Patents by Inventor Giangiacomo Torri

Giangiacomo Torri has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7754878
    Abstract: Polysaccharides are functionalized using a source of free radicals which forms stable radicals on the polysaccharides structure and wherein the formed radicals reacts with a functionalized unsaturated compound. The method comprises two steps: a first step, wherein the free radical on the polysaccharides chain is formed, and a second step, wherein said radical reacts with the unsaturated compound in the absence of the radical source.
    Type: Grant
    Filed: March 20, 2003
    Date of Patent: July 13, 2010
    Assignees: Next Technology Tecnotessile Societa Nazionale Di Ricerca R.L., Instuto Scientifico Di Chimica E Biochimica “G. Rozoni”
    Inventors: Giangiacomo Torri, Angelo Alberti, Sabrina Bertini, Gianluca Ciardelli, Giuseppe Gastaldi, Solitario Nesti, Elena Vismara
  • Patent number: 7737692
    Abstract: The invention relates to methods for analyzing polysaccharides. In particular, compositional and sequence information about the polysaccharides are derived. Some methods use NMR in conjunction with another experimental method, such as, capillary electrophoretic techniques for the analysis.
    Type: Grant
    Filed: October 29, 2008
    Date of Patent: June 15, 2010
    Assignees: Massachusetts Institute of Technology, Istituto di Ricerche Chimiche e Biochimiche G. Ronzoni
    Inventors: Ram Sasisekharan, Ganesh Venkataraman, Rahul Raman, Benito Casu, Giangiacomo Torri, Marco Guerrini
  • Patent number: 7728589
    Abstract: The invention relates to methods for analyzing polysaccharides. In particular, compositional and sequence information about the polysaccharides are derived. Some methods use NMR in conjunction with another experimental method, such as, capillary electrophoretic techniques for the analysis.
    Type: Grant
    Filed: June 24, 2008
    Date of Patent: June 1, 2010
    Assignees: Massachusetts Institute of Technology, Instituto di Ricerche Chimiche e Biochimiche G. Ronzoni
    Inventors: Ram Sasisekharan, Ganesh Venkataraman, Rahul Raman, Benito Casu, Giangiacomo Torri, Marco Guerrini
  • Patent number: 7508206
    Abstract: The invention relates to methods for analyzing polysaccharides. In particular, compositional and sequence information about the polysaccharides are derived. Some methods use NMR in conjunction with another experimental method, such as, capillary electrophoretic techniques for the analysis.
    Type: Grant
    Filed: May 20, 2003
    Date of Patent: March 24, 2009
    Assignee: Massachusetts Institute of Technology
    Inventors: Ram Sasisekharan, Ganesh Venkataraman, Rahul Raman, Benito Casu, Giangiacomo Torri, Marco Guerrini
  • Publication number: 20090045811
    Abstract: The invention relates to methods for analyzing polysaccharides. In particular, compositional and sequence information about the polysaccharides are derived. Some methods use NMR in conjunction with another experimental method, such as, capillary electrophoretic techniques for the analysis.
    Type: Application
    Filed: October 29, 2008
    Publication date: February 19, 2009
    Applicant: Massachusetts Institute of Technology
    Inventors: RAM SASISEKHARAN, Ganesh Venkataraman, Rahul Raman, Benito Casu, Giangiacomo Torri, Marco Guerrini
  • Publication number: 20080312575
    Abstract: The present invention regards the use of hemofilters for the removal of bacterial toxins (lipopolysaccharides) from the blood, said hemofilters comprising a solid support to which cyclodextrins are covalently bonded. The solid support can be a fabric or non-woven fabric or a polymeric resin obtained by means of cross-linking of the cyclodextrins with appropriate cross-linking agents, for example epichlorohydrin.
    Type: Application
    Filed: July 27, 2006
    Publication date: December 18, 2008
    Inventors: Giorgio Graziani, Annamaria Naggi, Giangiacomo Torri
  • Publication number: 20080278164
    Abstract: The invention relates to methods for analyzing polysaccharides. In particular, compositional and sequence information about the polysaccharides are derived. Some methods use NMR in conjunction with another experimental method, such as, capillary electrophoretic techniques for the analysis.
