Patents by Inventor Gerald Tometzki

Gerald Tometzki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8673586
    Abstract: A method of inhibiting or effecting the activity of protein kinase activity which comprises contacting a protein kinase with a compound of formula (I) being a derivative of a furanose or pyranose form of a monosaccharide, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: May 1, 2012
    Date of Patent: March 18, 2014
    Assignee: Alchemia Limited
    Inventors: Wim Meutermans, Karl Schafer, Michael L. West, Craig Muldoon, Fiona Foley, Natalie Bouloc, Gerald Tometzki
  • Publication number: 20130011852
    Abstract: A method of inhibiting or effecting the activity of protein kinase activity which comprises contacting a protein kinase with a compound of formula (I) being a derivative of a furanose or pyranose form of a monosaccharide, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: May 1, 2012
    Publication date: January 10, 2013
    Applicant: Alchemia Limited
    Inventors: Wim Meutermans, Karl Schafer, Michael L. West, Craig Muldoon, Fiona Foley, Natalie Bouloc, Gerald Tometzki
  • Publication number: 20110201794
    Abstract: Methods are described for the preparation of combinatorial libraries of potentially biologically active disaccharide compounds. These compounds are variously functionalized, with a view to varying lipid solubility size, function an other properties, with the particular aim of discovering novel drug or drug-like compounds, or compounds with useful properties. The invention provides intermediates, processes and synthetic strategies for the solution or solid phase synthesis of disaccharides, variously functionalized about the sugar ring, including the addition of aromaticity and charge, and the placement of pharmaceutically useful groups and isosteres.
    Type: Application
    Filed: December 17, 2010
    Publication date: August 18, 2011
    Applicant: Alchemia Limited
    Inventors: Wim Meutermans, Michael L. West, George Adamson, Giang Thanh Le, Nicholas B. Drinnan, Giovani Abbenante, Bernd Becker, Matthias Grathwohl, Premraj Rajaratnam, Gerald Tometzki
  • Patent number: 7994140
    Abstract: The present invention relates to a method of identifying a candidate therapeutic agent. The method comprises contacting a G-Protein Coupled Receptor (GPCR) with a compound of General Formula (I), or a pharmaceutically acceptable salt thereof determining whether the compound inhibits or effects signal transduction activity of the GPCR, wherein a compound that inhibits or effects the activity of the GPCR is a candidate therapeutic agent.
    Type: Grant
    Filed: October 10, 2003
    Date of Patent: August 9, 2011
    Assignee: Alchemia Limited
    Inventors: Wim Meutermans, Glang Le Thanh, Giovanni Abbenante, Gerald Tometzki, Judy Halliday, Johannes Zuegg
  • Patent number: 7875707
    Abstract: Methods are described for the preparation of combinatorial libraries of potentially biologically active disaccharide compounds. These compounds are variously functionalized, with a view to varying lipid solubility size, function an other properties, with the particular aim of discovering novel drug or drug-like compounds, or compounds with useful properties. The invention provides intermediates, processes and synthetic strategies for the solution or solid phase synthesis of disaccharides, variously functionalized about the sugar ring, including the addition of aromaticity and charge, and the placement of pharmaceutically useful groups and isosteres.
    Type: Grant
    Filed: April 24, 2003
    Date of Patent: January 25, 2011
    Assignee: Alchemia Limited
    Inventors: Wim Meutermans, Michael West, George Adamson, Giang Thanh Le, Nicholas B. Drinnan, Giovanni Abbenante, Bernd Becker, Matthias Grathwohl, Premraj Rajaratnam, Gerald Tometzki
  • Patent number: 7700577
    Abstract: A method of inhibiting bacterial growth by contacting a bacteria with at least one disaccharide compound of General Formula I,
    Type: Grant
    Filed: October 16, 2003
    Date of Patent: April 20, 2010
    Assignee: Alchemia Limited
    Inventors: Wim Meutermans, Giang Le Thanh, Giovani Abbenante, Gerald Tometzki, George Adamson, Bernd Becker, Matthias Grathwohl, Premraj Rajaratnam
  • Publication number: 20080280837
    Abstract: A method for inhibiting angiogenesis in a subject comprising administering to the subject at least one compound of General Formula (I), wherein the ring or any chiral center(s) may be of any configuration; Z is sulphur, oxygen, CH2, C(O), C(O)HN, NH, NRA or hydrogen, in the case where Z is hydrogen then R1 is not present, RA is selected from the set defined for R1 to R5, X and X? are independently oxygen or nitrogen providing that at least one X of General Formula (I) is nitrogen, X or X? may also combine independently with one of R1 to R5 to form an azide, R1 to R5 are independently selected from the following definition which includes but is not limited to H or an alkyl, acyl, alkenyl, alkynyl, heteroalkyl, aryl, heteroaryl, arylalkyl or heteroarylalkyl substituent of 1 to 20 atoms, which is optionally substituted, and can be branched or linear, and R6 and R7 are hydrogen, or may combine to form a carbonyl function.
