Patents by Inventor George M. Whitesides

George M. Whitesides has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9193988
    Abstract: Embodiments of the invention provide lateral flow and flow-through bioassay devices based on patterned porous media, methods of making same, and methods of using same. Under one aspect, an assay device includes a porous, hydrophilic medium; a fluid impervious barrier comprising polymerized photoresist, the barrier substantially permeating the thickness of the porous, hydrophilic medium and defining a boundary of an assay region within the porous, hydrophilic medium; and an assay reagent in the assay region.
    Type: Grant
    Filed: November 21, 2013
    Date of Patent: November 24, 2015
    Assignee: President and Fellows of Harvard College
    Inventors: George M. Whitesides, Scott T. Phillips, Andres W. Martinez, Manish J. Butte, Amy Wong, Samuel W. Thomas, Hayat Sindi, Sarah J. Vella, Emanuel Carrilho, Katherine A. Mirica, Yanyan Liu
  • Patent number: 9192933
    Abstract: Microfluidic, electrochemical devices are described. The microfluidic, electrochemical device comprises one or more electrode(s) on a substrate and a patterned porous, hydrophilic layer having a fluid-impermeable barrier which substantially permeates the thickness of the porous, hydrophilic layer and defines boundaries of one or more hydrophilic channels within the patterned porous, hydrophilic layer, wherein the hydrophilic channel(s) comprises a hydrophilic region which is in fluidic communication with the electrode(s). In some embodiments, the electrodes comprise a working electrode, a counter electrode, and a reference electrode. In some embodiments, the microfluidic, electrochemical device further comprises a fluid sink. The method of assembling the microfluidic, electrochemical device is described. The method of using the device for electrochemical analysis of one or more analytes is also described.
    Type: Grant
    Filed: March 8, 2010
    Date of Patent: November 24, 2015
    Assignee: President and Fellows of Harvard College
    Inventors: George M. Whitesides, Zhihong Nie, Christian Nijhuis, Xin Chen, Andres W. Martinez, Max Narovlyansky
  • Patent number: 9176105
    Abstract: The disclosed methods use a multi-phase system to separate samples according to the density of an analyte of interest. The method uses a multi-phase system that comprises two or more phase-separated solutions and a phase component such as a surfactant or polymer. The density of the analyte of interest differs from the densities of the rest of the sample. The density of the analyte of interest is substantially the same as one or more phases. Thus, when the sample is introduced to the multi-phase system, the analyte of interest migrates to the phase having the same density as the analyte of interest, passing through one or more phases sequentially.
    Type: Grant
    Filed: August 22, 2011
    Date of Patent: November 3, 2015
    Assignee: President and Fellows of Harvard College
    Inventors: Charles R. Mace, Ashok A. Kumar, Dyann F. Wirth, George M. Whitesides
  • Publication number: 20150283699
    Abstract: Systems and methods for providing flexible robotic actuators are disclosed. Some embodiments of the disclosed subject matter include a soft robot capable of providing a radial deflection motions; a soft tentacle actuator capable of providing a variety of motions and providing transportation means for various types of materials; and a hybrid robotic system that retains desirable characteristics of both soft robots and hard robots. Some embodiments of the disclosed subject matter also include methods for operating the disclosed robotic systems.
    Type: Application
    Filed: September 8, 2014
    Publication date: October 8, 2015
    Inventors: Stephen A. MORIN, Robert F. SHEPHERD, Adam STOKES, Filip ILIEVSKI, Ramses V. MARTINEZ, Jamie L. BRANCH, Carina R. FISH, Lihua JIN, Rui M.D. NUNES, Zhigang SUO, George M. WHITESIDES
  • Publication number: 20150284613
    Abstract: The present invention is directed to adhesive systems and methods of making and using such systems. Exemplary adhesive systems comprise protrusions and/or grooves that can interleave to form a reversible adhesive interaction.
