Patents by Inventor George Acosta

George Acosta has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7606608
    Abstract: An optical sampling interface system is disclosed that minimizes and compensates for errors that result from sampling variations and measurement site state fluctuations. Embodiments of the invention use a guide that does at least one of, induce the formation of a tissue meniscus, minimize interference due to surface irregularities, control variation in the volume of tissue sampled, use a two-part guide system, use a guide that controls rotation of a sample probe and allows z-axis movement of the probe, use a separate base module and sample module in conjunction with a guide, and use a guide that controls rotation. Optional components include an occlusive element and a coupling fluid.
    Type: Grant
    Filed: December 8, 2004
    Date of Patent: October 20, 2009
    Assignee: Sensys Medical, Inc.
    Inventors: Thomas B. Blank, George Acosta, Mutua Mattu, Marcy Makarewicz, Stephen L. Monfre, Alexander D. Lorenz, Timothy L. Ruchti, Kevin H. Hazen, Donovan D. Berry, Roxanne E. Abul-Haj
  • Patent number: 7333843
    Abstract: A placement guide apparatus with an improved hydration inducing plug used in coupling a noninvasive analyzer to a sampling site to determine analyte in the human body is disclosed. The hydration inducing plug includes at least one fluoropolymer that may be used as a coupling agent. The guide apparatus may further include an automated or semi-automated coupling fluid delivery system. Use of either of these couplers mitigates issues associated with related technology and enhances noninvasive analyte measurements, such as a near-IR diffuse reflectance based noninvasive glucose concentration analyzer.
    Type: Grant
    Filed: April 13, 2004
    Date of Patent: February 19, 2008
    Assignee: Sensys Medical, Inc.
    Inventors: Stephen L. Monfre, George Acosta, Thomas B. Blank, Kevin H. Hazen
  • Publication number: 20070293744
    Abstract: A noninvasive glucose concentration analyzer having an optical probe with incident and collection optics and a channel for coupling fluid delivery is disclosed. Fluid is delivered through the channel to a skin tissue site that is subsequently optically sampled using the analyzer.
    Type: Application
    Filed: August 30, 2007
    Publication date: December 20, 2007
    Inventors: Stephen Monfre, George Acosta, Thomas Blank, Kevin Hazen
  • Publication number: 20070293743
    Abstract: A placement guide apparatus with an improved hydration inducing plug used in coupling a noninvasive analyzer to a sampling site to determine analyte in the human body is disclosed. The hydration inducing plug includes at least one fluoropolymer that may be used as a coupling agent. The guide apparatus may further include an automated or semi-automated coupling fluid delivery system. Use of either of these couplers mitigates issues associated with related technology and enhances noninvasive analyte measurements, such as a near-IR diffuse reflectance based noninvasive glucose concentration analyzer.
    Type: Application
    Filed: August 30, 2007
    Publication date: December 20, 2007
    Inventors: Stephen Monfre, George Acosta, Thomas Blank, Kevin Hazen
  • Patent number: 7299080
    Abstract: A near IR spectrometer-based analyzer attaches continuously or semi-continuously to a human subject and collects spectral measurements for determining a biological parameter in the sampled tissue, such as glucose concentration. The analyzer includes an optical system optimized to target the cutaneous layer of the sampled tissue so that interference from the adipose layer is minimized. The optical system includes at least one optical probe. Spacing between optical paths and detection fibers of each probe and between probes is optimized to minimize sampling of the adipose subcutaneous layer and to maximize collection of light backscattered from the cutaneous layer. Penetration depth is optimized by limiting range of distances between paths and detection fibers. Minimizing sampling of the adipose layer greatly reduces interference contributed by the fat band in the sample spectrum, increasing signal-to-noise ratio.
    Type: Grant
    Filed: April 7, 2004
    Date of Patent: November 20, 2007
    Assignee: Sensys Medical, Inc.
