Patents by Inventor Gerardus Johannes Kemperman

Gerardus Johannes Kemperman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20140154322
    Abstract: The present invention provides a formulation comprising asenapine hemipamoate suspended particles, which formulation can be administered via a Depot provided by an IM injection of the formulation, and which depot does not display a particle-size dependent release rate. The present invention provides also methods of treatment using the same.
    Type: Application
    Filed: December 17, 2013
    Publication date: June 5, 2014
    Inventors: Werenfridus Adrianus Faassen, Gerardus Johannes Kemperman, Johannes Antonius van Laarhoven
  • Patent number: 8426610
    Abstract: Disclosed are novel amino acid derivatives of formula (I) and (II) processes for the preparation thereof, and their use in the preparation of trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino-[4,5-c]pyrrole.
    Type: Grant
    Filed: May 2, 2011
    Date of Patent: April 23, 2013
    Assignee: Merck Sharp & Dohme B.V.
    Inventors: Gerardus Johannes Kemperman, Jacobus Johannes Maria Van Der Linden, Michael R. Reeder
  • Patent number: 8227623
    Abstract: The invention relates to a novel process for the preparation of asenapine, i.e. trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole, as well as to novel intermediate products for use in said process.
    Type: Grant
    Filed: May 24, 2010
    Date of Patent: July 24, 2012
    Assignee: MSD Oss B.V.
    Inventors: Gerardus Johannes Kemperman, Timothy Lee Stuk, Jacobus Johannes Maria Van Der Linden
  • Patent number: 8058436
    Abstract: The invention provides a method for the preparation of enantiomerically pure mirtazapine, said method comprising a step of ring closure of a compound of formula (II) wherein X is a leaving group, said step comprising treatment with an acid, whereby mirlazapine with enantiomeric excess is formed by the ring closure of the compound of formula (II) with enantiomeric excess by treatment with a suitable acid in the absence of a solvent or a suitable combination of an acid and an organic solvent.
    Type: Grant
    Filed: July 5, 2004
    Date of Patent: November 15, 2011
    Assignee: N.V. Organon
    Inventors: Johannes Hubertus Wieringa, Adrianus Antonius Martinus Van De Ven, Gerardus Johannes Kemperman
  • Publication number: 20110207942
    Abstract: Disclosed are novel amino acid derivatives of formula (I) and (II) processes for the preparation thereof, and their use in the preparation of trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino-[4,5-c]pyrrole.
    Type: Application
    Filed: May 2, 2011
    Publication date: August 25, 2011
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Gerardus Johannes Kemperman, Jacobus Johannes Maria Van Der Linden, Michael R. Reeder
  • Patent number: 7994314
    Abstract: The invention relates to the preparation of mirtazapine precursors and mirtazapine preferably having a substantial enantiomeric excess.
    Type: Grant
    Filed: April 7, 2008
    Date of Patent: August 9, 2011
    Assignee: N.V. Organon
    Inventors: Gerardus Johannes Kemperman, Johannes Paulus Gerardus Seerden
  • Publication number: 20110166363
    Abstract: The invention relates to a novel process for the preparation of asenapine, i.e. trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole, as well as to novel intermediate products for use in said process.
    Type: Application
    Filed: March 16, 2011
    Publication date: July 7, 2011
    Inventor: Gerardus Johannes Kemperman
  • Patent number: 7964739
    Abstract: The invention relates to a novel process for the preparation of asenapine, i.e. trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole, as well as to novel intermediate products for use in said process.
    Type: Grant
    Filed: December 22, 2008
    Date of Patent: June 21, 2011
    Assignee: N.V. Organon
    Inventor: Gerardus Johannes Kemperman
  • Patent number: 7956202
    Abstract: Disclosed are novel amino acid derivatives of formula (I) and (II) processes for the preparation thereof, and their use in the preparation of trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino-[4,5-c]pyrrole.
    Type: Grant
    Filed: December 7, 2009
    Date of Patent: June 7, 2011
    Inventors: Gerardus Johannes Kemperman, Jacobus Johannes Maria Van Der Linden, Michael R. Reeder
  • Patent number: 7872147
    Abstract: Disclosed are novel amino acid derivatives of formula (I) and (II) processes for the preparation thereof, and their use in the preparation of trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino-[4,5-c]pyrrole.
    Type: Grant
    Filed: April 6, 2006
    Date of Patent: January 18, 2011
    Assignee: N. V. Organon
    Inventors: Gerardus Johannes Kemperman, Jacobus Johannes Maria Van Der Linden, Michael R. Reeder
  • Publication number: 20100234618
    Abstract: The invention relates to a novel process for the preparation of asenapine, i.e. trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole, as well as to novel intermediate products for use in said process.
