Patents by Inventor Gary L. Bowlin
Gary L. Bowlin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11202850Abstract: As described below, the present invention features compositions and methods for inhibiting inflammation in connection with an acellular template (e.g., an electrospun template). In one embodiment, the template is impregnated with an agent (e.g., N-?-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide (Cl-amidine)) that inhibits a peptidylarginine deaminase (e.g., PAD4).Type: GrantFiled: March 11, 2019Date of Patent: December 21, 2021Assignees: The University of Memphis Research Foundation, The University of Tennessee Research FoundationInventors: Gary L. Bowlin, Allison E. Fetz, Marko Z. Radic
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Publication number: 20210047653Abstract: The invention features compositions and methods for the inducible regulation of one or more target genes using a CRISPR-based synthetic gene regulatory network that responds to spatiotemporally-controlled agents present, for example, on a substrate (e.g., an electrospun template).Type: ApplicationFiled: January 29, 2019Publication date: February 18, 2021Applicant: The University of Memphis Research FoundationInventors: Gary L. Bowlin, Diego Augusto Velasquez Pulgarin, Alexander Espinosa
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Publication number: 20190275200Abstract: As described below, the present invention features compositions and methods for inhibiting inflammation in connection with an acellular template (e.g., an electrospun template). In one embodiment, the template is impregnated with an agent (e.g., N-?-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide (Cl-amidine)) that inhibits a peptidylarginine deaminase (e.g., PAD4).Type: ApplicationFiled: March 11, 2019Publication date: September 12, 2019Applicant: THE UNIVERSITY OF MEMPHIS RESEARCH FOUNDATIONInventors: GARY L. BOWLIN, ALLISON E. FETZ, MARKO Z. RADIC
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Patent number: 9399082Abstract: The invention generally relates to dextran fibers which are preferably electrospun and devices formed from such fibers. In particular, such devices may include substances of interest (such as therapeutic substances) associated with the electrospun fibers. Upon exposure to a liquid the electrospun fibers dissolve immediately and the substances of interest are released into the liquid. Exemplary devices include bandages formed from electrospun dextran fibers and associated agents that promote hemostasis, such as thrombin and fibrinogen.Type: GrantFiled: April 10, 2009Date of Patent: July 26, 2016Assignees: The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Virginia Commonwealth UniversityInventors: Gary L. Bowlin, David G. Simpson, James R. Bowman, Stephen W. Rothwell
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Patent number: 8586345Abstract: The invention is directed to formation and use of electroprocessed collagen, including use as an extracellular matrix and, together with cells, its use in forming engineered tissue. The engineered tissue can include the synthetic manufacture of specific organs or tissues which may be implanted into a recipient. The electroprocessed collagen may also be combined with other molecules in order to deliver substances to the site of application or implantation of the electroprocessed collagen. The collagen or collagen/cell suspension is electrodeposited onto a substrate to form tissues and organs.Type: GrantFiled: March 21, 2011Date of Patent: November 19, 2013Assignee: Virginia Commonwealth University Intellectual Property FoundationInventors: David G. Simpson, Gary L. Bowlin, Gary E. Wnek, Peter J. Stevens, Marcus E. Carr, Jamil A. Matthews, Saravanamoorthy Rajendran
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Publication number: 20130266664Abstract: Electrospun scaffolds crosslinked with acrylates and methods of making the same are provided. Because the cross-linking linking is carried out under mild conditions, biologically active agents are incorporated into the scaffolds in a facile manner.Type: ApplicationFiled: December 20, 2011Publication date: October 10, 2013Applicant: VIRGINIA COMMONWEALTH UNIVERSITYInventors: Hu Yang, Gary L. Bowlin, Alpana Dongargaonkar
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Publication number: 20130178949Abstract: Electrospun materials are fabricated using air-flow impedance technology, which results in the production of scaffolds in which some regions are dense with low porosity and others regions are less dense and more porous. The dense regions provide structural support for the scaffold while the porous regions permit entry of cells and other materials into the scaffold, e.g. when used for tissue engineering.Type: ApplicationFiled: June 28, 2011Publication date: July 11, 2013Applicant: Virginia Commonwealth UniversityInventors: Gary L. Bowlin, Michael J. McClure, David G. Simpson, Hu Yang
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Publication number: 20130177623Abstract: Activated platelet-rich plasma (aPRP) is electrospun into fibrous matrices which are used to deliver components of aPRP to a site of action in a sustained manner. The electrospun matrices are used, for example, for tissue engineering applications and for the treatment of wounds.Type: ApplicationFiled: September 21, 2011Publication date: July 11, 2013Inventors: Gary L. Bowlin, Patricia S. Wolfe, Scott A. Sell
