Patents by Inventor Gary Piazza

Gary Piazza has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for identifying compounds for inhibition of neoplastic lesions, and pharmacetical compositions containing such compounds
    Publication number: 20040009464
    Abstract: This invention provides pharmaceutical compositions containing compounds for the treatment of neoplasia in mammals. The phosphodiesterase inhibitory activity of a compound is determined along with COX inhibitory activity. Growth inhibitory and apoptosis inducing effects on cultured tumor cells are also determined. Compounds that exhibit phosphodiesterase inhibiton, growth inhibition and apoptosis induction, but prefereably not substantial prostaglandin inhibitory activity, are desirable for the treatment of neoplasia.
    Type: Application
    Filed: September 24, 2002
    Publication date: January 15, 2004
    Inventors: Li Liu, Bing Zhu, Han Li, W. Joseph Thompson, Rifat Pamukcu, Gary A. Piazza
  • Methods for identifying compounds for inhibition of neoplastic lesions, and pharmacetical compositions containing such compounds
    Publication number: 20030190686
    Abstract: This invention provides pharmaceutical compositions containing compounds for the treatment of neoplasia in mammals. The phosphodiesterase inhibitory activity of a compound is determined along with COX inhibitory activity. Growth inhibitory and apoptosis inducing effects on cultured tumor cells are also determined. Compounds that exhibit phosphodiesterase inhibiton, growth inhibition and apoptosis induction, but prefereably not substantial prostaglandin inhibitory activity, are desirable for the treatment of neoplasia.
    Type: Application
    Filed: September 24, 2002
    Publication date: October 9, 2003
    Inventors: Rifat Pamukcu, Gary A. Piazza
  • Packaged pharmaceuticals and methods for causing compounds and pharmaceutical compositions to be used as inhibitors of neoplastic lesions
    Publication number: 20030175833
    Abstract: This invention provides pharmaceutical compositions containing compounds for the treatment of neoplasia in mammals. The phosphodiesterase inhibitory activity of a compound is determined along with COX inhibitory activity. Growth inhibitory and apoptosis inducing effects on cultured tumor cells are also determined. Compounds that exhibit phosphodiesterase inhibiton, growth inhibition and apoptosis induction, but prefereably not substantial prostaglandin inhibitory activity, are desirable for the treatment of neoplasia.
    Type: Application
    Filed: September 20, 2002
    Publication date: September 18, 2003
    Inventors: Li Liu, Bing Zhu, Han Li, W. Joseph Thompson, Rifat Pamukcu, Gary A. Piazza
  • Substituted condensation products of N-benzyl-3-indenylacentamides with heterocyclic aldehydes for neoplasia
    Patent number: 6610854
    Abstract: Substituted condensation products of N-benzyl-3-indenylacetamides with heterocyclic aldehydes are useful for inducing or promoting apotosis and for arresting uncontrolled neoplastic cell proliferation, and are specifically useful in the arresting and treatment of neoplasias, including precancerous and cancerous lesions.
    Type: Grant
    Filed: July 26, 2002
    Date of Patent: August 26, 2003
    Assignees: Cell Pathways, Inc., University of Arizona
    Inventors: Gerhard J. Sperl, Paul Gross, Klaus Brendel, Gary A. Piazza, Rifat Pamukcu
  • Method of treating a patient having precancerous lesions with phenyl quinazolinone derivatives
    Patent number: 6562830
    Abstract: Derivatives of 2-phenyl quinazolinones are useful for the treatment of patients having precancerous lesions. These compounds are also useful to inhibit growth of neoplastic cells.
    Type: Grant
    Filed: November 9, 1999
    Date of Patent: May 13, 2003
    Assignee: Cell Pathways, Inc.
    Inventors: Rifat Pamukcu, Gary A. Piazza
  • Methods for treating a patient with neoplasia by administering cGMP-specific PDE-inhibiting compounds
    Publication number: 20030064421
    Abstract: This invention provides a method to identify compounds potentially useful for the treatment of neoplasia in mammals. The phosphodiesterase inhibitory activity of a compound is determined along with COX inhibitory activity. Growth inhibitory and apoptosis inducing effects on cultured tumor cells are also determined. Compounds that exhibit phosphodiesterase inhibiton, growth inhibition and apoptosis induction, but not substantial prostaglandin inhibitory activity, are desirable for the treatment of neoplasia.
