Patents by Inventor Gerd-Reudiger Burmester

Gerd-Reudiger Burmester has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BIOMARKERS PREDICTIVE OF THE RESPONSIVENESS TO TNFALPHA INHIBITORS IN AUTOIMMUNE DISORDERS
    Publication number: 20120039900
    Abstract: The invention provides methods for predicting responsiveness to TNF? inhibitors in a subject suffering from an autoimmune disorder, such as rheumatoid arthritis. The methods involve assaying for expression of one or more biomarkers in the subject that are predictive of responsiveness to TNF? inhibitors. A preferred biomarker of the invention is CD11c. The methods can further comprise selecting a treatment regimen with a TNF? inhibitor in an autoimmune disorder subject based upon expression of the biomarker(s) in the subject. The methods can further comprise administering a TNF? inhibitor to the subject according to the selected treatment regimen. Kits that include means for measuring expression of one or more biomarkers that are predictive of responsiveness to TNF? inhibitors for an autoimmune disorder are also provided. Methods of preparing and using databases, and computer program products therefore, for selecting an autoimmune disorder subject for treatment with a TNF? inhibitor are also provided.
    Type: Application
    Filed: October 27, 2011
    Publication date: February 16, 2012
    Applicant: Abbott Laboratories
    Inventors: Bruno Stuhlmüller, Gerd-Reudiger Burmester
  • Biomarkers predictive of the responsiveness to TNF? inhibitors in autoimmune disorders
    Patent number: 8092998
    Abstract: The invention provides methods for predicting responsiveness to TNF? inhibitors in a subject suffering from an autoimmune disorder, such as rheumatoid arthritis. The methods involve assaying for expression of one or more biomarkers in the subject that are predictive of responsiveness to TNF? inhibitors. A preferred biomarker of the invention is CD11c. The methods can further comprise selecting a treatment regimen with a TNF? inhibitor in an autoimmune disorder subject based upon expression of the biomarker(s) in the subject. The methods can further comprise administering a TNF? inhibitor to the subject according to the selected treatment regimen. Kits that include means for measuring expression of one or more biomarkers that are predictive of responsiveness to TNF? inhibitors for an autoimmune disorder are also provided. Methods of preparing and using databases, and computer program products therefore, for selecting an autoimmune disorder subject for treatment with a TNF? inhibitor are also provided.
    Type: Grant
    Filed: May 30, 2008
    Date of Patent: January 10, 2012
    Assignee: Abbott Laboratories
    Inventors: Bruno Stuhlmüller, Gerd-Reudiger Burmester
  • BIOMARKERS PREDICTIVE OF THE RESPONSIVENESS TO TNFalpha INHIBITORS IN AUTOIMMUNE DISORDERS
    Publication number: 20090017472
    Abstract: The invention provides methods for predicting responsiveness to TNF? inhibitors in a subject suffering from an autoimmune disorder, such as rheumatoid arthritis. The methods involve assaying for expression of one or more biomarkers in the subject that are predictive of responsiveness to TNF? inhibitors. A preferred biomarker of the invention is CD11c. The methods can further comprise selecting a treatment regimen with a TNF? inhibitor in an autoimmune disorder subject based upon expression of the biomarker(s) in the subject. The methods can further comprise administering a TNF? inhibitor to the subject according to the selected treatment regimen. Kits that include means for measuring expression of one or more biomarkers that are predictive of responsiveness to TNF? inhibitors for an autoimmune disorder are also provided. Methods of preparing and using databases, and computer program products therefore, for selecting an autoimmune disorder subject for treatment with a TNF? inhibitor are also provided.
    Type: Application
    Filed: May 30, 2008
    Publication date: January 15, 2009
    Inventors: BRUNO STUHLMULLER, Gerd-Reudiger Burmester