Patents by Inventor Gary L. McKnight

Gary L. McKnight has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10546651
    Abstract: Systems and methods are described for modifying a cosmetic product based on a microbe profile including an ingredient-microbe interaction dataset including information associated with interactions between reference cosmetic ingredients and types of reference microbes; and a computing device including circuitry configured to receive information associated with the microbe profile of an individual, receive information associated with an ingredient list of the cosmetic product, compare the microbe profile of the individual and the ingredient list of the cosmetic product to the ingredient-microbe interaction dataset, identify an interaction between at least one cosmetic ingredient in the ingredient list of the cosmetic product and at least one of the one or more types of microbes in the microbe profile of the individual, recommend a modification to the ingredient list in response to an identified interaction, and report to a user the recommended modification.
    Type: Grant
    Filed: November 15, 2018
    Date of Patent: January 28, 2020
    Assignee: Elwha LLC
    Inventors: Michael H. Baym, Roderick A. Hyde, Jordin T. Kare, Eric C. Leuthardt, Gary L. McKnight, Tony S. Pan, Elizabeth A. Sweeney, Clarence T. Tegreene, Lowell L. Wood, Jr.
  • Patent number: 10497191
    Abstract: An system includes, but is not limited to, a control system; and a device including a deformable substrate, a sensor assembly including one or more identity sensors configured to generate identity sense signals associated with a physical characteristic of an individual subject, circuitry configured to receive the identity sense signals, the circuitry including an identity comparison module configured to compare identity sense signals to reference data indicative of physical characteristics associated with an identity of at least one individual to determine whether the identity sense signals correspond to the identity of the at least one individual, and a reporter configured to generate communication signals associated with a comparison of the identity sense signals to reference data, the reporter including a transmitter or transceiver configured to transmit the communication signals to a system for association with a file corresponding to at least one of the individual subject or the device.
    Type: Grant
    Filed: July 23, 2018
    Date of Patent: December 3, 2019
    Assignee: ELWHA LLC
    Inventors: Roderick A. Hyde, Jordin T. Kare, Melanie K. Kitzan, Gary L. McKnight, Robert C. Petroski, Elizabeth A. Sweeney
  • Publication number: 20190352385
    Abstract: Compositions and methods are disclosed herein for producing one or more immunoglobulins in an isolated cytotoxic B lymphocyte cell line. An isolated cell line includes an isolated B lymphocyte cell line capable of expressing at least one exogenously incorporated membrane immunoglobulin capable of binding to a first antigen and at least one endogenous secreted immunoglobulin capable of binding to a second antigen, and further capable of expressing at least one exogenously incorporated recombinant B cell receptor that signals for expression of cytotoxic effector molecules.
    Type: Application
    Filed: July 26, 2019
    Publication date: November 21, 2019
    Inventors: Roderick A. Hyde, Wayne R. Kindsvogel, Gary L. McKnight
  • Patent number: 10448929
    Abstract: Devices, systems, and methods for assessing microbiota of skin are described, including: a skin-covering material including an inner surface and an outer surface, the inner surface substantially conforming to a topography of a skin surface of an individual and including a plurality of signal-generating complexes, one or more of the plurality of signal-generating complexes configured to emit one or more signals in response to at least one type of microbe; an image capture device to capture an image of the inner surface of the skin-covering material, the image including one or more signals emitted from the plurality of signal-generating complexes, and to transform the image into a digital output; and a computing device including circuitry configured to receive the digital output, compare the properties of the imaged one or more signals with a database of reference signal-generating complexes, and generate a digital spatial profile of microbes on the skin-covering material.
    Type: Grant
    Filed: February 11, 2019
    Date of Patent: October 22, 2019
    Assignee: Elwha LLC
    Inventors: Mahalaxmi Gita Bangera, Michael H. Baym, Roderick A. Hyde, Jordin T. Kare, Eric C. Leuthardt, Gary L. McKnight, Tony S. Pan, Katherine E. Sharadin, Elizabeth A. Sweeney, Clarence T. Tegreene, Lowell L. Wood, Jr.
  • Patent number: 10424407
    Abstract: An identification device includes, but is not limited to, a deformable substrate configured to conform to a skin surface of a body portion of a healthcare provider; a sensor assembly coupled to the deformable substrate, the sensor assembly including one or more identity sensors configured to generate one or more identity sense signals associated with at least one physical characteristic of an individual subject other than the healthcare provider; circuitry configured to compare the one or more identity sense signals generated by the sensor assembly to reference data indicative of one or more physical characteristics associated with an identity; and a reporter configured to generate one or more communication signals associated with a comparison of the one or more identity sense signals generated by the sensor assembly to reference data indicative of one or more physical characteristics associated with an identity of at least one individual.
