Patents by Inventor George Phillip Vlasuk

George Phillip Vlasuk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nematode-extracted serine protease inhibitors and anticoagulant proteins
    Publication number: 20100240584
    Abstract: Proteins which have activity as anticoagulants and/or serine protease inhibitors and have at least one NAP domain and are described. Certain of these proteins have factor Xa inhibitory activity and others have activity as inhibitors of factor VIIa/TF. These proteins can be isolated from natural sources as nematodes, chemically synthesized or made by recombinant methods using various DNA, expression systems.
    Type: Application
    Filed: October 27, 2008
    Publication date: September 23, 2010
    Inventors: George Phillip Vlasuk, Patrick Eric Hugo Stanssens, Joris Hilda Lieven Messens, Marc Josef Lauwereys, Yves Rene LaRoche, Laurent Stephane Jespers, Yannick Georges Jozef Gansemans, Matthew Moyle, Peter W. Bergum
  • Nematode-extracted serine protease inhibitors and anticoagulant proteins
    Patent number: 6872808
    Abstract: Proteins which have activity as anticoagulants and/or serine protease inhibitors and have at least one NAP domain and are described. Certain of these proteins have factor Xa inhibitory activity and others have activity as inhibitors of factor VIIa/TF. These proteins can be isolated from natural sources as nematodes, chemically synthesized or made by recombinant methods using various DNA expression systems.
    Type: Grant
    Filed: February 4, 2000
    Date of Patent: March 29, 2005
    Assignee: Corvas International, Inc.
    Inventors: George Phillip Vlasuk, Patrick Eric Hugo Stanssens, Joris Hilda Lieven Messens, Marc Josef Lauwereys, Yves Rene LaRoche, Laurent Stephane Jespers, Yannick Georges Jozef Gansemans, Matthew Moyle, Peter W. Bergum
  • Nematode-extracted serine protease inhibitors and anticoagulant proteins
    Publication number: 20030113890
    Abstract: Proteins which have activity as anticoagulants and/or serine protease inhibitors and have at least one NAP domain and are described. Certain of these proteins have factor Xa inhibitory activity and others have activity as inhibitors of factor VIIa/TF. These proteins can be isolated from natural sources as nematodes, chemically synthesized or made by recombinant methods using various DNA expression systems.
    Type: Application
    Filed: February 4, 2000
    Publication date: June 19, 2003
    Inventors: George Phillip Vlasuk, Patrick Eric Hugo Stanssens, Joris Hilda Lieven Messens, Marc Josef Lauwereys, Yves Rene LaRoche, Laurent Stephane Jespers, Yannick Georges Jozef Gansemans, Matthew Moyle, Peter W. Bergum
  • Nematode-extracted serine protease inhibitors and anticoagulant proteins
    Patent number: 6534629
    Abstract: Proteins which have activity as anticoagulants and/or serine protease inhibitors and have at least one NAP domain and are described. Certain of these proteins have factor Xa inhibitory activity and others have activity as inhibitors of factor VIIa/TF. These proteins can be isolated from natural sources as nematodes, chemically synthesized or made by recombinant methods using various DNA expression systems.
    Type: Grant
    Filed: February 12, 1999
    Date of Patent: March 18, 2003
    Assignee: Corvas International, Inc.
    Inventors: George Phillip Vlasuk, Patrick Eric Hugo Stanssens, Joris Hilda Lieven Messens, Marc Josef Lauwereys, Yves Rene LaRoche, Laurent Stephane Jespers, Yannick Georges Jozef Gansemans, Matthew Moyle, Peter W. Bergum
  • Nematode-extracted serine protease inhibitors and anticoagulant proteins
    Patent number: 6121435
    Abstract: Proteins which have activity as anticoagulants and/or serine protease inhibitors and have at least one NAP domain and are described. Certain of these proteins have factor Xa inhibitory activity and others have activity as inhibitors of factor VIIa/TF. These proteins can be isolated from natural sources as nematodes, chemically synthesized or made by recombinant methods using various DNA expression systems.
    Type: Grant
    Filed: February 12, 1999
    Date of Patent: September 19, 2000
    Assignee: Corvas International, Inc.
    Inventors: George Phillip Vlasuk, Patrick Eric Hugo Stanssens, Joris Hilda Lieven Messens, Marc Josef Lauwereys, Yves Rene LaRoche, Laurent Stephane Jespers, Yannick Georges Jozef Gansemans, Matthew Moyle, Peter W. Bergum
  • Nematode-extracted serine protease inhibitors and anticoagulant proteins
    Patent number: 6096877
    Abstract: Proteins which have activity as anticoagulants and/or serine protease inhibitors and have at least one NAP domain and are described. Certain of these proteins have factor Xa inhibitory activity and others have activity as inhibitors of factor VIIa/TF. These proteins can be isolated from natural sources as nematodes, chemically synthesized or made by recombinant methods using various DNA expression systems.
    Type: Grant
    Filed: February 12, 1999
    Date of Patent: August 1, 2000
    Assignee: Corvas International, Inc.
