Patents by Inventor Gerard Le Fur

Gerard Le Fur has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5256649
    Abstract: The invention relates to a cosmetic composition comprising a mixture of(a) betaine,(b) ATP or an ATP generating system,(c) a magnesium salt, and(d) a potassium salt,in a cosmetically acceptable vehicle for topical administration and to a method for counteracting aging of the skin in a living human which utilizes the new composition.
    Type: Grant
    Filed: May 22, 1992
    Date of Patent: October 26, 1993
    Assignee: Elf Sanofi
    Inventors: Gerard Le Fur, Michel Sabadie
  • Patent number: 5134124
    Abstract: The invention relates to the use of N-(3-pyridylpropionyl)phenylalanylhistidyl (cyclohexyl)statyl-N-(1,3-dihydroxy-2-methylpropyl)isoleucinamide, which has the formula ##STR1## in which: Phe is the (L)-phenylalanine residue, His is the (L)-histidine residue, Ile is the (L)-isoleucine residue and (cyclohexyl)Sta is the cyclohexylstatin residue, i.e. the (3S, 4S)-4-amino-5-cyclohexyl-3-hydroxypentanoic acid residue, for the preparation of drugs useful in the treatment of eye complaints. Application: treatment of eye complaints.
    Type: Grant
    Filed: June 4, 1990
    Date of Patent: July 28, 1992
    Assignee: Sanofi
    Inventors: Dino Nisato, Gerard Le Fur
  • Patent number: 5026716
    Abstract: A method of treatment of anxiety and depression in mammals is described which comprises administering to a mammal in need thereof an effective amount of a trifluoromethylphenyl-tetrahydropyridine derivative of formula I ##STR1## wherein Alk represents a straight or branched (C.sub.1 -C.sub.4)alkylene chain and R is selected from the group consisting of cyano, acetyl, (C.sub.3 -C.sub.7)cycloalkyl, pyridyl, 1-oxide-pyridyl and naphthyl, or of a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: November 17, 1989
    Date of Patent: June 25, 1991
    Assignee: Sanofi
    Inventors: Alberto Bianchetti, Gerard Le Fur, Jacques Simiand, Philippe Soubrie
  • Patent number: 5017579
    Abstract: The present invention is directed to the use of aminoalkoxyphenyl derivatives for reducing and/or controlling excessive intraocular pressure and compositions suitable for this case.
    Type: Grant
    Filed: February 6, 1989
    Date of Patent: May 21, 1991
    Assignee: Sanofi
    Inventors: Jean Gubin, Pierre Chatelain, Marcel Descamps, Dino Nisato, Henri Inion, Jean Lucchetti, Jean-Marie Mahaux, Jean-Noel Vallat, Gerard Le Fur
  • Patent number: 4956173
    Abstract: The present invention relates to the use of ademetionine or one of its salts for the preparation of pharmaceutical or cosmetic compositions for counteracting ageing of the skin.It further relates to the said cosmetic compositions.
    Type: Grant
    Filed: November 25, 1988
    Date of Patent: September 11, 1990
    Assignee: Societe Anonyme: SANOFI
    Inventors: Gerard Le Fur, Michele Bousquet, Emilio Crisafulli, Michel Sabadie
  • Patent number: 4788199
    Abstract: Amides of formula: ##STR1## in which A is ##STR2## V and W are H, halogen, alkyl (1-3C), alkoxy (1-3C), NO.sub.2 or CF.sub.3, Z is bound in the ortho or para position with respect to B and is phenyl, optionally substituted, thienyl or pyridyl, the chain X--(CH.sub.2).sub.n --(CHR).sub.m --CO--NR.sub.1 R.sub.2 is bound in the ortho or para position with respect to B,R is H or alkyl (1-3C),R.sub.1 and R.sub.2 are alkyl (1-6C), cycloalkyl (3-6C), phenyl, phenylalkyl, cycloalkylalkyl, alkenyl (3-6C),R.sub.1 and R.sub.2 can also form, with the nitrogen atom to which they are attached, a pyrrolidine, piperidine, morpholine or thiomorpholine ring,X is >CH--R.sub.3, >N--R.sub.4, >SO, >SO.sub.2, >O or >S,R.sub.3 is H, alkyl (1-3C),R.sub.4 is alkyl (1-3C)m=0 or 1 and n=0, 1 or 2,provided that, if X is >SO, >SO.sub.2 or >N--R.sub.4 , the sum m+n is equal to at least 1, that, when A and B are N and Z is in the para position with respect to B, X cannot denote the group >CH--R.sub.
    Type: Grant
    Filed: March 11, 1988
    Date of Patent: November 29, 1988
    Assignee: Rhone-Poulenc Sante
    Inventors: Jesus Benavides, Marie-Christine Dubroeucq, Gerard Le Fur, Christian Renault
  • Patent number: 4728647
    Abstract: Compounds of formula: ##STR1## in which V and W are H, halogen, alkyl (1-4C) or alkoxy (1-4C), amino, or acylamino,Z is phenyl, optionally substituted, thienyl, or pyridyl,R.sub.1 is alkyl (1-6C), alkoxyalkyl, cycloalkyl (3-6C), phenyl, phenylalkyl, or cycloalkylalkyl,R.sub.2 is alkyl (1-6C), alkoxyalkyl, cycloalkyl (3-6C), phenyl, phenylalkyl, cycloalkylalkyl, or morpholino, andNR.sub.1 R.sub.2 can also be pyrrolidino, optionally substituted piperidino, optionally substituted morpholino, thiomorpholino, optionally substituted piperazino, or an optionally substituted piperazinone, are useful as anxiolytic agents.
    Type: Grant
    Filed: May 28, 1986
    Date of Patent: March 1, 1988
    Assignee: Rhone-Poulenc Sante
    Inventors: Jesus Benavides, Marie-Christine Dubroeucq, Gerard Le Fur, Christian Renault
  • Patent number: 4499094
    Abstract: Compounds with the formula: ##STR1## in which R.sub.1 and R.sub.2 represent independently, a linear or branched alkyl, cycloalkyl, phenylalkyl or cycloalkylalkyl group. R.sub.1 and R.sub.2 may also represent an alkenyl or alkynyl group. R.sub.1 and R.sub.2 may also represent a group of the formula --R.sub.3 --Z--R.sub.4 in which R.sub.3 represents an alkylene group, on condition that at least 2 carbon atoms separate the nitrogen atom from the group Z; R.sub.4 represents an alkyl group, and Z an atom of oxygen, sulphur or the group >N--R.sub.5, R.sub.5 representing a hydrogen atom or an alkyl group. R.sub.1 and R.sub.2 may form, with the nitrogen atom to which they are attached, a heterocyclic ring. Ar represents a phenyl, pyridyl or thienyl group, or a substituted phenyl group, A and B representing independently, N or CH--, the group C representing the residue of a benzene or thiophene ring. These compounds can be used as medicaments, in particular, for the various applications of benzodiazepines.
    Type: Grant
    Filed: April 5, 1983
    Date of Patent: February 12, 1985
    Assignee: Pharmuka Laboratoires
    Inventors: Marie-Christine Dubroeucq, Christian Renault, Gerard Le Fur