    Type: Grant
    Filed: July 6, 2018
    Date of Patent: September 24, 2019
    Assignee: Elwha LLC
    Inventors: Roderick A. Hyde, Jordin T. Kare, Gary L. McKnight, Robert C. Petroski, Elizabeth A. Sweeney
  • Patent number: 10390755
    Abstract: Systems and methods are described for monitoring an individual subject and facilitating a motion regimen of the individual subject. In an aspect, a system includes, but is not limited to, a deformable substrate; a sensor assembly configured to generate one or more sense signals based on detection of at least one of a movement of the body portion or at least one physiological parameter of the body portion; a processor configured to receive the one or more sense signals, the processor including circuitry configured to identify a physiological state of the individual subject based on at least one of the movement of the body portion or the at least one physiological parameter of the body portion; and an effector operably coupled to the processor and configured to effect at least one predetermined motion of the body portion corresponding to a motion regimen responsive to control by the processor.
    Type: Grant
    Filed: December 21, 2016
    Date of Patent: August 27, 2019
    Assignee: Elwha LLC
    Inventors: Eleanor V. Goodall, Roderick A. Hyde, Jordin T. Kare, Eric C. Leuthardt, Mark A. Malamud, Gary L. McKnight, Tony S. Pan, Katherine E. Sharadin, Elizabeth A. Sweeney, Clarence T. Tegreene, Charles Whitmer, Lowell L. Wood, Jr.
  • Publication number: 20190254642
    Abstract: Devices, systems, and methods for assessing microbiota of skin are described, including: a skin-covering material including an inner surface and an outer surface, the inner surface substantially conforming to a topography of a skin surface of an individual and including a plurality of signal-generating complexes, one or more of the plurality of signal-generating complexes configured to emit one or more signals in response to at least one type of microbe; an image capture device to capture an image of the inner surface of the skin-covering material, the image including one or more signals emitted from the plurality of signal-generating complexes, and to transform the image into a digital output; and a computing device including circuitry configured to receive the digital output, compare the properties of the imaged one or more signals with a database of reference signal-generating complexes, and generate a digital spatial profile of microbes on the skin-covering material.
    Type: Application
    Filed: February 11, 2019
    Publication date: August 22, 2019
    Inventors: Mahalaxmi Gita Bangera, Michael H. Baym, Roderick A. Hyde, Jordin T. Kare, Eric C. Leuthardt, Gary L. McKnight, Tony S. Pan, Katherine E. Sharadin, Elizabeth A. Sweeney, Clarence T. Tegreene, Lowell L. Wood, JR.
  • Patent number: 10383550
    Abstract: Systems and methods are described for monitoring an individual and facilitating a motion regimen of the individual. In an aspect, a system includes, but is not limited to, a deformable substrate; a sensor assembly to generate sense signals based on detection of a movement of the body portion and a physiological parameter of the body portion during a motion regimen executed by the individual; a processor including circuitry configured to identify a pain state of the individual based on at least one of the movement or the physiological parameter, and to compare at least one of the pain state, the movement, or the physiological parameter to threshold target values; and a communicator configured to generate communication signals responsive to instruction by the processor, the communication signals associated with comparison between at least one of the pain state, the movement, or the physiological parameter to threshold target values.
    Type: Grant
    Filed: December 21, 2016
    Date of Patent: August 20, 2019
    Assignee: Elwha LLC
    Inventors: Roderick A. Hyde, Jordin T. Kare, Eric C. Leuthardt, Mark A. Malamud, Gary L. McKnight, Tony S. Pan, Katherine E. Sharadin, Elizabeth A. Sweeney, Clarence T. Tegreene, Charles Whitmer, Lowell L. Wood, Jr.
  • Publication number: 20190153388
    Abstract: Compositions and methods are disclosed herein for producing one or more immunoglobulins in an isolated cytotoxic B lymphocyte cell line. An isolated cell line includes an isolated B lymphocyte cell line capable of expressing at least one exogenously incorporated membrane immunoglobulin reactive to a first antigen and at least one endogenous secreted immunoglobulin reactive to a second antigen, and further capable of expressing at least one exogenously incorporated recombinant B cell receptor that signals for expression of cytotoxic effector molecules.