    Type: Application
    Filed: October 27, 2014
    Publication date: October 8, 2015
    Inventors: Brian MAYERS, Sandip Agarwal, Jeffrey Carbeck, David Ledoux, Kevin Randall Stewart, George M. Whitesides, Adam Winkleman
  • Publication number: 20150268234
    Abstract: A system and method that quantifies the concentration of an immunoactive analyte by detecting a chemically amplified change in density. This method, termed DeLISA for Density-Linked Immunosorbent Assay, but useful for any biomolecular recognition event, uses magnetic levitation (MagLev) to detect the changes in density. The present disclosure provides a quantitative measure of detecting binding events, does not require the use of electricity, and can be easily multiplexed to detect multiple analytes since several beads can be placed in single serum sample to detect, for example, HIV, Syphilis, Hepatitis C, and the like, simultaneously.
    Type: Application
    Filed: July 29, 2013
    Publication date: September 24, 2015
    Inventors: George M. Whitesides, Nathan D. Shapiro, Anand Bala Subramaniam
  • Publication number: 20150266186
    Abstract: An actuator includes a plurality of chambers comprised of an extensible material, the chambers having interior side walls and exterior walls, wherein at least a portion of the interior side wall is separated from an interior side wall of an adjacent chamber; and a strain limiting base; and a channel that fluidically interconnects the plurality of chambers, wherein the interior walls are configured to be more compliant than the exterior walls.
    Type: Application
    Filed: August 20, 2014
    Publication date: September 24, 2015
    Inventors: Bobak MOSADEGH, Robert F. SHEPHERD, George M. WHITESIDES
  • Publication number: 20150240958
    Abstract: A pneumatic controller for controllably providing pressurized gas to a target location is disclosed. The pneumatic controller can include an elastomeric manifold comprising a body and a first membrane coupled to a lower portion of the body. The body and the first membrane can form a first integrated channel having a first inlet, a first outlet, and an exhaust, and the first integrated channel is configured to receive pressurized gas at a first pressure at the first inlet and provide the pressurized gas to the first outlet. The body also has a sufficient stiffness to withstand an elevated pressure of the pressurized gas. The pneumatic controller can also include an actuator configured to change the first membrane from a first configuration to a second configuration to control a flow of the pressurized gas in the first integrated channel.
    Type: Application
    Filed: October 22, 2013
    Publication date: August 27, 2015
    Applicant: President and Fellows of Harvard College
    Inventors: Bobak Mosadegh, George M. Whitesides
  • Patent number: 9116148
    Abstract: A method and apparatus for delivering one or more fluids. Fluids may be delivered sequentially from a common vessel to a chemical, biological or biochemical process.
    Type: Grant
    Filed: January 31, 2013
    Date of Patent: August 25, 2015
    Assignee: President and Fellows of Harvard College
    Inventors: Vincent Linder, Samuel K. Sia, George M. Whitesides
  • Publication number: 20150231841
    Abstract: Exemplary method and system can be implemented and/or used for providing a diffractive configuration in an optical arrangement can be provided. For example, an elastomeric material can be provided with at least one patterned surface. The elastomeric material can be connected with at least one portion of a waveguide arrangement using a pre-polymer adhesive composition. Further, the pre-polymer adhesive composition can be caused to polymerize so as to form the diffractive configuration which at least approximately replicate a structure or at least one feature of an elastomeric mold.
    Type: Application
    Filed: August 21, 2013
    Publication date: August 20, 2015
    Inventors: Guillermo J. Tearney, Brett Eugene Bouma, Dongkyun Kang, George M. Whitesides, Rames Martinez
  • Publication number: 20150233901
    Abstract: A method and apparatus for delivering one or more fluids. Fluids may be delivered from a common vessel to a chemical, biological or biochemical process.
