Patents by Inventor Ghassan S. Kassab

Ghassan S. Kassab has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190175110
    Abstract: Autoexpandable devices for obtaining impedance, pressure, and other measurements in the gastrointestinal tract and other organs. In an exemplary embodiment of a capsule of the present disclosure, the capsule comprises an outer shell configured to dissolve or otherwise be digested within a stomach after ingestion, an expandable material positioned within the outer shell, the expandable material configured for expansion within the stomach after the outer shell has dissolved, and at least one element or sensor selected from the group consisting of an impedance element and a pressure sensor.
    Type: Application
    Filed: July 31, 2017
    Publication date: June 13, 2019
    Inventors: Hans Gregersen, Ghassan S. Kassab
  • Patent number: 10314686
    Abstract: The disclosure of the present application provides devices, systems, and methods for replacing damaged or compromised blood vessels and engineering luminal grafts for various medical applications. Such devices are capable of providing viable, small-diameter grafts for use in anastomotic procedures and comprise a tubular construct consisting largely of elastin and some collagen fibers and having at least one diameter of less than or equal to about 5 mm. In one exemplary embodiment, the graft comprises at least one layer of pulmonary ligament tissue and/or pulmonary visceral pleura. Systems and methods for the manufacture of the graft are also provided, which include the use of at least one layer of tissue, a mandrel and a closure mechanism.
    Type: Grant
    Filed: December 17, 2014
    Date of Patent: June 11, 2019
    Assignee: DTherapeutics, LLC
    Inventors: Ghassan S. Kassab, Xiao Lu
  • Publication number: 20190167147
    Abstract: Injection-less methods to determine cross-sectional areas using multiple frequencies. An exemplary method comprises the steps of operating an impedance device to introduce three signals having different frequencies into a mammalian luminal organ and obtaining conductance data in connection with each of the three signals using an impedance detector of the impedance device, and determining a cross-sectional area of the mammalian luminal organ based upon the conductance data in connection with each of the three signals, a conductivity of blood within the mammalian luminal organ, and a known distance between detection elements of the impedance detector.
    Type: Application
    Filed: August 4, 2017
    Publication date: June 6, 2019
    Inventor: Ghassan S. Kassab
  • Publication number: 20190167864
    Abstract: A minimally invasive system for monitoring and treating high intracranial pressure levels resulting from traumatic brain injury comprises an intravenous access device, an elongate member, a console, and an aspiration and injection catheter. The system is capable of monitoring pressure levels and relocating fluid from the brain to another part of the patient's body to sustain overall constant fluid volume. The method of using the minimally invasive system is also described.
    Type: Application
    Filed: December 5, 2018
    Publication date: June 6, 2019
    Inventors: Ghassan S. Kassab, Ali Dabiri
  • Publication number: 20190150937
    Abstract: Devices, systems, and methods to precondition, arterialize, and/or occlude a mammalian luminal organ. In an exemplary embodiment of a device for preconditioning, arterializing, and/or occluding a mammalian luminal organ of the present disclosure, the device comprises a frame comprising a plurality of struts, wherein at least one strut of the plurality of struts forms a local general perimeter or boundary of the device, and an expandable occluder coupled to the frame and comprising a membrane or other expandable material that can generally expand and/or unfold as device shifts from a first configuration to a second configuration.
    Type: Application
    Filed: January 24, 2019
    Publication date: May 23, 2019
    Applicant: CVDevices, LLC
    Inventor: Ghassan S. Kassab
  • Patent number: 10285814
    Abstract: Devices and methods for controlling blood perfusion pressure. In an exemplary device for controlling blood perfusion pressure within a vessel of the present disclosure, the device comprises an elongated body having a lumen, a proximal end configured for placement in a first area having a first blood pressure, and a distal end configured for placement in a second area having a second blood pressure, partial occluder positioned within the lumen of the elongated body between the proximal end and the distal end, the partial occluder configured so not to fully occlude a blood vessel, wherein the partial occluder is configured to equalize the first blood pressure at the first area with the second blood pressure at the second area.
    Type: Grant
    Filed: February 28, 2017
    Date of Patent: May 14, 2019
    Assignee: CVDevices, LLC
    Inventors: Ghassan S. Kassab, Jose A. Navia, Sr.
  • Publication number: 20190133528
    Abstract: Luminal organ sizing devices and methods. In a method of the present disclosure, the method includes performing a valve replacement procedure using a valve device positioned within a valve annulus or opening of a luminal organ while a system including a balloon configured for inflation is at least partially introduced into a luminal organ so that the balloon is adjacent to a valve annulus or opening.