    Inventors: George Acosta, James R. Henderson, N. Alan Abul-Haj, Timothy L. Ruchti, Stephen L. Monfre, Thomas B. Blank, Kevin H. Hazen
  • Patent number: 7233816
    Abstract: An optical sampling interface system minimizes and compensates error resulting from sampling variations and measurement site state fluctuations. Components include: An optical probe placement guide having an aperture wherein the optical probe is received, facilitates repeatable placement accuracy on surface of a tissue measurement site with minimal, repeatable disturbance to surface tissue. The aperture creates a tissue meniscus that minimizes interference due to surface irregularities and controls variation in tissue volume sampled; an occlusive element placed over the tissue meniscus isolates the meniscus from environmental fluctuations, stabilizing hydration at the site and thus, surface tension; an optical coupling medium eliminates air gaps between skin surface and optical probe; a bias correction element applies a bias correction to spectral measurements, and associated analyte measurements. When the guide is replaced, a new bias correction is determined for measurements done with the new placement.
    Type: Grant
    Filed: August 12, 2004
    Date of Patent: June 19, 2007
    Assignee: Sensys Medical, Inc.
    Inventors: Thomas B. Blank, George Acosta, Mutua Mattu, Marcy Makarewicz, Stephen L. Monfre, Alexander D. Lorenz, Timothy L. Ruchti
  • Patent number: 7206623
    Abstract: An optical sampling interface system minimizes and compensates error resulting from sampling variations and measurement site state fluctuations. Components include: An optical probe placement guide having an aperture wherein the optical probe is received, facilitates repeatable placement accuracy on surface of a tissue measurement site with minimal, repeatable disturbance to surface tissue. The aperture creates a tissue meniscus that minimizes interference due to surface irregularities and controls variation in tissue volume sampled; an occlusive element placed over the tissue meniscus isolates the meniscus from environmental fluctuations, stabilizing hydration at the site and thus, surface tension; an optical coupling medium eliminates air gaps between skin surface and optical probe; a bias correction element applies a bias correction to spectral measurements, and associated analyte measurements. When the guide is replaced, a new bias correction is determined for measurements done with the new placement.
    Type: Grant
    Filed: June 12, 2002
    Date of Patent: April 17, 2007
    Assignee: Sensys Medical, Inc.
    Inventors: Thomas B. Blank, George Acosta, Mutua Mattu, Marcy Makarewicz, Stephen L. Monfre, Alexander D. Lorenz, Timothy L. Ruchti
  • Publication number: 20070060805
    Abstract: An optical sampling interface system minimizes and compensates error resulting from sampling variations and measurement site state fluctuations. Components include: An optical probe placement guide having an aperture wherein the optical probe is received, facilitates repeatable placement accuracy on surface of a tissue measurement site with minimal, repeatable disturbance to surface tissue. The aperture creates a tissue meniscus that minimizes interference due to surface irregularities and controls variation in tissue volume sampled; an occlusive element placed over the tissue meniscus isolates the meniscus from environmental fluctuations, stabilizing hydration at the site and thus, surface tension; an optical coupling medium eliminates air gaps between skin surface and optical probe; a bias correction element applies a bias correction to spectral measurements, and associated analyte measurements. When the guide is replaced, a new bias correction is determined for measurements done with the new placement.
    Type: Application
    Filed: August 12, 2004
    Publication date: March 15, 2007
    Inventors: Thomas Blank, George Acosta, Mutua Mattu, Marcy Makarewicz, Stephen Monfre, Alexander Lorenz, Timothy Ruchti
  • Publication number: 20060247762
    Abstract: A venous valve prosthesis includes a hollow conduit (40) defining a central passageway through which blood may flow. Opposing, pliable leaflet members (30) are located within the conduit and move back and forth between a first, open position, whereby blood may flow through the central passageway in a first direction, and a second, closed position, whereby blood is prevented from backflowing through the central passageway in a second direction which is opposite the first direction. A hollow and generally cylindrical support member (10, 20) retains the leaflet members and is coaxially disposed within the conduit. The support member includes opposing cutaway regions (18) defining two axially extending struts (16) supporting the leaflet members. The cutaway regions, in cooperation with the struts, allow the leaflet members to collapse inwardly to the closed position.