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Publication number: 20110288026Abstract: The invention is directed to formation and use of electroprocessed collagen, including use as an extracellular matrix and, together with cells, its use in forming engineered tissue. The engineered tissue can include the synthetic manufacture of specific organs or tissues which may be implanted into a recipient. The electroprocessed collagen may also be combined with other molecules in order to deliver substances to the site of application or implantation of the electroprocessed collagen. The collagen or collagen/cell suspension is electrodeposited onto a substrate to form tissues and organs.Type: ApplicationFiled: March 21, 2011Publication date: November 24, 2011Inventors: David G. Simpson, Gary L. Bowlin, Gary E. Wnek, Peter J. Stevens, Marcus E. Carr, Jamil A. Matthews, Saravanamoorthy Rajendran
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Publication number: 20110280841Abstract: The invention is directed to novel compositions comprising an electroprocessed material and a substance, their formation and use. The electroprocessed material can, for example, be one or more natural materials, one or more synthetic materials, or a combination thereof. The substance can be one or more therapeutic or cosmetic substances or other compounds, molecules, cells, vesicles. The compositions can be used in substance delivery, including drug delivery within an organism by, for example, releasing substances or containing cells that release substances. The compositions can be used for other purposes, such as prostheses or similar implants.Type: ApplicationFiled: January 18, 2011Publication date: November 17, 2011Applicant: Virginia Commonwealth University Intellectual Property FoundationInventors: Gary L. Bowlin, Gary E. Wnek, David G. Simpson
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Publication number: 20110150973Abstract: The invention generally relates to dextran fibers which are preferably electrospun and devices formed from such fibers. In particular, such devices may include substances of interest (such as therapeutic substances) associated with the electrospun fibers. Upon exposure to a liquid the electrospun fibers dissolve immediately and the substances of interest are released into the liquid. Exemplary devices include bandages formed from electrospun dextran fibers and associated agents that promote hemostasis, such as thrombin and fibrinogen.Type: ApplicationFiled: April 10, 2009Publication date: June 23, 2011Inventors: Gary L. Bowlin, David G. Simpson, James R. Bowman, Stephen W. Rothwell
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Publication number: 20100310658Abstract: The invention is directed to formation and use of electroprocessed fibrin as an extracellular matrix and, together with cells, its use in forming engineered tissue. The engineered tissue can include the synthetic manufacture of specific organs or tissues which may be implanted into a recipient. The electroprocessed fibrin may also be combined with other molecules in order to deliver the molecules to the site of application or implantation of the electroprocessed fibrin. The fibrin or fibrin/cell suspension is electrodeposited onto a substrite to form the tissues and organs.Type: ApplicationFiled: June 8, 2010Publication date: December 9, 2010Inventors: Gary L. Bowlin, Gary E. Wnek, David G. Simpson, Philippe Lam, Marcus E. Carr, JR.
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Publication number: 20100291058Abstract: The present invention relates to sealants for skin and other tissues. The sealants include an electroprocessed material. The sealants may contain more than one electroprocessed materials and may contain additional substances. The invention further relates to methods of making and using such sealants.Type: ApplicationFiled: April 12, 2010Publication date: November 18, 2010Applicants: Virginia Commonwealth University, Nanomatrix, Inc.Inventors: Gary L. Bowlin, David G. Simpson, Gary E. Wnek, Marcus E. Carr, JR., Peter J. Stevens, Gary Cadd, I. Kelman Cohen
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Patent number: 7759082Abstract: The invention is directed to formation and use of electroprocessed fibrin as an extracellular matrix and, together with cells, its use in forming engineered tissue. The engineered tissue can include the synthetic manufacture of specific organs or tissues which may be implanted into a recipient. The electroprocessed fibrin may also be combined with other molecules in order to deliver the molecules to the site of application or implantation of the electroprocessed fibrin. The fibrin or fibrin/cell suspension is electrodeposited onto a substrate to form the tissues and organs.Type: GrantFiled: January 26, 2004Date of Patent: July 20, 2010Assignee: Virginia Commonwealth University Intellectual Property FoundationInventors: Gary L. Bowlin, Gary E. Wnek, David G. Simpson, Philippe Lam, Marcus E. Carr, Jr.
