Patents by Inventor George J. Collins
George J. Collins has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240117073Abstract: The present invention relates to specific binding members, particularly antibodies and fragments thereof, which bind to amplified epidermal growth factor receptor (EGFR) and to the de2-7 EGFR truncation of the EGFR. In particular, the epitope recognized by the specific binding members, particularly antibodies and fragments thereof, is enhanced or evident upon aberrant post-translational modification. These specific binding members are useful in the diagnosis and treatment of cancer. The binding members of the present invention may also be used in therapy in combination with chemotherapeutics or anti-cancer agents and/or with other antibodies or fragments thereof.Type: ApplicationFiled: April 26, 2023Publication date: April 11, 2024Inventors: Lloyd J. Old, Terrance Grant Johns, Con Panousis, Andrew M. Scott, Christoph Renner, Gerd Ritter, Achim Jungbluth, Elisabeth Stockert, Vincent Peter Collins, Webster K. Cavenee, Huei-Jen Su Huang, Antony Wilks Burgess, Edouard C. Nice, Anne Murray, George Mark
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Patent number: 9288886Abstract: The present disclosure provides for a plasma system including a plasma device coupled to a power source, an ionizable media source and a precursor source. During operation, the ionizable media source provides ionizable media and the precursor ionizable media source provides one or more chemical species, photons at specific wavelengths, as well as containing various reactive functional groups and/or components to treat the workpiece surface by working in concert for synergetic selective tissue effects. The chemical species and the ionizable gas are mixed either upstream or midstream from an ignition point of the plasma device and once mixed, are ignited therein under application of electrical energy from the power source. As a result, a plasma effluent and photon source is formed, which carries the ignited plasma feedstock and resulting mixture of reactive species to a workpiece surface to perform a predetermined reaction.Type: GrantFiled: May 29, 2009Date of Patent: March 15, 2016Assignee: Colorado State University Research FoundationInventors: Il-Gyo Koo, Cameron A. Moore, George J. Collins
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Patent number: 9287091Abstract: A plasma system includes a plasma device, an ionizable media source, and a power source. The plasma device includes an inner electrode and an outer electrode coaxially disposed around the inner electrode. The inner electrode includes a distal portion and an insulative layer that covers at least a portion of the inner electrode. The ionizable media source is coupled to the plasma device and is configured to supply ionizable media thereto. The power source is coupled to the inner and outer electrodes, and is configured to ignite the ionizable media at the plasma device to form a plasma effluent having an electron sheath layer about the exposed distal portion.Type: GrantFiled: March 26, 2015Date of Patent: March 15, 2016Assignee: Colorado State University Research FoundationInventors: Il-Gyo Koo, Cameron A. Moore, George J. Collins, Jin-Hoon Cho
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Patent number: 9272359Abstract: A plasma system for treating a workpiece is disclosed. The plasma system includes: a plasma device including an electrode formed from a metal alloy and a dielectric layer covering the electrode, the dielectric layer including a distal portion extending distally past a distal end of the electrode by a predetermined distance; a liquid source configured to supply a liquid to a workpiece; an ionizable media source coupled to the plasma device and configured to supply ionizable media thereto; and a power source coupled to the electrode and configured to ignite the ionizable media at the plasma device to form a plasma effluent in the presence of the liquid, whereby the plasma effluent reacts with the liquid to form at least one reactive species that interacts with the workpiece.Type: GrantFiled: March 31, 2010Date of Patent: March 1, 2016Assignee: Colorado State University Research FoundationInventors: Il-Gyo Koo, George J. Collins
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Patent number: 9271790Abstract: An electrosurgical generator is disclosed. The generator includes a radio frequency output stage configured to generate a radio frequency waveform and a sensor circuit configured to measure a property of the radio frequency waveform during a predetermined sampling period to determine whether an arc event has occurred. The generator also includes a controller configured to determine a total charge and/or total energy deposited by the radio frequency waveform during the predetermined sampling period associated with the arc event. The controller is further configured to adjust the output of the electrosurgical generator based on at least one parameter to limit arcing.Type: GrantFiled: August 20, 2013Date of Patent: March 1, 2016Assignees: Coviden LP, Colorado State University Research FoundationInventors: George J. Collins, Cameron A. Moore, Arlen K. Ward
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Patent number: 9269544Abstract: A plasma system is disclosed. The system includes a plasma device including an inner electrode and an outer electrode coaxially disposed around the inner electrode, wherein at least one of the inner electrode and the outer electrode is temperature controlled; an ionizable media source coupled to the plasma device and configured to supply ionizable media thereto; and a power source coupled to the inner and outer electrodes and configured to ignite the ionizable media at the plasma device to form a plasma effluent.Type: GrantFiled: January 15, 2014Date of Patent: February 23, 2016Assignee: COLORADO STATE UNIVERSITY RESEARCH FOUNDATIONInventors: Il-Gyo Koo, Myeong Yeol Choi, Doreene Hyatt, Amber Zagrodzki, Dean A. Hendrickson, George J. Collins
