Patents by Inventor Germar Engelke

Germar Engelke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5843709
    Abstract: A bacterial host is described which is transformed by a plasmid coding for a polypeptide precursor wherein the host comprises a multi-enzyme complex capable of reacting with the expressed polypeptide precursor to produce a polypeptide comprising at least one dehydroamino acid and/or at least one lanthione bridge. A process for producing a polypeptide comprising at least one dehydroamino acid and/or at least one lanthione bridge, such as gallidermin, is also described. A plasmid capable of transforming a bacterial host is additionally described.Also disclosed are recombinant DNA molecules which specify Epi B, Epi C, Epi D, Epi P and Epi Q, enzymes which are involved in the biosynthesis of lantibiotic epidermin.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: December 1, 1998
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Karl-Dieter Entian, Friedrich Gotz, Norbert Schnell, Johannes Augustin, Germar Engelke, Ralf Rosenstein, Cortina Kaletta, Cora Klein, Bernd Wieland, Thomas Kupke, Gunther Jung, Roland Kellner
  • Patent number: 5837485
    Abstract: A bacterial host is described which is transformed by a plasmid coding for a polypeptide precursor wherein the host comprises a multi-enzyme complex capable of reacting with the expressed polypeptide precursor to produce a polypeptide comprising at least one dehydroamino acid and/or at least one lanthionine bridge. A process for producing a polypeptide comprising at least one dehydroamino acid and/or at least one lanthionine bridge, such as gallidermin, is also described. A plasmid capable of transforming a bacterial host is additionally described.Also disclosed are recombinant DNA molecules which specify Epi B, Epi C, Epi D, Epi P and Epi Q, enzymes which are involved in the biosynthesis of lantibiotic epidermin.
    Type: Grant
    Filed: February 22, 1995
    Date of Patent: November 17, 1998
    Assignee: Dr. Karl Tomae GmbH
    Inventors: Karl-Dieter Entian, Friedrich Gotz, Norbert Schnell, Johannes Augustin, Germar Engelke, Ralf Rosenstein, Cortina Kaletta, Cora Klein, Bernd Wieland, Thomas Kupke, Gunther Jung, Roland Kellner