Patents by Inventor Georg Thierbach

Georg Thierbach has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20120214211
    Abstract: The invention relates to a recombinant coryneform bacterium which secretes an organic chemical compound and in which the sugR gene which codes for a polypeptide having the activity of an SugR regulator has been attenuated. The invention further relates to a processes for using this bacterium for the fermentative preparation of organic chemical compounds.
    Type: Application
    Filed: January 21, 2012
    Publication date: August 23, 2012
    Applicants: Forschungszentrum Julich GmbH, Evonik Degussa GmbH
    Inventors: Brigitte Bathe, Bastian Blombach, Bernhard Eikmanns, Verena Engels, Georg Thierbach, Volker Wendisch
  • Patent number: 8153404
    Abstract: The invention relates to mutants and alleles of the zwf gene of coryneform bacteria, which encode variants of the Zwf subunit of glucose 6-phosphate dehydrogenase (EC: 1.1.1.49), and to processes for preparing amino acids, in particular L-lysine and L-tryptophan, by using bacteria which harbor said alleles.
    Type: Grant
    Filed: July 28, 2009
    Date of Patent: April 10, 2012
    Assignee: Evonik Degussa GmbH
    Inventors: Brigitte Bathe, Natalie Schischka, Georg Thierbach
  • Patent number: 8143032
    Abstract: Alleles of the thrA gene from Enterobacteriaceae encoding desensitized aspartokinase I-homoserine dehydrogenase I enzymes and methods for the fermentative production of L-threonine using bacteria containing these alleles.
    Type: Grant
    Filed: April 8, 2011
    Date of Patent: March 27, 2012
    Assignee: Evonik Degussa GmbH
    Inventors: Mechthild Rieping, Georg Thierbach
  • Publication number: 20120064582
    Abstract: The invention relates to an isolated polynucleotide having a polynucleotide sequence which codes for the alr gene, and a host-vector system having a coryneform host bacterium in which the alr gene is present in attenuated form and a vector which carries at least the alr gene according to SEQ ID No 1, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.
    Type: Application
    Filed: September 22, 2011
    Publication date: March 15, 2012
    Inventors: Andreas Tauch, Michael Binder, Walter Pfefferle, Georg Thierbach, Jörn Kalinowski, Alfred Pühler
  • Patent number: 8133714
    Abstract: The invention relates to a recombinant coryneform bacterium which secretes an organic chemical compound and in which the sugR gene which codes for a polypeptide having the activity of an SugR regulator has been attenuated. The invention further relates to a processes for using this bacterium for the fermentative preparation of organic chemical compounds.
    Type: Grant
    Filed: September 19, 2008
    Date of Patent: March 13, 2012
    Assignees: Evonik Degussa GmbH, Forschungszentrum Jülich GmbH
    Inventors: Brigitte Bathe, Bastian Blombach, Bernhard Eikmanns, Verena Engels, Georg Thierbach, Volker Wendisch
  • Publication number: 20110318791
    Abstract: The invention relates to processes for fermentative production of L-proline using bacteria which contain mutated variants of the proB gene.
    Type: Application
    Filed: May 31, 2011
    Publication date: December 29, 2011
    Applicant: DEGUSSA GmbH
    Inventors: Stephan HANS, Brigitte Bathe, Georg Thierbach
  • Patent number: 8080395
    Abstract: An isolated mutant of coryneform bacteria comprising a gene encodes a polypeptide having 2-methylcitrate dehydratase activity, where the polypeptide comprises an amino acid sequence in which one of the proteinogenic amino acids except L-proline is present at position 272 or a corresponding or comparable position. In addition, an isolated polynucleotide encoding a polypeptide having 2-methylcitrate dehydratase enzymic activity, which comprises at position 272 of the amino acid sequence or a corresponding or comparable position a proteinogenic amino acid except L-proline is described. A method for producing a recombinant coryneform bacterium and L-amino acids. A recombinant microorganism, L-Lysine-containing feed additive, and L-Tryptophan-containing feed additive is also described.
    Type: Grant
    Filed: January 19, 2011
    Date of Patent: December 20, 2011
    Assignee: Evonik Degussa GmbH
    Inventors: Brigitte Bathe, Caroline Kreutzer, Georg Thierbach
  • Patent number: 8048665
    Abstract: The invention relates to an isolated polynucleotide having a polynucleotide sequence which codes for the alr gene, and a host-vector system having a coryneform host bacterium in which the alr gene is present in attenuated form and a vector which carries at least the alr gene according to SEQ ID No 1, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.
