Patent number: 6355653
Abstract: The invention relates to compounds of formula
wherein
R1 is a 5 or 6 membered heteroaryl group, containing 1 to 3 heteroatoms, selected from N, O or S, and which groups are optionally substituted by one or two substituents, which are lower alkyl, —(CH2)nOH, halogen or lower alkoxy, and wherein the heteroaryl groups may be optionally linked to the pyrazole ring via an alkylene or alkenyl group, or is
phenyl, optionally substituted by one or two substituents being lower alkyl, hydroxy-lower alkyl, halogen, hydroxy or lower alkoxy or is
—O(CH2)n,phenyl, benzofuryl, indolyl or benzothiophenyl, or is
—S-lower alkyl;
R2 and R4 are independently from each other hydrogen, cyano or —S(O)2-phenyl;
R3 is hydrogen, halogen or is
a 5 or 6 membered heteroaryl group, containing 1 to 3 heteroatoms, selected from N, O or S, and which groups are optionally substituted by one or two substituents, which are lower alkyl, —(CH2)n-aryl, hydroxy, halogen, lower alkoxy, morpholin
Type:
Grant
Filed:
August 24, 2000
Date of Patent:
March 12, 2002
Assignee:
Hoffmann-La Roche Inc.
Inventors:
Gerda Huber Trottmann, Walter Hunkeler, Roland Jakob-Roetne, Gavin John Kilpatrick, Matthias Heinrich Nettekoven, Claus Riemer