Abstract: Treatment systems, methods, and apparatuses for treating acne, hyperhidrosis, and other skin conditions are described. Aspects of the technology can include cooling a surface of a patient's skin and detecting changes in the tissue. The tissue can be cooled a sufficient length of time and to a temperature low enough to affect glands or other targeted structures in the skin.

Abstract: Compositions and formulations for use with devices and systems that enable tissue cooling, such as cryotherapy applications, for alteration and reduction of adipose tissue are described. Aspects of the technology are further directed to methods, compositions and devices that provide protection of non-targeted cells (e.g., non-lipid-rich cells) from freeze damage during dermatological and related aesthetic procedures that require sustained exposure to cold temperatures. Further aspects of the technology include systems for enhancing sustained and/or replenishing release of cryoprotectant to a treatment site prior to and during cooling applications.

Abstract: Systems for treating a subject's tissue can include a thermally conductive cup, a tissue-receiving cavity, and a vacuum port. The vacuum port is in fluid communication with the tissue-receiving cavity to provide a vacuum for drawing the submental tissue, or other targeted tissue, into the tissue-receiving cavity. A thermal device can cool and/or heat the conductive cup such that the conductive cup non-invasively controls the temperature of subcutaneous lipid-rich cells in the tissue. A restraint apparatus can hold a the conductive cup in thermal contact with the target region.

Abstract: A method in accordance with a particular embodiment of the present invention includes increasing a concentration of a modified or unmodified saccharide within a subject's skin, applying an applicator to the subject's skin, and cooling the subject's skin via a heat-transfer surface of the applicator. The saccharide within the subject's skin can enhance a resistance of at least some cells within the subject's skin to damage associated with the cooling. A corresponding system includes the applicator, the saccharide, and an energy-delivery device. The energy-delivery device can be configured to apply ultrasound, optical, thermal, or another type of energy to the subject's skin to drive the saccharide into the subject's skin. The system can also include a penetration enhancer configured to enhance penetration of the saccharide into the subject's skin. The penetration enhancer can be applied with the saccharide or separately.

Abstract: Treatment systems, methods, and apparatuses for improving the appearance of skin and other treatments are described. Aspects of the technology are directed to improving the appearance of skin by transcutaneously cooling and affecting nerve tissue so as to inhibit facial muscular contractions and thereby reduce dynamic wrinkling. A non-invasive nerve cooling device can be applied to the subject's head to attenuate nervous system signals to facial muscles.

Abstract: Provided herein are systems, compositions, and methods for improving one or more skin characteristics in a subject. These systems, compositions, and methods are configured to cool the subject's skin at a target site to a degree that alters adipocyte signaling but does not produce significant destruction of subcutaneous lipid-rich cells. In some embodiments, alteration of adipocyte signaling produces an improvement in one or more skin characteristics.

Abstract: A method and system in accordance with a particular embodiments of the technology includes applying a substance onto skin of a human subject. An applicator is then applied to the subject to cool a region of the subject. After cooling the tissue, a nucleation initiator is used to initiate a freeze event in the tissue. The nucleation initiator can be an ice crystal that inoculates the skin upon contact to create a predictable freeze event therein. The time of contact between the ice crystal and the skin can be controlled to achieve desired effects.

Abstract: Treatment systems, methods, and apparatuses for improving the appearance of skin or other target regions are described. Aspects of the technology are directed to improving the appearance of skin by tightening the skin, improving skin tone or texture, eliminating or reducing wrinkles, increasing skin smoothness, or improving the appearance sites with cellulite. Treatments can include cooling a surface of a patient's skin and detecting freezing in the cooled skin. The tissue can be cooled after the freeze event is detected so to maintain the frozen state of the tissue to improve the appearance of the treatment site.

Abstract: Provided herein are systems, compositions, and methods for improving one or more skin characteristics in a subject. These systems, compositions, and methods are configured to cool the subject's skin at a target site to a degree that alters adipocyte signaling but does not produce significant destruction of subcutaneous lipid-rich cells. In some embodiments, alteration of adipocyte signaling produces an improvement in one or more skin characteristics.

Abstract: A method and system in accordance with a particular embodiments of the technology includes applying a substance onto skin of a human subject. An applicator is then applied to the subject to cool a region of the subject. After cooling the tissue, a nucleation initiator is used to initiate a freeze event in the tissue. The nucleation initiator can be an ice crystal that inoculates the skin upon contact to create a predictable freeze event therein. The time of contact between the ice crystal and the skin can be controlled to achieve desired effects.

