Patents by Inventor George B. Guckenberger

George B. Guckenberger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10802003
    Abstract: A column-sealing tool is provided for use during decoupling of a capillary column from a gas chromatography-mass spectrometry (GC-MS) system. The column-sealing tool includes an engagement structure for removably securing the column-sealing tool within a high vacuum enclosure of the GC-MS system, at a location between a high vacuum end of a transfer line and a mass analyzer of the GC-MS system. Additionally, the column-sealing tool includes a sealing element that is actuatable between a non-sealing position and a sealing position. During use the sealing element forms a secondary vacuum seal with the first end of the transfer line when the column-sealing tool is inserted into the GC-MS system and when the sealing element is in the sealing position.
    Type: Grant
    Filed: December 14, 2018
    Date of Patent: October 13, 2020
    Assignee: THERMO FINNIGAN LLC
    Inventors: James M. Hitchcock, George B. Guckenberger
  • Patent number: 10755914
    Abstract: A multipole assembly configured to be disposed in a mass spectrometer includes a plurality of elongate electrodes arranged about an axis extending along a longitudinal trajectory of the plurality of elongate electrodes and configured to confine ions radially about the axis, and a piezoelectric actuator configured to adjust a position of a first electrode included in the plurality of elongate electrodes.
    Type: Grant
    Filed: December 5, 2019
    Date of Patent: August 25, 2020
    Assignee: Thermo Finnigan LLC
    Inventors: Edward B. McCauley, Scott T. Quarmby, George B. Guckenberger, James M. Hitchcock
  • Publication number: 20200111657
    Abstract: A multipole assembly configured to be disposed in a mass spectrometer includes a plurality of elongate electrodes arranged about an axis extending along a longitudinal trajectory of the plurality of elongate electrodes and configured to confine ions radially about the axis, and a piezoelectric actuator configured to adjust a position of a first electrode included in the plurality of elongate electrodes.
    Type: Application
    Filed: December 5, 2019
    Publication date: April 9, 2020
    Inventors: Edward B. McCAULEY, Scott T. QUARMBY, George B. GUCKENBERGER, James M. HITCHCOCK
  • Patent number: 10566180
    Abstract: A multipole assembly configured to be disposed in a mass spectrometer includes a plurality of elongate electrodes arranged about an axis extending along a longitudinal trajectory of the plurality of elongate electrodes and configured to confine ions radially about the axis, and a piezoelectric actuator configured to adjust a position of a first electrode included in the plurality of elongate electrodes.
    Type: Grant
    Filed: July 11, 2018
    Date of Patent: February 18, 2020
    Assignee: THERMO FINNIGAN LLC
    Inventors: Edward B. McCauley, Scott T. Quarmby, George B. Guckenberger, James M. Hitchcock
  • Publication number: 20200020518
    Abstract: A multipole assembly configured to be disposed in a mass spectrometer includes a plurality of elongate electrodes arranged about an axis extending along a longitudinal trajectory of the plurality of elongate electrodes and configured to confine ions radially about the axis, and a piezoelectric actuator configured to adjust a position of a first electrode included in the plurality of elongate electrodes.
    Type: Application
    Filed: July 11, 2018
    Publication date: January 16, 2020
    Inventors: Edward B. McCAULEY, Scott T. QUARMBY, George B. GUCKENBERGER, James M. HITCHCOCK
  • Patent number: 10529550
    Abstract: A multipole assembly configured to be disposed in a mass spectrometer includes a plurality of elongate electrodes arranged about an axis extending along a longitudinal trajectory of the plurality of elongate electrodes and configured to confine ions radially about the axis, and a piezoelectric actuator configured to adjust a position of a first electrode included in the plurality of elongate electrodes.
    Type: Grant
    Filed: July 11, 2018
    Date of Patent: January 7, 2020
    Assignee: THERMO FINNIGAN LLC
    Inventors: Edward B. McCauley, Scott T. Quarmby, George B. Guckenberger, James M. Hitchcock
  • Patent number: 10515789
    Abstract: A method of operating a mass spectrometer comprising: detecting a first ion species using a first gain setting of a detector or a first emission current for a first mass-to-charge range; detecting a second ion species using a second gain setting of the detector or a second emission current for a second mass-to-charge range; and using the detected first and second ion species to calibrate the mass range of a mass analyzer of the mass spectrometer, to tune the resolution of the mass analyzer, or to tune an ion optic of the mass spectrometer.
    Type: Grant
    Filed: March 13, 2018
    Date of Patent: December 24, 2019
    Assignee: THERMO FINNIGAN LLC
    Inventors: George B. Guckenberger, Scott T. Quarmby, John G. Voss, Michael B. Young
  • Patent number: 10438782
    Abstract: A method includes producing ions from one or more calibrant species and delivering the ions to a mass analyzer, and measuring a first set of mass related physical values for the ions from the one or more calibrant species. The method further includes producing ions from a sample and delivering the ions to a mass analyzer, and measuring a second mass related physical value for a first sample ion species. The first sample ion species has a mass-to-charge ratio outside of the range of the mass-to-charge ratios of the calibrant ion species. Additionally, the method includes calculating a calibration curve based on the first set of mass related physical values and second mass related physical value, and modifying at least one instrument parameter based on the calibration curve.