    Type: Application
    Filed: May 1, 2015
    Publication date: August 20, 2015
    Applicant: President and Fellows of Harvard College
    Inventors: Vincent Linder, Samuel K. Sia, George M. Whitesides
  • Publication number: 20150217459
    Abstract: Apparatus, systems, and methods for providing modular soft robots are disclosed. In particular, the disclosed modular soft robot can include a flexible actuator having a plurality of molded flexible units. Each molded flexible unit can include a mechanical connector configured to provide a physical coupling to another molded flexible unit, and the plurality of molded flexible units are arranged to form an embedded fluidic channel. The modular soft robot can also include an inlet coupled to the embedded fluidic channel, where the inlet is configured to receive pressurized or depressurized fluid to inflate or deflate a portion of the flexible actuator, thereby causing an actuation of the flexible actuator.
    Type: Application
    Filed: July 18, 2013
    Publication date: August 6, 2015
    Inventors: Stephen A. Morin, Sen Wai Kwok, Robert F. Shepherd, George M. Whitesides
  • Patent number: 9090868
    Abstract: Alginate hydrogel fibers and related materials as well as methods for preparing such materials are provided. An alginate hydrogel fiber includes water in an amount of more than about 92% by weight of the fiber and a cross-linked alginate in an amount of about 0.1% to about 8% by weight of the fiber, wherein the cross-link is a cation. An alginate hydrogel paper includes one or more alginate hydrogel fibers, which form a non-woven matrix. Three-dimensional cellular arrays are also provided, wherein the alginate hydrogel making up the alginate paper is substantially index-matched with a predetermined culture medium. A method for making alginate hydrogel fiber and a method for index-matching alginate hydrogel paper with culture medium are provided. A kit for conducting biochemical, diagnostic, cellular, and/or non-cellular analysis comprises alginate hydrogel paper index-matched to culture medium.
    Type: Grant
    Filed: July 12, 2011
    Date of Patent: July 28, 2015
    Inventors: Charles R. Mace, Jabulani Barber, Anna Laromaine Sagué, George M. Whitesides, Rebecca Cademartiri
  • Publication number: 20150135829
    Abstract: This present disclosure describes the utility of paramagnetic ionic liquids for density-based measurements using magnetic levitation (MagLev), The physical properties of paramagnetic ionic liquids, including density, magnetic susceptibility, glass transition temperature, melting point, thermal decomposition temperature, viscosity, and hydrophobicity can be tuned by altering the cation or anion.
    Type: Application
    Filed: June 14, 2013
    Publication date: May 21, 2015
    Inventors: George M. Whitesides, David Bwambok, Martin Mwangi Thuo, Katherine A. Mirica, Manza Atkinson
  • Publication number: 20150132742
    Abstract: Microfluidic devices fabricated from paper that has been covalently modified to increase its hydrophobicity, as well as methods of making and using thereof are provided herein. The devices are typically small, portable, flexible, and both easy and inexpensive to fabricate. Microfluidic devices contain a network of microfluidic components, including microfluidic channels, microfluidic chambers, microwells, or combinations thereof, designed to carry, store, mix, react, and/or analyze liquid samples. The microfluidic channels may be open channels, closed channels, or combinations thereof. The microfluidic devices may be used to detect and/or quantify an analyte, such as a small molecules, proteins, lipids polysaccharides, nucleic acids, prokaryotic cells, eukaryotic cells, particles, viruses, metal ions, and combinations thereof.
    Type: Application
    Filed: June 3, 2013
    Publication date: May 14, 2015
    Inventors: Martin Mwangi Thuo, Ramses V. Martinez, Ana C. Glavan, Wenjie Lan, Xinyu Liu, Jean-Francis Bloch, George M. Whitesides
  • Patent number: 9027336
    Abstract: Self-regulating pressure source. The pressure source includes a chamber enclosing a chemical monopropellant. A moveable boss is attached to a deformable membrane sealing an air chamber, the moveable boss and air chamber being disposed within the chamber. A catalyst is disposed around the membrane so as to be covered by the boss in a retracted position so that the monopropellant is broken down by the catalyst to produce a gas. The gas pressure will increase within the chamber causing air in the air chamber to compress thereby to pull the boss into the retracted position to cover the catalyst thereby to regulate the pressure within the chamber. The self-regulating pressure source is particularly suited to power fluidic elastomeric actuators.
