Patents by Inventor Gerhard Jaehne

Gerhard Jaehne has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted indoles
    Patent number: 7342029
    Abstract: Compounds of the formula I are suitable for preparing pharmaceuticals for the prophylaxis and therapy of disorders in whose course an increased activity of NF?B is involved.
    Type: Grant
    Filed: July 22, 2005
    Date of Patent: March 11, 2008
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Olaf Ritzeler, Hans Ulrich Stilz, Bernhard Neises, Gerhard Jaehne, Joerg Habermann
  • SUBSTITUTED 8-AMINOALKOXY-XANTHINE COMPOUNDS AND COMPOSITIONS USEFUL IN THE TREATMENT OF HYPERLIPIDEMIA AND DIABETES
    Publication number: 20070299090
    Abstract: Compounds for the treatment of elevated blood glucose levels and the physiological and metabolic disorders arising therefrom are disclosed which are inhibitors of the enzyme dipeptidyl peptidase IV (DDP-IV) and comprise novel substituted bicyclic 8-pyrrolidinoxanthines of formula I and their derivatives: wherein the various R-groups are defined herein. These compounds may be combined with other secondary active compounds which also are effective in the treatment of said disorders and the disease states or physiological manifestations arising therefrom.
    Type: Application
    Filed: February 13, 2007
    Publication date: December 27, 2007
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Karl Schoenafinger, Gerhard Jaehne, Elisabeth Defossa, Christian Buning, Georg Tschank, Ulrich Werner
  • SUBSTITUTED 8-AMINOALKYLTHIOXANTHINES, AND THEIR USE AS INHIBITORS OF DIPEPTIDYL PEPTIDASE IV
    Publication number: 20070265284
    Abstract: The invention 8-aminothioxanthines and the derivatives of formula I wherein the various R groups and substituents are comprised of a number of different (C1-C10)-alkyl, cycloalkyl, aryl, alkene, alkyne, etc.
    Type: Application
    Filed: January 11, 2007
    Publication date: November 15, 2007
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Karl Schoenafinger, Gerhard Jaehne, Elisabeth Defossa, Guenter Billen, Christian Buning, Georg Tschank, Ulrich Werner
  • Indole derivatives or benzimidazole derivatives for modulating I?B kinase
    Patent number: 7285560
    Abstract: The present invention relates to indole derivatives or benzimidazole derivatives, to processes for preparing such compounds, to pharmaceutical compositions comprising such compounds, and methods for the prophylaxis and therapy of a disease associated with an increased activity of I?B kinase comprising administering such compounds.
    Type: Grant
    Filed: August 18, 2003
    Date of Patent: October 23, 2007
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Olaf Ritzeler, Gerhard Jaehne
  • Indole Derivatives or Benzimidazole Derivatives for Modulating IkB Kinase
    Publication number: 20070244139
    Abstract: The present invention relates to indole derivatives or benzimidazole derivatives, to processes for preparing such compounds, to pharmaceutical compositions comprising such compounds, and methods for the prophylaxis and therapy of a disease associated with an increased activity of I?B kinase comprising administering such compounds.
    Type: Application
    Filed: June 6, 2007
    Publication date: October 18, 2007
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Olaf RITZELER, Gerhard JAEHNE
  • Novel diphenylazetidinones, process for their preparation, medicaments comprising these compounds and their use
    Publication number: 20070208179
    Abstract: Compounds of the formula I, in which R1, R2, R3, R4, R5, and R6 have the meanings given in the description, and their physiologically acceptable salts. The compounds are suitable for use, for example, as hypolipidemics.
    Type: Application
    Filed: May 7, 2007
    Publication date: September 6, 2007
    Inventors: Heiner Glombik, Werner Krame, Stefanie Flohr, Wendelin Frick, Hubert Heuer, Gerhard Jaehne, Andreas Lindenschmidt, Hans-Ludwig Schafer
  • Adenosine analogues and their use as pharmaceutical agents
    Patent number: 7265111
    Abstract: The present invention relates to compounds according to the general formula (I) wherein X is selected from the group consisting of wherein n and p are independently 0, 1, 2, or 3, provided that n+p is a least 1; and unsubstituted and at least monosubstituted C1-C10-alkylene-Y, C2-C10-alkylene-Y, C3-C10-cycloalkylene-Y and C3-C10-cycloalkenylene-Y; and R1, A, B, Q, T, Y, E and W have the meanings given in the description. These compounds are useful for the manufacture of a medicament for the treatment of insulin resistance, type 2 diabetes, metabolic syndrome, lipid disorders or cardiovasular disease or for providing an anti-lipolytic effect.