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Patent number: 7615373Abstract: The invention is directed to formation and use of electroprocessed collagen, including use as an extracellular matrix and, together with cells, its use in forming engineered tissue. The engineered tissue can include the synthetic manufacture of specific organs or tissues which may be implanted into a recipient. The electroprocessed collagen may also be combined with other molecules in order to deliver substances to the site of application or implantation of the electroprocessed collagen. The collagen or collagen/cell suspension is electrodeposited onto a substrate to form tissues and organs.Type: GrantFiled: May 28, 2003Date of Patent: November 10, 2009Assignees: Virginia Commonwealth University Intellectual Property Foundation, Organogenesis, Inc.Inventors: David G. Simpson, Gary L. Bowlin, Gary E. Wnek, Peter J. Stevens, Marcus E. Carr, Jamil A. Matthews, Saravanamoorthy Rajendran
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Publication number: 20080319476Abstract: The invention generally relates to compositions and methods for promoting hemostasis and sealing a wound by producing an adhesive cast. In particular, the invention provides compositions comprising clay minerals with specified particle sizes, which, when applied to a bleeding area, allow for a desired result in at least one of the following activities: stopping blood flow from a wound, forming a cohesive mass, sealing a wound, promoting coagulant activity, sorbing a body fluid, and adhering to tissue. For example, the desired result can be sealing the wound using an adhesive cast made of clay minerals mixed with blood or other wound fluids.Type: ApplicationFiled: May 22, 2008Publication date: December 25, 2008Inventors: Kevin R. Ward, Richard Brown, Robert F. Diegelmann, Gary L. Bowlin
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Publication number: 20080159985Abstract: The invention is directed to novel compositions comprising an electroprocessed material and a substance, their formation and use. The electroprocessed material can, for example, be one or more natural materials, one or more synthetic materials, or a combination thereof. The substance can be one or more therapeutic or cosmetic substances or other compounds, molecules, cells, vesicles. The compositions can be used in substance delivery, including drug delivery within an organism by, for example, releasing substances or containing cells that release substances. The compositions can be used for other purposes, such as prostheses or similar implants.Type: ApplicationFiled: December 21, 2007Publication date: July 3, 2008Applicant: Virginia Commonwealth University Intellectual Property FoundationInventors: Gary L. Bowlin, Gary E. Wnek, David G. Simpson
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Patent number: 7374774Abstract: The invention is directed to novel compositions comprising an electroprocessed material and a substance, their formation and use. The electroprocessed material can, for example, be one or more natural materials, one or more synthetic materials, or a combination thereof. The substance can be one or more therapeutic or cosmetic substances or other compounds, molecules, cells, vesicles. The compositions can be used in substance delivery, including drug delivery within an organism by, for example, releasing substances or containing cells that release substances. The compositions can be used for other purposes, such as prostheses or similar implants.Type: GrantFiled: September 22, 2003Date of Patent: May 20, 2008Assignee: Virginia Commonwealth University Intellectual Property FoundationInventors: Gary L. Bowlin, Gary E. Wnek, David G. Simpson
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Publication number: 20040229333Abstract: The invention is directed to formation and use of electroprocessed fibrin as an extracellular matrix and, together with cells, its use in forming engineered tissue. The engineered tissue can include the synthetic manufacture of specific organs or tissues which may be implanted into a recipient. The electroprocessed fibrin may also be combined with other molecules in order to deliver the molecules to the site of application or implantation of the electroprocessed fibrin. The fibrin or fibrin/cell suspension is electrodeposited onto a substrate to form the tissues and organs.Type: ApplicationFiled: January 26, 2004Publication date: November 18, 2004Inventors: Gary L. Bowlin, Gary E. Wnek, David G. Simpson, Philippe Lam, Marcus E. Carr
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Patent number: 6787357Abstract: The invention is directed to use of fibrin as an extracellular matrix and, together with cells, its use in forming engineered tissue. The engineered tissue can include the synthetic manufacture of specific organs or “organ-like” tissue. A preferred embodiment is a plasma-derived fibrin matrix containing cells.Type: GrantFiled: October 5, 2001Date of Patent: September 7, 2004Assignee: Virginia Commonwealth UniversityInventors: Gary L. Bowlin, Gary Wnek, David G. Simpson, Philippe Lam, Marcus E. Carr, Helen Fillmore