Patents by Inventor George E. M. Husbands

George E. M. Husbands has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1, 4-benzodiozan
    Patent number: 7041683
    Abstract: Compounds of the formula useful for the treatment of depression and other conditions such as obsessive compulsive disorder, panic attacks, generalized anxiety disorder, sexual dysfunction, eating disorders, addictive disorders caused by ethanol or cocaine abuse and related illnesses.
    Type: Grant
    Filed: March 17, 2003
    Date of Patent: May 9, 2006
    Assignee: Wyeth
    Inventors: George E. M. Husbands, Gary P. Stack, Richard E. Mewshaw, Ian A. Cliffe
  • Azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-dioxino[2,3-f]-quinoline as 5-HT1A antagonists
    Patent number: 6821981
    Abstract: Compounds of the formula useful for the treatment of disorders, such as anxiety, aggression and stress, and for the control of various physiological phenomena, such as appetite, thermoregulation, sleep and sexual behavior.
    Type: Grant
    Filed: April 25, 2002
    Date of Patent: November 23, 2004
    Assignee: Wyeth
    Inventors: Gary P. Stack, Megan Tran, Jonathan L. Gross, George E. M. Husbands
  • Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-benzodioxan
    Publication number: 20030236241
    Abstract: Compounds of the formula 1
    Type: Application
    Filed: March 17, 2003
    Publication date: December 25, 2003
    Applicant: Wyeth
    Inventors: George E.M. Husbands, Gary P. Stack, Richard E. Mewshaw, Ian A. Cliffe
  • Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-dioxino[2,3-f]quinazoline
    Patent number: 6656947
    Abstract: Compounds of the formula: useful for the treatment of depression and other diseases such as obsessive compulsive disorder, panic attacks, generalized anxiety disorder, social anxiety disorder, sexual dysfunction, eating disorders, obesity, addictive disorders caused by ethanol or cocaine abuse and related illnesses
    Type: Grant
    Filed: April 23, 2002
    Date of Patent: December 2, 2003
    Assignee: Wyeth
    Inventors: George E. M. Husbands, Gary P. Stack
  • Antidepressant azaheterocyclymethyl derivatives of 2,3-dihydro-1,4-benzodioxan
    Patent number: 6559169
    Abstract: Compounds of the formula useful for the treatment of depression and other conditions such as obsessive compulsive disorder, panic attacks, generalized anxiety disorder, sexual dysfunction, eating disorders, addictive disorders caused by ethanol or cocaine abuse and related illnesses.
    Type: Grant
    Filed: April 23, 2002
    Date of Patent: May 6, 2003
    Assignee: Wyeth
    Inventors: George E. M. Husbands, Gary P. Stack, Richard E. Mewshaw, Ian A. Cliffe
  • Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-benzodioxan
    Publication number: 20020193400
    Abstract: Compounds of the formula 1
    Type: Application
    Filed: April 23, 2002
    Publication date: December 19, 2002
    Applicant: Wyeth
    Inventors: George E.M. Husbands, Gary P. Stack, Richard E. Mewshaw, Ian A. Cliffe
  • Azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-dioxino[2,3-f]-quinoline as 5-HT1A antagonists
    Publication number: 20020193366
    Abstract: Compounds of the formula 1
    Type: Application
    Filed: April 25, 2002
    Publication date: December 19, 2002
    Applicant: Wyeth
    Inventors: Gary P. Stack, Megan Tran, Jonathan L. Gross, George E. M. Husbands
  • Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-dioxino[2,3-f]quinazoline
    Publication number: 20020183341
    Abstract: Compounds of the formula: 1
    Type: Application
    Filed: April 23, 2002
    Publication date: December 5, 2002
    Applicant: Wyeth
    Inventors: George E.M. Husbands, Gary P. Stack
  • Quinuclidine and azabicyclo 2.2.1! heptane pyrazinyl ethers as muscarinic agonists
    Patent number: 5512574
    Abstract: The compound of the formula: ##STR1## in which Y is oxygen or sulfur; A is oxygen, sulfur or --NR.sub.2, where R.sub.2 is hydrogen or alkyl; R is --CH.sub.2 CH.sub.3, --CH.sub.2 CH.sub.2 CH.sub.3, --CH(CH.sub.3).sub.2, --CH.sub.2 CH(CH.sub.3).sub.2, --CH.sub.2 CF.sub.3, --CH.sub.2 CH.sub.2 CF.sub.3, --CH(CF.sub.3).sub.2, --CH.sub.2 CH(CF.sub.3).sub.2, --C.sub.3 H.sub.5, --CH.sub.2 C.sub.3 H.sub.5, --CH.sub.2 CH.sub.2 C.sub.3 H.sub.5, --C.sub.4 H.sub.7, --CH.sub.2 C.sub.4 H.sub.7, --C.sub.5 H.sub.9, --CH.sub.2 C.sub.9, --C.sub.6 H.sub.10, --CH.sub.2 C.sub.6 H.sub.10, --C.sub.4 H.sub.3 S, --CH.sub.2 C.sub.4 H.sub.3 S, --C.sub.6 H.sub.5 or --CH.sub.2 C.sub.6 H.sub.5 ; and n is one of the integers 1 or 2; or a pharmaceutically acceptable salt thereof are centrally active muscarinic agents.