    Type: Application
    Filed: January 7, 2019
    Publication date: May 9, 2019
    Applicant: 3DT Holdings, LLC
    Inventors: Ghassan S. Kassab, Joanna Mleczko
  • Publication number: 20190133489
    Abstract: Devices, systems, and methods for the localization of body lumen junctions and other intraluminal structure are disclosed. Various embodiments permit clinicians to identify the locations of intraluminal structures and medical devices during non-surgical medical techniques, by determining the conductance and/or cross-sectional area at a plurality of locations within the body lumen.
    Type: Application
    Filed: January 7, 2019
    Publication date: May 9, 2019
    Inventor: Ghassan S. Kassab
  • Patent number: 10265100
    Abstract: Transradial access devices, systems, and methods. An exemplary device of the present disclosure for providing access to a vessel or other luminal organ and to prevent overperforation of the same comprises a needle having a needle tip and at least one current element positioned thereon or embedded therein at or near the needle tip, a sheath positioned around at least part of the needle, and a protractor in communication with the needle, whereby engagement of the protractor causes the needle tip to protract from the sheath through the aperture, and whereby release of the protractor causes the needle tip to retract through the aperture into the sheath. Activation of the at least one current element can facilitation vasodilation of the vessel or other luminal organ.
    Type: Grant
    Filed: January 20, 2016
    Date of Patent: April 23, 2019
    Assignee: DTherapeutics, LLC
    Inventor: Ghassan S. Kassab
  • Publication number: 20190110844
    Abstract: Systems and methods for navigation and positioning a central venous catheter within a patient. The system may include a first pole and a second pole designed to generate an electric field sufficient to obtain a plurality of field measurements. The system may include a stylet inserted into a medical device. The stylet may include a magnetic assembly configured to produce a magnetic field positioned along a distal portion of the stylet, and a stylet electrode positioned distal of the magnetic assembly. The stylet electrode may be designed to function as both an interior excitation electrode and an interior detection electrode. Advancement of the medical device in the patient may include using a conductance curve generated from the plurality of field measurements to identify an obstruction or malposition in the patient.
    Type: Application
    Filed: December 13, 2018
    Publication date: April 18, 2019
    Inventors: Anthony K. Misener, Paul D. Morgan, William R. McLaughlin, Ghassan S. Kassab, William Combs, Mark Svendsen, H. T. Markowitz
  • Publication number: 20190111181
    Abstract: Methods for denucleation of biological tissue. A method of denucleating biological tissue can include exposing a target tissue to at least one hyperosmotic solution and at least one hypoosmotic solution in an alternating fashion, and then applying a glutaraldehyde solution to the target tissue to fix the extracellular matrix and cytoskeleton of the target tissue.
    Type: Application
    Filed: October 12, 2018
    Publication date: April 18, 2019
    Inventors: Ghassan S. Kassab, Xiao Lu
  • Patent number: 10258458
    Abstract: Endoprosthesis assemblies and methods for using the same. In at least one embodiment, the endoprosthesis assembly comprises an endoprosthesis comprising an impermeable inner wall defining an endoprosthesis lumen sized and shaped to permit fluid to flow therethrough, a distal balloon positioned at or near a distal end of the endoprosthesis and capable of inflation to anchor the distal end of the endoprosthesis within a luminal organ, and a proximal balloon positioned at or near a proximal end of the endoprosthesis and capable of inflation to anchor the proximal end of the endoprosthesis within the luminal organ, wherein when the endoprosthesis assembly is positioned within the luminal organ at or near an aneurysm sac, inflation of the distal balloon and the proximal balloon effectively isolates the aneurysm sac and prevents fluid within the aneurysm sac from flowing past the distal balloon and the proximal balloon.
    Type: Grant
    Filed: July 11, 2017
    Date of Patent: April 16, 2019
    Assignee: CVDevices, LLC
    Inventors: Ghassan S. Kassab, Jose A. Navia, Sr.
  • Patent number: 10245049
    Abstract: Thrombus removal systems and devices and methods of using the same. In an exemplary embodiment of a thrombus removal system of the present disclosure, the thrombus removal system comprises an umbrella catheter comprising an umbrella catheter tube and an umbrella positioned at least partially within the umbrella catheter tube when in a compressed configuration and positioned external to the umbrella catheter tube when in a deployed configuration, and a balloon catheter configured to fit around at least part of the umbrella catheter, the balloon catheter comprising a balloon catheter tube and a balloon coupled thereto, the balloon capable of inflation within a lumen of a mammalian vessel to substantially or completely occlude the lumen of the mammalian vessel, wherein the thrombus removal system is configured to disrupt and/or dissolve and remove at least a portion of a thrombus positioned within the lumen of the mammalian vessel.
