Patents by Inventor George L. Blackburn

George L. Blackburn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5231085
    Abstract: The invention provides immunostimulatory compositions comprising an aggregate immunostimulatory amount ofa) a compound associated with the synthesis of polyamines,b) a nucleobase source,c) omega-3 polyunsaturated fatty acids, andd) omega-6 polyunsaturated fatty acidsthe use of such compositions and their manufacture.
    Type: Grant
    Filed: February 19, 1992
    Date of Patent: July 27, 1993
    Assignee: Sandoz Ltd.
    Inventors: J. Wesley Alexander, Vigen K. Babayan, George L. Blackburn, Frank B. Cerra, John Daly, Mitchell T. Gersovitz, John E. Kinsella, Jerome J. LiCari, Frederick Rudolph, Charles T. Van Buren
  • Patent number: 4952606
    Abstract: The present invention features a transesterification product of a mixture of fatty acids and triglycerides which include dairy fat as a primary component. This composition shows unexpected benefits in nutritional applications either as a food or as an enteral or parenteral supplement. The method of nutritional support using this composition is also disclosed.
    Type: Grant
    Filed: April 5, 1988
    Date of Patent: August 28, 1990
    Assignee: New England Deaconess Hospital Corporation
    Inventors: Vigen K. Babayan, George L. Blackburn, Bruce R. Bistrian
  • Patent number: 4906664
    Abstract: A method of treating cancer cachexia syndrome has been discovered. Total parenteral nutrition using structured lipids in place of long chain fatty acids as the primary lipid source provides improvements in nitrogens balance, plasma serum albumin levels, and glucose clearance rate.
    Type: Grant
    Filed: January 15, 1988
    Date of Patent: March 6, 1990
    Assignee: New England Deaconess Hospital Corporation
    Inventors: Bruce R. Bistrian, Vigen R. Babayan, George L. Blackburn
  • Patent number: 4871768
    Abstract: A new dietary supplement has been developed which yields the benefits of both .omega.3 oils and medium chain triglycerides for lipid nutrition. A structured lipid containing .omega.3 fatty acids and medium chain fatty acids is also disclosed.
    Type: Grant
    Filed: September 3, 1987
    Date of Patent: October 3, 1989
    Assignee: New England Deaconess Hospital Corporation
    Inventors: Bruce R. Bistrian, Vigen K. Babayan, George L. Blackburn, Edward A. Mascioli
  • Patent number: 4847296
    Abstract: Chemically synthesized structured triglycerides (lipids) for enteral administration as the lipid calorie source, is subjects undergoing severe metabolic stress.
    Type: Grant
    Filed: March 20, 1987
    Date of Patent: July 11, 1989
    Inventors: Vigen K. Babayan, George L. Blackburn, Bruce R. Bistrian
  • Patent number: 4820731
    Abstract: Disclosed is a method of minimizing infection and minimizing the risks of infection in at risk animals and patients. A dietary supplement to accomplish this objective is also disclosed. The method includes the step of administering a diet rich in .omega.3 fatty acids, for example by adding a substantial proportion of fish oils to the diet. The dietary supplement is particularly well suited to patients receiving total parenteral nutrition. A parenteral diet or diet supplement containing a mixture of oils, one rich in .omega.3 fatty acids and the other rich in .omega.6 fatty acids is disclosed.
    Type: Grant
    Filed: June 15, 1988
    Date of Patent: April 11, 1989
    Assignee: New England Deaconess Hospital Corporation
    Inventors: Edward A. Mascioli, George L. Blackburn, Bruce R. Bistrian, Vigen K. Babayan
  • Patent number: 4810726
    Abstract: A method of treating, and a diet composition for treating patients needing a controlled diet, wherein C.sub.12 fatty acids are the primary fatty acid source. Preferably lauric fats constitute 33-80% of the diet, while LCT's constitute no more than 20%. The lauric fats may be derived from a natural or fractionated kernel oil, selected from a group consisting of babassu oil, coconut oil, cohune oil, palm kernel oil, and tucum oil. A lipid emulsion with diverse additives is described.