    Inventors: George Phillip Vlasuk, Patrick Eric Hugo Stanssens, Joris Hilda Lieven Messens, Marc Josef Lauwereys, Yves Rene LaRoche, Laurent Stephane Jespers, Yannick Georges Jozef Gansemans, Matthew Moyle, Peter W. Bergum
  • Nematode-extracted serine protease inhibitors and anticoagulant proteins
    Patent number: 6090916
    Abstract: Proteins which have activity as anticoagulants and/or serine protease inhibitors and have at least one NAP domain and are described. Certain of these proteins have factor Xa inhibitory activity and others have activity as inhibitors of factor VIIa/TF. These proteins can be isolated from natural sources as nematodes, chemically synthesized or made by recombinant methods using various DNA expression systems.
    Type: Grant
    Filed: November 24, 1997
    Date of Patent: July 18, 2000
    Assignee: Corvas International, Inc.
    Inventors: George Phillip Vlasuk, Patrick Eric Hugo Stanssens, Joris Hilda Lieven Messens, Marc Josef Lauwereys, Yves Rene LaRoche, Laurent Stephane Jespers, Yannick Georges Jozef Gansemans, Matthew Moyle, Peter W. Bergum
  • Nematode-extracted serine protease inhibitors and anticoagulant proteins
    Patent number: 6087487
    Abstract: Proteins which have activity as anticoagulants and/or serine protease inhibitors and have at least one NAP domain and are described. Certain of these proteins have factor Xa inhibitory activity and others have activity as inhibitors of factor VIIa/TF. These proteins can be isolated from natural sources as nematodes, chemically synthesized or made by recombinant methods using various DNA expression systems.
    Type: Grant
    Filed: February 12, 1999
    Date of Patent: July 11, 2000
    Assignee: Corvas International, Inc.
    Inventors: George Phillip Vlasuk, Patrick Eric Hugo Stanssens, Joris Hilda Lieven Messens, Marc Josef Lauwereys, Yves Rene LaRoche, Laurent Stephane Jespers, Yannick Georges Jozef Gansemans, Matthew Moyle, Peter W. Bergum
  • Nematode-extracted serine protease inhibitors and anticoagulant proteins
    Patent number: 6046318
    Abstract: Proteins which have activity as anticoagulants and/or serine protease inhibitors and have at least one NAP domain and are described. Certain of these proteins have factor Xa inhibitory activity and others have activity as inhibitors of factor VIIa/TF. These proteins can be isolated from natural sources as nematodes, chemically synthesized or made by recombinant methods using various DNA expression systems.
    Type: Grant
    Filed: February 12, 1999
    Date of Patent: April 4, 2000
    Assignee: Corvas International, Inc.
    Inventors: George Phillip Vlasuk, Patrick Eric Hugo Stanssens, Joris Hilda Lieven Messens, Marc Josef Lauwereys, Yves Rene LaRoche, Laurent Stephane Jespers, Yannick Georges Jozef Gansemans, Matthew Moyle, Peter W. Bergum
  • Nematode-extracted serine protease inhibitors and anticoagulant proteins
    Patent number: 6040441
    Abstract: Proteins which have activity as anticoagulants and/or serine protease inhibitors and have at least one NAP domain and are described. Certain of these proteins have factor Xa inhibitory activity and others have activity as inhibitors of factor VIIa/TF. These proteins can be isolated from natural sources as nematodes, chemically synthesized or made by recombinant methods using various DNA expression systems.
    Type: Grant
    Filed: February 12, 1999
    Date of Patent: March 21, 2000
    Assignee: Corvas International, Inc.
    Inventors: George Phillip Vlasuk, Patrick Eric Hugo Stanssens, Joris Hilda Lieven Messens, Marc Josef Lauwereys, Yves Rene LaRoche, Laurent Stephane Jespers, Yannick Georges Jozef Gansemans, Matthew Moyle, Peter W. Bergum
  • Inhibitors of thrombosis
    Patent number: 5955576
    Abstract: This invention relates to peptide aldehyde analogs that inhibit the thrombin or Factor Xa. The compounds are thought useful for preventing or treating conditions in mammal characterized by abnormal thrombosis.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: September 21, 1999
    Assignee: Corvas International, Inc.
    Inventors: George Phillip Vlasuk, Thomas Roy Webb, Matthew Mark Abelman, Daniel Andrew Pearson, Todd Anthony Miller
  • Nematode-extracted serine protease inhibitors and anticoagulant proteins
    Patent number: 5955294
    Abstract: Proteins which have activity as anticoagulants and/or serine protease inhibitors and have at least one NAP domain and are described. Certain of these proteins have factor Xa inhibitory activity and others have activity as inhibitors of factor VIIa/TF. These proteins can be isolated from natural sources as nematodes, chemically synthesized or made by recombinant methods using various DNA expression systems.
    Type: Grant
    Filed: April 19, 1996
    Date of Patent: September 21, 1999
    Assignee: Corvas International, Inc.
