Patents by Inventor Gerald R. Crabtree

Gerald R. Crabtree has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Regulated apoptosis
    Patent number: 5834266
    Abstract: We have developed a general procedure for the regulated (inducible) dimerization or oligomerization of intracellular proteins and disclose methods and materials for using that procedure to regulatably initiate cell-specific apoptosis (programmed cell death) in genetically engineered cells.
    Type: Grant
    Filed: August 18, 1994
    Date of Patent: November 10, 1998
    Assignees: President & Fellows of Harvard College, Board of Trustees of Leland Stanford Jr. University
    Inventors: Gerald R. Crabtree, Stuart L. Schreiber, David M. Spencer, Thomas J. Wandless, Peter Belshaw
  • Regulated transcription of targeted genes and other biological events
    Patent number: 5830462
    Abstract: Dimerization and oligomerization of proteins are general biological control mechanisms that contribute to the activation of cell membrane receptors, transcription factors, vesicle fusion proteins, and other classes of intra- and extracellular proteins. We have developed a general procedure for the regulated (inducible) dimerization or oligomerization of intracellular proteins. In principle, any two target proteins can be induced to associate by treating the cells or organisms that harbor them with cell permeable, synthetic ligands. To illustrate the practice of this invention, we have induced: (1) the intracellular aggregation of the cytoplasmic tail of the .zeta.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 3, 1998
    Assignees: President & Fellows of Harvard College, Board of Trustees of Leland S. Stanford, Jr. University
    Inventors: Gerald R. Crabtree, Stuart L. Schreiber, David M. Spencer, Thomas J. Wandless, Peter Belshaw
  • Transcriptional cofactor DCoH
    Patent number: 5620887
    Abstract: Methods and compositions are provided for producing and utilizing nucleic acid and peptide sequences associated with cofactors which bind to transcription factors to enhance transcriptional activity of the transcriptional factors and maintain the transcriptional factors as dimers. The compositions can be used for modulating expression of genes, particularly coordinately regulated genes, as evidenced by the combination of the transcription factors HNF-1.alpha. and -1.beta. with the cofactor DCoH.
    Type: Grant
    Filed: November 15, 1994
    Date of Patent: April 15, 1997
    Assignee: The Board of Trustees fot the Leland Stanford Junior University
    Inventors: Gerald R. Crabtree, Dirk B. Mendel
  • DNA encoding calcium-signal modulating cyclophilin ligand
    Patent number: 5523227
    Abstract: DNA and protein compositions are provided for calcium-signal modulating cyclophilin ligand which are shown to act in the calcium-dependent pathway for activation of a number of genes. The DNA composition and proteins may be used in investigating the processes associated with calcium-dependent activation of genes, as well as screening of drugs for interaction with the subject proteins for modulating cell processes, e.g. T-cell activation.
    Type: Grant
    Filed: June 17, 1994
    Date of Patent: June 4, 1996
    Assignee: The Board of Trustees of the Leland Stanford Junior Univ.
    Inventors: Richard J. Bram, Gerald R. Crabtree
  • Transcription cofactor assay
    Patent number: 5403712
    Abstract: Methods and compositions are provided for producing and utilizing nucleic acid and peptide sequences associated with cofactors which bind to transcription factors to enhance transcriptional activity of the transcriptional factors and maintain the transcriptional factors as dimers. The compositions can be used for modulating expression of genes, particularly coordinately regulated genes, as evidenced by the combination of the transcription factors HNF-1.alpha. and -1.beta. with the cofactor DCoH.
    Type: Grant
    Filed: November 22, 1993
    Date of Patent: April 4, 1995
    Assignee: The Board of Trustees of the Leland Stanford Jr. University
    Inventors: Gerald R. Crabtree, Dirk B. Mendel