Patents by Inventor George Cox

George Cox has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20060078878
    Abstract: The present invention provides methods for modulating expression of endogenous cellular genes using recombinant zinc finger proteins.
    Type: Application
    Filed: August 15, 2002
    Publication date: April 13, 2006
    Inventors: George Cox, Casey Case, Stephen Eisenberg, Eric Jarvis, Sharon Spratt
  • Publication number: 20060014286
    Abstract: Disclosed herein are compositions comprising an engineered zinc finger protein and a nuclear hormone receptor transcriptional control domain, polynucleotides encoding one or more components of the compositions, methods of making the compositions and methods of using these compositions, for example to modulate gene expression and/or to generate transgenic plants or animals.
    Type: Application
    Filed: June 5, 2003
    Publication date: January 19, 2006
    Inventors: George Cox, Casey Case, Stephen Eisenberg, Eric Jarvis, Sharon Spratt
  • Publication number: 20050239203
    Abstract: The present invention provides methods for modulating expression of endogenous cellular genes using engineered zinc finger proteins.
    Type: Application
    Filed: June 8, 2005
    Publication date: October 27, 2005
    Inventors: Casey Case, George Cox, Stephen Eisenberg, Qiang Liu, Edward Rebar
  • Publication number: 20050227330
    Abstract: The growth hormone supergene family comprises greater than 20 structurally related cytokines and growth factors. A general method is provided for creating site-specific, biologically active conjugates of these proteins. The method involves adding cysteine residues to non-essential regions of the proteins or substituting cysteine residues for non-essential amino acids in the proteins using site-directed mutagenesis and then covalently coupling a cysteine-reactive polymer or other type of cysteine-reactive moiety to the proteins via the added cysteine residue. Disclosed herein are preferred sites for adding cysteine residues or introducing cysteine substitutions into the proteins, and the proteins and protein derivatives produced thereby.
    Type: Application
    Filed: March 2, 2005
    Publication date: October 13, 2005
    Inventor: George Cox
  • Publication number: 20050215502
    Abstract: The present invention provides methods for modulating expression of endogenous cellular genes using recombinant zinc finger proteins.
    Type: Application
    Filed: November 9, 2004
    Publication date: September 29, 2005
    Inventors: George Cox, Casey Case, Stephen Eisenberg, Eric Jarvis, Sharon Spratt
  • Publication number: 20050214254
    Abstract: The growth hormone supergene family comprises greater than 20 structurally related cytokines and growth factors. A general method is provided for creating site-specific, biologically active conjugates of these proteins. The method involves adding cysteine residues to non-essential regions of the proteins or substituting cysteine residues for non-essential amino acids in the proteins using site-directed mutagenesis and then covalently coupling a cysteine-reactive polymer or other type of cysteine-reactive moiety to the proteins via the added cysteine residue. Disclosed herein are preferred sites for adding cysteine residues or introducing cysteine substitutions into the proteins, and the proteins and protein derivatives produced thereby.
    Type: Application
    Filed: March 2, 2005
    Publication date: September 29, 2005
    Inventor: George Cox
  • Publication number: 20050187160
    Abstract: The present invention relates to novel methods of making soluble proteins having free cysteines in which a host cell is exposed to a cysteine blocking agent. The soluble proteins produced by the methods can then be modified to increase their effectiveness. Such modifications include attaching a PEG moiety to form pegylated proteins.
    Type: Application
    Filed: March 29, 2005
    Publication date: August 25, 2005
    Applicant: Bolder Biotechnology Inc.
    Inventors: George Cox, Daniel Doherty, Mary Rosendahl
  • Publication number: 20050168018
    Abstract: An pneumatic seating system for use with a motorcycle including a mount for pivotally mounting a motorcycle seat to the frame of a motorcycle. The system includes an air spring mountable between an end portion of the motorcycle seat and the frame. The air spring being adjustable between inflated and deflated positions, the inflated position wherein pressurized air is retained in the cavity such that a length of the air spring is extended so that the seat is spaced from the frame, the deflated position wherein the air spring is in a retracted position. An air compressor is provided for inflating the air spring. An air release valve is coupled to the opening of the air spring for releasing pressurized air from the air spring. The system providing adjustable cushioning between the seat and the frame of the motorcycle for improving the comfort of a rider on the motorcycle.