    Type: Application
    Filed: April 7, 2005
    Publication date: November 13, 2008
    Inventors: Judy Halliday, Wim Meutermans, Gerald Tometzki, Tracie E. Ramsdale, Johannes Zuegg, Bernd Becker, Craig Muldoon, Declan McKeveney, Rajaratnam Premraj, Glenn Condie
  • Publication number: 20080176815
    Abstract: A method of inhibiting or effecting the activity of protein kinase activity which comprises contacting a protein kinase with a compound of formula (I) being a derivative of a furanose or pyranose form of a monosaccharide, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: September 19, 2007
    Publication date: July 24, 2008
    Applicant: ALCHEMIA LIMITED
    Inventors: Wim Meutermans, Karl Schafer, Michael L. West, Craig Muldoon, Fiona Foley, Natalie Bouloc, Gerald Tometzki
  • Publication number: 20080009418
    Abstract: A method of identifying biologically active compounds with defined selectivity profile comprises: (c) designing a library of compounds of formula (1) to scan molecular diversity; and (d) assaying the library of compounds in at least two different biological assays.
    Type: Application
    Filed: October 4, 2005
    Publication date: January 10, 2008
    Applicant: Alchemia LTD.
    Inventors: Gerald Tometzki, Wim Meutermans, Bernd Becker, Johannes Zuegg, Rajaratnam Premraj, Craig Muldoon, Declan McKeveney, Glenn Condie
  • Patent number: 7291623
    Abstract: A method of inhibiting or effecting the activity of protein kinase activity which comprises contacting a protein kinase with a compound of formula (I) being a derivative of a furanose or pyranose form of a monosaccharide, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: September 5, 2003
    Date of Patent: November 6, 2007
    Assignee: Alchemia Limited
    Inventors: Wim Meutermans, Karl Schafer, Michael L. West, Craig Muldoon, Fiona Foley, Natalie Bouloc, Gerald Tometzki
  • Publication number: 20060223764
    Abstract: A method of inhibiting or effecting the activity of a GPCR which comprises contacting a GPCR with a compound of general formula 1, or a pharmaceutically acceptable salt thereof
    Type: Application
    Filed: October 10, 2003
    Publication date: October 5, 2006
    Inventors: Wim Meutermans, Glang Le Thanh, Giovanni Abbenante, Gerald Tometzki, Judy Halliday, Johannes Zuegg
  • Publication number: 20060142217
    Abstract: A method of inhibiting bacterial growth by contacting a bacteria with at least one disaccharide compound of General Formula I,
    Type: Application
    Filed: October 16, 2003
    Publication date: June 29, 2006
    Inventors: Wim Meutermans, Giang Le Thanh, Giovani Abbenante, Gerald Tometzki, George Adamson, Bernd Becker, Matthias Grathwohl, Premraj Rajaratnam
  • Publication number: 20060121530
    Abstract: Methods are described for the preparation of combinatorial libraries of potentially biologically active disaccharide compounds. These compounds are variously functionalized, with a view to varying lipid solubility size, function an other properties, with the particular aim of discovering novel drug or drug-like compounds, or compounds with useful properties. The invention provides intermediates, processes and synthetic strategies for the solution or solid phase synthesis of disaccharides, variously functionalized about the sugar ring, including the addition of aromaticity and charge, and the placement of pharmaceutically useful groups and isosteres.
    Type: Application
    Filed: April 24, 2003
    Publication date: June 8, 2006
    Inventors: Wim Meutermans, Michael West, George Adamson, Giang Thanh Le, Nicholas Drinnan, Giovani Abbenante, Bernd Becker, Matthias Grathwohl, Premraj Rajaratnam, Gerald Tometzki
  • Publication number: 20050209176
    Abstract: A method of inhibiting or effecting the activity of protein kinase activity which comprises contacting a protein kinase with a compound of formula (I) being a derivative of a furanose or pyranose form of a monosaccharide, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: September 5, 2003
    Publication date: September 22, 2005
    Applicant: ALCHEMIA LIMITED
    Inventors: Wim Meutermans, Karl Schafer, Michael West, Craig Muldoon, Fiona Foley, Natalie Bouloc, Gerald Tometzki