Patents by Inventor Geoffrey von Maltzahn

Geoffrey von Maltzahn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20180296582
    Abstract: Compositions comprising microbiome regulators are provided, as well as methods of using the same for the modulation of the human microbiota and to treat or prevent related diseases, disorders, or conditions.
    Type: Application
    Filed: April 23, 2016
    Publication date: October 18, 2018
    Inventors: Geoffrey A. von Maltzahn, John M. Geremia
  • Patent number: 10076120
    Abstract: This application relates to methods and materials for providing a benefit to a seed or seedling of an agricultural plant (e.g., an agricultural grass plant), or the agricultural plant derived from the seed or seedling. For example, this application provides purified bacterial populations that include novel seed-origin bacterial endophytes, and synthetic combinations of seeds and/or seedlings (e.g., cereal seeds and/or seedlings) with heterologous seed-derived bacterial endophytes.
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: September 18, 2018
    Assignee: Indigo Agriculture, Inc.
    Inventors: Geoffrey von Maltzahn, Richard Bailey Flavell, Gerardo V. Toledo, Slavica Djonovic, Luis Miguel Marquez, David Morris Johnston, Yves Alain Millet, Jeffrey Lyford, Alexander Naydich, Craig Sadowski
  • Patent number: 10064900
    Abstract: Methods and compositions for populating the gastrointestinal tract of a subject are described. Methods include administering to a subject a therapeutic composition comprising a purified population of spore-forming bacteria produced by providing a fecal material and subjecting the material to a treatment step resulting in purification of spore-forming bacteria. Methods include administering an amount effective to engraft and/or augment in the gastrointestinal tract in order to treat or prevent a dysbiosis in the mammalian subject.
    Type: Grant
    Filed: February 4, 2014
    Date of Patent: September 4, 2018
    Assignee: Seres Therapeutics, Inc.
    Inventors: Geoffrey Von Maltzahn, Matthew R. Henn, David N. Cook, David Arthur Berry, Noubar B. Afeyan, Brian Goodman, Mary-Jane Lombardo McKenzie, Marin Vulic
  • Patent number: 10064901
    Abstract: Disclosed herein are therapeutic compositions containing non-pathogenic, germination-competent bacterial spores, for the prevention, control, and treatment of gastrointestinal diseases, disorders and conditions and for general nutritional health.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: September 4, 2018
    Assignee: Seres Therapeutics, Inc.
    Inventors: Gregory McKenzie, Mary-Jane Lombardo McKenzie, David N. Cook, Marin Vulic, Geoffrey von Maltzahn, Brian Goodman, John Grant Aunins, Matthew R. Henn, David Arthur Berry, Jonathan Winkler
  • Patent number: 10058101
    Abstract: This application relates to methods and materials for providing a benefit to a seed or seedling of an agricultural plant (e.g., an agricultural grass plant), or the agricultural plant derived from the seed or seedling. For example, this application provides purified bacterial populations that include novel seed-origin bacterial endophytes, and synthetic combinations of seeds and/or seedlings (e.g., cereal seeds and/or seedlings) with heterologous seed-derived bacterial endophytes.
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: August 28, 2018
    Assignee: Indigo Agriculture, Inc.
    Inventors: Geoffrey von Maltzahn, Richard Bailey Flavell, Gerardo V. Toledo, Slavica Djonovic, Luis Miguel Marquez, David Morris Johnston, Yves Alain Millet, Jeffrey Lyford, Alexander Naydich, Craig Sadowski
  • Publication number: 20180235987
    Abstract: Compositions comprising glycan therapeutics, optionally comprising one or more oligo- or polysaccharides, probiotics, prebiotics and other agents are provided. Further, methods of generating said glycan therapeutics using polymeric catalysts are described. Also provided are methods of using said gycan therapeutics, e.g. for the modulation of vaginal microbiota.
    Type: Application
    Filed: August 25, 2016
    Publication date: August 23, 2018
    Inventors: Geoffrey A. von Maltzahn, Yvonne J. Yamanaka
  • Publication number: 20180213800
    Abstract: This invention relates to methods and compositions for providing a benefit to a plant by associating the plant with a beneficial endophyte of the genus Penicillium, including benefits to a plant derived from a seed or other plant element treated with said endophyte. For example, this invention provides purified endophytes, synthetic combinations comprising endophytes, and methods of making and using the same. In particular, this invention relates to compositions and methods of improving soybean and maize plants.
    Type: Application
    Filed: June 24, 2016
    Publication date: August 2, 2018
    Applicant: INDIGO AG, INC.