Abstract: Systems and methods can be implemented in which an electromagnetic charge is used to strengthen, tone, and firm muscle tissues. For example, a magnetic muscle stimulation device may be provided that includes a processor and a device applicator having a housing and a coil positioned within in the housing. The processor may be configured to receive parameters for operation of the device applicator, and to cause, based on the received parameters, an alternating current to flow through the coil to generate a time-varying magnetic field that induces an integrated electric charge or electrical conductivity in a portion of tissue under a skin surface of a patient.

Abstract: Systems and methods can be implemented in which an electromagnetic charge is used to strengthen, tone, and firm muscle tissues. For example, the method may include receiving parameters for operation of a magnetic muscle stimulation device. The method may also include causing, based on the received parameters, a first alternating current having a first phase to flow through a first coil and generate a first time-varying magnetic field that induces a first electric charge in muscle tissue under a skin surface of a patient when the first applicator surface is positioned substantially on and parallel to the skin surface of the patient. The method may also include causing a second alternating current having a second phase to flow through a second coil in a similar manner. Optionally, a phase offset between the first and second phases may be adjusted to limit to a predetermined maximum electric charge.

Abstract: Systems, methods, and devices for treating a subject are described herein. In some embodiments, an applicator for selectively affecting a subject's subcutaneous tissue is provided. The applicator can include: a housing; a treatment cup mounted in the housing, wherein the treatment cup defines a tissue-receiving cavity and includes a temperature-controlled surface; at least one thermal device coupled to the treatment cup and configured to receive energy via a flexible connector coupled to the applicator and to cool the temperature-controlled surface; an at least one vacuum port coupled to the treatment cup and configured to provide a vacuum to draw the subject's tissue into the tissue-receiving cavity and against at least a portion of a treatment area of the temperature-controlled surface to selectively damage and/or reduce the subject's subcutaneous tissue.

Abstract: Systems for treating a subject's tissue can include a thermally conductive cup with vacuum features configured to facilitate removal of air located between the cup and the subject's skin. The vacuum features can extend along cup to provide airflow paths to a vacuum port. The applicator can cool and/or heat the retained tissue to affect targeted tissue. After the treat period, the vacuum can be reduced or stop and the applicator can be removed from the subject.

Abstract: Treatment systems, methods, and apparatuses for improving the appearance of skin and other treatments are described. Aspects of the technology are directed to improving the appearance of skin by reducing a vascular structure. A non-invasive cooling device can cover and cool the vascular structure to affect the blood vessels of the vascular structure.

Abstract: Compositions and formulations for use with devices and systems that enable tissue cooling, such as cryotherapy applications, for alteration and reduction of adipose tissue are described. Aspects of the technology are further directed to methods, compositions and devices that provide protection of non-targeted cells (e.g., non-lipid-rich cells) from freeze damage during dermatological and related aesthetic procedures that require sustained exposure to cold temperatures. Further aspects of the technology include systems for enhancing sustained and/or replenishing release of cryoprotectant to a treatment site prior to and during cooling applications.

Abstract: Systems for treating a subject's tissue can include a thermally conductive cup with vacuum features configured to facilitate removal of air located between the cup and the subject's skin. The vacuum features can extend along cup to provide airflow paths to a vacuum port. The applicator can cool and/or heat the retained tissue to affect targeted tissue. After the treat period, the vacuum can be reduced or stop and the applicator can be removed from the subject.

Abstract: A method for strengthening, toning, and firming muscle tissues, the method includes receiving parameters for operating a magnetic muscle stimulation device. The parameters include: a first waveform frequency; one or more pulse durations; a second waveform frequency that is non-zero; causing, a first alternating current having one or more first pulses to flow for a first length of time through a coil according to the first waveform frequency; causing, a second alternating current having one or more second pulses to flow through the coil for a second length of time according to the second waveform frequency lower than the first waveform frequency. The method includes repeating the causing of the first and second alternating currents for a plurality of iterations to provide a continuously pulsed time-varying magnetic field that alternates between the first and the second waveform frequencies to generate a treatment session.

Abstract: A system for treating a subject can include an adjustable vacuum applicator configured to receive the subject's tissue by applying a vacuum. The vacuum applicator can have an cavity adjustment mechanism with different modes for widening and narrowing a tissue-receiving cavity to adjust the thermal contact between the vacuum applicator and the subject's tissue within the applicator. Sidewalls of the vacuum applicator can be moved to positive draft angle positions to help draw tissue deeper into the tissue-receiving cavity.

Abstract: Systems for treating a subject's tissue can include a thermally conductive cup, a sealing member, and/or a liner assembly. The systems can include an applicator capable of being reconfigured for a particular treatment site. Components of the applicator can be replaced to achieve a desired configuration. The replaceable components can include contoured heads, liners, and/or sensors. The applicator can draw a vacuum to install various components and/or draw tissue into the applicator. The applicator can cool and/or heat the tissue to affect targeted tissue.