Patents by Inventor Gen-ichiro Nonaka

Gen-ichiro Nonaka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10183007
    Abstract: The present invention relates to a composition containing as its main component proanthocyanidin oligomer to which a substance having a phloroglucinol ring structure or resorcinol ring structure has been bonded and reduced in the molecular weight, which is obtained by heating plant materials containing proanthocyanidin polymer or extract thereof with a substance having a phloroglucinol ring structure or resorcinol ring structure in an acidic aqueous solution, production method thereof, and uses of the composition in health products and pharmaceutical products. According to the invention, proanthocyanidin oligomer having physiological activity, to which a substance having a phloroglucinol ring structure or resorcinol ring structure has been bonded and reduced in the molecular weight to such a level that the oligomer can be absorbed into living body, which has been conventionally difficult to obtain at high yield from plant raw materials, can be produced efficiently and easily.
    Type: Grant
    Filed: December 21, 2015
    Date of Patent: January 22, 2019
    Assignees: Usien Pharmaceutical Co., Ltd., Amino Up Chemical Co., Ltd., Nagasaki University
    Inventors: Takashi Tanaka, Gen-ichiro Nonaka, Isao Kohno, Hajime Fujii, Takashi Nakagawa, Hiroshi Nishioka
  • Publication number: 20160151329
    Abstract: The present invention relates to a composition containing as its main component proanthocyanidin oligomer to which a substance having a phloroglucinol ring structure or resorcinol ring structure has been bonded and reduced in the molecular weight, which is obtained by heating plant materials containing proanthocyanidin polymer or extract thereof with a substance having a phloroglucinol ring structure or resorcinol ring structure in an acidic aqueous solution, production method thereof, and uses of the composition in health products and pharmaceutical products. According to the invention, proanthocyanidin oligomer having physiological activity, to which a substance having a phloroglucinol ring structure or resorcinol ring structure has been bonded and reduced in the molecular weight to such a level that the oligomer can be absorbed into living body, which has been conventionally difficult to obtain at high yield from plant raw materials, can be produced efficiently and easily.
    Type: Application
    Filed: December 21, 2015
    Publication date: June 2, 2016
    Applicants: Nagasaki University, Usaien Pharmaceutical Co., Ltd., Amino Up Chemical Co., Ltd.
    Inventors: Takashi Tanaka, Gen-ichiro Nonaka, Isao Kohno, Hajime Fujii, Takashi Nakagawa, Hiroshi Nishioka
  • Patent number: 8088419
    Abstract: Provided are: method of producing a sulfur-containing proanthocyanidin oligomer by reducing the molecular weight of proanthocyanidin in plants so that they can be readily absorbed through the intestine of an organism; and a health food composition and a pharmaceutical composition which contain the resultant sulfur-containing proanthocyanidin oligomer as an active ingredient and which are useful for treating and preventing various lifestyle-related diseases and brain diseases caused by generation of active oxygen species as well as for preventing aging.
    Type: Grant
    Filed: October 6, 2010
    Date of Patent: January 3, 2012
    Assignees: Amino Up Chemical Co., Ltd., Usaien Pharmaceutical Co., Ltd.
    Inventors: Gen-ichiro Nonaka, Buxiang Sun, Lan Yuan, Takashi Nakagawa, Hajime Fujii, Young-Joon Surh
  • Patent number: 7939116
    Abstract: Provided are: method of producing a sulfur-containing proanthocyanidin oligomer by reducing the molecular weight of proanthocyanidin in plants so that they can be readily absorbed through the intestine of an organism; and a health food composition and a pharmaceutical composition which contain the resultant sulfur-containing proanthocyanidin oligomer as an active ingredient and which are useful for treating and preventing various lifestyle-related diseases and brain diseases caused by generation of active oxygen species as well as for preventing aging.
    Type: Grant
    Filed: October 6, 2010
    Date of Patent: May 10, 2011
    Assignees: Amino Up Chemical Co., Ltd., Usaien Pharmaceutical Co., Ltd.
    Inventors: Gen-ichiro Nonaka, Buxiang Sun, Lan Yuan, Takashi Nakagawa, Hajime Fujii, Young-Joon Surh
  • Publication number: 20110028742
    Abstract: Provided are: method of producing a sulfur-containing proanthocyanidin oligomer by reducing the molecular weight of proanthocyanidin in plants so that they can be readily absorbed through the intestine of an organism; and a health food composition and a pharmaceutical composition which contain the resultant sulfur-containing proanthocyanidin oligomer as an active ingredient and which are useful for treating and preventing various lifestyle-related diseases and brain diseases caused by generation of active oxygen species as well as for preventing aging.