    Inventors: Slavica DJONOVIC, Elizabeth Alexa MCKENZIE, Gerardo V. TOLEDO, Craig SADOWSKI, Geoffrey VON MALTZAHN, Karen V. AMBROSE, Xuecheng ZHANG, David Morris JOHNSTON, Trudi A. GULICK
  • Publication number: 20180200310
    Abstract: Disclosed herein are therapeutic compositions containing non-pathogenic, germination-competent bacterial spores, for the prevention, control, and treatment of gastrointestinal diseases, disorders and conditions and for general nutritional health.
    Type: Application
    Filed: December 19, 2017
    Publication date: July 19, 2018
    Inventors: Gregory McKenzie, Mary-Jane Lombardo McKenzie, David N. Cook, Marin Vulic, Geoffrey von Maltzahn, Brian Goodman, John Grant Aunins, Matthew R. Henn, David Arthur Berry, Jonathan Winkler
  • Publication number: 20180147222
    Abstract: Preparations of glycan therapeutics, pharmaceutical compositions and medical foods thereof, optionally comprising micronutrients, polyphenols, prebiotics, probiotics, or other agents are provided and methods of making same. Also provided are methods of using said gycan therapeutics, e.g. for the modulation of human gastrointestinal microbiota and to treat dysbioses.
    Type: Application
    Filed: June 15, 2017
    Publication date: May 31, 2018
    Inventors: Geoffrey A. von Maltzahn, Jared Silverman, Yvonne J. Yamanaka, John Miles Milwid, John M. Geremia
  • Publication number: 20180147221
    Abstract: Preparations of glycan therapeutics, pharmaceutical compositions, dietary supplements and medical foods thereof are provided, and methods of using said gycan therapeutics, e.g. in cancer therapy.
    Type: Application
    Filed: April 23, 2016
    Publication date: May 31, 2018
    Applicant: KALEIDO BIOSCIENCES, INC.
    Inventors: Geoffrey A. von Maltzahn, Yvonne J. Yamanaka, Jared Silverman, Jack Milwid, Jacob R. Rubens, John M. Geremia
  • Patent number: 9970941
    Abstract: The present invention relates to methods and products associated with in vivo enzyme profiling. In particular, the invention relates to methods of in vivo processing of exogenous molecules followed by detection of signature molecules as representative of the presence of active enzymes associated with diseases or conditions. The invention also relates to products, kits, and databases for use in the methods of the invention.
    Type: Grant
    Filed: January 28, 2014
    Date of Patent: May 15, 2018
    Assignee: Massachusetts Institute of Technology
    Inventors: Sangeeta N. Bhatia, Geoffrey A. von Maltzahn, Gabriel A. Kwong
  • Patent number: 9956282
    Abstract: Provided are compositions containing combinations of bacteria useful for the maintenance or restoration of a healthy microbiota in the gastrointestinal tract, or other niche of a mammalian subject, and methods for use thereof, in particular for the treatment, inhibition, or prevention of immune disorders such as allergies and asthma.
    Type: Grant
    Filed: December 16, 2014
    Date of Patent: May 1, 2018
    Assignee: Seres Therapeutics, Inc.
    Inventors: David N. Cook, David Arthur Berry, Geoffrey von Maltzahn, Matthew R. Henn, Han Zhang, Brian Goodman
  • Patent number: 9944681
    Abstract: Nutritive proteins are provided. In some embodiments the nutritive proteins comprise a first polypeptide sequence comprising a fragment of a naturally-occurring nutritive protein. In some embodiments the fragment comprises at least one of a) an enhanced ratio of branch chain amino acid residues to total amino acid residues present in the nutritive protein; b) an enhanced ratio of leucine residues to total amino acid residues present in the nutritive protein; and c) an enhanced ratio of essential amino acid residues to total amino acid residues present in the nutritive protein.
    Type: Grant
    Filed: February 10, 2017
    Date of Patent: April 17, 2018
    Assignee: Axcella Health Inc.
    Inventors: David Arthur Berry, Brett Adam Boghigian, Nathaniel W. Silver, Geoffrey von Maltzahn, Rajeev Chillakuru, Michael Hamill, John F. Kramarczyk
  • Patent number: 9901595
    Abstract: Preparations of glycan therapeutics, pharmaceutical compositions and medical foods thereof, optionally comprising micronutrients, polyphenols, prebiotics, probiotics, or other agents are provided and methods of making same. Also provided are methods of using said glycan therapeutics, e.g. for the modulation of human gastrointestinal microbiota and to treat dysbioses.
    Type: Grant
    Filed: October 5, 2016
    Date of Patent: February 27, 2018
    Assignee: KALEIDO BIOSCIENCES, INC.