    Type: Grant
    Filed: November 27, 2002
    Date of Patent: November 1, 2011
    Assignee: Evonik Degussa GmbH
    Inventors: Andreas Tauch, Michael Binder, Walter Pfefferle, Georg Thierbach, Jörn Kalinowski, Alfred Pühler
  • Patent number: 7982020
    Abstract: The invention relates to mutated variants of the proB gene from coryneform bacteria, which encode ?-glutamyl kinase, and to processes for fermentative production of L-proline using bacteria which contain this mutation.
    Type: Grant
    Filed: December 13, 2005
    Date of Patent: July 19, 2011
    Assignee: Evonik Degussa GmbH
    Inventors: Stephan Hans, Brigitte Bathe, Georg Thierbach
  • Publication number: 20110171695
    Abstract: An isolated mutant of coryneform bacteria comprising a gene encodes a polypeptide having 2-methylcitrate dehydratase activity, where the polypeptide comprises an amino acid sequence in which one of the proteinogenic amino acids except L-proline is present at position 272 or a corresponding or comparable position. In addition, an isolated polynucleotide encoding a polypeptide having 2-methylcitrate dehydratase enzymic activity, which comprises at position 272 of the amino acid sequence or a corresponding or comparable position a proteinogenic amino acid except L-proline is described. A method for producing a recombinant coryneform bacterium and L-amino acids. A recombinant microorganism, L-Lysine-containing feed additive, and L-Tryptophan-containing feed additive is also described.
    Type: Application
    Filed: January 19, 2011
    Publication date: July 14, 2011
    Applicant: EVONIK DEGUSSA GmbH
    Inventors: Brigitte BATHE, Caroline Kreutzer, Georg Thierbach
  • Patent number: 7915394
    Abstract: The invention relates to mutants and alleles of the opcA gene of coryneform bacteria, which encode variants of the OpcA subunit of glucose 6-phosphate dehydrogenase (EC: 1.1.1.49), and to processes for preparing amino acids, in particular L-lysine and L-tryptophan, by using bacteria which harbor said alleles.
    Type: Grant
    Filed: January 29, 2010
    Date of Patent: March 29, 2011
    Assignee: Evonik Degussa GmbH
    Inventors: Natalie Schischka, Brigitte Bathe, Georg Thierbach
  • Patent number: 7910715
    Abstract: The invention relates to mutants and alleles of the oxyR gene of coryneform bacteria coding for variants of the OxyR transcription regulator and processes for producing amino acids using bacteria which comprise these alleles.
    Type: Grant
    Filed: November 9, 2007
    Date of Patent: March 22, 2011
    Assignee: Evonik Degussa GmbH
    Inventors: Brigitte Bathe, Wilfried Claes, Silke Jerrentrup, Caroline Kreutzer, Georg Thierbach
  • Patent number: 7893231
    Abstract: An isolated mutant of coryneform bacteria comprising a gene encodes a polypeptide having 2-methylcitrate dehydratase activity, where the polypeptide comprises an amino acid sequence in which one of the proteinogenic amino acids except L-proline is present at position 272 or a corresponding or comparable position. In addition, an isolated polynucleotide encoding a polypeptide having 2-methylcitrate dehydratase enzymic activity, which comprises at position 272 of the amino acid sequence or a corresponding or comparable position a proteinogenic amino acid except L-proline is described. A method for producing a recombinant coryneform bacterium and L-amino acids. A recombinant microorganism, L-Lysine-containing feed additive, and L-Tryptophan-containing feed additive is also described.
    Type: Grant
    Filed: October 25, 2007
    Date of Patent: February 22, 2011
    Assignee: Evonik Degussa GmbH
    Inventors: Brigitte Bathe, Caroline Kreutzer, Georg Thierbach
  • Publication number: 20100311147
    Abstract: An isolated mutant of a coryneform bacterium comprising a gene coding for a polypeptide having GTP-pyrophosphate kinase activity, wherein said polypeptide comprises an amino acid sequence in which one of the proteinogenic amino acids other than L-proline is present in position 38 or a corresponding or comparable position. In addition, an isolated polynucleotide encoding a polypeptide having GTP-pyrophosphate kinase enzyme activity, a vector comprising the isolated polynucleotide, a recombinant microorganism comprising the vector, and a process for preparing the recombinant coryneform bacterium is described. A method for over-expressing a GTP-pyrophosphate kinase, a method of preparing an L-amino acid, an L-lysine comprising and L-tryptophan comprising feed is also described.