    Type: Application
    Filed: June 24, 2008
    Publication date: November 13, 2008
    Applicant: Massachusetts Institute of Technology
    Inventors: Ram Sasisekharan, Ganesh Venkataraman, Rahul Raman, Benito Casu, Giangiacomo Torri, Marco Guerrini
  • Publication number: 20080139503
    Abstract: Partially desulphated glycosaminoglycan derivatives are described, particularly heparin, and more particularly a compound of formula (I) where the U, R and R1 groups have the meanings indicated in the description. These glycosaminoglycan derivatives have antiangiogenic and heparanase-inhibiting activity and are devoid of anticoagulant activity.
    Type: Application
    Filed: October 31, 2007
    Publication date: June 12, 2008
    Applicant: SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.p.A.
    Inventors: Benito Casu, Giangiacomo Torri, Anna Maria Naggi, Giuseppe Giannini, Claudio Pisano, Sergio Penco
  • Publication number: 20080051567
    Abstract: Partially desulphated glycosaminoglycan derivatives are described, particularly heparin, and more particularly a compound of formula (I) where the U, R and R1 groups have the meanings indicated in the description. These glycosaminoglycan derivatives have antiangiogenic and heparanase-inhibiting activity and are devoid of anticoagulant activity.
    Type: Application
    Filed: August 8, 2007
    Publication date: February 28, 2008
    Applicant: Sigma-Tau Industrie FarmaceuticheRiunite S.p.A.
    Inventors: Benito Casu, Giangiacomo Torri, Anna Naggi, Giuseppe Giannini, Claudio Pisano, Sergio Penco
  • Patent number: 7208479
    Abstract: The present invention provides a peritoneal dialysis solution that contains heat stable osmotic agents such as D-glucitols, gluconic acids and alkylglycosides produced the reduction, oxidation or glycosylation of icodextrins respectively. As a result, osmotic agents that are stable under autoclaving or heat sterilization conditions are provided which reduces the amount of bioincompatible materials in the sterilized peritoneal dialysis solutions. Methods of preparing the D-glucitols, gluconic acids and alkylglycosides are disclosed.
    Type: Grant
    Filed: April 14, 2004
    Date of Patent: April 24, 2007
    Assignee: Baxter International, Inc.
    Inventors: Annamaria Naggi, Enrico Petrella, Giangiacomo Torri, Benito Casu
  • Publication number: 20070082869
    Abstract: The present invention is directed to a multistep process for the physical depolymerization of heparin wherein heparin is subjected to at least two ?-ray irradiations and wherein between two irradiation steps the depolymerised heparin is subjected to a separation step and only a fraction of the depolymerised heparin obtained from the first irradiation is subjected to the second irradiation step. It is also directed to heparin-derived oligosaccharide fractions obtainable by the process of the invention.
    Type: Application
    Filed: April 13, 2006
    Publication date: April 12, 2007
    Inventors: Luigi De Ambrosi, Sergio Gonella, Donata Bensi, Giangiacomo Torri, Antonella Bisio, Elena Vismara
  • Publication number: 20060172968
    Abstract: Partially desulphated glycosaminoglycan derivatives are described, particularly heparin, and more particularly a compound of formula (I) where the U, R and R1 groups have the meanings indicated in the description. These glycosaminoglycan derivatives have antiangiogenic and heparanase-inhibiting activity and are devoid of anticoagulant activity.
    Type: Application
    Filed: December 22, 2005
    Publication date: August 3, 2006
    Inventors: Benito Casu, Giangiacomo Torri, Anna Maria Naggi, Giuseppe Giannini, Claudio Pisano, Sergio Penco
  • Patent number: 7005508
    Abstract: The present invention provides a new class of compounds presenting a high compatibility with tissues and organic fluids. Such new compounds are polysaccharides essentially formed of units of uronic acid and/or hexosamine, containing nitro groups —ONO2 covalently bonded to the saccharide structure. Preferably, the polysaccharides according to the invention are prevalently formed of disaccharide repeating units formed of uronic acid and hexosamine. These compounds, in psychological conditions, selectively release NO, allowing a reduction in the amount of NO needed to achieve a determined therapeutical effect. This result has been achieved by functionalizing polysaccharides essentially formed of units of uronic acid and/or hexosamine, with subsituents containing a ONO2 ? group.
    Type: Grant
    Filed: August 10, 2001
    Date of Patent: February 28, 2006
    Assignee: NicOx S.A.
