Patents by Inventor Ghislain Schyns

Ghislain Schyns has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9631185
    Abstract: Fusion-proteins containing an enzyme, preferably a feed or food enzyme, coupled to a gut surface-binding domain are presented. The fusion-proteins can be used to promote feed utilization in animals. In a particular example, a Fusion enzyme according to the invention comprising a gut-surface-binding polypeptide segment linked to a phytase show an increased resident time in the gut, which leads to an increased amount of time given to the enzyme to catalyse the corresponding reaction which finally leads to improved feed utilisation.
    Type: Grant
    Filed: June 11, 2012
    Date of Patent: April 25, 2017
    Assignee: NOVOZYMES A/S
    Inventors: Ghislain Schyns, Stephane Duval, Aurelie Brelin
  • Publication number: 20140356478
    Abstract: Fusion-proteins containing an enzyme, preferably a feed or food enzyme, coupled to a gut surface-binding domain are presented. The fusion-proteins can be used to promote feed utilization in animals. In a particular example, a Fusion enzyme according to the invention comprising a gut-surface-binding polypeptide segment linked to a phytase show an increased resident time in the gut, which leads to an increased amount of time given to the enzyme to catalyse the corresponding reaction which finally leads to improved feed utilisation.
    Type: Application
    Filed: June 11, 2012
    Publication date: December 4, 2014
    Applicant: NOVOZYMES A/S
    Inventors: Ghislain Schyns, Stephane Duval, Aurelie Brelin
  • Publication number: 20140315278
    Abstract: This invention discloses novel bacterial spore systems. Genetically modified or genetically engineered viable spore systems expressing bioactive polypeptides, for example bacteriocins and/or enzymatically active feed enzymes, at the spore surface, have a great potential use in animal feeding. Genetically modified or “genetically engineered inert spore systems expressing affinity ligands or immobilized enzymes at the surface have a great potential use in biocatalysis and in the construction of biocatalytic films. Especially the resistance to harsh chemicals, desiccation, strong pressure, or high temperatures allows the spores to be a potentially valuable tool for the display of bioactive molecules, like biocatalytic enzymes or bioactive feed enzymes that must survive harsh conditions to deliver their full potential.
    Type: Application
    Filed: March 26, 2014
    Publication date: October 23, 2014
    Applicant: DSM IP Assets B.V.
    Inventors: Adriano O. HENRIQUES, Ghislain Schyns, Thibaut José Wenzel, Sebastien Potot
  • Publication number: 20130216653
    Abstract: The present invention relates to the display of bioactive molecules at the surface of spores for both in vitro and in vivo applications. Three small open reading frames (ORFs) have been identified which are very useful for display of bioactive molecules at the spore surface. The encoded small proteins have a molecular weight of less than 12 kDa, which corresponds to about less than 100 amino acids.
    Type: Application
    Filed: June 28, 2011
    Publication date: August 22, 2013
    Applicant: DSM IP ASSETS B.V.
    Inventors: John B. Perkins, Zoltan Pragai, Ghislain Schyns
  • Patent number: 8329395
    Abstract: The present invention provides a method for producing thiamin products using a microorganism containing a mutation that causes it to overproduce and release thiamin products into the medium. Biologically pure cultures of the microorganisms and isolated polynucleotides containing the mutations are also provided. In addition, methods for detecting a pathogenic microorganism in a clinical sample, assays for identifying an antibiotic, as well as, antibiotics identified by such assays are provided.
    Type: Grant
    Filed: March 2, 2009
    Date of Patent: December 11, 2012
    Assignee: DSM IP Assets B.V.
    Inventors: Markus G. Goese, John B. Perkins, Ghislain Schyns
  • Publication number: 20100055244
    Abstract: This invention discloses novel bacterial spore systems. It has now been found surprisingly that under certain conditions bacterial spore systems can be used in the food and feed industry, preferably in animal feeding and as biohybrid material. More precisely applicant has found the following: Genetically modified or genetically engineered viable spore systems expressing bioactive polypeptides, for example bacteriocins and/or enzymatically active feed enzymes, at the spore surface, have a great potential use in animal feeding. Further, it has been found that genetically modified or “genetically engineered inert spore systems expressing affinity ligands or immobilized enzymes at the surface have a great potential use in biocatalysis and in the construction of biocatalytic films.
    Type: Application
    Filed: August 9, 2007
    Publication date: March 4, 2010
    Inventors: Adriano O. Henriques, Ghislain Schyns, Thibaut José Wenzel, Sebastian Potot
  • Publication number: 20090233296
    Abstract: The present invention provides a method for producing thiamin products using a microorganism containing a mutation that causes it to overproduce and release thiamin products into the medium. Biologically pure cultures of the microorganisms and isolated polynucleotides containing the mutations are also provided. In addition, methods for detecting a pathogenic microorganism in a clinical sample, assays for identifying an antibiotic, as well as, antibiotics identified by such assays are provided.
    Type: Application
    Filed: March 2, 2009
    Publication date: September 17, 2009
    Inventors: Markus G. Goese, John B. Perkins, Ghislain Schyns
  • Patent number: 7435571
    Abstract: The present Invention relates to enzymes involved in the Synthesis of Coenzyme Q-10, i.e., decaprenyl diphosphate (DPP) synthase and 4-hydroxybenzoate polyprenyltransferase, to isolated DNA encoding said enzymes and to methods for the microbial production of Coenzyme Q-10.
    Type: Grant
    Filed: February 13, 2004
    Date of Patent: October 14, 2008
    Assignee: DSM IP Assets B.V.
    Inventors: Markus Huembelin, Rual Lopez-Ulibarri, John B. Perkins, Ghislain Schyns
  • Publication number: 20060127993
    Abstract: The present invention provides a method for producing thiamin products using a microorganism containing a mutation that causes it to overproduce and release thiamin products into the medium. Biologically pure cultures of the microorganisms and isolated polynucleotides containing the mutations are also provided. In addition, methods for detecting a pathogenic microorganism in a clinical sample, assays for identifying an antibiotic, as well as, antibiotics identified by such assays are provided.
    Type: Application
    Filed: May 27, 2004
    Publication date: June 15, 2006
    Inventors: Markus Goese, John Perkins, Ghislain Schyns
  • Publication number: 20060088920
    Abstract: The present Invention relates to enzymes involved in the Synthesis of Coenzyme Q-10, i.e., decaprenyl diphosphate (DPP) synthase and 4-hydroxybenzoate polyprenyltransferase, to isolated DNA encoding said enzymes and to methods for the microbial production of Coenzyme Q-10.
    Type: Application
    Filed: February 13, 2004
    Publication date: April 27, 2006
    Inventors: Markus Huembelin, Rual Lopez-Ulibarri, John Perkkins, Ghislain Schyns