    Type: Grant
    Filed: February 5, 2019
    Date of Patent: October 8, 2019
    Assignee: Thermo Finnigan LLC
    Inventors: Scott T. Quarmby, George B. Guckenberger
  • Publication number: 20190172692
    Abstract: A method includes producing ions from one or more calibrant species and delivering the ions to a mass analyzer, and measuring a first set of mass related physical values for the ions from the one or more calibrant species. The method further includes producing ions from a sample and delivering the ions to a mass analyzer, and measuring a second mass related physical value for a first sample ion species. The first sample ion species has a mass-to-charge ratio outside of the range of the mass-to-charge ratios of the calibrant ion species. Additionally, the method includes calculating a calibration curve based on the first set of mass related physical values and second mass related physical value, and modifying at least one instrument parameter based on the calibration curve.
    Type: Application
    Filed: February 5, 2019
    Publication date: June 6, 2019
    Inventors: Scott T. QUARMBY, George B. GUCKENBERGER
  • Publication number: 20190137459
    Abstract: A column-sealing tool is provided for use during decoupling of a capillary column from a gas chromatography-mass spectrometry (GC-MS) system. The column-sealing tool includes an engagement structure for removably securing the column-sealing tool within a high vacuum enclosure of the GC-MS system, at a location between a high vacuum end of a transfer line and a mass analyzer of the GC-MS system. Additionally, the column-sealing tool includes a sealing element that is actuatable between a non-sealing position and a sealing position. During use the sealing element forms a secondary vacuum seal with the first end of the transfer line when the column-sealing tool is inserted into the GC-MS system and when the sealing element is in the sealing position.
    Type: Application
    Filed: December 14, 2018
    Publication date: May 9, 2019
    Inventors: James M. HITCHCOCK, George B. GUCKENBERGER
  • Patent number: 10242850
    Abstract: A method includes producing ions from one or more calibrant species and delivering the ions to a mass analyzer, and measuring a first set of mass related physical values for the ions from the one or more calibrant species. The method further includes producing ions from a sample and delivering the ions to a mass analyzer, and measuring a second mass related physical value for a first sample ion species. The first sample ion species has a mass-to-charge ratio outside of the range of the mass-to-charge ratios of the calibrant ion species. Additionally, the method includes calculating a calibration curve based on the first set of mass related physical values and second mass related physical value, and modifying at least one instrument parameter based on the calibration curve.
    Type: Grant
    Filed: March 24, 2016
    Date of Patent: March 26, 2019
    Assignee: THERMO FINNIGAN LLC
    Inventors: Scott T. Quarmby, George B. Guckenberger
  • Patent number: 10184924
    Abstract: A column-sealing tool is provided for use during decoupling of a capillary column from a gas chromatography-mass spectrometry (GC-MS) system. The column-sealing tool includes an engagement structure for removably securing the column-sealing tool within a high vacuum enclosure of the GC-MS system, at a location between a high vacuum end of a transfer line and a mass analyzer of the GC-MS system. Additionally, the column-sealing tool includes a sealing element that is actuatable between a non-sealing position and a sealing position. During use the sealing element forms a secondary vacuum seal with the first end of the transfer line when the column-sealing tool is inserted into the GC-MS system and when the sealing element is in the sealing position.
    Type: Grant
    Filed: September 20, 2016
    Date of Patent: January 22, 2019
    Assignee: Thermo Finnigan LLC
    Inventors: James M. Hitchcock, George B. Guckenberger
  • Publication number: 20180286647
    Abstract: A method of operating a mass spectrometer comprising: detecting a first ion species using a first gain setting of a detector or a first emission current for a first mass-to-charge range; detecting a second ion species using a second gain setting of the detector or a second emission current for a second mass-to-charge range; and using the detected first and second ion species to calibrate the mass range of a mass analyzer of the mass spectrometer, to tune the resolution of the mass analyzer, or to tune an ion optic of the mass spectrometer.
    Type: Application
    Filed: March 13, 2018
    Publication date: October 4, 2018
    Inventors: George B. GUCKENBERGER, Scott T. QUARMBY, John G. VOSS, Michael B. YOUNG
  • Publication number: 20170010244
    Abstract: A column-sealing tool is provided for use during decoupling of a capillary column from a gas chromatography-mass spectrometry (GC-MS) system. The column-sealing tool includes an engagement structure for removably securing the column-sealing tool within a high vacuum enclosure of the GC-MS system, at a location between a high vacuum end of a transfer line and a mass analyzer of the GC-MS system. Additionally, the column-sealing tool includes a sealing element that is actuatable between a non-sealing position and a sealing position. During use the sealing element forms a secondary vacuum seal with the first end of the transfer line when the column-sealing tool is inserted into the GC-MS system and when the sealing element is in the sealing position.