    Type: Application
    Filed: May 24, 2010
    Publication date: September 16, 2010
    Applicant: N.V. Organon
    Inventors: Gerardus Johannes Kemperman, Timothy Lee Stuk, Jacobus Johannes Maria Van Der Linden
  • Patent number: 7750167
    Abstract: The invention relates to a novel process for the preparation of asenapine, i.e. trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole, as well as to novel intermediate products for use in said process.
    Type: Grant
    Filed: July 3, 2007
    Date of Patent: July 6, 2010
    Assignee: N.V. Organon
    Inventors: Gerardus Johannes Kemperman, Timothy Lee Stuk, Jacobus Johannes Maria Van Der Linden
  • Publication number: 20100152461
    Abstract: Disclosed are novel amino acid derivatives of formula (I) and (II) processes for the preparation thereof, and their use in the preparation of trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino-[4,5-c]pyrrole.
    Type: Application
    Filed: December 7, 2009
    Publication date: June 17, 2010
    Inventors: GERARDUS JOHANNES KEMPERMAN, JACOBUS JOHANNES MARIA VAN DER LINDEN, MICHAEL R. REEDER
  • Publication number: 20100036126
    Abstract: This invention provides for a compound according to Formula (1), wherein R1 is methyl, ethyl, n-propyl, isopropyl, benzyl or 2-haloethyl and the use thereof in a method to prepare (S)-1-methyl-3-phenylpiperazine by enzymatic hydrolysis of the compound, followed by separation and cleavage of the oxalamic groups, whereby the protease of Streptomyces griseus is used as enzyme for the enzymatic hydrolysis.
    Type: Application
    Filed: June 14, 2007
    Publication date: February 11, 2010
    Applicant: N.V. Organon
    Inventors: Michiel Christian Alexander van Vliet, Gerardus Johannes Kemperman, Marcel Schreuder Goedheijt
  • Publication number: 20090227803
    Abstract: The invention relates to a novel process for the preparation of asenapine, i.e. trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole, as well as to novel intermediate products for use in said process.
    Type: Application
    Filed: December 22, 2008
    Publication date: September 10, 2009
    Inventor: Gerardus Johannes Kemperman
  • Publication number: 20080255349
    Abstract: The invention relates to a method for the preparation of a cyclic compound according to formula III comprising reacting a compound according to Formula I and a compound according to formula II, wherein in Formula I, R1, R2, R3 and R4 may be hydrogen or substituent groups comprising one or more carbon atoms and/or hetero-atoms, wherein R1, R2, R3 and R4 can be combined in aromatic or aliphatic ring structures, —Y is a ring element comprising 1-3 substituted or unsubstituted carbon atoms and/or heteroatoms in the ring and —R5 is hydrogen or a hydrocarbon substituent group comprising one or more carbon atoms and optionally one or more hetero atoms, and wherein in Formula II, Z1 and Z2 are, leaving groups, X is a reactive functional hydrocarbon group for subsequent ring closure, comprising one or more carbon atoms and a reactive functional group and having a chain of between 1 to 6 atoms between the carbon atom attached to the central carbon atom of formula II and the reactive functional group and R8 is hydro
    Type: Application
    Filed: April 7, 2008
    Publication date: October 16, 2008
    Inventors: Gerardus Johannes Kemperman, Johannes Paulus Gerardus Seerden
  • Publication number: 20080255348
    Abstract: The present invention relates to a method for the preparation of mirtazapine and tetracyclic analogous compounds having substantial enantiomeric excess of the R or S form. The invention further relates to a novel intermediate and its use for the preparation of mirtazapine having a substantial enantiomeric excess of the R or S form. The method comprising the steps of a: providing a carboxylic acid compound according to Formula I having a substantial enantiomeric excess of the R or S form, b: converting the carboxylic acid group of compound I into a ketone group, producing a ketone compound of Formula II, c: optionally reducing ketone compound II with a mild reduction agent to form the intermediate hydroxy compound of Formula III and d: forming the mirtazapine of Formula IV by reduction of the ketone compound II or of the hydroxy compound III using a strong reduction agent.
    Type: Application
    Filed: April 7, 2008
    Publication date: October 16, 2008
    Inventor: Gerardus Johannes Kemperman
  • Publication number: 20080009619
    Abstract: The invention relates to a novel process for the preparation of asenapine, i.e. trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole, as well as to novel intermediate products for use in said process.
    Type: Application
    Filed: July 3, 2007
    Publication date: January 10, 2008
    Applicant: N.V. Organon
    Inventors: Gerardus Johannes Kemperman, Timothy Lee Stuk, Jacobus Johannes Maria Van Der Linden