    Inventors: Francesca Benedini, Benito Casu, Piero Del Soldato, Paolo Gresele, Annamaria Naggi, Giangiacomo Torri, Simona Venturini
  • Publication number: 20050222084
    Abstract: Partially desulfated glycosaminoglycan derivatives are described, particularly heparin, and more particularly formula (I) compounds where the U, R and R1 groups have the meanings indicated in the description. These glycosaminoglycan derivatives exhibit antiangiogenic activity and are devoid of anticoagulant activity.
    Type: Application
    Filed: January 4, 2005
    Publication date: October 6, 2005
    Applicant: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Benito Casu, Giangiacomo Torri, Anna Naggi, Giuseppe Giannini, Claudio Pisano, Sergio Penco
  • Publication number: 20050137167
    Abstract: Partially desulphated glycosaminoglycan derivatives are described, particularly heparin, and more particularly formula (I) compounds where the U, R and R1 groups have the meanings indicated in the description. Said glycosaminoglycan derivatives are endowed with antiangiogenic and heparanase-inhibiting activity ans are devoid of anticoagulant activity.
    Type: Application
    Filed: September 12, 2001
    Publication date: June 23, 2005
    Inventors: Benito Casu, Giangiacomo Torri, Annamaria Naggi, Claudio Pisano, Giuseppe Giannini, Sergio Penco
  • Publication number: 20050108832
    Abstract: The invention concerns a method for functionalizing polysaccharides using a source or free radicals which forms stable radicals on the polysaccharides structure and wherein the formed radicals reacts with a functionalized unsaturated compound, characterized in that the method comprises two steps: a first step, wherein the free radical on the polysaccharide chain is formed, and a second step, wherein said radical reacts with the unsaturated compound in the absence of the radical source. The invention also relates to the functionalized polysaccharide obtained by this process.
    Type: Application
    Filed: March 20, 2003
    Publication date: May 26, 2005
    Inventors: Giangiacomo Torri, Elena Vismara, Alberti Angelo, Bertini Sabrina, Ciardelli Gianluca, Gastaldi Giuseppe, Nesti Solitario
  • Publication number: 20040192648
    Abstract: The present invention provides a peritoneal dialysis solution that contains heat stable osmotic agents such as D-glucitols, gluconic acids and alkylglycosides produced the reduction, oxidation or glycosylation of icodextrins respectively. As a result, osmotic agents that are stable under autoclaving or heat sterilization conditions are provided which reduces the amount of bioincompatible materials in the sterilized peritoneal dialysis solutions. Methods of preparing the D-glucitols, gluconic acids and alkylglycosides are disclosed.
    Type: Application
    Filed: April 14, 2004
    Publication date: September 30, 2004
    Inventors: Annamaria Naggi, Enrico Petrella, Giangiacomo Torri, Benito Casu
  • Patent number: 6770148
    Abstract: The present invention provides a peritoneal dialysis solution that contains heat stable osmotic agents such as D-glucitols, gluconic acids and alkylglycosides produced the reduction, oxidation or glycosylation of icodextrins respectively. As a result, osmotic agents that are stable under autoclaving or heat sterilization conditions are provided which reduces the amount of bioincompatible materials in the sterilized peritoneal dialysis solutions. Methods of preparing the D-glucitols, gluconic acids and alkylglycosides are disclosed.
    Type: Grant
    Filed: December 4, 1998
    Date of Patent: August 3, 2004
    Assignee: Baxter International Inc.
    Inventors: Annamaria Naggi, Enrico Petrella, Giangiacomo Torri, Benito Casu
  • Publication number: 20040092037
    Abstract: The invention relates to methods for analyzing polysaccharides. In particular, compositional and sequence information about the polysaccharides are derived. Some methods use NMR in conjunction with another experimental method, such as, capillary electrophoretic techniques for the analysis.
    Type: Application
    Filed: May 20, 2003
    Publication date: May 13, 2004
    Inventors: Ram Sasisekharan, Ganesh Venkataraman, Rahul Raman, Benito Casu, Giangiacomo Torri, Marco Guerrini
  • Publication number: 20040072798
    Abstract: The present invention relates to composition comprising cyclodextrins and a NO-releasing drug of formula, A-X-L-NOn, wherein A is the radical deriving from a drug; X is a divalent radical connecting A with the NO-releasing group L-NOn; L is selected from the group consisting of: O and S; n is 1 or 2.
    Type: Application
    Filed: October 15, 2003
    Publication date: April 15, 2004
    Inventors: AnnaMaria Naggi, Giangiacomo Torri, Laura Trespidi