    Inventors: George Phillip Vlasuk, Patrick Eric Hugo Stanssens, Joris Hilda Lieven Messens, Marc Josef Lauwereys, Yves Rene LaRoche, Laurent Stephane Jespers, Yannick Georges Jozef Gansemans, Matthew Moyle, Peter W. Bergum
  • Nematode-extracted anticoagulant protein
    Patent number: 5945275
    Abstract: Proteins which are potent anticoagulants and have at least one NAP domain and are described. These proteins having anticoagulant activity can be isolated from natural sources as nematodes, chemically synthesized or made by recombinant methods using various DNA expression systems.
    Type: Grant
    Filed: October 18, 1994
    Date of Patent: August 31, 1999
    Assignee: Corvas International, Inc.
    Inventors: George Phillip Vlasuk, Patrick Eric Hugo Stanssens, Joris Hilda Lieven Messens, Marc Jozef Lauwereys, Yves Rene Laroche, Laurent Stephane Jespers, Yannick Georges Jozef Gansemans
  • Nematode-extracted anticoagulant protein
    Patent number: 5872098
    Abstract: Proteins which are potent anticoagulants and have at least one NAP domain and are described. These proteins having anticoagulant activity can be isolated from natural sources such as nematodes, chemically synthesized or made by recombinant methods using various DNA expression systems.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: February 16, 1999
    Assignee: Corvas International, Inc.
    Inventors: George Phillip Vlasuk, Patrick Eric Hugo Stanssens, Joris Hilda Lieven Messens, Marc Jozef Lauwereys, Yves Rene Laroche, Laurent Stephane Jespers, Yannick Georges Jozef Gansemans, Matthew Moyle, Peter W. Bergum
  • Arginine keto-amide enzyme inhibitors
    Patent number: 5869454
    Abstract: The present invention is directed to novel arginine alpha-keto-amide derivatives, their pharmaceutically acceptable salts and compositions thereof which are useful as antithrombotic agents in mammals and also the use of these compounds as antithrombotic agents. Also, described are methods of using these inhibitors as inhibitors of coagulation proteases and as therapeutic agents for disease states characterized by abnormal thrombus formation and/or disorders of the blood coagulation process. Further described herein are compounds useful as intermediates in the preparation of these compounds.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: February 9, 1999
    Assignee: Corvas International, Inc.
    Inventors: Thomas Roy Webb, Todd Anthony Miller, George Phillip Vlasuk, Matthew Mark Abelman
  • Nematode-extracted anticoagulant protein
    Patent number: 5866543
    Abstract: Proteins which are potent anticoagulants and have at least one NAP domain and are described. These proteins having anticoagulant activity can be isolated from natural sources such as nematodes, chemically synthesized or made by recombinant methods using various DNA expression systems.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: February 2, 1999
    Assignee: Corvas International, Inc.
    Inventors: George Phillip Vlasuk, Patrick Eric Hugo Stanssens, Joris Hilda Lieven Messens, Marc Jozef Lauwereys, Yves Rene Laroche, Laurent Stephane Jespers, Yannick Georges Jozef Gansemans, Matthew Moyle, Peter W. Bergum
  • Nematode-extracted anticoagulant protein
    Patent number: 5866542
    Abstract: Proteins which are potent anticoagulants and have at least one NAP domain and are described. These proteins having anticoagulant activity can be isolated from natural sources such as nematodes, chemically synthesized or made by recombinant methods using various DNA expression systems.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: February 2, 1999
    Assignee: Corvas International, Inc.
    Inventors: George Phillip Vlasuk, Patrick Eric Hugo Stanssens, Joris Hilda Lieven Messens, Marc Jozef Lauwereys, Yves Rene n Laroche, Laurent Stephane Jespers, Yannick George Jozef Gansemans, Matthew Moyle, Peter W. Bergum
  • Nematode-extracted anticoagulant protein
    Patent number: 5864009
    Abstract: Proteins which are potent anticoagulants and have at least one NAP domain and are described. These proteins having anticoagulant activity can be isolated from natural sources such as nematodes, chemically synthesized or made by recombinant methods using various DNA expression systems.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: January 26, 1999
    Assignee: Corvas International, Inc.
    Inventors: George Phillip Vlasuk, Patrick Eric Hugo Stanssens, Joris Hilda Lieven Messens, Marc Jozef Lauwereys, Yves Rene Laroche, Laurent Stephane Jespers, Yannick Georges Jozef Gansemans
  • Nematode-extracted anticoagulant protein
    Patent number: 5863894
    Abstract: Proteins which are potent anticoagulants and have at least one NAP domain and are described. These proteins having anticoagulant activity can be isolated from natural sources such as nematodes, chemically synthesized or made by recombinant methods using various DNA expression systems.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: January 26, 1999
    Assignee: Corvas International, Inc.
    Inventors: George Phillip Vlasuk, Patrick Eric Hugo Stanssens, Joris Hilda Lieven Messens, Marc Jozef Lauwereys, Yves Rene Laroche, Laurent Stephane Jespers, Yannick Georges Jozef Gansemans, Matthew Moyle, Peter W. Bergum