    Type: Application
    Filed: May 17, 2010
    Publication date: December 9, 2010
    Applicant: EVONIK DEGUSSA GMBH
    Inventors: BRIGITTE BATHE, CAROLINE KREUTZER, GEORG THIERBACH
  • Publication number: 20100255544
    Abstract: The invention relates to coryneform bacteria which, instead of the singular copy of an open reading frame (ORF), gene or allele naturally present at the particular desired site (locus), have at least two copies of the open reading frame (ORF), gene or allele in question, preferably in tandem arrangement, and optionally at least a third copy of the open reading frame (ORF), gene or allele in question at a further gene site, and processes for the preparation of chemical compounds by fermentation of these bacteria.
    Type: Application
    Filed: September 3, 2009
    Publication date: October 7, 2010
    Applicant: Evonik Degussa GmbH
    Inventors: Brigitte Bathe, Caroline Kreutzer, Bettina Mockel, Georg Thierbach
  • Publication number: 20100196959
    Abstract: The invention relates to mutants and alleles of the opcA gene of coryneform bacteria, which encode variants of the OpcA subunit of glucose 6-phosphate dehydrogenase (EC: 1.1.1.49), and to processes for preparing amino acids, in particular L-lysine and L-tryptophan, by using bacteria which harbor said alleles.
    Type: Application
    Filed: January 29, 2010
    Publication date: August 5, 2010
    Inventors: Natalie Schischka, Brigitte Bathe, Georg Thierbach
  • Publication number: 20100190653
    Abstract: The invention relates to an isolated polynucleotide having a polynucleotide sequence which codes for the alr gene, and a host-vector system having a coryneform host bacterium in which the alr gene is present in attenuated form and a vector which carries at least the alr gene according to SEQ ID No 1, and the use of polynucleotides which comprise the sequences according to the invention as hybridization probes.
    Type: Application
    Filed: November 27, 2002
    Publication date: July 29, 2010
    Inventors: Andreas Tauch, Michael Binder, Walter Pfefferle, Georg Thierbach, Jorn Kalinowski, Alfred Puhler
  • Patent number: 7754446
    Abstract: An isolated mutant of a coryneform bacterium comprising a gene coding for a polypeptide having GTP-pyrophosphate kinase activity, wherein said polypeptide comprises an amino acid sequence in which one of the proteinogenic amino acids other than L-proline is present in position 38 or a corresponding or comparable position. In addition, an isolated polynucleotide encoding a polypeptide having GTP-pyrophosphate kinase enzyme activity, a vector comprising the isolated polynucleotide, a recombinant microorganism comprising the vector, and a process for preparing the recombinant coryneform bacterium is described. A method for over-expressing a GTP-pyrophosphate kinase, a method of preparing an L-amino acid, an L-lysine comprising and L-tryptophan comprising feed is also described.
    Type: Grant
    Filed: October 16, 2007
    Date of Patent: July 13, 2010
    Assignee: Evonik Degussa GmbH
    Inventors: Brigitte Bathe, Caroline Kreutzer, Georg Thierbach
  • Publication number: 20100159523
    Abstract: The invention relates to coryneform bacteria which have, in addition to at least one copy, present at the natural site (locus), of an open reading frame (ORF), gene or allele which codes for the synthesis of a protein or an RNA, in each case a second, optionally third or fourth copy of this open reading frame (ORF), gene or allele at in each case a second, optionally third or fourth site in a form integrated into the chromosome and processes for the preparation of chemical compounds by fermentation of these bacteria.
    Type: Application
    Filed: September 23, 2009
    Publication date: June 24, 2010
    Applicant: EVONIK DEGUSSA GMBH
    Inventors: BRIGITTE BATHE, CAROLINE KREUTZER, BETTINA MOCKEL, GEORG THIERBACH
  • Patent number: 7700313
    Abstract: The invention relates to mutants and alleles of the opcA gene of coryneform bacteria, which encode variants of the OpcA subunit of glucose 6-phosphate dehydrogenase (EC: 1.1.1.49), and to processes for preparing amino acids, in particular L-lysine and L-tryptophan, by using bacteria which harbor said alleles.
    Type: Grant
    Filed: May 15, 2006
    Date of Patent: April 20, 2010
    Assignee: Evonik Degussa GmbH
    Inventors: Natalie Schischka, Brigitte Bathe, Georg Thierbach