    Type: Application
    Filed: September 1, 2005
    Publication date: November 2, 2006
    Inventors: George Acosta, George Kick
  • Publication number: 20060211927
    Abstract: The invention involves the monitoring of a biological parameter through a compact analyzer. The preferred apparatus is a spectrometer based system that is attached continuously or semi-continuously to a human subject and collects spectral measurements that are used to determine a biological parameter in the sampled tissue. The preferred target analyte is glucose. The preferred analyzer is a near-IR based glucose analyzer for determining the glucose concentration in the body.
    Type: Application
    Filed: January 9, 2006
    Publication date: September 21, 2006
    Inventors: George Acosta, James Henderson, N. Abul Haj, Timothy Ruchti, Stephen Monfre, Thomas Blank, Kevin Hazen
  • Publication number: 20060195023
    Abstract: The invention involves the monitoring of a biological parameter through a compact analyzer. The preferred apparatus is a spectrometer based system that is attached continuously or semi-continuously to a human subject and collects spectral measurements that are used to determine a biological parameter in the sampled tissue. The preferred target analyte is glucose. The preferred analyzer is a near-IR based glucose analyzer for determining the glucose concentration in the body.
    Type: Application
    Filed: January 5, 2006
    Publication date: August 31, 2006
    Inventors: George Acosta, James Henderson, N. Abul Haj, Timothy Ruchti, Stephen Monfre, Thomas Blank, Kevin Hazen
  • Publication number: 20060183983
    Abstract: The invention involves the monitoring of a biological parameter through a compact analyzer. The preferred apparatus is a spectrometer based system that is attached continuously or semi-continuously to a human subject and collects spectral measurements that are used to determine a biological parameter in the sampled tissue. The preferred target analyte is glucose. The preferred analyzer is a near-IR based glucose analyzer for determining the glucose concentration in the body.
    Type: Application
    Filed: January 18, 2006
    Publication date: August 17, 2006
    Inventors: George Acosta, James Henderson, N. Abul Haj, Timothy Ruchti, Stephen Monfre, Thomas Blank, Kevin Hazen
  • Publication number: 20060173255
    Abstract: The invention involves the monitoring of a biological parameter through a compact analyzer. The preferred apparatus is a spectrometer based system that is attached continuously or semi-continuously to a human subject and collects spectral measurements that are used to determine a biological parameter in the sampled tissue. The preferred target analyte is glucose. The preferred analyzer is a near-IR based glucose analyzer for determining the glucose concentration in the body.
    Type: Application
    Filed: January 9, 2006
    Publication date: August 3, 2006
    Inventors: George Acosta, James Henderson, N. Abul Haj, Timothy Ruchti, Stephen Monfre, Thomas Blank, Kevin Hazen
  • Publication number: 20060173254
    Abstract: The invention involves the monitoring of a biological parameter through a compact analyzer. The preferred apparatus is a spectrometer based system that is attached continuously or semi-continuously to a human subject and collects spectral measurements that are used to determine a biological parameter in the sampled tissue. The preferred target analyte is glucose. The preferred analyzer is a near-IR based glucose analyzer for determining the glucose concentration in the body.
    Type: Application
    Filed: January 3, 2006
    Publication date: August 3, 2006
    Inventors: George Acosta, James Henderson, N. Haj, Timothy Ruchti, Stephen Monfre, Thomas Blank, Kevin Hazen
  • Publication number: 20060116562
    Abstract: The invention involves the monitoring of a biological parameter through a compact analyzer. The preferred apparatus is a spectrometer based system that is attached continuously or semi-continuously to a human subject and collects spectral measurements that are used to determine a biological parameter in the sampled tissue. The preferred target analyte is glucose. The preferred analyzer is a near-IR based glucose analyzer for determining the glucose concentration in the body.
    Type: Application
    Filed: January 18, 2006
    Publication date: June 1, 2006
    Inventors: George Acosta, James Henderson, N. Abul Haj, Timothy Ruchti, Stephen Monfre, Thomas Blank, Kevin Hazen
  • Publication number: 20050267342
    Abstract: A method and apparatus are provided for noninvasive sampling. More particularly, the method and apparatus relate to control of motion of an optical sample probe interface relative to a tissue sample site. A dynamic probe interface, is used to collect spectra of a targeted sample, control positioning of the sample probe relative to the tissue sample in terms of at least one of x-, y-, and z-axes, and/or control of sample tissue displacement to minimize spectral variations resulting from the sampling process and increase analyte property estimation precision and accuracy.
