Abstract: Devices, systems, and methods useful to engage tissue using suction and to perform medical procedures during sectional engagement. The present disclosure includes disclosure of a tension apparatus, comprising an elongated portion; and a head portion at a distal end of the elongated portion, the head portion comprising one or more arms, whereby a suction lumen extending along the elongated portion and the one or more arms terminates at one or more suction openings at each of the one or more arms.

Abstract: Methods and products for diagnosing, treating and/or delaying onset of chronic allograft rejection, including cardiac allograft vasculopathy. In an exemplary embodiment of a noninvasive method of screening a cardiac allograft recipient for being at-risk for developing cardiac allograft vasculopathy of the present disclosure, the method comprises the steps of withdrawing at least one biological sample from a cardiac allograft recipient; and analyzing the at least one biological sample for one or more biomarkers indicative of the presence of fibrin deposits within the cardiac allograft microvasculature; wherein detection of the one or more biomarkers indicates that the cardiac allograft recipient is at-risk for or developing cardiac allograft vasculopathy.

Abstract: Atrial appendage occlusion devices and methods of using the same that employ the application of light having a desired wavelength range. The devices of the present disclosure comprise a telescoping catheter assembly coupled with an adhesive delivery device and a suction source, and comprise at least one optical fiber disposed therein. The catheter assembly is configured to isolate an atrial appendage cavity, deliver suction and adhesive thereto, and, using the optical fiber(s), cure the adhesive present within the cavity all without withdrawing any components of the catheter assembly from the body. Methods for using such device in the treatment of atrial appendage occlusion are also provided.

Abstract: Single injection methods for obtaining conductance measurements within luminal organs using impedance devices. In at least one method embodiment, the method is performed by introducing at least part of an impedance device into a mammalian luminal organ, the impedance device comprising an elongated body and a detector positioned along the elongated body, obtaining conductance measurements indicative of a fluid native to the mammalian luminal organ and indicative of a fluid injection while the detector is present within and outside of the lumen of the outer sheath, and calculating a size parameter of the mammalian luminal organ based in part upon some of the obtained conductance measurements.

Abstract: Disclosed is a method of treating respiratory viruses including coronaviruses such as SARS-CoV-2 using surfactant, surfactant protein A and/or surfactant protein D. The surfactant and surfactant protein treatment can be used in combination with immunoglobulin M administered intravenously. Surfactant proteins used in these embodiments, especially surfactant protein D, can be harvested from an exogenous source such as pigs, as they show improved resilience against viruses.

Abstract: Engagement catheter devices, systems, and methods to use the same under suctional tissue engagement. A method of the present disclosure comprises the steps of engaging a targeted tissue under suction/vacuum using an engagement catheter, delivering a substance to, into, or through the targeted tissue from within a lumen of the engagement catheter, and injecting a fluid within a different lumen of the engagement catheter to flush the catheter and target tissue area with the fluid, and subsequently suctionally removing the injected fluid from the target area and lumens of the engagement catheter.

Abstract: A non-invasive and minimally-invasive system and method of detecting iron content in nail and hair samples to diagnose iron deficiency anemia. The system comprises a portable and ultra sensitive magnetometer. A sample of hair or nail is collected from the patient and placed in the magnetometer. The magnetometer is sufficiently sensitive to detect or otherwise indicate the iron content of the sample. Diagnosis can be made based on the detected iron level.

Abstract: In at least one embodiment of a device configured for insertion into a gastrointestinal tract of the present disclosure, the device comprises a core comprising a core material which is solid, semi-solid or compressible, one or more sensors embedded in an interior of the device and/or on a surface of the device, at least one of the one or more sensors configured to obtain a pressure measurement within the gastrointestinal tract and during defecation of the device, and a plurality of electrodes within or upon the device and configured to obtain impedance planimetric measurements within the gastrointestinal tract and during defecation of the device, the impedance planimetric measurements useful to determine cross-sectional areas.

Abstract: A method of using ultraviolet (UV) radiation to treat an infection in the respiratory system and far infrared radiation (FIR) to treat inflammation. The method uses a light probe inserted into the airway of a patient to apply UV radiation and FIR to a target site in the upper respiratory tract. The UV radiation applied may be broad-spectrum UV radiation or UVC radiation in the 222 nm range. FIR applied may be in the 3-10 ?m range. The UV radiation kills any organisms, including COVID-19 and FIR reduces inflammation resulting from infection and subsequent UV treatment. The treatment may be applied to intubated or spontaneously breathing patients and via the oral or nasal passages.