    Type: Grant
    Filed: June 8, 2012
    Date of Patent: April 2, 2019
    Assignee: CVDevices, LLC
    Inventor: Ghassan S. Kassab
  • Patent number: 10238392
    Abstract: A device and system are described that are capable of isolating at least one targeted tissue and forming an anastomosis between two internal body structures though a completely endoscopic procedure. Further, the device and system described generally comprise two tubular members that are capable of moving in a telescopic fashion relative to one another. Additionally, a method is described for using the device and/or system to bypass the duodenum from digestion.
    Type: Grant
    Filed: February 9, 2015
    Date of Patent: March 26, 2019
    Assignee: CVDevices, LLC
    Inventors: Ghassan S. Kassab, Jose A. Navia, Sr.
  • Patent number: 10238311
    Abstract: Devices and methods are disclosed which relate to the detection of cardiovascular efficiency and risk of disease. The rate of volumetric change of the heart can be determined by measuring the parallel conductance across electrodes attached to the heart. Measurements from a lumen would consider the total conductance. The rate of volumetric or lumen cross-section area change can then be compared to an average model to determine the health of a patient.
    Type: Grant
    Filed: January 22, 2008
    Date of Patent: March 26, 2019
    Assignee: CVDevices, LLC
    Inventor: Ghassan S. Kassab
  • Patent number: 10238483
    Abstract: Devices and methods for assisting valve function, replacing venous valves, and predicting valve treatment successes. In at least one embodiment of an endograft valve device of the present disclosure, the device comprises an endograft body configured for expansion from a collapsed configuration to an expanded configuration within a luminal organ and comprising a first portion having a proximal end defining a proximal end aperture and a distal end defining a distal end aperture, the first portion tapering toward the distal end so that the distal end aperture has a relatively smaller cross-sectional area than the proximal end aperture when the valve device is expanded, and a valve portion positioned at or near the distal end of the first portion, the valve portion configured to receive fluid flowing through the distal end aperture of the first portion.
    Type: Grant
    Filed: July 2, 2012
    Date of Patent: March 26, 2019
    Assignee: 3DT Holdings, LLC
    Inventor: Ghassan S. Kassab
  • Patent number: 10219720
    Abstract: Impedance devices for obtaining conductance measurements within luminal organs. In at least one embodiment of an impedance device of the present disclosure, the device, comprises an elongated body and an detector positioned upon the elongated body, the detector comprising at least five electrodes and configured to obtain one or more conductance measurements generated using a first arrangement of four of the at least five electrodes and further configured to obtain one or more fluid velocity measurements using a second arrangement of four of the at least five electrodes when the elongated body is positioned within a fluid environment of a mammalian luminal organ, wherein the first arrangement is different from the second arrangement.
    Type: Grant
    Filed: November 11, 2014
    Date of Patent: March 5, 2019
    Assignee: 3DT Holdings, LLC
    Inventor: Ghassan S. Kassab
  • Patent number: 10219828
    Abstract: Devices, systems, and methods for transradial access. In at least one embodiment of a device for providing access to a vessel or other luminal organ of the present disclosure, the device comprises a needle having a needle tip, a sheath positioned around at least part of the needle, the sheath defining an aperture at a distal sheath end, and a protractor in communication with the needle, whereby engagement of the protractor causes the needle tip to protract from the sheath, and whereby release of the protractor causes the needle tip to retract into the sheath.
    Type: Grant
    Filed: October 27, 2011
    Date of Patent: March 5, 2019
    Assignee: DTherapeutics, LLC
    Inventor: Ghassan S. Kassab
  • Patent number: 10213207
    Abstract: A magnetic device and method are disclosed for providing a safer and more reliable technique for closing a hole or rupture in the septum of the heart. A device is disclosed with proximal and distal occluders that are connected to one another via a catheter and are inserted on either side of the hole or rupture. Also disclosed are two patches that are placed on either side of the hole or rupture with at least one of the patches being composed of magnetic material with the other being magnetic or metallic.
    Type: Grant
    Filed: December 1, 2015
    Date of Patent: February 26, 2019
    Assignee: CVDevices, LLC
    Inventors: Ghassan S. Kassab, Jose A. Navia, Sr.
  • Patent number: 10213129
    Abstract: Devices, systems, and methods to measure parallel tissue conductance, luminal cross-sectional areas, fluid velocity, and/or determine plaque vulnerability using temperature. In at least one embodiment of a method to obtain parallel tissue conductance, the method comprises the steps of inserting at least part of a detection device into a luminal organ, applying current thereto, obtaining a native temperature measurement, injecting a solution of a known conductivity into the luminal organ, detecting a temperature change indicative of the fluid within the luminal organ, measuring an output conductance, and calculating a parallel tissue conductance based upon the output conductance and the conductivity of the injected solution.
    Type: Grant
    Filed: May 31, 2016
    Date of Patent: February 26, 2019
    Assignee: 3DT Holdings, LLC
    Inventor: Ghassan S. Kassab