    Type: Application
    Filed: April 27, 2005
    Publication date: December 1, 2005
    Inventors: Thomas Blank, George Acosta, Timothy Ruchti, Mutua Mattu, Alexander Lorenz, Kevin Hazen, James Henderson
  • Publication number: 20050267341
    Abstract: An optical sampling interface system minimizes and compensates error resulting from sampling variations and measurement site state fluctuations. Components include: an optical probe placement guide having an aperture wherein the optical probe is received, facilitates repeatable placement accuracy on surface of a tissue measurement site with minimal, repeatable disturbance to surface tissue. The aperture creates a tissue meniscus that minimizes interference due to surface irregularities and controls variation in tissue volume sampled; an occlusive element placed over the tissue meniscus isolates the meniscus from environmental fluctuations, stabilizing hydration at the site and thus, surface tension; an optical coupling medium eliminates air gaps between skin surface and optical probe; a bias correction element applies a bias correction to spectral measurements, and associated analyte measurements. When the guide is replaced, a new bias correction is determined for measurements done with the new placement.
    Type: Application
    Filed: July 8, 2005
    Publication date: December 1, 2005
    Inventors: Thomas Blank, George Acosta, Mutua Mattu, Stephen Monfre
  • Publication number: 20050203359
    Abstract: An optical sampling interface system is disclosed that minimizes and compensates for errors that result from sampling variations and measurement site state fluctuations. Embodiments of the invention use a guide that does at least one of, induce the formation of a tissue meniscus, minimize interference due to surface irregularities, control variation in the volume of tissue sampled, use a two-part guide system, use a guide that controls rotation of a sample probe and allows z-axis movement of the probe, use a separate base module and sample module in conjunction with a guide, and use a guide that controls rotation. Optional components include an occlusive element and a coupling fluid.
    Type: Application
    Filed: December 8, 2004
    Publication date: September 15, 2005
    Inventors: Thomas Blank, George Acosta, Mutua Mattu, Marcy Makarewicz, Stephen Monfre, Alexander Lorenz, Timothy Ruchti, Kevin Hazen, Donovan Berry, Roxanne Abul-Haj
  • Publication number: 20050187439
    Abstract: Sampling is controlled to enhance analyte concentration estimation derived from noninvasive sampling. Means of assuring that the same tissue sample volume is repeatably sampled are presented, thus minimizing sampling errors due to mechanical tissue distortion, specular reflectance, and probe placement. In a first embodiment of the invention, sampling is controlled using automated delivery of a coupling fluid to a region between a tip of a sample probe and a tissue measurement site in a manner requiring minimal user interaction. In a second embodiment of the invention, sampling is controlled by controlling temperature variations, preferably with a coupling fluid, at a region about the tip of a sample probe and a sample site. In a third embodiment, sampling is procedurally controlled via timing and location of coupling fluid delivery to a sample site.
    Type: Application
    Filed: January 6, 2005
    Publication date: August 25, 2005
    Inventors: Thomas Blank, George Acosta, Stephen Monfre, Roxanne Abul-Haj, Kevin Hazen, Sedar Brown, Benjamin Richie, James Henderson, Barry Elliott, Josh Hope
  • Publication number: 20050107676
    Abstract: A near-infrared spectrometer-based analyzer attaches continuously or semi-continuously to a human subject and is used to collect spectral measurements of a tissue sample. The spectral readings are used to estimate a biological parameter in the sampled tissue noninvasively, such as glucose concentration. The preferred apparatus is a near-infrared analyzer that includes a base module and a sample module connected together with a communication bundle. The base module contains the bulk of the analyzer, such as a spectrograph and a central processing unit with an algorithm used for converting the optical signal into a glucose concentration. The sample module is typically in a smaller module that interfaces to a tissue sample. The sample module is preferably handheld and provides minimal sampling distortion due to heat or pressure.
    Type: Application
    Filed: October 21, 2004
    Publication date: May 19, 2005
    Inventors: George Acosta, James Henderson, N. Abul-Haj, Timothy Ruchti, Stephen Monfre, Thomas Blank, Kevin Hazen