    Type: Grant
    Filed: June 27, 2003
    Date of Patent: September 4, 2007
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Antony Bigot, Siegfried Stengelin, Gerhard Jaehne, Andreas Herling, Guenter Mueller, Franz Jakob Hock, Michael R Myers
  • NOVEL DIPHENYLAZETIDINONE WITH IMPROVED PHYSIOLOGICAL PROPERTIES, PROCESS FOR ITS PREPARATION, MEDICAMENTS COMPRISING THIS COMPOUND, AND ITS USE
    Publication number: 20070197498
    Abstract: Novel diphenylazetidinone, process for its preparation, medicaments comprising this compound and their use The invention relates to the compound of the formula 1 and to its physiologically acceptable salts. The compound is suitable, for example, as a hypolipidemic.
    Type: Application
    Filed: March 26, 2007
    Publication date: August 23, 2007
    Applicant: Sanofi-Aventis Deutschland GmbH
    Inventors: Gerhard JAEHNE, Wendelin Frick, Andreas Lindenschmidt, Stefanie Flohr, Hubert Heuer, Hans-Ludwig Schaefer, Werner Kramer, Eric Galia, Heiner Glombik
  • SUBSTITUTED, BICYCLIC 8-PYRROLIDINOXANTHINES, AND METHODS FOR THEIR USE AS INHIBITORS OF DIPEPTIDYL PEPTIDASE
    Publication number: 20070197563
    Abstract: The present invention involves substituted bicyclic 8-pyrrolidinoxanthines and their derivatives of formula I: wherein the various R groups are defined herein. The present invention also comprises pharmaceutical compositions comprising them as well as processes for the preparation of these compounds and methods for the treatment of metabolic disorders such as type-2 diabetes, insulin resistance, hyperglycemia, arteriosclerosis diseases and the like through the administration of said compositions.
    Type: Application
    Filed: January 18, 2007
    Publication date: August 23, 2007
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Karl SCHOENAFINGER, Gerhard JAEHNE, Elisabeth DEFOSSA, Lothar SCHWINK, Holger WAGNER, Christian BUNING, Georg TSCHANK, Ulrich WERNER
  • SUBSTITUTED BICYCLIC 8-PYRR0LIDINOXANTHINES, METHODS FOR THEIR PRODUCTION, PHARMACEUTICAL FORMULATIONS AND THEIR USE
    Publication number: 20070167468
    Abstract: Compounds for the treatment of elevated blood glucose levels and the physiological and metabolic disorders arising therefrom are disclosed and comprise novel substituted bicyclic 8-pyrrolidinoxanthines and their derivatives of formula l: wherein the various R groups are hereinafter defined. The present invention also comprises pharmaceutical compositions comprising them as well as processes for the preparation of these compounds. Particular blood glucose disorders treatable thereby include type-2 diabetes, insulin resistance, hyperglycemia, arteriosclerotic diseases and the like.
    Type: Application
    Filed: January 17, 2007
    Publication date: July 19, 2007
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Karl SCHOENAFINGER, Gerhard JAEHNE, Elisabeth DEFOSSA, Lothar SCHWINK, Holger WAGNER, Christian BUNING, Georg TSCHANK, Ulrich WERNER
  • METHOD FOR PRODUCING 1,4-DIPHENYL AZETIDINONE DERIVATIVES
    Publication number: 20070149776
    Abstract: The present invention is directed to the preparation of novel compounds useful in the treatment of hyperlipidemia, arteriosclerosis, hypercholesterolemia, and other related metabolic disorders.
    Type: Application
    Filed: November 20, 2006
    Publication date: June 28, 2007
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Andreas LINDENSCHMIDT, David WILL, Gerhard JAEHNE, Theodor WOLLMANN, Wendelin FRICK, Bernd JUNKER, David RIGAL, Guenter BILLEN, Heiner JENDRALLA
  • Acid-group-substituted diphenylazetidinones process for their preparation, medicaments comprising these compounds, and their use
    Publication number: 20070123506
    Abstract: One embodiment of the invention relates to compounds of the formula I: in which R1, R2, R3, R4, R5 and R6 have the meanings given in the specification. Other embodiments of the invention relate to physiologically acceptable salts of the compounds of formula I, to processes for their preparation and to medicaments comprising these compounds. The compounds of the invention are suitable for use, for example, as hypolipidemics.
    Type: Application
    Filed: December 22, 2006
    Publication date: May 31, 2007
    Inventors: Gerhard Jaehne, Wendelin Frick, Stefanie Flohr, Andreas Lindenschmidt, Heiner Glombik, Werner Kramer, Hubert Heuer, Hans-Ludwig Schaefer
  • Diphenylazetidinone with improved physiological properties, process for its preparation, medicaments comprising this compound, and its use
    Patent number: 7205290
    Abstract: The invention relates to the compound of the formula 1 and to its physiologically acceptable salts. The compound is suitable, for example, as a hypolipidemic.
    Type: Grant
    Filed: March 31, 2004
    Date of Patent: April 17, 2007
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Gerhard Jaehne, Wendelin Frick, Andreas Lindenschmidt, Stefanie Flohr, Hubert Heuer, Hans-Ludwig Schaefer, Werner Kramer, Eric Galia, Heiner Glombik
  • Ring-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use
    Publication number: 20070043017
    Abstract: One embodiment of the invention relates to compounds of the formula I, in which R1, R2, R3, R4, R5 and R6 have the meanings given in the specification. Other embodiments of the invention relate to physiologically acceptable salts of compounds of formula I, to processes for their preparation and to medicaments comprising these compounds. The compounds of the invention are suitable for use, for example, as hypolipidemics.