    Type: Grant
    Filed: April 1, 1987
    Date of Patent: March 7, 1989
    Assignee: New England Deaconess Hospital Corporation
    Inventors: Bruce R. Bistrian, Vigen K. Babayan, George L. Blackburn
  • Patent number: 4752618
    Abstract: Disclosed is a method of minimizing infection and minimizing the risks of infection in at risk animals and patients. A dietary supplement to accomplish this objective is also disclosed. The method includes the step of administering a diet rich in .omega.3 fatty acids, for example by adding a substantial proportion of fish oils to the diet. The dietary supplement is particularly well suited to patients receiving total parenteral nutrition.
    Type: Grant
    Filed: July 12, 1984
    Date of Patent: June 21, 1988
    Assignee: New England Deaconess Hospital
    Inventors: Edward A. Mascioli, George L. Blackburn, Bruce R. Bistrian, Vigen K. Babayan
  • Patent number: 4703062
    Abstract: Medium chain triglyceride containing lipid emulsions for the nutrition of liver diseased or septicemic patients are improved by the inclusion in the emulsions of long chain triglycerides. The emulsions may also contain amino acids in proportions desirable for the nutrition of liver diseased patients, as well as carbohydrates, drugs, vitamins and electrolytes.
    Type: Grant
    Filed: September 9, 1985
    Date of Patent: October 27, 1987
    Assignee: Baxter Travenol Laboratories, Inc.
    Inventors: George L. Blackburn, Vigen K. Babayan, Bruce Bistrian, Lyle L. Moldawer, Richard Cotter
  • Patent number: 4542017
    Abstract: Exogenous LEM (Leukocyte Endogenous Mediator, also referred to as endogenous pyrogen) is parenterally administered to humans who are protein malnourished and are infected with bacteria, in order to preinitiate and then maintain the normal metabolic responses to the tissue damage occurring during infection, and thereby promote the normal metabolic response by the human.
    Type: Grant
    Filed: December 9, 1982
    Date of Patent: September 17, 1985
    Inventors: Lyle L. Moldawer, George L. Blackburn, Bruce R. Bistrian
  • Patent number: 4528197
    Abstract: Method and composition for enhancing protein anabolism in an hypercatabolic mammal. The method comprises parenterally administering to the mammal nutritionally sufficient sources for amino acids, carbohydrates and lipids, the lipids comprising a controlled triglyceride source which, on hydrolysis, yields both long chain fatty acids and medium chain fatty acids, preferably about 20 to 80% long chain fatty acids and about 80 to 20% medium chain fatty acids. In one embodiment, the composition has the additional benefit of being capable of providing more than 60% of the total caloric requirements of the mammal via the lipid source without immunological impairment of the reticuloendothelial system of the mammal.
    Type: Grant
    Filed: January 26, 1983
    Date of Patent: July 9, 1985
    Assignee: KabiVitrum AB
    Inventor: George L. Blackburn
  • Patent number: 4512974
    Abstract: Exogenous LEM (Leukocyte Endogenous Mediator, also referred to as endogenous pyrogen) is parenterally administered to humans who are protein malnourished and are to undergo surgery, in order to preinitiate and then maintain the normal metabolic responses to the tissue damage occurring during surgery, and thereby promote the normal metabolic response by the human (patient).
    Type: Grant
    Filed: December 8, 1982
    Date of Patent: April 23, 1985
    Inventors: Lyle L. Moldawer, George L. Blackburn, Bruce R. Bistrian
  • Patent number: 4438144
    Abstract: Disclosed is a novel nutritional branched chain amino acid composition and its use for treatment of a patients suffering stress or injury, especially useful for parenteral or enteral alimentation of a patient suffering total or partial dysfunction or disuse of the gastrointestinal tract. The novel composition promotes and even optimizes patient wound healing, immune competence, host defense, and/or survival. The amino acids comprise from about 70 to 100% valine, isoleucine, and leucine, collectively, in a ratio of A:B:C, respectively, where A, B and C each independently has value from about 1 to 2. The novel composition is preferably used in the form of a parenteral infusion solution of from about 2 to 6%, most preferably 4% concentration.
    Type: Grant
    Filed: April 29, 1982
    Date of Patent: March 20, 1984
    Inventor: George L. Blackburn