Abstract: A helical nerve cuff and an implantable device comprising the helical nerve cuff and a body comprising a wireless communication system are described herein. The implantable device can include a body having a wireless communication system; electrodes that can detect an electrophysiological signal transmitted by a nerve or emit an electrical pulse to the nerve; and a helical nerve cuff. Also described are methods of implanting the helical nerve cuff and the implantable device, as well as methods of making the helical nerve cuff and the implantable device.

Abstract: Described herein are methods and devices for monitoring or modulating an immune system in a subject with cancer, and methods and devices for treating a cancer in a subject. The implanted device can electrically stimulate the splenic nerve of the subject, which can modulate the inflammatory system (for example, by increasing or decreasing the blood level of one or more pro-inflammatory cytokines and/or anti-inflammatory cytokines to increase or decrease inflammation in the subject) and/or activate or increase circulation of one or more immune cells (such as natural killer cells and/or cytotoxic T-cells), for the treatment of cancer. The implanted medical device includes two or more electrodes configured to electrically stimulate the splenic nerve, and may further include an ultrasonic transducer configured to receive ultrasonic waves and convert energy from the ultrasonic waves into an electrical energy that powers the device.

Abstract: A device for measuring an intraocular pressure that includes: a pressure sensor configured to measure the intraocular pressure; an ultrasonic transducer electrically coupled to the pressure sensor and configured to receive ultrasonic waves and emit ultrasonic backscatter encoding a pressure measured by the pressure sensor, and a substrate attached to the pressure sensor and the ultrasonic transducer, and configured to interface a surface on or within an eye.