Abstract: This invention provides for a network of cell-derived microfilaments. Also provided are methods of producing a network of microfilaments via culturing cells in a matrix support and cell culture medium wherein the cells proliferate and form aggregated cell masses, which produce microfilaments external to and surrounding the cell masses, and wherein the extracellular microfilaments connect and form a continuous extracellular microfilament network, and methods for treating a medical condition as well as facilitating wound repair and tissue regeneration comprising applying the microfilament network to an area in need of treatment.

Abstract: Provided herein are compounds (e.g., compounds of Formulae (I), (II), and (III)) which are anti-fungal agents and can be used in the treatment of diseases, including infectious diseases. The invention provides methods of treating diseases in a subject (e.g., infectious diseases such as fungal infections), and methods of killing or inhibiting the growth of fungi in or on a subject or biological sample. The compounds may be used in subjects, in clinical settings, or in agricultural settings.

Abstract: A rolling-element bearing cage includes a first side ring and a second side ring connected to the first side ring by a plurality of bridges defining a plurality of pockets configured to receive a rolling-element. The first side ring includes a joint at which the first side ring is configured to be opened to increase a diameter of the first side ring, and the first side ring and the second side ring and the plurality of bridges are made of steel and an outer diameter of the second side ring is greater than 500 mm.

Abstract: A bearing cage segment for a rolling-element bearing includes at least one sliding surface on which a surface of at least one rolling element of the rolling-element bearing is rotatable, a first support element, such as an axial projection on an axial side of the cage segment having a radially open radially facing channel, at a first radial position for supporting a first band section of a band clamp during an assembling of the rolling-element bearing, and at least one second support element at a second radial position different from the first radial position for supporting a second band section of the band clamp.

Abstract: A bearing ring for a rolling-element bearing or plain bearing has at least one first region that is inductively hardened or is configured to be inductively hardened and at least one second region that is not inductively hardened and is not intended to be inductively hardened, and the at least one second region includes at least one stress-relief recess and/or at least one stress-relief projection.

Abstract: The present invention relates to compositions containing (fat-soluble) active ingredients and/or colorants in a matrix based on modified plant gums, i.e. plant gums that have been submitted to hydrolysis to degrade either the protein portion and/or where appropriate, the polysaccharide, and to a process for preparing these compositions as well as to modified plant gums, whose protein part is hydrolyzed up to a degree of about 30%, preferably to a degree of from about 0.05 to about 30%, and/or whose polysaccharide part is hydrolyzed up to a degree of about 50%, a process for the manufacture thereof and such modified plant gums themselves. The present invention further relates to the use of the compositions of this invention for the enrichment, fortification and/or for the coloration of food, beverages, animal feed, cosmetics and pharmaceutical compositions and to such food, beverages, animal feed, cosmetics and pharmaceutical compositions themselves.

Abstract: This invention provides for methods and compositions for generation of cytocapsulae and cytocapsular tubes in a 3D matrix.

Abstract: Described herein are methods and compositions relating to nanodiscs, e.g., phospholipid bilayers with a proteinaceous belt or border. Further provided herein are loopable membrane scaffold proteins, e.g., for forming nanodiscs.

Abstract: This invention provides for methods and compositions for generation of cytocapsulae and cytocapsular tubes in a 3D matrix.

Abstract: Described are methods and apparatus, referred to as “temperature-lock,” which can control and stabilize the sample temperature in an NMR spectrometer, in some instances with a precision and an accuracy of below about 0.1 K. In conventional setups, sample heating caused by experiments with high-power radio frequency pulses is not readily detected and is corrected by a cumbersome manual procedure. In contrast, the temperature-lock disclosed herein automatically maintains the sample at the same reference temperature over the course of different NMR experiments. The temperature-lock can work by continuous or non-continuous measurement of the resonance frequency of a suitable temperature-lock nucleus and simultaneous adaptation of a temperature control signal to stabilize the sample at a reference temperature value. Inter-scan periods with variable length can be used to maintain the sample at thermal equilibrium over the full length of an experiment.

Abstract: Methods that enable one to specifically measure the metabolic product of a particular molecule in relatively few cells, e.g. primary cells, are described. The methods involve optionally preloading cells with labeled substrate (e.g. labeled by 13C, 15N, or 31P). The methods allow for easy identification of metabolites that are differentially generated in cells of different phenotypes. The new methods for unbiased multi-dimensional NMR screening and rapid and efficient analysis of the NMR screening identify differentially expressed metabolites in different cell or tissue types. Analysis of the differentially expressed metabolites can present unique druggable targets to which small molecule therapeutics can be designed.

Abstract: Methods for inhibiting translation, treating a cellular proliferative disorder, and inhibiting proliferation of cells using the compounds disclosed herein are provided.

Abstract: A bearing ring of a rolling-element bearing includes a raceway for rolling elements and at least one flange for guiding the rolling elements, the flange merging into a bearing ring shoulder and extending to a height above the raceway. A free space such as a recess is formed between the bearing ring shoulder and the flange such that the flange is freestanding over its entire height.

Abstract: A bearing cage segment for a rolling-element bearing includes at least one sliding surface on which a surface of at least one rolling element of the rolling-element bearing is rotatable, a first support element, such as an axial projection on an axial side of the cage segment having a radially open radially facing channel, at a first radial position for supporting a first band section of a band clamp during an assembling of the rolling-element bearing, and at least one second support element at a second radial position different from the first radial position for supporting a second band section of the band clamp.

Abstract: A bearing ring of a rolling-element bearing includes a raceway for rolling elements and at least one flange for guiding the rolling elements, the flange merging into a bearing ring shoulder and extending to a height above the raceway. A free space such as a recess is formed between the bearing ring shoulder and the flange such that the flange is freestanding over its entire height.

Abstract: A rolling-element bearing cage includes a first side ring and a second side ring connected to the first side ring by a plurality of bridges defining a plurality of pockets configured to receive a rolling-element. The first side ring includes a joint at which the first side ring is configured to be opened to increase a diameter of the first side ring, and the first side ring and the second side ring and the plurality of bridges are made of steel and an outer diameter of the second side ring is greater than 500 mm.

Abstract: Methods that enable one to specifically measure the metabolic product of a particular molecule in relatively few cells, e.g. primary cells, are described. The methods involve optionally preloading cells with labeled substrate (e.g. labeled by 13C, 15N, or 31P). The methods allow for easy identification of metabolites that are differentially generated in cells of different phenotypes. The new methods for unbiased multi-dimensional NMR screening and rapid and efficient analysis of the NMR screening identify differentially expressed metabolites in different cell or tissue types. Analysis of the differentially expressed metabolites can present unique druggable targets to which small molecule therapeutics can be designed.

Abstract: An inductor for an induction hardening system includes a heating element for heating a heating zone of a workpiece, and the heating element includes a first induction coil and a second induction coil and a gas escape device disposed between the first induction coil and the second induction coil. The gas escape device is configured to substantially prevent a liquid from a quenching device from reaching the heating zone while the heating zone is being heated by the first and second inductors.

Abstract: A roller bearing element for a large roller bearing includes the following features: at least one contact zone for a roller bearing counter element, the contact zone has an induction-hardened surface layer, the roller bearing element is comprised of a steel, which includes an admixture of carbon of at least 0.46 mass %.

Abstract: Methods for inhibiting translation, treating a cellular proliferative disorder, and inhibiting proliferation of cells using the compounds disclosed herein are provided.