Patents by Inventor Gerald Tometzki
Gerald Tometzki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8673586Abstract: A method of inhibiting or effecting the activity of protein kinase activity which comprises contacting a protein kinase with a compound of formula (I) being a derivative of a furanose or pyranose form of a monosaccharide, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: May 1, 2012Date of Patent: March 18, 2014Assignee: Alchemia LimitedInventors: Wim Meutermans, Karl Schafer, Michael L. West, Craig Muldoon, Fiona Foley, Natalie Bouloc, Gerald Tometzki
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Publication number: 20130011852Abstract: A method of inhibiting or effecting the activity of protein kinase activity which comprises contacting a protein kinase with a compound of formula (I) being a derivative of a furanose or pyranose form of a monosaccharide, or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: May 1, 2012Publication date: January 10, 2013Applicant: Alchemia LimitedInventors: Wim Meutermans, Karl Schafer, Michael L. West, Craig Muldoon, Fiona Foley, Natalie Bouloc, Gerald Tometzki
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Publication number: 20110201794Abstract: Methods are described for the preparation of combinatorial libraries of potentially biologically active disaccharide compounds. These compounds are variously functionalized, with a view to varying lipid solubility size, function an other properties, with the particular aim of discovering novel drug or drug-like compounds, or compounds with useful properties. The invention provides intermediates, processes and synthetic strategies for the solution or solid phase synthesis of disaccharides, variously functionalized about the sugar ring, including the addition of aromaticity and charge, and the placement of pharmaceutically useful groups and isosteres.Type: ApplicationFiled: December 17, 2010Publication date: August 18, 2011Applicant: Alchemia LimitedInventors: Wim Meutermans, Michael L. West, George Adamson, Giang Thanh Le, Nicholas B. Drinnan, Giovani Abbenante, Bernd Becker, Matthias Grathwohl, Premraj Rajaratnam, Gerald Tometzki
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Patent number: 7994140Abstract: The present invention relates to a method of identifying a candidate therapeutic agent. The method comprises contacting a G-Protein Coupled Receptor (GPCR) with a compound of General Formula (I), or a pharmaceutically acceptable salt thereof determining whether the compound inhibits or effects signal transduction activity of the GPCR, wherein a compound that inhibits or effects the activity of the GPCR is a candidate therapeutic agent.Type: GrantFiled: October 10, 2003Date of Patent: August 9, 2011Assignee: Alchemia LimitedInventors: Wim Meutermans, Glang Le Thanh, Giovanni Abbenante, Gerald Tometzki, Judy Halliday, Johannes Zuegg
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Patent number: 7875707Abstract: Methods are described for the preparation of combinatorial libraries of potentially biologically active disaccharide compounds. These compounds are variously functionalized, with a view to varying lipid solubility size, function an other properties, with the particular aim of discovering novel drug or drug-like compounds, or compounds with useful properties. The invention provides intermediates, processes and synthetic strategies for the solution or solid phase synthesis of disaccharides, variously functionalized about the sugar ring, including the addition of aromaticity and charge, and the placement of pharmaceutically useful groups and isosteres.Type: GrantFiled: April 24, 2003Date of Patent: January 25, 2011Assignee: Alchemia LimitedInventors: Wim Meutermans, Michael West, George Adamson, Giang Thanh Le, Nicholas B. Drinnan, Giovanni Abbenante, Bernd Becker, Matthias Grathwohl, Premraj Rajaratnam, Gerald Tometzki
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Patent number: 7700577Abstract: A method of inhibiting bacterial growth by contacting a bacteria with at least one disaccharide compound of General Formula I,Type: GrantFiled: October 16, 2003Date of Patent: April 20, 2010Assignee: Alchemia LimitedInventors: Wim Meutermans, Giang Le Thanh, Giovani Abbenante, Gerald Tometzki, George Adamson, Bernd Becker, Matthias Grathwohl, Premraj Rajaratnam