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Patent number: 9192422Abstract: A system for performing a surgical procedure includes a source of energy, a surgical instrument, and an impedance matching network. The source of energy is an electrosurgical generator or a microwave generator. The surgical instrument is coupled to the source of energy and receives the energy therefrom. The surgical instrument is adapted to treat tissue with the energy. The impedance matching network is interposed along a path of the energy and matches an input impedance of the source of energy to an output impedance (or thereabouts).Type: GrantFiled: July 19, 2011Date of Patent: November 24, 2015Assignee: Covidien LPInventor: George J. Collins
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Patent number: 9117636Abstract: A plasma device is disclosed. The plasma device includes: at least one electrode including a nanoporous dielectric layer disposed on at least a portion thereof, the nanoporous dielectric layer including a plurality of pores, wherein at least a portion of the plurality of pores include a catalyst embedded therein.Type: GrantFiled: January 16, 2014Date of Patent: August 25, 2015Assignee: Colorado State University Research FoundationInventors: Il-Gyo Koo, Jin Hoon Cho, Myeong Yeol Choi, Cameron A. Moore, George J. Collins
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Publication number: 20150200076Abstract: A plasma system includes a plasma device, an ionizable media source, and a power source. The plasma device includes an inner electrode and an outer electrode coaxially disposed around the inner electrode. The inner electrode includes a distal portion and an insulative layer that covers at least a portion of the inner electrode. The ionizable media source is coupled to the plasma device and is configured to supply ionizable media thereto. The power source is coupled to the inner and outer electrodes, and is configured to ignite the ionizable media at the plasma device to form a plasma effluent having an electron sheath layer about the exposed distal portion.Type: ApplicationFiled: March 26, 2015Publication date: July 16, 2015Inventors: IL-GYO KOO, CAMERON A. MOORE, GEORGE J. COLLINS, JIN-HOON CHO
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Patent number: 9028656Abstract: A method for whitening teeth is disclosed. The method includes supplying a liquid sufficient to at least partially submerge a portion of a tooth; positioning a plasma device adjacent to the submerged portion of the tooth; supplying ionizable media to the plasma device; and igniting the ionizable media at the plasma device sufficient to form a plasma effluent in the presence of the liquid at the distal portion, whereby the plasma effluent reacts with the liquid to form at least one reactive species that interacts selectively with foreign matter disposed on the tooth.Type: GrantFiled: March 31, 2010Date of Patent: May 12, 2015Assignee: Colorado State University Research FoundationInventors: Il-Gyo Koo, Myeong Yeol Choi, Jeremiah H. Collins, Cameron A. Moore, Abdur Rahman, George J. Collins
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Patent number: 9028482Abstract: An electrosurgical system and method for performing electrosurgery is disclosed. The electrosurgical system includes an electrosurgical generator adapted to supply electrosurgical energy to tissue. The electrosurgical system includes an electrosurgical instrument, such as an electrosurgical antenna, knife, forceps, suction coagulator, or vessel sealer. The disclosed system includes an impedance sensor, a controller, dynamic impedance matching network, and an electrosurgical energy generator. The dynamic impedance matching network includes a PIN diode switching array configured to selectively activate a plurality of reactive elements. The disclosed arrangement of reactive elements provides real-time impedance correction over a wide range of impedance mismatch conditions.Type: GrantFiled: July 19, 2011Date of Patent: May 12, 2015Assignee: Covidien LPInventor: George J. Collins
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Patent number: 8994270Abstract: The present disclosure provides for a plasma system. The plasma system includes a plasma device, an ionizable media source, and a power source. The plasma device includes an inner electrode and an outer electrode coaxially disposed around the inner electrode. The inner electrode includes a distal portion and an insulative layer that covers at least a portion of the inner electrode. The ionizable media source is coupled to the plasma device and is configured to supply ionizable media thereto. The power source is coupled to the inner and outer electrodes, and is configured to ignite the ionizable media at the plasma device to form a plasma effluent having an electron sheath layer about the exposed distal portion.Type: GrantFiled: September 27, 2010Date of Patent: March 31, 2015Assignee: Colorado State University Research FoundationInventors: Il-Gyo Koo, Cameron A. Moore, George J. Collins, Jin-Hoon Cho
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Patent number: 8968297Abstract: An electrosurgical system and method for performing electrosurgery is disclosed. The electrosurgical system includes an electrosurgical generator adapted to supply electrosurgical energy to tissue. The electrosurgical system includes an electrosurgical instrument, such as an electrosurgical antenna, knife, forceps, suction coagulator, or vessel sealer. The disclosed system includes an impedance sensor, a controller, dynamic impedance matching network, and an electrosurgical energy generator. The dynamic impedance matching network includes a PIN diode switching array configured to selectively activate a plurality of reactive elements. The disclosed arrangement of reactive elements provides real-time impedance correction over a wide range of impedance mismatch conditions.Type: GrantFiled: July 19, 2011Date of Patent: March 3, 2015Assignee: Covidien LPInventor: George J. Collins
