Patents by Inventor George P. Anderson

George P. Anderson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Single domain antibodies to SARS-CoV-2 nucleocapsid protein
    Patent number: 11739137
    Abstract: A number of single domain antibodies (sdAb, also known as nanobodies or VHH) were developed that bind nucleocapsid protein of the SARS-CoV-2 virus. They are useful for detecting the virus and could also find application in therapeutics.
    Type: Grant
    Filed: October 28, 2021
    Date of Patent: August 29, 2023
    Assignee: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Ellen R. Goldman, George P. Anderson, Jinny L. Liu, Thomas J. Esparza
  • Single Domain Antibodies that Bind and Neutralize Venezuelan Equine Encephalitis Virus
    Publication number: 20230050657
    Abstract: Described herein are single-domain antibodies that might serve as alternatives to conventional monoclonal antibodies for either the detection or treatment of Venezuelan equine encephalitis virus (VEEV).
    Type: Application
    Filed: June 29, 2022
    Publication date: February 16, 2023
    Inventors: Jinny Lin Liu, Dan Zabetakis, Ellen R. Goldman, George P. Anderson
  • Nucleic acids encoding single domain antibodies to chikungunya virus
    Patent number: 11542320
    Abstract: Described herein are nucleic acids encoding single-domain antibodies that might serve as alternatives to conventional monoclonal antibodies for either the detection or treatment of Chikungunya Virus (CHIKV).
    Type: Grant
    Filed: July 9, 2021
    Date of Patent: January 3, 2023
    Assignee: The Government of the United States of Americas, as represented by the Secretary of the Navy
    Inventors: Jinny Lin Liu, George P. Anderson, Ellen R. Goldman
  • Single Domain Antibodies to SARS-CoV-2 Nucleocapsid Protein
    Publication number: 20220135654
    Abstract: A number of single domain antibodies (sdAb, also known as nanobodies or VHH) were developed that bind nucleocapsid protein of the SARS-CoV-2 virus. They are useful for detecting the virus and could also find application in therapeutics.
    Type: Application
    Filed: October 28, 2021
    Publication date: May 5, 2022
    Inventors: Ellen R. Goldman, George P. Anderson, Jinny L. Liu, Thomas J. Esparza
  • Nucleic Acids Encoding Single Domain Antibodies to Chikungunya Virus
    Publication number: 20210347863
    Abstract: Described herein are nucleic acids encoding single-domain antibodies that might serve as alternatives to conventional monoclonal antibodies for either the detection or treatment of Chikungunya Virus (CHIKV).
    Type: Application
    Filed: July 9, 2021
    Publication date: November 11, 2021
    Inventors: Jinny Lin Liu, George P. Anderson, Ellen R. Goldman
  • Single domain antibodies to Chikungunya virus
    Patent number: 11028152
    Abstract: Described herein are single-domain antibodies that might serve as alternatives to conventional monoclonal antibodies for either the detection or treatment of Chikungunya Virus (CHIKV).
    Type: Grant
    Filed: July 17, 2019
    Date of Patent: June 8, 2021
    Assignee: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Jinny Lin Liu, George P. Anderson, Ellen R. Goldman
  • Use of Specific Covalent Bonding for Oriented Immobilization of Recombinant Antibody Fragments
    Publication number: 20200240982
    Abstract: Expression of single-domain antibodies with a C-terminal binding partner (such as SpyTag) enables their orientation on surfaces, improving detection capability.
    Type: Application
    Filed: January 17, 2020
    Publication date: July 30, 2020
    Inventors: George P. Anderson, Jinny Lin Liu, Ellen R. Goldman
  • Single-domain antibody fusion proteins with the acid tail of alpha-synuclein
    Patent number: 10611809
    Abstract: A single-domain antibody (sdAb) is produced by causing a bacteria to express the sdAb into cytoplasm of the bacteria, wherein the sdAb is expressed as a fusion protein with the acid tail of ?-synuclein. In embodiments, the protein is free of a periplasmic location tag. Such antibodies have the unexpected ability to refold after thermal denaturation.
    Type: Grant
    Filed: March 27, 2019
    Date of Patent: April 7, 2020
    Assignee: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Daniel Zabetakis, George P. Anderson, Ellen R. Goldman, Kendrick Turner, P. Audrey Brozozog Lee
  • Nucleic acids for single-domain antibodies with thermal stability under cytoplasmic expression
    Patent number: 10577401
    Abstract: A nucleic acid encodes a single-domain antibody (sdAb) is produced by causing a bacteria to express the sdAb into cytoplasm of the bacteria, wherein the sdAb is expressed as a fusion protein with the acid tail of ?-synuclein. In embodiments, the protein is free of a periplasmic location tag. Such antibodies have the unexpected ability to refold after thermal denaturation.
    Type: Grant
    Filed: March 27, 2019
    Date of Patent: March 3, 2020
    Assignee: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Daniel Zabetakis, George P. Anderson, Ellen R. Goldman, Kendrick Turner, P. Audrey Brozozog Lee
  • Single Domain Antibodies to Chikungunya Virus
    Publication number: 20200024331
    Abstract: Described herein are single-domain antibodies that might serve as alternatives to conventional monoclonal antibodies for either the detection or treatment of Chikungunya Virus (CHIKV).
    Type: Application
    Filed: July 17, 2019
    Publication date: January 23, 2020
    Inventors: Jinny Lin Liu, George P. Anderson, Ellen R. Goldman
  • Nucleic Acids for Single-Domain Antibodies with Thermal Stability Under Cytoplasmic Expression
    Publication number: 20190211069
    Abstract: A nucleic acid encodes a single-domain antibody (sdAb) is produced by causing a bacteria to express the sdAb into cytoplasm of the bacteria, wherein the sdAb is expressed as a fusion protein with the acid tail of ?-synuclein. In embodiments, the protein is free of a periplasmic location tag. Such antibodies have the unexpected ability to refold after thermal denaturation.