    Type: Application
    Filed: September 24, 2002
    Publication date: April 3, 2003
    Inventors: Rifat Pamukcu, Gary A. Piazza
  • Method for diagnosing neoplasia
    Publication number: 20030044861
    Abstract: This invention provides a method for diagnosing a patient with neoplasia.
    Type: Application
    Filed: April 22, 2002
    Publication date: March 6, 2003
    Inventors: Li Liu, Bing Zhu, Han Li, W. Joseph Thompson, Gary A. Piazza, Rifat Pamukcu
  • Substituted condensation products of N-benzyl-3-indenylacent amides with heterocyclic aldehydes for neoplasia
    Publication number: 20030009033
    Abstract: Substituted condensation products of N-benzyl-3-indenylacetamides with heterocyclic aldehydes are useful for inducing or promoting apotosis and for arresting uncontrolled neoplastic cell proliferation, and are specifically useful in the arresting and treatment of neoplasias, including precancerous and cancerous lesions.
    Type: Application
    Filed: July 26, 2002
    Publication date: January 9, 2003
    Inventors: Gerhard J. Sperl, Paul Gross, Klaus Brendel, Gary A. Piazza, Rifat Pamukcu
  • Method of inhibiting neoplastic cells with benzimidazole derivatives
    Publication number: 20030008832
    Abstract: A method for inhibiting neoplasia, particularly cancerous and precancerous lesions by exposing the affected cells to benzimidazole derivatives.
    Type: Application
    Filed: October 24, 2001
    Publication date: January 9, 2003
    Inventors: Rifat Pamukcu, Gary A. Piazza
  • Method for identifying compounds for inhibition of neoplastic lesions
    Publication number: 20030004093
    Abstract: This invention provides a method to identify compounds potentially useful for the treatment of neoplasia in mammals. The phosphodiesterase inhibitory activity of a compound is determined along with COX inhibitory activity. Growth inhibitory and apoptosis inducing effects on cultured tumor cells are also determined. Compounds that exhibit phosphodiesterase inhibiton, growth inhibition and apoptosis induction, but not substantial prostaglandin inhibitory activity, are desirable for the treatment of neoplasia.
    Type: Application
    Filed: January 7, 2002
    Publication date: January 2, 2003
    Inventors: Gary A. Piazza, Rifat Pamukcu, W. Joseph Thompson
  • Methods for identifying compounds for inhibiting of neoplastic lesions, and pharmaceutical compositions containing such compounds
    Patent number: 6500610
    Abstract: This invention provides pharmaceutical compositions containing compounds for the treatment of neoplasia in mammals. The phosphodiesterase inhibitory activity of a compound is determined along with COX inhibitory activity. Growth inhibitory and apoptosis inducing effects on cultured tumor cells are also determined. Compounds that exhibit phosphodiesterase inhibiton, growth inhibition and apoptosis induction, but prefereably not substantial prostaglandin inhibitory activity, are desirable for the treatment of neoplasia.
    Type: Grant
    Filed: October 8, 1999
    Date of Patent: December 31, 2002
    Assignee: Cell Pathways, INC
    Inventors: Rifat Pamukcu, Gary A. Piazza
  • Method of inhibiting neoplastic cells with imidazoquinazoline derivatives
    Publication number: 20020193389
    Abstract: A method for inhibiting neoplasia, particularly cancerous and precancerous lesions by exposing the affected cells to imidazoquinazoline derivatives.
    Type: Application
    Filed: May 30, 2002
    Publication date: December 19, 2002
    Inventors: Rifat Pamukeu, Gary A. Piazza
  • Method of inhibiting neoplastic cells with isoquinoline derivatives
    Patent number: 6486155
    Abstract: A method for inhibiting neoplasia, particularly cancerous and precancerous lesions by exposing the affected cells to isoquinoline derivatives.