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Publication number: 20140225495Abstract: A plasma system is disclosed. The system includes a plasma device including an inner electrode and an outer electrode coaxially disposed around the inner electrode, wherein at least one of the inner electrode and the outer electrode is temperature controlled; an ionizable media source coupled to the plasma device and configured to supply ionizable media thereto; and a power source coupled to the inner and outer electrodes and configured to ignite the ionizable media at the plasma device to form a plasma effluent.Type: ApplicationFiled: January 15, 2014Publication date: August 14, 2014Applicant: Colorado State University Research FoundationInventors: IL-GYO KOO, MYEONG YEOL CHOI, DOREENE HYATT, AMBER ZAGRODZKI, DEAN A. HENDRICKSON, GEORGE J. COLLINS
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Publication number: 20140224643Abstract: A plasma system is disclosed. The system includes: a plasma device including at least one electrode; an ionizable media source coupled to the plasma device and configured to supply ionizable media thereto; a precursor source configured to supply at least one precursor feedstock to the plasma device, wherein the at least one precursor feedstock includes at least one catalyst material; and a power source coupled to the inner and outer electrodes and configured to ignite the ionizable media and the at least one precursor feedstock at the plasma device to form a plasma effluent.Type: ApplicationFiled: January 27, 2014Publication date: August 14, 2014Applicant: Colorado State University Research FoundationInventors: GEORGE J. COLLINS, IL-GYO KOO, HEESANG YOUN, MYEONG YEOL CHOI, CARL W. ALMGREN
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Publication number: 20140225498Abstract: A plasma device is disclosed. The plasma device includes: at least one electrode including a nanoporous dielectric layer disposed on at least a portion thereof, the nanoporous dielectric layer including a plurality of pores, wherein at least a portion of the plurality of pores include a catalyst embedded therein.Type: ApplicationFiled: January 16, 2014Publication date: August 14, 2014Applicant: Colorado State University Research FoundationInventors: IL-GYO KOO, JIN HOON CHO, MYEONG YEOL CHOI, CAMERON A. MOORE, GEORGE J. COLLINS
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Publication number: 20140025064Abstract: An electrosurgical generator is disclosed. The generator includes a radio frequency output stage configured to generate a radio frequency waveform and a sensor circuit configured to measure a property of the radio frequency waveform during a predetermined sampling period to determine whether an arc event has occurred. The generator also includes a controller configured to determine a total charge and/or total energy deposited by the radio frequency waveform during the predetermined sampling period associated with the arc event. The controller is further configured to adjust the output of the electrosurgical generator based on at least one parameter to limit arcing.Type: ApplicationFiled: August 20, 2013Publication date: January 23, 2014Applicants: COVIDIEN LP, COLORADO STATE UNIVERSITY RESEARCH FOUNDATIONInventors: GEORGE J. COLLINS, CAMERON A. MOORE, ARLEN K. WARD
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Patent number: 8575843Abstract: A plasma generating system, related method and device are disclosed. The plasma generation system includes a plasma generation device, a source of ionizable gas and a driver network. The plasma generation device includes a housing, an electrode, and a resonant circuit. The housing includes a passage defined therein and directs a flow of ionizable gas therethrough. The electrode is coupled to the ionizable gas flowing through the passage of the housing. The resonant circuit includes a capacitor and an inductor connected together in series. The resonant circuit has a resonance frequency and is coupled to the electrode. The resonant circuit receives an AC signal. The driver network provides the AC signal such that the AC signal has a frequency and excites the ionizable gas flowing through the passage of the housing to a plasma.Type: GrantFiled: May 29, 2009Date of Patent: November 5, 2013Assignee: Colorado State University Research FoundationInventors: Cameron A. Moore, Douglas A. Scott, George J. Collins
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Patent number: 8512332Abstract: An electrosurgical generator is disclosed. The generator includes a radio frequency output stage configured to generate a radio frequency waveform and a sensor circuit configured to measure a property of the radio frequency waveform during a predetermined sampling period to determine whether an arc event has occurred. The generator also includes a controller configured to determine a total charge and/or total energy deposited by the radio frequency waveform during the predetermined sampling period associated with the arc event. The controller is further configured to adjust the output of the electrosurgical generator based on at least one parameter to limit arcing.Type: GrantFiled: September 21, 2007Date of Patent: August 20, 2013Assignees: Covidien LP, Colorado State University Research FoundationInventors: George J. Collins, Cameron A. Moore, Arlen K. Ward
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Publication number: 20130116682Abstract: The present disclosure provides a plasma system including a plasma device having at least one electrode; an ionizable media source coupled to the plasma device and configured to supply ionizable media thereto; a precursor source configured to supply at least one monomer precursor to the plasma device; and a power source coupled to the at least one electrode and configured to ignite the ionizable media at the plasma device to form a plasma effluent at atmospheric conditions, wherein the plasma effluent polymerizes the at least one monomer precursor to form a hydrophobic, electrically-conductive polymer.Type: ApplicationFiled: November 9, 2011Publication date: May 9, 2013Applicant: Colorado State University Research FoundationInventors: IL-GYO KOO, Paul Y. Kim, Sunggil Kang, George J. Collins