    Type: Application
    Filed: January 24, 2019
    Publication date: May 23, 2019
    Inventors: Roderick A. Hyde, Wayne R. Kindsvogel, Gary L. McKnight
  • Publication number: 20190147984
    Abstract: Systems and methods are described for modifying a cosmetic product based on a microbe profile including an ingredient-microbe interaction dataset including information associated with interactions between reference cosmetic ingredients and types of reference microbes; and a computing device including circuitry configured to receive information associated with the microbe profile of an individual, receive information associated with an ingredient list of the cosmetic product, compare the microbe profile of the individual and the ingredient list of the cosmetic product to the ingredient-microbe interaction dataset, identify an interaction between at least one cosmetic ingredient in the ingredient list of the cosmetic product and at least one of the one or more types of microbes in the microbe profile of the individual, recommend a modification to the ingredient list in response to an identified interaction, and report to a user the recommended modification.
    Type: Application
    Filed: November 15, 2018
    Publication date: May 16, 2019
    Inventors: Michael H. Baym, Roderick A. Hyde, Jordin T. Kare, Eric C. Leuthardt, Gary L. McKnight, Tony S. Pan, Elizabeth A. Sweeney, Clarence T. Tegreene, Lowell L. Wood, Jr.
  • Patent number: 10289806
    Abstract: Various embodiments disclosed herein include systems, methods, and devices for automated delivery of medical services and products. In certain embodiments, the systems and/or methods are at least partially controlled by a computer.
    Type: Grant
    Filed: November 14, 2013
    Date of Patent: May 14, 2019
    Assignee: Elwha LLC
    Inventors: Roderick A. Hyde, Muriel Y. Ishikawa, Jordin T. Kare, Gary L. McKnight, Robert C. Petroski
  • Patent number: 10279201
    Abstract: Systems and methods are described for monitoring, treating, and preventing a pain state of an individual. In an aspect, a system includes, but is not limited to, a deformable substrate; a sensor assembly coupled to the deformable substrate, the sensor assembly including a motion sensor and a physiological sensor, the sensor assembly configured to generate one or more sense signals based on detection of a movement of the body portion by the motion sensor and a physiological parameter of the body portion by the physiological sensor; a processor including circuitry configured to identify a physiological state of the individual subject based on at least one of the movement of the body portion or the physiological parameter; and an effector operably coupled to the processor and configured to affect the body portion responsive to control by the processor.
    Type: Grant
    Filed: November 28, 2016
    Date of Patent: May 7, 2019
    Assignee: Elwha LLC
    Inventors: Roderick A. Hyde, Jordin T. Kare, Eric C. Leuthardt, Mark A. Malamud, Gary L. McKnight, Tony S. Pan, Katherine E. Sharadin, Elizabeth A. Sweeney, Clarence T. Tegreene, Charles Whitmer, Lowell L. Wood, Jr.
  • Patent number: 10279200
    Abstract: Systems and methods are described for monitoring, treating, and preventing a pain state of an individual. In an aspect, a system includes, but is not limited to, a deformable substrate; a sensor assembly coupled to the deformable substrate, the sensor assembly including a motion sensor and a physiological sensor, the sensor assembly configured to generate one or more sense signals based on detection of a movement of the body portion by the motion sensor and a physiological parameter of the body portion by the physiological sensor; a processor including circuitry configured to identify a physiological state of the individual subject based on at least one of the movement of the body portion or the physiological parameter; and an effector operably coupled to the processor and configured to affect the body portion responsive to control by the processor.
    Type: Grant
    Filed: November 28, 2016
    Date of Patent: May 7, 2019
    Assignee: Elwha LLC
    Inventors: Roderick A. Hyde, Jordin T. Kare, Eric C. Leuthardt, Mark A. Malamud, Gary L. McKnight, Tony S. Pan, Katherine E. Sharadin, Elizabeth A. Sweeney, Clarence T. Tegreene, Charles Whitmer, Lowell L. Wood, Jr.
  • Patent number: 10245366
    Abstract: Treatment of cardiac tissue via an implantable heart treatment device is described. A device embodiment includes, but is not limited to, a substrate configured for implantation within a body; an electromagnetic signal generator coupled to the substrate and configured to generate one or more electric signals configured to stimulate one or more tissues of a heart within the body; and an energy-carrier molecule delivery device coupled to the substrate and configured to supply one or more non-oxygen cellular energy sources to one or more tissues of the heart within the body.
    Type: Grant
    Filed: January 23, 2017
    Date of Patent: April 2, 2019
    Assignee: Elwha LLC
    Inventors: Roderick A. Hyde, Edward K. Y. Jung, Eric C. Leuthardt, Gary L. McKnight, Lowell L. Wood, Jr.