Abstract: A method of using nanoparticle (NP) spray to treat an infection in the respiratory system and far infrared radiation (FIR) to treat inflammation. The method uses a spray probe inserted into the airway of a patient to apply mSiO2 and FIR to a target site in the upper respiratory tract. FIR applied may be in the 3-10 ?m range. The mSiO2 spray kills any organisms, including COVID-19 and FIR reduces inflammation resulting from infection. The treatment may be applied to intubated or spontaneously breathing patients and via the oral or nasal passages.

Abstract: Devices and methods are disclosed which relate to the detection of cardiovascular efficiency and risk of disease. The rate of volumetric change of the heart can be determined by measuring the parallel conductance across electrodes attached to the heart. Measurements from a lumen would consider the total conductance. The rate of volumetric or lumen cross-section area change can then be compared to an average model to determine the health of a patient.

Abstract: Impedance devices and methods of using the same to obtain luminal organ measurements. In at least one embodiment of an impedance device of the present disclosure, the impedance device comprises an elongated body having a distal body end, and a first electrode located along the elongated body at or near the distal body end, the first electrode configured to obtain one or more conductance values within a mammalian luminal organ within an electric field, wherein a measured parameter of the mammalian luminal organ can be calculated based in part upon the one or more conductance values obtained by the first electrode.

Abstract: Devices and systems to fit around a tissue or organ and methods of using the same. In at least one embodiment of an implantable device of the present disclosure, the implantable device comprises a first engaging component comprising a first rigid inner plate at least partially surrounded by a first flexible coating, a second engaging component comprising a second rigid inner plate at least partially surrounded by a coating selected from the group consisting of the first flexible coating and the second flexible coating, a first c-ring and a second c-ring coupled to the engaging components, and a cover flap coupled to either the first engaging component or the second engaging component and capable of either further coupling to the second engaging component when initially coupled to the first engaging component or further coupling to the first engaging component when initially coupled to the second engaging component.

Abstract: Intestinal devices and methods for facilitating weight loss. In at least one embodiment of a method of patient treatment of the present disclosure, the method comprises the step of positioning a device, that is configured to reduce or limit localized intestinal distension, around a portion of an intestine of a patient.

Abstract: A wearable patch for the transdermal delivery of cannabidiol (CBD). Cannabidiol is delivered in in the form of a CBD mixture which comprises CBD oil loaded into liposomes. The CBD mixture can be delivered without the use of dermal enhancers. A transdermal patch is preloaded with the CBD mixture and placed upon the skin to penetrate the dermis layer, where the CBD mixture will diffuse into the interstitial body fluid. The patch comprises microneedles and the CBD mixture which is preloaded into or on the needles depending on the type of microneedles used.

Abstract: A catheter for the gentle opening of luminal valves and method of use is disclosed. The catheter comprises a suction lumen and a guidewire within. The suction lumen provides an atraumatic amount of suction force to draw valve leaflets open whereupon the guidewire can be advanced through the now open valve or the contents of the luminal organ beyond the valve can be aspirated into the device. When the guidewire is advanced, the catheter can follow the guide wire beyond the opened valve, thereby allowing retrograde access of luminal organs beyond normally closed valves. The process can be repeated to open a second valve located upstream of a first valve.

Abstract: A wearable support device for use with heavy clothing is disclosed. The device relieves the shoulders and back of weight by transferring the weight to the waist and hips of the users. The device comprises a frame attached to a waistband. The heavy clothing is worn over the device in a normal fashion. The clothing rests on the frame which, by its construction and by virtue of being rigid and positioned off the torso, transfers the weight to the waistband. An optional cushion is contemplated. Weight supporting posts attached to the waistband are also contemplated.

Abstract: A portable urine collection device comprising a receiving cup, a discharge tube, and a storage bottle. The device may also comprise snap coupling connectors, an air vent, a one-way valve and a protrusion in the receiving cup for male genitalia. The device may also be used with female genitalia without a protrusion. A support may also be used with the portable urine collection device. Methods of use are also provided.

Abstract: Devices, systems, and methods to determine fractional flow reserve. At least one method for determining fractional flow reserve of the present disclosure comprises the steps positioning a device comprising at least two sensors within a luminal organ at or near a stenosis, wherein the at least two sensors are separated a predetermined distance from one another, operating the device to determine flow velocity of a second fluid introduced into me luminal organ to temporarily displace a first fluid present within the luminal organ, and determining fractional flow reserve at or near the stenosis based upon the flow velocity, a mean aortic pressure within the luminal organ, and at least one cross-sectional area at or near the stenosis. Devices and systems useful for performing such exemplary methods are also disclosed herein.

Abstract: Devices, systems, and methods useful to engage tissue using suction and to perform medical procedures during sectional engagement. The present disclosure includes disclosure of a tension apparatus, comprising an elongated portion; and a head portion at a distal end of the elongated portion, the head portion comprising one or more arms, whereby a suction lumen extending along the elongated portion and the one or more arms terminates at one or more suction openings at each of the one or more arms.