    Type: Application
    Filed: February 2, 2005
    Publication date: August 4, 2005
    Inventor: George Cox
  • Publication number: 20050165667
    Abstract: A system for pre-authenticating a magnetic stripped card or smart card holder for a non-checking account transaction at the point-of-sale that includes a database that contains sensitive data, corresponding to digital photographic images of said account holders that employs a pre-authentication process whereby all account holders undergo a meticulous comparison with their submitted data against a plethora of objective public, private and internal databases culminating in a video displayed image at some point in the future enabling a merchant to make a visual comparison of the account holder either on site or during a mail order or telephone order transaction corresponding to the pre-authenticated image to prevent identity theft. While the invention has been described with respect to particular illustrated embodiments, those skilled in the art of technology to which the invention pertains will have no difficulty devising variations which in no way depart from the invention.
    Type: Application
    Filed: January 27, 2004
    Publication date: July 28, 2005
    Inventor: George Cox
  • Publication number: 20050130304
    Abstract: The present invention provides methods for modulating expression of endogenous cellular genes using recombinant zinc finger proteins.
    Type: Application
    Filed: November 12, 2004
    Publication date: June 16, 2005
    Inventors: George Cox, Casey Case, Stephen Eisenberg, Eric Jarvis, Sharon Spratt
  • Publication number: 20050107591
    Abstract: The growth hormone supergene family comprises greater than 20 structurally related cytokines and growth factors. A general method is provided for creating site-specific, biologically active conjugates of these proteins. The method involves adding cysteine residues to non-essential regions of the proteins or substituting cysteine residues for non-essential amino acids in the proteins using site-directed mutagenesis and then covalently coupling a cysteine-reactive polymer or other type of cysteine-reactive moiety to the proteins via the added cysteine residue. Disclosed herein are preferred sites for adding cysteine residues or introducing cysteine substitutions into the proteins, and the proteins and protein derivatives produced thereby.
    Type: Application
    Filed: February 5, 2004
    Publication date: May 19, 2005
    Inventor: George Cox
  • Publication number: 20050092825
    Abstract: A robust system, method and environment for the programming, collection, manipulation, and propagation of RFID data enhances the integration of RFID elements into new and existing enterprise systems.
    Type: Application
    Filed: November 4, 2004
    Publication date: May 5, 2005
    Inventors: George Cox, Daniel George
  • Publication number: 20050096461
    Abstract: The growth hormone supergene family comprises greater than 20 structurally related cytokines and growth factors. A general method is provided for creating site-specific, biologically active conjugates of these proteins. The method involves adding cysteine residues to non-essential regions of the proteins or substituting cysteine residues for non-essential amino acids in the proteins using site-directed mutagenesis and then covalently coupling a cysteine-reactive polymer or other type of cysteine-reactive moiety to the proteins via the added cysteine residue. Disclosed herein are preferred sites for adding cysteine residues or introducing cysteine substitutions into the proteins, and the proteins and protein derivatives produced thereby.
    Type: Application
    Filed: June 10, 2004
    Publication date: May 5, 2005
    Inventor: George Cox
  • Publication number: 20050058621
    Abstract: The growth hormone supergene family comprises greater than 20 structurally related cytokines and growth factors. A general method is provided for creating site-specific, biologically active conjugates of these proteins. The method involves adding cysteine residues to non-essential regions of the proteins or substituting cysteine residues for non-essential amino acids in the proteins using site-directed mutagenesis and then covalently coupling a cysteine-reactive polymer or other type of cysteine-reactive moiety to the proteins via the added cysteine residue. Disclosed herein are preferred sites for adding cysteine residues or introducing cysteine substitutions into the proteins, and the proteins and protein derivatives produced thereby. Also disclosed are therapeutic methods for using the cysteine variants of the invention.
    Type: Application
    Filed: October 13, 2003
    Publication date: March 17, 2005
    Inventor: George Cox
  • Publication number: 20050026834
    Abstract: The present invention relates to novel methods of making soluble proteins having free cysteines in which a host cell is exposed to a cysteine blocking agent. The soluble proteins produced by the methods can then be modified to increase their effectiveness. Such modifications include attaching a PEG moiety to form pegylated proteins.