    Inventors: Geoffrey A. von Maltzahn, Jared Silverman, Yvonne J. Yamanaka, John Miles Milwid, John M. Geremia
  • Publication number: 20180020677
    Abstract: Materials and methods for improving plant traits and for providing plant fitness benefits are provided. In some embodiments, the materials, and methods employing the same, can comprise endophytes.
    Type: Application
    Filed: December 30, 2015
    Publication date: January 25, 2018
    Inventors: Karen V. AMBROSE, Nathan A. BILLINGS, Slavica DJONOVIC, Richard Bailey FLAVELL, Trudi A. GULICK, David Morris JOHNSTON, Jonathan W. LEFF, Stephanie M. LIVA, Jeffrey LYFORD, Geoffrey VON MALTZAHN, Luis Miguel MARQUEZ, Yves Alain MILLET, Craig SADOWSKI, Phillip SAMAYOA, Gerardo V. TOLEDO, David R. WEISMAN, Xuecheng ZHANG
  • Patent number: 9855303
    Abstract: Disclosed herein are therapeutic compositions containing non-pathogenic, germination-competent bacterial spores, for the prevention, control, and treatment of gastrointestinal diseases, disorders and conditions and for general nutritional health.
    Type: Grant
    Filed: January 25, 2017
    Date of Patent: January 2, 2018
    Assignee: Seres Therapeutics, Inc.
    Inventors: Gregory McKenzie, Mary-Jane Lombardo McKenzie, David N. Cook, Marin Vulic, Geoffrey von Maltzahn, Brian Goodman, John Grant Aunins, Matthew R. Henn, David Arthur Berry, Jonathan Winkler
  • Publication number: 20170327548
    Abstract: Charged nutritive proteins provided. In some embodiments the nutritive proteins an aqueous solubility of at least 12.5 g/L at pH 7. In some embodiments the nutritive proteins an aqueous solubility of at least 50 g/L at pH 7. In some embodiments the nutritive proteins an aqueous solubility of at least 100 g/L at pH 7.
    Type: Application
    Filed: April 19, 2017
    Publication date: November 16, 2017
    Inventors: Michael J. Hamill, Nathaniel W. Silver, Rajeev Chillakuru, John F. Kramarczyk, David Arthur Berry, Brett Adam Boghigian, Geoffrey von Maltzahn
  • Publication number: 20170298102
    Abstract: Nutritive proteins are provided. In some embodiments the nutritive proteins comprise at least one of a level of a) a ratio of branch chain amino acid residues to total amino acid residues present in the nutritive protein equal to or greater than the ratio of branch chain amino acid residues to total amino acid residues present in whey protein; b) a ratio of leucine residues to total amino acid residues present in the nutritive protein equal to or greater than the ratio of leucine residues to total amino acid residues present in whey protein; and c) a ratio of essential amino acid residues to total amino acid residues present in the nutritive protein equal to or greater than the ratio of essential amino acid residues to total amino acid residues present in whey protein.
    Type: Application
    Filed: February 10, 2017
    Publication date: October 19, 2017
    Inventors: Geoffrey von Maltzahn, Michael J. Hamill, Rajeev Chillakuru, John F. Kramarczyk, David Arthur Berry, Brett Adam Boghigian, Nathaniel W. Silver
  • Patent number: 9757403
    Abstract: Preparations of glycan therapeutics, pharmaceutical compositions and medical foods thereof, optionally comprising micronutrients, polyphenols, prebiotics, probiotics, or other agents are provided and methods of making same. Also provided are methods of using said glycan therapeutics, e.g. for the modulation of human gastrointestinal microbiota and to treat dysbioses.
    Type: Grant
    Filed: December 20, 2016
    Date of Patent: September 12, 2017
    Assignee: KALEIDO BIOSCIENCES, INC.
    Inventors: Geoffrey A. von Maltzahn, Jared Silverman, Yvonne J. Yamanaka, John Miles Milwid, John M. Geremia
  • Publication number: 20170253639
    Abstract: Nutritive proteins are provided. In some embodiments the nutritive proteins comprise a first polypeptide sequence comprising a fragment of a naturally-occurring nutritive protein. In some embodiments the fragment comprises at least one of a) an enhanced ratio of branch chain amino acid residues to total amino acid residues present in the nutritive protein; b) an enhanced ratio of leucine residues to total amino acid residues present in the nutritive protein; and c) an enhanced ratio of essential amino acid residues to total amino acid residues present in the nutritive protein.
    Type: Application
    Filed: February 10, 2017
    Publication date: September 7, 2017
    Inventors: David Arthur Berry, Brett Adam Boghigian, Nathaniel W. Silver, Geoffrey von Maltzahn, Rajeev Chillakuru, Michael Hamill, John F. Kramarczyk