Patents by Inventor Gerard A. Ateshian
Gerard A. Ateshian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230248570Abstract: The presently disclosed subject matter provides techniques for inducing collagen cross-linking in human tissue, such as cartilage, by inducing ionization of the water contained in the tissue to produce free radicals that induce chemical cross-linking in the human tissue. In an embodiment, a femtosecond laser operates at sufficiently low laser pulse energy to avoid optical breakdown of the tissue being treated. In an embodiment, the femtosecond laser operates in the infrared frequency range.Type: ApplicationFiled: January 12, 2023Publication date: August 10, 2023Applicant: The Trustees of Columbia University in the City of New YorkInventors: Sinisa VUKELIC, Gerard A. ATESHIAN
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Patent number: 11559433Abstract: The presently disclosed subject matter provides techniques for inducing collagen cross-linking in human tissue, such as cartilage, by inducing ionization of the water contained in the tissue to produce free radicals that induce chemical cross-linking in the human tissue. In an embodiment, a femtosecond laser operates at sufficiently low laser pulse energy to avoid optical breakdown of the tissue being treated. In an embodiment, the femtosecond laser operates in the infrared frequency range.Type: GrantFiled: February 23, 2021Date of Patent: January 24, 2023Assignee: The Trustees of Columbia University in the City of New YorkInventors: Sinisa Vukelic, Gerard A. Ateshian
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Patent number: 11497403Abstract: The present application discloses methods, devices, and systems for generating spatially-resolved quantification of cross-linking in cartilage based on Raman scattering of excitation light. The examples presented demonstrate that the method provides a discriminating power sufficient to distinguish early onset of osteo-arthritis even before a patient is symptomatic.Type: GrantFiled: June 10, 2017Date of Patent: November 15, 2022Assignee: The Trustees of Columbia University in the City of New YorkInventors: Sinisa Vukelic, Gerard A. Ateshian
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Publication number: 20210196509Abstract: The presently disclosed subject matter provides techniques for inducing collagen cross-linking in human tissue, such as cartilage, by inducing ionization of the water contained in the tissue to produce free radicals that induce chemical cross-linking in the human tissue. In an embodiment, a femtosecond laser operates at sufficiently low laser pulse energy to avoid optical breakdown of the tissue being treated. In an embodiment, the femtosecond laser operates in the infrared frequency range.Type: ApplicationFiled: February 23, 2021Publication date: July 1, 2021Applicant: The Trustees of Columbia University in the City of New YorkInventors: Sinisa VUKELIC, Gerard A. ATESHIAN
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Publication number: 20210187165Abstract: Treatment systems and methods are disclosed that may be used to strengthen cartilage. The disclosed subject matter includes description of this advantage and associated experimental results. The systems and methods employ ultrafast laser-based treatment to induce crosslinks into the collagen network of the tissue media without the addition of a chemical agent. The system and related methods may also be used for other purposes discussed herein.Type: ApplicationFiled: December 15, 2020Publication date: June 24, 2021Applicant: The Trustees of Columbia University in the City of New YorkInventors: Sinisa VUKELIC, Gerard A. ATESHIAN, Chao WANG, Krista M. DURNEY
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Patent number: 10722370Abstract: A customized allograft that is bendable and suitable for allo-grafting of an articular joint, including the thumb.Type: GrantFiled: February 21, 2019Date of Patent: July 28, 2020Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventors: Melvin P. Rosenwasser, Gerard A. Ateshian, Clark T. Hung, Brian K. Jones
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Publication number: 20190246907Abstract: The present application discloses methods, devices, and systems for generating spatially-resolved quantification of cross-linking in cartilage based on Raman scattering of excitation light. The examples presented demonstrate that the method provides a discriminating power sufficient to distinguish early onset of osteo-arthritis even before a patient is symptomatic.Type: ApplicationFiled: June 10, 2017Publication date: August 15, 2019Applicant: The Trustees of Columbia University in the City of New YorkInventors: Sinisa VUKELIC, Gerard A. ATESHIAN
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Publication number: 20190175349Abstract: A customized allograft that is bendable and suitable for allo-grafting of an articular joint, including the thumb.Type: ApplicationFiled: February 21, 2019Publication date: June 13, 2019Inventors: Melvin P. Rosenwasser, Gerard A. Ateshian, Clark T. Hung, Brian K. Jones
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Patent number: 10251751Abstract: A customized allograft that is bendable and suitable for allo-grafting of an articular joint, including the thumb.Type: GrantFiled: March 11, 2015Date of Patent: April 9, 2019Assignee: The Trustees of Columbia University In The City of New YorkInventors: Melvin P. Rosenwasser, Gerard A. Ateshian, Clark T. Hung, Brian K. Jones