  • Publication number: 20190091263
    Abstract: Embodiments described herein relate to methods, devices, and computer systems thereof for the derivation of T CAR libraries (Universal Subject or Individual Subject) for personalized treatment of disease in a subject. In certain embodiments, differential screening of normal and diseased tissue expression data is utilized to determine disease-specific antigens and thereby generate T CAR cells reactive to such antigens to form a disease-specific library. In certain embodiments, determination of the most effective T CAR clones from the disease-specific library is based on the subject's own disease-specific antigens. In certain embodiments, a subject is treated with a therapeutically effective amount of T CAR clones.
    Type: Application
    Filed: November 30, 2018
    Publication date: March 28, 2019
    Inventors: Roderick A. Hyde, Wayne R. Kindsvogel, Gary L. McKnight
  • Publication number: 20190087479
    Abstract: Systems and methods are described for generating a treatment map based on a microbe profile, which include receiving a two-dimensional microbe profile of a skin surface of an individual, selecting one or more treatment agents from a database of treatment agents, generating the treatment map by mapping the selected one or more treatment agents to each of one or more corresponding locations on the two-dimensional microbe profile of the skin surface of the individual, and reporting the treatment map to a user.
    Type: Application
    Filed: November 15, 2018
    Publication date: March 21, 2019
    Inventors: Roderick A. Hyde, Gary L. McKnight
  • Patent number: 10232102
    Abstract: Treatment of cardiac tissue via an implantable heart treatment device is described. A device embodiment includes, but is not limited to, a substrate configured for implantation within a body; an electromagnetic signal generator coupled to the substrate and configured to generate one or more electric signals configured to stimulate one or more tissues of a heart; and an oxygenator coupled to the substrate and configured to supply one or more oxygenated molecules to one or more tissues of the heart, the oxygenator including a blood inlet portion, a blood outlet portion, and an oxygen exchange portion positioned between the blood inlet portion and the blood outlet portion, the oxygen exchange portion including a high surface area oxygen exchanger configured to transfer one or more oxygenated molecules from the high surface area oxygen exchanger to blood passing from the blood inlet portion to the blood outlet portion.
    Type: Grant
    Filed: January 23, 2017
    Date of Patent: March 19, 2019
    Assignee: Elwha LLC
    Inventors: Roderick A. Hyde, Edward K. Y. Jung, Eric C. Leuthardt, Gary L. McKnight, Lowell L. Wood, Jr.
  • Patent number: 10233424
    Abstract: Compositions and methods are disclosed herein for producing one or more immunoglobulins in an isolated cytotoxic B lymphocyte cell line. An isolated cell line includes an isolated B lymphocyte cell line capable of expressing at least one exogenously incorporated membrane immunoglobulin reactive to a first antigen and at least one endogenous secreted immunoglobulin reactive to a second antigen, and further capable of expressing at least one exogenously incorporated recombinant B cell receptor that signals for expression of cytotoxic effector molecules.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: March 19, 2019
    Assignee: Elwha LLC
    Inventors: Roderick A. Hyde, Wayne R. Kindsvogel, Gary L. McKnight
  • Publication number: 20190076081
    Abstract: Identifying gut microbiota in a specific site of the gut through production of a measurable response following introduction of a challenge agent to the specific site of the gut is disclosed. A composition embodiment includes, but is not limited to, a challenge agent configured to elicit a measurable response by the at least one targeted microbe at the specific site in the gut, the measurable response detectable in a bodily gaseous emission; and a controlled release system encompassing at least a portion of the challenge agent, the controlled release system configured to access the specific site of the gut.
    Type: Application
    Filed: September 12, 2017
    Publication date: March 14, 2019
    Inventors: Roderick A. Hyde, Gary L. McKnight, Elizabeth A. Sweeney
  • Publication number: 20190079073
    Abstract: Identifying gut microbiota in a specific site of the gut through production of a measurable response following introduction of a challenge agent to the specific site of the gut is disclosed. A system embodiment includes, but is not limited to, a composition including the challenge agent; and an emissions analysis device including a body structure defining an orifice configured to receive a biofluid; a sensor operably coupled to the orifice and configured to detect at least one analyte from the biofluid and generate one or more sense signals, the one or more sense signals associated with the measurable response; circuitry operably coupled to the sensor and configured to receive the one or more sense signals associated with the measurable response; and a reporter operably coupled to the circuitry and configured to generate one or more communication signals associated with at least one targeted microbe.
    Type: Application
    Filed: September 12, 2017
    Publication date: March 14, 2019
    Inventors: Roderick A. Hyde, Gary L. McKnight, Elizabeth A. Sweeney