    Type: Grant
    Filed: November 24, 1998
    Date of Patent: November 26, 2002
    Assignee: Cell Pathways Inc
    Inventors: Rifat Pamukcu, Gary A. Piazza
  • [4,5]-fused-3,6-disubstituted-pyridazines with sulfur-containing substituents in position three for the treatment of neoplasia
    Patent number: 6486158
    Abstract: [4,5]-Fused-3,6 disubstituted-pydidazines of Formula I are useful for inducing or promoting apoptosis and for arresting uncontrolled neoplastic cell proliferation, and are specifically useful in the arresting and treatment of neoplasia: wherein Y1 and Y2 are independently selected from the group consisting of (CH2)n,—C(X)—NH—,—(CH2)n—C(X)—O—, and X is O or S; R1 is selected from the group consisting of lower alkyl, lower alkenyl, lower alkynyl, and substituted or unsubstituted phenyl, pyridinyl, and the like; R2 is selected from the group consisting of substituted or unsubstituted phenyl, benzyl, pyridinyl, and the like; “A” is a benzene ring fused with the pyridazine ring; and R3 is independently selected in each instance form the group consisting of halogen, lower alkyl, and the like.
    Type: Grant
    Filed: June 6, 2001
    Date of Patent: November 26, 2002
    Assignee: Cell Pathways, Inc.
    Inventors: Xiaojing Wang, Gerhard Sperl, Paul Gross, Rifat Pamukcu, Gary A. Piazza
  • Method of treating a patient having precancerous lesions with phenyl pyridinone derivatives
    Patent number: 6479520
    Abstract: Derivatives of phenyl pyridinone are useful for the treatment of patients having precancerous lesions. These compounds are also useful to inhibit the growth of neoplastic cells.
    Type: Grant
    Filed: March 8, 2000
    Date of Patent: November 12, 2002
    Assignee: Cell Pathways, Inc.
    Inventors: Gary Piazza, Rifat Pamukcu
  • Method of inhibiting neoplastic cells with indole derivatives
    Publication number: 20020143022
    Abstract: A method for inhibiting neoplastic cells and related conditions by exposing them to substituted indole derivatives.
    Type: Application
    Filed: February 7, 2002
    Publication date: October 3, 2002
    Inventors: Rifat Pamukcu, Gary A. Piazza
  • Method for inhibiting neoplastic cells and related conditions by exposure to 2,9-disubstituted purin-6-ones
    Patent number: 6440981
    Abstract: A method for inhibiting the growth of neoplastic cells by exposure to 2,9-disubstituted purin-6-ones.
    Type: Grant
    Filed: July 30, 2001
    Date of Patent: August 27, 2002
    Assignee: Cell Pathways, Inc.
    Inventors: Rifat Pamukcu, Gary A. Piazza
  • Method for inhibiting neoplastic cells and related conditions by exposure to benzothienopyrimidine derivatives
    Patent number: 6432950
    Abstract: Benzothienopyrimidine derivatives for inducing or promoting apoptosis and for arresting uncontrolled neoplastic cell proliferation, and specifically for arresting and treating neoplasia, including precancerous and cancerous lesions.
    Type: Grant
    Filed: July 12, 2000
    Date of Patent: August 13, 2002
    Assignee: Cell Pathways
    Inventors: Rifat Pamukcu, Gary A. Piazza
  • Substituted condensation products of N-benzyl-3-indenylacetamides with heterocyclic aldehydes for neoplasia
    Patent number: 6426349
    Abstract: Substituted condensation products of N-benzyl-3-indenylacetamides with heterocyclic aldehydes are useful for inducing or promoting apotosis and for arresting uncontrolled neoplastic cell proliferation, and are specifically useful in the arresting and treatment of neoplasias, including precancerous and cancerous lesions.
    Type: Grant
    Filed: December 20, 2000
    Date of Patent: July 30, 2002
    Assignee: Cell Pathway and the University of Arizona
    Inventors: Gerhard J. Sperl, Paul Gross, Klaus Brendel, Gary A. Piazza, Rifat Pamukeu
  • Method for treating neoplasia by exposure to N,N?-substituted benzimidazol-2-ones
    Patent number: 6420410
    Abstract: A method for inhibiting neoplastic cells and related conditions by exposing them to N,N′-substituted benzimidazol-2-ones.
    Type: Grant
    Filed: August 16, 2000
    Date of Patent: July 16, 2002
    Assignee: Cell Pathways, Inc.
    Inventors: Gerhard Sperl, Ulrich Ixkes, Rifat Pamukcu, Gary A. Piazza