    Type: Application
    Filed: September 20, 2016
    Publication date: January 12, 2017
    Inventors: James M. HITCHCOCK, George B. GUCKENBERGER
  • Patent number: 9463534
    Abstract: A column-sealing tool is provided for use during decoupling of a capillary column from a gas chromatography-mass spectrometry (CG-MS) system. The column-sealing tool includes an engagement structure for removably securing the column-sealing tool within a high vacuum enclosure of the GC-MS system, at a location between a high vacuum end of a transfer line and a mass analyzer of the GC-MS system. Additionally, the column-sealing tool includes a sealing element that is actuatable between a non-sealing position and a sealing position. During use the sealing element forms a secondary vacuum seal with the first end of the transfer line when the column-sealing tool is inserted into the GC-MS system and when the sealing element is in the sealing position.
    Type: Grant
    Filed: July 29, 2014
    Date of Patent: October 11, 2016
    Assignee: Thermo Finnigan LLC
    Inventors: James M. Hitchcock, George B. Guckenberger
  • Publication number: 20160284527
    Abstract: A method includes producing ions from one or more calibrant species and delivering the ions to a mass analyzer, and measuring a first set of mass related physical values for the ions from the one or more calibrant species. The method further includes producing ions from a sample and delivering the ions to a mass analyzer, and measuring a second mass related physical value for a first sample ion species. The first sample ion species has a mass-to-charge ratio outside of the range of the mass-to-charge ratios of the calibrant ion species. Additionally, the method includes calculating a calibration curve based on the first set of mass related physical values and second mass related physical value, and modifying at least one instrument parameter based on the calibration curve.
    Type: Application
    Filed: March 24, 2016
    Publication date: September 29, 2016
    Inventors: Scott T. QUARMBY, George B. GUCKENBERGER
  • Publication number: 20160031047
    Abstract: A column-sealing tool is provided for use during decoupling of a capillary column from a gas chromatography-mass spectrometry (CG-MS) system. The column-sealing tool includes an engagement structure for removably securing the column-sealing tool within a high vacuum enclosure of the GC-MS system, at a location between a high vacuum end of a transfer line and a mass analyzer of the GC-MS system. Additionally, the column-sealing tool includes a sealing element that is actuatable between a non-sealing position and a sealing position. During use the sealing element forms a secondary vacuum seal with the first end of the transfer line when the column-sealing tool is inserted into the GC-MS system and when the sealing element is in the sealing position.
    Type: Application
    Filed: July 29, 2014
    Publication date: February 4, 2016
    Inventors: James M. Hitchcock, George B. Guckenberger
  • Patent number: 7902529
    Abstract: An electron source can selectively provide a first stream of electrons that travels in a direction along an imaginary line to a location remote from the electron source, or a second stream of electrons that travels in the direction along the line to the location. The electron source includes a first electron emitter for selectively emitting electrons for the first stream, and a second electron emitter for selectively emitting electrons for the second stream. A different aspect relates to a method for operating an apparatus having an electron source that includes first and second electron emitters. The method includes selectively producing a first stream of electrons that travels from the first electron emitter in a direction along an imaginary line to a location remote from the electron source, or a second stream of electrons that travels from the second electron emitter in the direction along the line to the location.
    Type: Grant
    Filed: August 2, 2007
    Date of Patent: March 8, 2011
    Assignee: Thermo Finnigan LLC
    Inventors: Scott T. Quarmby, George B. Guckenberger
  • Patent number: 7709790
    Abstract: A method and apparatus of combining an ion volume, a lens stack, and an ion optic that similarly cooperates with a detached multipole ion guide is herein incorporated into a single sub-assembly that can be removed from a mass spectrometer instrument without venting. Such an arrangement allows an operator to clean all parts of the ion path that get contaminated in normal operation, reassemble and reinsert in a timely manner and then pump down to an acceptable vacuum without having to vent the system.
    Type: Grant
    Filed: April 1, 2008
    Date of Patent: May 4, 2010
    Assignee: Thermo Finnigan LLC
    Inventors: George B. Guckenberger, Joseph B. Wieck, Edward B. McCauley, Scott T. Quarmby
  • Patent number: 7638763
    Abstract: A method includes: accumulating ions having a plurality of m/z values in an ion trap during a time interval; deriving from the accumulated ions a respective intensity value for each of the m/z values; and adjusting each of the intensity values as a function of the time needed by the ion trap to begin collecting ions with the corresponding m/z value. According to a different aspect, an apparatus includes a first portion with an ion trap, and a second portion. The second portion causes the ion trap to accumulate ions with a plurality of m/z values during a time interval, derives from the accumulated ions in the ion trap a respective intensity value for each of the m/z values, and adjusts each of the intensity values as a function of the time needed by the ion trap to begin collecting ions with the corresponding m/z value.
    Type: Grant
    Filed: May 4, 2007
    Date of Patent: December 29, 2009
    Assignee: Thermo Finnigan LLC
    Inventors: George B. Guckenberger, Scott T. Quarmby