength and/or stiffness.
    Type: Grant
    Filed: July 15, 2013
    Date of Patent: July 31, 2018
    Assignee: TRUSTEES OF TUFTS COLLEGE
    Inventors: David L. Kaplan, Fiorenzo Omenetto, Gary G. Leisk, Tim Jia-Ching Lo, Benjamin Partlow, Rosario Friedman
  • Patent number: 9694082
    Abstract: This invention provides for compositions, methods and devices for rapidly converting silk fibroin solution into a silk fibroin gel using direct application of voltage, in a process called electrogelation. The silk fibroin gel may be reversibly converted back to liquid form by applying reverse voltage or may be converted further to ?-sheet structure by applying shear force or other treatments. The electrogelated silk may be used as an extracted bulk gel, spray or stream of gel for processing into materials or devices, or may be used as silk gel coating to devices. Active agents may be embedded in the silk gel for various medical applications. This invention also provides for methods and compositions for preparing adhesive silk pH-gels. For example, the method comprises reducing pH level of a silk fibroin solution to increase the bulk or local proton concentration of the silk fibroin solution, thereby forming adhesive silk gels.
    Type: Grant
    Filed: July 2, 2013
    Date of Patent: July 4, 2017
    Assignee: Trustees of Tufts College
    Inventors: David L. Kaplan, Tuna Yucel, Tim Jia-Ching Lo, Gary G. Leisk
  • Publication number: 20170007738
    Abstract: The inventions provided herein relate to compositions, methods, delivery devices and kits for repairing or augmenting a tissue in a subject. The compositions described herein can be injectable such that they can be placed in a tissue to be treated with a minimally-invasive procedure (e.g., by injection). In some embodiments, the composition described herein comprises a compressed silk fibroin matrix, which can expand upon injection into the tissue and retain its original expanded volume within the tissue for a period of time. The compositions can be used as a filler to replace a tissue void, e.g., for tissue repair and/or augmentation, or as a scaffold to support tissue regeneration and/or reconstruction. In some embodiments, the compositions described herein can be used for soft tissue repair or augmentation.
    Type: Application
    Filed: September 22, 2016
    Publication date: January 12, 2017
    Inventors: Gary G. Leisk, Tim Jia-Ching Lo, Lei Li, Evangelia Bellas, David L. Kaplan
  • Patent number: 9492504
    Abstract: The inventions provided herein relate to compositions, methods, delivery devices and kits for repairing or augmenting a tissue in a subject. The compositions described herein can be injectable such that they can be placed in a tissue to be treated with a minimally-invasive procedure (e.g., by injection). In some embodiments, the composition described herein comprises a compressed silk fibroin matrix, which can expand upon injection into the tissue and retain its original expanded volume within the tissue for a period of time. The compositions can be used as a filler to replace a tissue void, e.g., for tissue repair and/or augmentation, or as a scaffold to support tissue regeneration and/or reconstruction. In some embodiments, the compositions described herein can be used for soft tissue repair or augmentation.
    Type: Grant
    Filed: November 9, 2012
    Date of Patent: November 15, 2016
    Assignee: Trustees of Tufts College
    Inventors: Gary G. Leisk, Tim Jia-Ching Lo, Lei Li, Evangelia Bellas, David L. Kaplan
  • Publication number: 20160067071
    Abstract: A bioresorbable biopolymer stents can be deployed within a blood vessel and resorbed by the body over a predetermined time period after the blood vessel has been remodeled. A ratcheting biopolymer stent can include a ratcheting mechanism that allows the biopolymer stent to be deployed on a small diameter configuration and then expanded to a predefined larger diameter configuration wherein after expansion, the ratcheting mechanism locks the biopolymer stent in the expanded configuration. A folding biopolymer stent can be deployed in a folded, small diameter configuration and then expanded to an unfolded configuration having a larger diameter. The bioresorbable biopolymer can include silk fibroin and blend that include silk fibroin materials.
    Type: Application
    Filed: April 24, 2014
    Publication date: March 10, 2016
    Inventors: Rodrigo Jose, David L. Kaplan, Mark Iafrati, Eun Seok Gil, Gary G. Leisk
  • Patent number: 9254333
    Abstract: This invention provides for a process of rapidly forming silk fibroin gelation through ultrasonication. Under the appropriate conditions, gelation can be controlled to occur within two hours after the ultrasonication treatment. Biological materials, including viable cells, or therapeutic agents can be encapsulated in the hydrogels formed from the process and be used as delivery vehicles.
    Type: Grant
    Filed: January 23, 2015
    Date of Patent: February 9, 2016
    Assignee: Trustees of Tufts College
    Inventors: Xiaoqin Wang, Jon Kluge, Gary G. Leisk, David L. Kaplan
  • Publication number: 20150258199
    Abstract: This invention provides for a process of rapidly forming silk fibroin gelation through ultrasonication. Under the appropriate conditions, gelation can be controlled to occur within two hours after the ultrasonication treatment. Biological materials, including viable cells, or therapeutic agents can be encapsulated in the hydrogels formed from the process and be used as delivery vehicles.
    Type: Application
    Filed: January 23, 2015
    Publication date: September 17, 2015
    Inventors: Xiaoqin Wang, Jon Kluge, Gary G. Leisk, David L. Kaplan
  • Publication number: 20150202351
    Abstract: Provided herein relates to implantable devices and systems with dynamic silk coatings. In some embodiments, the dynamic silk coatings can be formed in situ or in vivo.
