Abstract: The invention relates to a method for determining the presence of a tissue injury and repair (TIAR) process in the uterus of a subject. The presence of TIAR is employed as a marker for the presence of a preliminary stage and/or increased risk of developing a medical disorder associated with abnormal formation of endometrial tissue. Such medical conditions are preferably an archimetrosis, such as endometriosis or adenomyosis. The method comprises determining a level of CXCL12 and/or CXCR4 in a sample from a subject.

Abstract: The present invention relates to a method for diagnosing endometriosis. The method comprises obtaining a sample of menstrual blood, measuring basal cells in said sample or measuring at least one gene product typical for cells of the basal endometrium in said sample and correlating said measurement to the diagnosis of endometriosis.

Abstract: A device for the intermittent pulsatory application of fluid medicaments, particular for the application of LH-RH for initiating ovulation in women having hypothalamic and hyperprolactinamic amenorrhea. Said device has a reservoir for the medicament and a hose connected to said reservoir for delivering said medicament to a patient, which reservoir and which hose are a prefabricated unit which can be inserted into the device and removed when the content of the reservoir is exhausted. Furthermore, said device has a roller-type pump acting onto said hose when it is stretched onto the needle-like rollers of said roller-type pump, and a D.C. motor for driving said pump and further control means for controlling said motor, said control means having a timer for pulse and pause times so that the motor is energized only for short periods not longer than several minutes while it is between each two of such running periods stopped for more than one hour. At least one battery is provided as energy source for the D.C.