    Type: Application
    Filed: October 6, 2010
    Publication date: February 3, 2011
    Applicants: AMINO UP CHEMICAL CO., LTD., USAIEN PHARMACEUTICAL CO., LTD.
    Inventors: Gen-ichiro NONAKA, Buxiang SUN, Lan YUAN, Takashi NAKAGAWA, Hajime FUJII, Young-Joon SURH
  • Publication number: 20110021792
    Abstract: Provided are: method of producing a sulfur-containing proanthocyanidin oligomer by reducing the molecular weight of proanthocyanidin in plants so that they can be readily absorbed through the intestine of an organism; and a health food composition and a pharmaceutical composition which contain the resultant sulfur-containing proanthocyanidin oligomer as an active ingredient and which are useful for treating and preventing various lifestyle-related diseases and brain diseases caused by generation of active oxygen species as well as for preventing aging.
    Type: Application
    Filed: October 6, 2010
    Publication date: January 27, 2011
    Applicants: Amino Up Chemical Co., Ltd., Usaien Pharmaceutical Co., Ltd.
    Inventors: Gen-ichiro NONAKA, Buxiang SUN, Lan YUAN, Takashi NAKAGAWA, Hajime FUJII, Young-Joon SURH
  • Patent number: 7833553
    Abstract: Provided are: method of producing a sulfur-containing proanthocyanidin oligomer by reducing the molecular weight of proanthocyanidin in plants so that they can be readily absorbed through the intestine of an organism; and a health food composition and a pharmaceutical composition which contain the resultant sulfur-containing proanthocyanidin oligomer as an active ingredient and which are useful for treating and preventing various lifestyle-related diseases and brain diseases caused by generation of active oxygen species as well as for preventing aging.
    Type: Grant
    Filed: May 25, 2004
    Date of Patent: November 16, 2010
    Assignees: Amino Up Chemical Co. Ltd., Usaien Pharmaceutical Co., Ltd
    Inventors: Gen-ichiro Nonaka, Buxiang Sun, Lan Yuan, Takashi Nakagawa, Hajime Fujii, Young-Joon Surh
  • Publication number: 20090047305
    Abstract: The present invention relates to a composition containing as its main component proanthocyanidin oligomer to which a substance having a phloroglucinol ring structure or resorcinol ring structure has been bonded, and reduced in the molecular weight, which is obtained by heating plant materials containing proanthocyanidin polymer or extract thereof with a substance having a phloroglucinol ring structure or resorcinol ring structure in an acidic aqueous solution, production method thereof, and uses of the composition in health products and pharmaceutical products. According to the invention, proanthocyanidin oligomer having physiological activity, to which a substance having a phloroglucinol ring structure or resorcinol ring structure has been bonded and reduced in the molecular weight to such a level that the oligomer can be absorbed into living body, which has been conventionally difficult to obtain at high yield from plant raw materials, can be produced efficiently and easily.
    Type: Application
    Filed: February 24, 2006
    Publication date: February 19, 2009
    Applicants: NAGASAKI UNIVERSITY, USAIEN PHARMACEUTICAL CO., LTD., AMINO UP CHEMICAL CO., LTD.
    Inventors: Takashi Tanaka, Gen-ichiro Nonaka, Isao Kohno, Hajime Fujii, Takashi Nakagawa, Hiroshi Nishioka
  • Publication number: 20050261198
    Abstract: Provided are: method of producing a sulfur-containing proanthocyanidin oligomer by reducing the molecular weight of proanthocyanidin in plants so that they can be readily absorbed through the intestine of an organism; and a health food composition and a pharmaceutical composition which contain the resultant sulfur-containing proanthocyanidin oligomer as an active ingredient and which are useful for treating and preventing various lifestyle-related diseases and brain diseases caused by generation of active oxygen species as well as for preventing aging.
    Type: Application
    Filed: May 25, 2004
    Publication date: November 24, 2005
    Inventors: Gen-ichiro Nonaka, Buxiang Sun, Lan Yuan, Takashi Nakagawa, Hajime Fujii, Young-Joon Surh