    Type: Application
    Filed: April 20, 2012
    Publication date: July 23, 2015
    Applicant: TRUSTEES OF TUFTS COLLEGE
    Inventors: David L. Kaplan, Lee W. Tien, Gary G. Leisk, Tim Jia-Ching Lo, Cinzia Metallo, Fiorenzo Omenetto
  • Patent number: 9074302
    Abstract: The present invention relates to compositions and method for drawing egel silk fibroin fibers. The resulting fibers can transmit light and hence can be used as optical fiber. Silk fibroin fiber is produced by a method comprising applying an electric field to a solubilized silk fibroin solution to create a silk fibroin gel; converting the silk fibroin gel to a viscous silk liquid; and drawing a silk fiber from the viscous silk liquid. The silk fiber of the invention can be used in materials such as textile, medical sutures, and tissue materials, as well as conferring optical properties into these materials.
    Type: Grant
    Filed: September 28, 2010
    Date of Patent: July 7, 2015
    Assignee: Trustees of Tufts College
    Inventors: Tim Jia-Ching Lo, Gary G. Leisk, David L. Kaplan
  • Publication number: 20150183841
    Abstract: Provided herein relates to high molecular weight silk-based materials, compositions comprising the same, and processes of preparing the same. The silk-based materials produced from high molecular weight silk can be used in various applications ranging from biomedical applications such as tissue engineering scaffolds to construction applications. In some embodiments, the high molecular weight silk can be used to produce high strength silk-based materials. In some embodiments, the high molecular weight silk can be used to produce silk-based materials that are mechanically strong with tunable degradation properties.
    Type: Application
    Filed: July 9, 2013
    Publication date: July 2, 2015
    Inventors: Tim Jia-Ching Lo, Gary G. Leisk, Benjamin Partlow, Fiorenzo Omenetto, David L. Kaplan, Jonathan A. Kluge, Matthew A. Kluge
  • Publication number: 20150174256
    Abstract: The present disclosure relates generally to compositions and methods for production of three-dimensional constructs with high mechanical strength and/or stiffness.
    Type: Application
    Filed: July 15, 2013
    Publication date: June 25, 2015
    Inventors: David L. Kaplan, Fiorenzo Omenetto, Gary G. Leisk, Tim Jia-Ching Lo, Benjamin Partlow, Rosario Friedman
  • Publication number: 20140378661
    Abstract: The present disclosure provides methods for fabricating various regenerated silk geometries using temperature control. In addition to temperature control, mechanical processing can be used to enhance properties of the fabricated article. The present disclosure also provides silk foam and paper-like materials molded using freezer processing.
    Type: Application
    Filed: April 20, 2012
    Publication date: December 25, 2014
    Applicant: TRUSTEES OF TUFTS COLLEGE
    Inventors: Tim Jia-Ching Lo, Gary G. Leisk, Lei Li, David L. Kaplan
  • Publication number: 20140314817
    Abstract: The inventions provided herein relate to compositions, methods, delivery devices and kits for repairing or augmenting a tissue in a subject. The compositions described herein can be injectable such that they can be placed in a tissue to be treated with a minimally-invasive procedure (e.g., by injection). In some embodiments, the composition described herein comprises a compressed silk fibroin matrix, which can expand upon injection into the tissue and retain its original expanded volume within the tissue for a period of time. The compositions can be used as a filler to replace a tissue void, e.g., for tissue repair and/or augmentation, or as a scaffold to support tissue regeneration and/or reconstruction. In some embodiments, the compositions described herein can be used for soft tissue repair or augmentation.
    Type: Application
    Filed: November 9, 2012
    Publication date: October 23, 2014
    Inventors: Gary G. Leisk, Tim Jia-Ching Lo, Lei Li, Evangelia Bellas, David L. Kaplan
  • Publication number: 20140303346
    Abstract: This invention provides for a process of rapidly forming silk fibroin gelation through ultrasonication. Under the appropriate conditions, gelation can be controlled to occur within two hours after the ultrasonication treatment. Biological materials, including viable cells, or therapeutic agents can be encapsulated in the hydrogels formed from the process and be used as delivery vehicles.
    Type: Application
    Filed: April 7, 2014
    Publication date: October 9, 2014
    Applicant: TRUSTEES OF TUFTS COLLEGE
    Inventors: Xiaoqin Wang, Jon Kluge, Gary G. Leisk, David L. Kaplan
  • Publication number: 20140134240
    Abstract: This invention provides for compositions, methods and devices for rapidly converting silk fibroin solution into a silk fibroin gel using direct application of voltage, in a process called electrogelation. The silk fibroin gel may be reversibly converted back to liquid form by applying reverse voltage or may be converted further to ?-sheet structure by applying shear force or other treatments. The electrogelated silk may be used as an extracted bulk gel, spray or stream of gel for processing into materials or devices, or may be used as silk gel coating to devices. Active agents may be embedded in the silk gel for various medical applications. This invention also provides for methods and compositions for preparing adhesive silk pH-gels. For example, the method comprises reducing pH level of a silk fibroin solution to increase the bulk or local proton concentration of the silk fibroin solution, thereby forming adhesive silk gels.
    Type: Application
    Filed: July 2, 2013
    Publication date: May 15, 2014
    Inventors: David L. Kaplan, Tuna Yucel, Tim Jia-Ching Lo, Gary G. Leisk