    Type: Grant
    Filed: March 31, 1995
    Date of Patent: April 30, 1996
    Assignee: American Home Products Corporation
    Inventors: George E. M. Husbands, Joseph Tokolics
  • Phenoxyethylamine derivatives
    Patent number: 4609758
    Abstract: This invention provides a group of hydroxycycloalkanephenoxyethylamine antidepressant derivatives of the following structural formula: ##STR1## in which R.sub.1 is hydrogen or alkyl of 1 to 6 carbon atoms;R.sub.2 is alkyl of 1 to 6 carbon atoms;R.sub.3 and R.sub.4 are independently hydrogen, hydroxyl, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, alkanoyloxy of 2 to 7 carbon atoms, halo or trifluoromethyl;R.sub.5 is hydrogen, alkyl of 1 to 6 carbon atoms or alkanoyl of 2 to 7 carbon atoms;and n is one of the integers 0, 1, 2 or 3;or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: May 9, 1985
    Date of Patent: September 2, 1986
    Assignee: American Home Products Corporation
    Inventor: George E. M. Husbands
  • Prostaglandin derivatives
    Patent number: 4151361
    Abstract: Derivatives of 13,14-dihydro-PGE.sub.2 and 5,6; 13,14-tetrahydro-PGE.sub.2 are prepared. These new compounds not heretofore found in nature display activity as bronchodilator agents.
    Type: Grant
    Filed: March 6, 1978
    Date of Patent: April 24, 1979
    Assignee: American Home Products Corporation
    Inventor: George E. M. Husbands
  • Prostaglandin derivatives
    Patent number: 4089885
    Abstract: Derivatives of 13,14-dihydro-PGE.sub.2 and 5,6; 13,14-tetrahydro-PGE.sub.2 are prepared. These new compounds not heretofore found in nature display activity as bronchodilator agents.
    Type: Grant
    Filed: November 5, 1976
    Date of Patent: May 16, 1978
    Assignee: American Home Products Corporation
    Inventor: George E. M. Husbands
  • 15-Ethynyl-PGE.sub.1
    Patent number: 4064165
    Abstract: 7-(2.beta.-[(3S)-3-Ethynyl-3-hydroxy-trans-1-octenyl]-3.alpha.-hydroxy-5-ox o-1.alpha.-cyclopentyl)-cis-5-heptenoic acid, 2.beta.-[(3S)-3-ethynyl-3-hydroxy-trans-1-octenyl]-3.alpha.-hydroxy-5-oxo- 1.alpha.-cyclopentane heptanoic acid, related compounds, and intermediates thereto are disclosed. The final products have activity as bronchodilators and in reducing gastric secretion.
    Type: Grant
    Filed: August 25, 1976
    Date of Patent: December 20, 1977
    Assignee: American Home Products Corporation
    Inventor: George E. M. Husbands
  • 15-Ethynyl-PGE.sub.2
    Patent number: 4001314
    Abstract: 7-(2-62 -[(3S)-3-Ethynyl-3-hydroxy-trans-1-octenyl]-3.alpha.-hydroxy-5-oxo-1.alpha .-cyclopentyl)-cis-5-heptenoic acid, 2.beta.-[(3S)-3-ethynyl-3-hydroxy-trans-1-octenyl]-3.alpha.-hydroxy-5-oxo- 1.alpha.-cyclopentane heptanoic acid, related compounds, and intermediates thereto are disclosed. The final products have activity as bronchodilators and in reducing gastric secretion.
    Type: Grant
    Filed: April 14, 1975
    Date of Patent: January 4, 1977
    Assignee: American Home Products Corporation
    Inventor: George E. M. Husbands