    Type: Application
    Filed: March 27, 2019
    Publication date: July 11, 2019
    Inventors: Daniel Zabetakis, George P. Anderson, Ellen R. Goldman, Kendrick Turner, P. Audrey Brozozog Lee
  • Single-Domain Antibody Fusion Proteins with the Acid Tail of Alpha-Synuclein
    Publication number: 20190211068
    Abstract: A single-domain antibody (sdAb) is produced by causing a bacteria to express the sdAb into cytoplasm of the bacteria, wherein the sdAb is expressed as a fusion protein with the acid tail of ?-synuclein. In embodiments, the protein is free of a periplasmic location tag. Such antibodies have the unexpected ability to refold after thermal denaturation.
    Type: Application
    Filed: March 27, 2019
    Publication date: July 11, 2019
    Inventors: Daniel Zabetakis, George P. Anderson, Ellen R. Goldman, Kendrick Turner, P. Audrey Brozozog Lee
  • Single-domain antibodies with improved thermal stability under cytoplasmic expression
    Patent number: 10294283
    Abstract: Methods of producing a single-domain antibody (sdAb) include causing a bacteria to express the sdAb into cytoplasm of the bacteria, wherein the sdAb is expressed as a fusion protein with the acid tail of ?-synuclein; and then purifying the sdAb, wherein the fusion protein is expressed free of a periplasmic location tag. Such antibodies have the unexpected ability to refold after thermal denaturation.
    Type: Grant
    Filed: January 17, 2014
    Date of Patent: May 21, 2019
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: Daniel Zabetakis, George P. Anderson, Ellen R. Goldman, Kendrick Turner, P. Audrey Brozozog Lee
  • Single domain antibodies that bind to human CD20
    Patent number: 10246514
    Abstract: Described herein is the development of recombinant single domain antibodies, also known as nanobodies, that may provide better therapeutic results or be useful for diagnostic applications of B-cell lymphomas, or in other applications where an antibody to CD20 may be useful.
    Type: Grant
    Filed: September 12, 2017
    Date of Patent: April 2, 2019
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: Jinny Lin Liu, Daniel Zabetakis, Ellen R. Goldman, George P. Anderson
  • Antibody and recombinant derivative for the detection of trinitrotoluene
    Patent number: 10247716
    Abstract: Described herein are new recognition elements (antibodies or functional fragments thereof) that effectively bind to trinitrotoluene (TNT). Also disclosed is a single chain fragment recognition element.
    Type: Grant
    Filed: January 6, 2016
    Date of Patent: April 2, 2019
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: Jinny Lin Liu, Daniel Zabetakis, Ellen R. Goldman, George P. Anderson
  • Single Domain Antibodies that Bind to Human CD20
    Publication number: 20180079822
    Abstract: Described herein is the development of recombinant single domain antibodies, also known as nanobodies, that may provide better therapeutic results or be useful for diagnostic applications of B-cell lymphomas, or in other applications where an antibody to CD20 may be useful.
    Type: Application
    Filed: September 12, 2017
    Publication date: March 22, 2018
    Inventors: Jinny Lin Liu, Daniel Zabetakis, Ellen R. Goldman, George P. Anderson
  • Charged peptide appendage to facilitate oriented protein covalent immobilization
    Patent number: 9778265
    Abstract: Genetic fusions of proteins, for example single-domain antibodies (sdAbs), with a positively-charged domain enhanced immobilization of active protein in a desired orientation.
    Type: Grant
    Filed: April 16, 2015
    Date of Patent: October 3, 2017
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: George P. Anderson, Jinny Lin Liu, Marc P. Raphael, Ellen R. Goldman
  • Charged Peptide Appendage to Facilitate Oriented Protein Covalent Immobilization
    Publication number: 20160305948
    Abstract: Genetic fusions of proteins, for example single-domain antibodies (sdAbs), with a positively-charged domain enhanced immobilization of active protein in a desired orientation.
    Type: Application
    Filed: April 16, 2015
    Publication date: October 20, 2016
    Applicant: The Govemment of The US, as represented by the Secretary of the Navy
    Inventors: George P. Anderson, Jinny Lin Liu, Marc P. Raphael, Ellen R. Goldman
  • Enzyme/Protein Packaged Bacterial Vesicles for Therapeutic Delivery
    Publication number: 20160222372
    Abstract: A method of producing a protein includes providing a bacterial cell expressing both (a) a protein of interest fused to one of the SpyTag/SpyCatcher pair and (b) an outer membrane protein fused to the other of the SpyTag/SpyCatcher pair; causing the bacterial cell to express both of the protein of interest fusion and the outer membrane protein fusion in outer membrane vesicles; and purifying the outer membrane vesicles.
    Type: Application
    Filed: January 29, 2016
    Publication date: August 4, 2016
    Inventors: Scott Walper, Nathan Alves, Kendrick Turner, Igor L. Medintz, George P. Anderson
  • Antibody and Recombinant Derivative for the Detection of Trinitrotoluene
    Publication number: 20160200834
    Abstract: Described herein are new recognition elements (antibodies or functional fragments thereof) that effectively bind to trinitrotoluene (TNT). Also disclosed is a single chain fragment recognition element.
    Type: Application
    Filed: January 6, 2016
    Publication date: July 14, 2016
    Inventors: Jinny Lin Liu, Daniel Zabetakis, Ellen R. Goldman, George P. Anderson