    Type: Application
    Filed: October 10, 2006
    Publication date: February 22, 2007
    Inventors: Gerhard Jaehne, Wendelin Frick, Stefanie Flohr, Andreas Lindenschmidt, Heiner Glombik, Werner Kramer, Hubert Heuer, Hans-Ludwig Schaefer
  • Ring-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use
    Publication number: 20070037787
    Abstract: One embodiment of the invention relates to compounds of the formula I, in which R1, R2, R3, R4, R5 and R6 have the meanings given in the specification. Other embodiments of the invention relate to physiologically acceptable salts of compounds of formula I, to processes for their preparation and to medicaments comprising these compounds. The compounds of the invention are suitable for use, for example, as hypolipidemics.
    Type: Application
    Filed: October 10, 2006
    Publication date: February 15, 2007
    Inventors: Gerhard Jaehne, Wendelin Frick, Stefanie Flohr, Andreas Lindenschmidt, Heiner Glombik, Werner Kramer, Hubert Heuer, Hans-Ludwig Schaefer
  • Ring-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use
    Patent number: 7176194
    Abstract: One embodiment of the invention relates to compounds of the formula I, in which R1, R2, R3, R4, R5 and R6 have the meanings given in the specification. Other embodiments of the invention relate to physiologically acceptable salts of compounds of formula I, to processes for their preparation and to medicaments comprising these compounds. The compounds of the invention are suitable for use, for example, as hypolipidemics.
    Type: Grant
    Filed: June 18, 2003
    Date of Patent: February 13, 2007
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Gerhard Jaehne, Wendelin Frick, Stefanie Flohr, Andreas Lindenschmidt, Heiner Glombik, Werner Kramer, Hubert Heuer, Hans-Ludwig Schaefer
  • Acid-group-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use
    Patent number: 7176193
    Abstract: One embodiment of the invention relates to compounds of the formula I: in which R1, R2, R3, R4, R5 and R6 have the meanings given in the specification. Other embodiments of the invention relate to physiologically acceptable salts of the compounds of formula 1, to processes for their preparation and to medicaments comprising these compounds. The compounds of the invention are suitable for use, for example, as hypolipidemics.
    Type: Grant
    Filed: June 18, 2003
    Date of Patent: February 13, 2007
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Gerhard Jaehne, Wendelin Frick, Stefanie Flohr, Andreas Lindenschmidt, Heiner Glombik, Werner Kramer, Hubert Heuer, Hans-Ludwig Schaefer
  • Ring-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use
    Publication number: 20060270613
    Abstract: One embodiment of the invention relates to compounds of the formula I, in which R1, R2, R3, R4, R5 and R6 have the meanings given in the specification. Other embodiments of the invention relate to physiologically acceptable salts of compounds of formula I, to processes for their preparation and to medicaments comprising these compounds. The compounds of the invention are suitable for use, for example, as hypolipidemics.
    Type: Application
    Filed: August 10, 2006
    Publication date: November 30, 2006
    Inventors: Gerhard Jaehne, Wendelin Frick, Stefanie Flohr, Andreas Lindenschmidt, Heiner Glombik, Werner Kramer, Hubert Heuer, Hans-Ludwig Schaefer
  • Cyanopyrrolidides, process for their preparation and their use as medicaments
    Patent number: 7094800
    Abstract: The invention relates to compounds of the formula I in which the radicals have the meanings stated in the text, their stereoisomeric forms, and their physiologically tolerated salts, physiologically functional derivatives and process for their preparation. The compounds are suitable for the treatment of disorders of metabolism, such as type 2 diabetes.
    Type: Grant
    Filed: July 26, 2004
    Date of Patent: August 22, 2006
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Karl Schoenafinger, Holger Wagner, Gerhard Jaehne, Holger Gaul, Christian Buning, Georg Tschank, Ulrich Werner
  • C2-disubstituted indan-1-ones and their derivatives, processes for their preparation and their use as pharmaceuticals
    Patent number: 7081467
    Abstract: The present invention is directed C2-disubstituted indan-1-ones of the Formula I, physiologically acceptable salts, and physiologically functional derivatives thereof, and pharmaceutical compositions comprising such compounds, salts and derivatives, which are useful for reducing weight, for the prophylaxis or treatment of obesity, and for the prophylaxis or treatment of type II diabetes in mammals. The invention is directed also to methods for reducing weight and such treatments and prophylaxis. The invention is directed also to processes for the preparation of such compounds.
    Type: Grant
    Filed: August 29, 2002
    Date of Patent: July 25, 2006
    Assignee: Sanofi-aventis Deutschland GmbH
    Inventors: Gerhard Jaehne, Volker Krone, Martin Bickel, Matthias Gossel