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Publication number: 20080280837Abstract: A method for inhibiting angiogenesis in a subject comprising administering to the subject at least one compound of General Formula (I), wherein the ring or any chiral center(s) may be of any configuration; Z is sulphur, oxygen, CH2, C(O), C(O)HN, NH, NRA or hydrogen, in the case where Z is hydrogen then R1 is not present, RA is selected from the set defined for R1 to R5, X and X? are independently oxygen or nitrogen providing that at least one X of General Formula (I) is nitrogen, X or X? may also combine independently with one of R1 to R5 to form an azide, R1 to R5 are independently selected from the following definition which includes but is not limited to H or an alkyl, acyl, alkenyl, alkynyl, heteroalkyl, aryl, heteroaryl, arylalkyl or heteroarylalkyl substituent of 1 to 20 atoms, which is optionally substituted, and can be branched or linear, and R6 and R7 are hydrogen, or may combine to form a carbonyl function.Type: ApplicationFiled: April 7, 2005Publication date: November 13, 2008Inventors: Judy Halliday, Wim Meutermans, Gerald Tometzki, Tracie E. Ramsdale, Johannes Zuegg, Bernd Becker, Craig Muldoon, Declan McKeveney, Rajaratnam Premraj, Glenn Condie
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Publication number: 20080176815Abstract: A method of inhibiting or effecting the activity of protein kinase activity which comprises contacting a protein kinase with a compound of formula (I) being a derivative of a furanose or pyranose form of a monosaccharide, or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: September 19, 2007Publication date: July 24, 2008Applicant: ALCHEMIA LIMITEDInventors: Wim Meutermans, Karl Schafer, Michael L. West, Craig Muldoon, Fiona Foley, Natalie Bouloc, Gerald Tometzki
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Publication number: 20080009418Abstract: A method of identifying biologically active compounds with defined selectivity profile comprises: (c) designing a library of compounds of formula (1) to scan molecular diversity; and (d) assaying the library of compounds in at least two different biological assays.Type: ApplicationFiled: October 4, 2005Publication date: January 10, 2008Applicant: Alchemia LTD.Inventors: Gerald Tometzki, Wim Meutermans, Bernd Becker, Johannes Zuegg, Rajaratnam Premraj, Craig Muldoon, Declan McKeveney, Glenn Condie
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Patent number: 7291623Abstract: A method of inhibiting or effecting the activity of protein kinase activity which comprises contacting a protein kinase with a compound of formula (I) being a derivative of a furanose or pyranose form of a monosaccharide, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: September 5, 2003Date of Patent: November 6, 2007Assignee: Alchemia LimitedInventors: Wim Meutermans, Karl Schafer, Michael L. West, Craig Muldoon, Fiona Foley, Natalie Bouloc, Gerald Tometzki
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Publication number: 20060223764Abstract: A method of inhibiting or effecting the activity of a GPCR which comprises contacting a GPCR with a compound of general formula 1, or a pharmaceutically acceptable salt thereofType: ApplicationFiled: October 10, 2003Publication date: October 5, 2006Inventors: Wim Meutermans, Glang Le Thanh, Giovanni Abbenante, Gerald Tometzki, Judy Halliday, Johannes Zuegg
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Publication number: 20060142217Abstract: A method of inhibiting bacterial growth by contacting a bacteria with at least one disaccharide compound of General Formula I,Type: ApplicationFiled: October 16, 2003Publication date: June 29, 2006Inventors: Wim Meutermans, Giang Le Thanh, Giovani Abbenante, Gerald Tometzki, George Adamson, Bernd Becker, Matthias Grathwohl, Premraj Rajaratnam
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Publication number: 20060121530Abstract: Methods are described for the preparation of combinatorial libraries of potentially biologically active disaccharide compounds. These compounds are variously functionalized, with a view to varying lipid solubility size, function an other properties, with the particular aim of discovering novel drug or drug-like compounds, or compounds with useful properties. The invention provides intermediates, processes and synthetic strategies for the solution or solid phase synthesis of disaccharides, variously functionalized about the sugar ring, including the addition of aromaticity and charge, and the placement of pharmaceutically useful groups and isosteres.Type: ApplicationFiled: April 24, 2003Publication date: June 8, 2006Inventors: Wim Meutermans, Michael West, George Adamson, Giang Thanh Le, Nicholas Drinnan, Giovani Abbenante, Bernd Becker, Matthias Grathwohl, Premraj Rajaratnam, Gerald Tometzki
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Publication number: 20050209176Abstract: A method of inhibiting or effecting the activity of protein kinase activity which comprises contacting a protein kinase with a compound of formula (I) being a derivative of a furanose or pyranose form of a monosaccharide, or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: September 5, 2003Publication date: September 22, 2005Applicant: ALCHEMIA LIMITEDInventors: Wim Meutermans, Karl Schafer, Michael West, Craig Muldoon, Fiona Foley, Natalie Bouloc, Gerald Tometzki