    Type: Application
    Filed: May 27, 2004
    Publication date: February 3, 2005
    Inventors: George Cox, Daniel Doherty, Mary Rosendahl
  • Publication number: 20040039940
    Abstract: A data packet filtering accelerator processor operates in parallel with a host processor and is arranged on an integrated circuit with the host processor. The accelerator processor classifies data packets by executing a sequence machine code instructions converted directly from a set of rules. Portions of data packets are passed to the accelerator processor from the host processor. The accelerator processor includes packet parser circuit for parsing the data packets into relevant data units and storing the relevant data units in memory. A packet analysis circuit executes the sequence of machine code instructions converted directly from the set of rules. The machine code instruction sequence operates on the relevant data units to classify the data packet. The packet analysis circuit returns the results of the classification to the host processor by storing the classification results in a register accessible by the host processor.
    Type: Application
    Filed: August 23, 2002
    Publication date: February 26, 2004
    Applicant: Koninklijke Philips Electronics N.V.
    Inventors: George Cox, Jeff Courington
  • Patent number: 6692196
    Abstract: An apparatus for manufacturing a series of discrete hygienic articles. The apparatus includes a supply means, at least one manipulation means, a reception means spatially separated from the supply means, a manufacturing path segment extending from the supply means to the manipulation means and continuing to the reception means and a transportation system. The transportation system includes a plurality of independent transportation means for transportation of at least one discrete hygienic article along the manufacturing path segment and a guide means to guide all of the transportation means.
    Type: Grant
    Filed: January 31, 2002
    Date of Patent: February 17, 2004
    Assignee: The Procter & Gamble Company
    Inventors: Rolf Simm, Robert George Cox, Nicholas Minde, Timothy Alan Burkett
  • Publication number: 20030092000
    Abstract: The invention provides criteria and methods for selecting optimum subsequence(s) from a target gene for targeting by a zinc finger protein. Some of the methods of target site selection seek to identify one or more target segments having a DNA motif containing one or more so-called D-able subsites having the sequence 5′NNGK3′. Other methods of the invention are directed to selection of target segments within target genes using a correspondence regime between different triplets of three bases and the three possible positions of a triplet within a nine-base site. In another aspect, the invention provides methods of designing zinc finger proteins that bind to a preselected target site. These methods can be used following the preselection of target sites according to the procedures and criteria described above. The methods of design use a database containing information about previously characterized zinc finger proteins.
    Type: Application
    Filed: April 2, 2001
    Publication date: May 15, 2003
    Inventors: Stephen Eisenberg, Casey Case, George Cox, Andrew Jamieson, Edward Rebar
  • Patent number: 6175626
    Abstract: A method and apparatus of communicating information comprising providing a datum which includes a digital certificate containing data. The digital certificate including an extension which includes: a first identifier which specifies a major classification of the data; a second identifier which specifies a minor classification of the data; and data in a format according to the major classification and the minor classification, the data indicating an owner of the datum and a use for which the datum is intended. The certificate allows authentication of the certificate itself and the data contained therein, and the data contained in the certificate can include information allowing verification of the identity of the holder of the certificate.
    Type: Grant
    Filed: October 30, 1998
    Date of Patent: January 16, 2001
    Assignee: Intel Corporation
    Inventors: David W. Aucsmith, George Cox, Paul E. Onnen
  • Patent number: 5878144
    Abstract: A method and apparatus of communicating information comprising providing a datum which includes a digital certificate containing data. The digital certificate including an extension which includes: a first identifier which specifies a major classification of the data; a second identifier which specifies a minor classification of the data; and data in a format according to the major classification and the minor classification, the data indicating an owner of the datum and a use for which the datum is intended. The certificate allows authentication of the certificate itself and the data contained therein, and the data contained in the certificate can include information allowing verification of the identity of the holder of the certificate.
    Type: Grant
    Filed: October 14, 1997
    Date of Patent: March 2, 1999
    Assignee: Intel Corporation
    Inventors: David W. Aucsmith, George Cox, Paul E. Onnen