    Type: Grant
    Filed: March 15, 2012
    Date of Patent: May 12, 2015
    Assignees: Massachusetts Institute of Technology, President and Fellows of Harvard College
    Inventors: Cagdas Denizel Onal, Daniela Rus, Xin Chen, George M. Whitesides
  • Publication number: 20150125874
    Abstract: Described herein are assays for determining total suspended solids (TSS) in liquids. Here TSS can be determined by flowing turbid liquid samples in a porous medium. Using such an assay, TSS can be determined with small volumes of liquid and in short times without the need for dedicated optics and instruments. The assays can be used to determine total suspended solids in any liquid medium, for example, the assay can be used in an immunoprecipitin assay to determine the amount of antigen or antibody present in blood or other fluid.
    Type: Application
    Filed: May 2, 2013
    Publication date: May 7, 2015
    Inventors: Anand Bala Subramaniam, George M. Whitesides, Olga Taran, Elizabeth Jane Maxwell
  • Patent number: 9023458
    Abstract: In one aspect, methods of patterning of thin films of an ionotropic polymer (e.g., poly(acrylic acid)) are provided. These processes can create micron or sub-micron-scale patterns of ionotropic polymers such as cation crosslinked poly(acrylic acid) (CCL-PAA). In one embodiment, patterning may be performed within microfluidic channels by flowing a solution of crosslinking agent (e.g., metal cations such as Ag+, Ca2+, Pd2+, Al3+, La3+, and Ti4+) that can crosslink a portion of an ionotropic polymer in contact with the solution. In another embodiment, methods of patterning ionotropic polymers involve photolithography. Upon patterning a positive photoresist (e.g., diazonaphthoquinone-novolac resin) on a film of CCL-PAA, the exposed regions of CCL-PAA can be etched by an aqueous solution. Advantageously, the patterned, crosslinked polymer may also serve as both a reactant and a matrix for subsequent chemistry.
    Type: Grant
    Filed: October 18, 2007
    Date of Patent: May 5, 2015
    Assignee: President and Fellows of Harvard College
    Inventors: Michal Lahav, Adam Winkleman, Max Narovlyansky, Raquel Perez-Castillejos, Emily A. Weiss, Leonard N. J. Rodriguez, George M. Whitesides
  • Publication number: 20150112130
    Abstract: A surgical device for displacement of organs within a body cavity for providing at least visual access to a selected site includes an expandable bladder, wherein the elasticity of the bladder varies across the surface of the bladder, said variation in elasticity selected to provide a predetermined, non-spherical shape when expanded; and a valve on the proximal end on the inflatable bladder for introduction of a pressurizing gas into the soft bladder.
    Type: Application
    Filed: October 20, 2014
    Publication date: April 23, 2015
    Inventors: Robert F. SHEPHERD, George M. WHITESIDES, Bobak MOSADEGH
  • Patent number: 8985547
    Abstract: A microfluidic valve assembly includes a structure defining a microfluidic fluid path and an actuator that can be moved between different positions controlling flow through the channel. In one embodiment, the actuator can be threaded into at least a portion of the structure, and can be moved rotationally between a first position, causing relatively greater constriction of a microfluidic fluid path, and a second position causing relatively lesser constriction of the fluid path. Actuating the actuator, e.g., by rotation, can deform material between the valve and the fluid path, thereby constricting at least a portion of the underlying fluid path and regulating the flow of a fluid in the fluid path. In another aspect, the invention provides a reservoir into which fluid can be placed and from which fluid can be introduced into a microfluidic system. In one embodiment, the reservoir is expandable and thereby able to store fluid under pressure for delivery to a microfluidic system.
    Type: Grant
    Filed: January 31, 2006
    Date of Patent: March 24, 2015
    Assignee: President and Fellows of Harvard College
    Inventors: Douglas B. Weibel, Andrew Lee, Scott Potenta, Adam Siegel, Maarten Kruithof, George M. Whitesides