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Publication number: 20170056181Abstract: A customized allograft that is bendable and suitable for allo-grafting of an articular joint, including the thumb.Type: ApplicationFiled: March 11, 2015Publication date: March 2, 2017Inventors: Melvin P. Rosenwasser, Gerard A. Ateshian, Clark T. Hung, Brian K. Jones
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Publication number: 20140091491Abstract: Implants for resurfacing or repairing one or more articular cartilage bearing surfaces of a biological organism include an engineered tissue and a biocompatible porous substrate secured to the engineered tissue for attaching the implant to a native bone of the biological organism. The engineered tissue includes a scaffold containing a biocompatible material, and a plurality of living chondrocytes supported by the scaffold. Methods for culturing chondrocytes for incorporation into a biocompatible implant are provided. A bioreactor for producing functional cartilaginous tissue from a cell-seeded scaffold and a system for producing functional cartilaginous tissue are also provided.Type: ApplicationFiled: December 12, 2013Publication date: April 3, 2014Applicants: The Trustees of Columbia University in the City of New York, THE CURATORS OF THE UNIVERSITY OF MISSOURIInventors: Clark T. Hung, Gerard A. Ateshian, Eric G. Lima, James L. Cook, Li Ming Bian
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Patent number: 8608801Abstract: Implants for resurfacing or repairing one or more articular cartilage bearing surfaces of a biological organism include an engineered tissue and a biocompatible porous substrate secured to the engineered tissue for attaching the implant to a native bone of the biological organism. The engineered tissue includes a scaffold containing a biocompatible material, and a plurality of living chondrocytes supported by the scaffold. Methods for culturing chondrocytes for incorporation into a biocompatible implant are provided. A bioreactor for producing functional cartilaginous tissue from a cell-seeded scaffold and a system for producing functional cartilaginous tissue are also provided.Type: GrantFiled: July 6, 2009Date of Patent: December 17, 2013Assignees: The Trustees of Columbia University in the City of New York, The Curators of the University of MissouriInventors: Clark T. Hung, Gerard A. Ateshian, Eric G. Lima, James L. Cook, Li Ming Bian
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Publication number: 20100036492Abstract: Implants for resurfacing or repairing one or more articular cartilage bearing surfaces of a biological organism include an engineered tissue and a biocompatible porous substrate secured to the engineered tissue for attaching the implant to a native bone of the biological organism. The engineered tissue includes a scaffold containing a biocompatible material, and a plurality of living chondrocytes supported by the scaffold. Methods for culturing chondrocytes for incorporation into a biocompatible implant are provided. A bioreactor for producing functional cartilaginous tissue from a cell-seeded scaffold and a system for producing functional cartilaginous tissue are also provided.Type: ApplicationFiled: July 6, 2009Publication date: February 11, 2010Applicants: THE CURATORS OF THE UNIVERSITY OF MISSOURI, The Trustees of Columbia University in the City of New YorkInventors: Clark T. Hung, Gerard A. Ateshian, Eric G. Lima, James L. Cook, Li Ming Bian
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Publication number: 20060036331Abstract: This invention pertains to materials and methods relating to the biological fixation of one tissue type to another different tissue type, i.e., the fixation of cartilage to bone. A scaffold apparatus for osteochondral tissue engineering is described. The apparatus comprises regions of varying matrices which provide a functional interface between multiple tissue types. Further, a method for preparing the scaffold apparatus is provided. Methods for treating osteochondral tissue injury and cartilage degeneration using the scaffold apparatus are also described. In addition, a method for evaluating cell-mediated and scaffold-related parameters of development and maintenance of multiple tissue zones in vitro is described.Type: ApplicationFiled: March 4, 2005Publication date: February 16, 2006Inventors: Helen Lu, Jie Jiang, Clark Hung, X. Guo, Gerard Ateshian
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Patent number: 6459948Abstract: A joint prosthesis for attachment to a bone of a patient, comprising an anchor with a head surface and a stem for attachment to an end of the bone, the head surface having an anatomically accurate shape.Type: GrantFiled: October 8, 1999Date of Patent: October 1, 2002Assignee: The Trustees of Columbia University in the City of New YorkInventors: Gerard A. Ateshian, Van C. Mow, Robert J. Pawluk, Melvin P. Rosenwasser
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Patent number: 6126690Abstract: A joint prosthesis for attachment to a bone of a patient, comprising an anchor with a head surface and a stem for attachment to an end of the bone, the head surface having an anatomically accurate shape.Type: GrantFiled: July 3, 1996Date of Patent: October 3, 2000Assignee: The Trustees of Columbia University in the City of New YorkInventors: Gerard A. Ateshian, Van C. Mow, Robert J. Pawluk, Melvin P. Rosenwasser